Iron specific growth inhibition of Burkitt's lymphoma cells in vitro, associated with a decrease in translocated c-myc expression.

abstract：:The role of cyclic adenosine monophosphate (cAMP) is poorly understood in the regulation of normal and abnormal hepatic cell growth. In this study, we examined the regulation of intracellular cAMP levels and its effect on nuclear cAMP responsive elements (CREs) in a rat model of hepatocellular carcinoma (HCC). Tumorig...

journal_title：Journal of cellular physiology

authors： Kovach SJ,Price JA,Shaw CM,Theodorakis NG,McKillop IH

更新日期：2006-02-01 00:00:00

abstract：:C6 glioma cells possess beta adrenergic receptors coupled with adenylate cyclase which can be irreversibly blocked by bromoacetylaminomethylpindolol (Br-AAM-pindolol), a beta adrenergic antagonist. With 1 microM Br-AAM-pindolol, more than 80% of beta adrenergic receptors, labeled by (3H)-dihydroalprenolol [3H)-DHA), w...

journal_title：Journal of cellular physiology

authors： Homburger V,Pantaloni C,Lucas M,Gozlan H,Bockaert J

更新日期：1984-12-01 00:00:00

abstract：:Ovarian cancer (OC) is a fatal cancer in women, mainly due to its aggressive nature and poor survival rate. The lncRNA-miRNA-mRNA (long noncoding RNA-microRNA-messenger RNA) interaction is promising biomarkers for the improving prognosis of OC. Therefore, we explored the regulatory mechanism of WDFY3-AS2/miR-18a/RORA ...

journal_title：Journal of cellular physiology

authors： Li W,Ma S,Bai X,Pan W,Ai L,Tan W

更新日期：2020-02-01 00:00:00

abstract：:Aberrant promoter hypermethylation of several known or putative tumor suppressor genes occurs frequently during the etiopathogenesis of lung cancer and is a promising tool for cancer detection. In the present study, promoter hypermethylation of p16INK4A and CDH13 genes was investigated in tumor tissue and in matched s...

journal_title：Journal of cellular physiology

authors： Ulivi P,Zoli W,Calistri D,Fabbri F,Tesei A,Rosetti M,Mengozzi M,Amadori D

更新日期：2006-03-01 00:00:00

abstract：:Sirtuins are a family of enzymes, which govern a number of cellular processes essential for maintaining physiological balance. SIRT6, a nuclear sirtuin, is implicated in the development of metabolic disorders. The role of SIRT6 in regulation of cardiac metabolism is unexplored. Although glucose is not the primary ener...

journal_title：Journal of cellular physiology

authors： Khan D,Sarikhani M,Dasgupta S,Maniyadath B,Pandit AS,Mishra S,Ahamed F,Dubey A,Fathma N,Atreya HS,Kolthur-Seetharam U,Sundaresan NR

更新日期：2018-07-01 00:00:00

abstract：:The myelin basic protein (MBP) gene contains sequences located upstream of its transcription start site which play a key role in glial-specific transcription of the MBP promoter. Earlier analysis of the 320 bp upstream regulatory sequence of MBP has revealed multiple cis-acting regulatory motifs which differentially r...

journal_title：Journal of cellular physiology

authors： Haque NS,Haas S,Knobler RL,Khalili K

更新日期：1995-05-01 00:00:00

abstract：:The effect of retinoic acid on human fibroblasts was studied in a cell culture model of chronologic aging and photoaging. During early exponential phase, all trans-retinoic acid significantly stimulated growth rate of adult arm-derived dermal fibroblasts but not of newborn or adult foreskin-derived fibroblasts. Retino...

journal_title：Journal of cellular physiology

authors： Stanulis-Praeger BM,Gilchrest BA

更新日期：1989-04-01 00:00:00

abstract：:Nerve-evoked contractile activity in skeletal muscle regulates transcript and protein levels of many metabolic genes in a coordinate fashion, including the muscle isozyme of glycogen phosphorylase (MGP). Cellular signaling mechanisms mediating the activity-dependent modulation of MGP transcript levels were investigate...

journal_title：Journal of cellular physiology

authors： Vali S,Carlsen R,Pessah I,Gorin F

更新日期：2000-11-01 00:00:00

abstract：:Myocardin is a transcriptional co-activator of serum response factor (SRF) and can be degraded through ubiquitin-proteasome system. Our preliminary studies unexpectedly revealed that accumulation of myocardin in response to proteasome inhibition by MG132 or lactacystin resulted in decrease of transcriptional activity ...

journal_title：Journal of cellular physiology

authors： Yin H,Jiang Y,Li H,Li J,Gui Y,Zheng XL

更新日期：2011-07-01 00:00:00

abstract：:Cardiac fibrosis is a pathological remodeling response to myocardial infarction (MI) and impairs cardiac contractility. Long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is increased in patients with MI. However, the functions of MALAT1 in cardiac fibrosis have not been elucid...

journal_title：Journal of cellular physiology

authors： Huang S,Zhang L,Song J,Wang Z,Huang X,Guo Z,Chen F,Zhao X

更新日期：2019-03-01 00:00:00

abstract：:Drug discovery is an onerous, extremely expensive, and time-consuming process. Instead, drug repurposing is an attractive strategy for exploiting novel indications for a drug beyond its original use. The untapped potential of drug repurposing compensates the barriers associated with the drug discovery pipeline. Psoria...

journal_title：Journal of cellular physiology

authors： Thatikonda S,Pooladanda V,Godugu C

更新日期：2020-06-01 00:00:00

abstract：:Serum-free mouse embryo cells, cultured in basal nutrient medium supplemented with insulin, transferrin, epidermal growth factor, fibronectin, and high-density lipoprotein, do not exhibit growth crisis, lack detectable chromosomal aberrations, are nontumorigenic in vivo, are dependent on epidermal growth factor for su...

journal_title：Journal of cellular physiology

authors： Shirahata S,Rawson C,Loo D,Chang YJ,Barnes D

更新日期：1990-07-01 00:00:00

abstract：:Although glucocorticoids strongly affect numerous biological processes including cell growth, development, and homeostasis, their effects on migration of human mesenchymal stem cells (hMSCs) are unclear. Therefore, we investigated the role of dexamethasone (DEX) and its related signaling pathways on migration of hMSCs...

journal_title：Journal of cellular physiology

authors： Yun SP,Ryu JM,Han HJ

更新日期：2011-03-01 00:00:00

abstract：:Adipose-derived stem cells (ADSCs) are a type of mesenchymal stem cells isolated from adipose tissue and have the ability to differentiate into adipogenic, osteogenic, and chondrogenic lineages. Despite their great therapeutic potentials, previous studies showed that ADSCs could enhance the proliferation and metastati...

journal_title：Journal of cellular physiology

authors： Chan YW,So C,Yau KL,Chiu KC,Wang X,Chan FL,Tsang SY

更新日期：2020-10-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is a common urinary neoplasm, looking for useful candidates to establish scientific foundation for the therapy of ccRCC is urgent. We downloaded genomic profiles of GSE781, GSE6244, GSE53757, and GSE66271 from the Gene Expression Omnibus (GEO) database. GEO2R was used to analyze...

journal_title：Journal of cellular physiology

authors： Xu S,Zhang H,Liu T,Chen Y,He D,Li L

更新日期：2019-11-01 00:00:00

abstract：:Acidic pH of the Golgi lumen is known to be crucial for correct glycosylation, transport and sorting of proteins and lipids during their transit through the organelle. To better understand why Golgi acidity is important for these processes, we have examined here the most pH sensitive events in N-glycosylation by seque...

journal_title：Journal of cellular physiology

authors： Rivinoja A,Hassinen A,Kokkonen N,Kauppila A,Kellokumpu S

更新日期：2009-07-01 00:00:00

abstract：:Resistin, firstly reported as an adipocyte-specific hormone, is suggested to be an important link between obesity and diabetes. Recent studies have suggested an association between resistin and atherogenic processes. The adhesion of circulating monocytes to endothelial cells is a critical step in the early stages of a...

journal_title：Journal of cellular physiology

authors： Hsu WY,Chao YW,Tsai YL,Lien CC,Chang CF,Deng MC,Ho LT,Kwok CF,Juan CC

更新日期：2011-08-01 00:00:00

abstract：:Many critical factors such as hypoxia, nutrient deficiency, activation of glycolytic pathway/Warburg effect contribute to the observed low pH in tumors compared to normal tissue. Studies suggest that such tumor specific acidic environment can be exploited for the development of therapeutic strategies against cancer. I...

journal_title：Journal of cellular physiology

authors： Shamim U,Hanif S,Albanyan A,Beck FW,Bao B,Wang Z,Banerjee S,Sarkar FH,Mohammad RM,Hadi SM,Azmi AS

更新日期：2012-04-01 00:00:00

abstract：:Elevated levels of follistatin-like protein 1 (FSTL1) have been found both in mouse models for human rheumatoid arthritis (RA) and collagen-induced arthritis (CIA). In this study, we elucidated the potential mechanisms by which FSTL1 contributes to the pathogenesis of RA. Fibroblast-like synoviocytes (FLSs) were estab...

journal_title：Journal of cellular physiology

authors： Ni S,Li C,Xu N,Liu X,Wang W,Chen W,Wang Y,van Wijnen AJ

更新日期：2018-01-01 00:00:00

abstract：:Exposure of cultured endothelial cells to endotoxin causes an increase in the amount of cellular heparan sulfate proteoglycan and a depletion of this molecule in the extracellular matrix. Concomitant with the decrease in the extracellular matrix is the appearance of a fraction of proteoglycan bearing altered carbohydr...

journal_title：Journal of cellular physiology

authors： Colburn P,Kobayashi E,Buonassisi V

更新日期：1994-04-01 00:00:00

abstract：:Pathological calcification represents an event that consequently leads to a distinct elevation in the morbidity and mortality of patients with chronic kidney disease (CKD) in addition to strengthening its correlation with hyperphosphatemia. Epigenomic regulation by specific microRNAs (miRNAs) is reported to be involve...

journal_title：Journal of cellular physiology

authors： Xu TH,Qiu XB,Sheng ZT,Han YR,Wang J,Tian BY,Yao L

更新日期：2019-08-01 00:00:00

abstract：:Ephrin A1 has a role in a variety of biological events, including cell proliferation, differentiation, migration, and angiogenesis. Ephrin A1 expression is abundant in trophoblasts and endometrial cells during the implantation period; however, its intracellular activities have not yet been reported in bovine endometri...

journal_title：Journal of cellular physiology

authors： Lim W,Bae H,Bazer FW,Song G

更新日期：2019-04-01 00:00:00

abstract：:The untransformed stable cell line Met murine hepatocytes (MMH), generated from liver explants of transgenic mice expressing a constitutively active truncated form of the human hepatocyte growth factor receptor (cyto-Met), represents an innovative tool for in vitro studies of liver function. In the present report, we ...

journal_title：Journal of cellular physiology

authors： Bellovino D,Lanyau Y,Garaguso I,Amicone L,Cavallari C,Tripodi M,Gaetani S

更新日期：1999-10-01 00:00:00

abstract：:The zafirlukast has been reported to be anti-inflammatory and widely used to alleviate the symptoms of asthma. However, its influence on insulin secretion in pancreatic β-cells has not been investigated. Herein, we examined the effects of zafirlukast on insulin secretion and the potential underlying mechanisms. Among ...

journal_title：Journal of cellular physiology

authors： Hwang HJ,Park KS,Choi JH,Cocco L,Jang HJ,Suh PG

更新日期：2018-11-01 00:00:00

abstract：:Formation of human T lymphocyte colonies in semisolid medium from T lymphocyte colony-forming units (TL-CFUs) under stimulation of phytohemagglutinin (PHA) has been reported by several authors. These TL-CFUs were present in unsensitized lymphocyte populations. We report here that such TL-CFUs are capable of renewing t...

journal_title：Journal of cellular physiology

authors： Wu AM

更新日期：1983-10-01 00:00:00

abstract：:The percentage of T and B lymphocytes expressing a distinct cytoplasmic aggregate enriched in spectrin, ankyrin, and in several other proteins including protein kinase C greatly increases following various activation protocols. Members of the 70 kDa family of heat shock proteins (hsp70) temporarily bind to and stabili...

journal_title：Journal of cellular physiology

authors： Di YP,Repasky E,Laszlo A,Calderwood S,Subjeck J

更新日期：1995-11-01 00:00:00

abstract：:Normal FBAE AG 7680 cells and chemically transformed FBAE GM 7373 cells were compared for their capacity to produce and to respond to bFGF. Normal FBAE cells showed higher levels of bFGF protein and of poly(A)+ bFGF mRNA than transformed GM 7373 cells, indicating that chemical transformation in FBAE cells is parallele...

journal_title：Journal of cellular physiology

authors： Presta M,Maier JA,Rusnati M,Ragnotti G

更新日期：1989-12-01 00:00:00

abstract：:The effect of cell culture age and concomitant changes in cell density on the biosynthesis of sulfated-proteoglycan by rabbit articular chondrocytes in secondary monolayer culture was studied. Low density (LD, 2 d), middle density (MD, 5-7 d), and high density (HD, 12-15 d) cultures demonstrated changes in cellular mo...

journal_title：Journal of cellular physiology

authors： Malemud CJ,Papay RS

更新日期：1984-12-01 00:00:00

abstract：:We determined whether the multi-kinase inhibitor sorafenib or its derivative regorafenib interacted with phosphodiesterase 5 (PDE5) inhibitors such as Viagra (sildenafil) to kill tumor cells. PDE5 and PDGFRα/β were over-expressed in liver tumors compared to normal liver tissue. In multiple cell types in vitro sorafeni...

journal_title：Journal of cellular physiology

authors： Tavallai M,Hamed HA,Roberts JL,Cruickshanks N,Chuckalovcak J,Poklepovic A,Booth L,Dent P

更新日期：2015-09-01 00:00:00

abstract：:Arterial smooth muscle cells undergo marked biochemical and morphological changes upon culturing. We have studied the time course of these changes in smooth muscle cells isolated from normal rabbit aortas by enzymic digestion and then maintained in Dulbecco's modified Eagle's medium with or without 10% rabbit serum. S...

journal_title：Journal of cellular physiology

authors： Yau-Young AO,Shio H,Fowler S

更新日期：1981-09-01 00:00:00