Clonal hematopoiesis: Genes and underlying mechanisms in cardiovascular disease development.

abstract：:It has been reported by us and other groups that the expression of small GTP binding protein RhoB can be induced by genotoxic stressors and glucocorticoid (GC), a stress hormone that plays a key role in stress response. Until now stress-induced genes that confer cytoprotection under stressed conditions are largely unk...

journal_title：Journal of cellular physiology

authors： Li YD,Liu YP,Cao DM,Yan YM,Hou YN,Zhao JY,Yang R,Xia ZF,Lu J

更新日期：2011-03-01 00:00:00

abstract：:CRSBP-1 (mammalian LYVE-1) is a membrane glycoprotein highly expressed in lymphatic endothelial cells (LECs). It has multiple ligands, including hyaluronic acid (HA) and growth factors/cytokines (e.g., PDGF-BB and VEGF-A) containing CRS motifs (clusters of basic amino-acid residues). The ligand binding activities are ...

journal_title：Journal of cellular physiology

authors： Huang SS,Li YW,Wu JL,Johnson FE,Huang JS

更新日期：2018-04-01 00:00:00

abstract：:The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is a pleiotropic enzyme involved in DNA repair, cell cycle control, and transcription regulation. A potential role for DNA-PKcs in the regulation of osteoblastogenesis remains to be established. We show that pharmacological inhibition of DNA-PKcs kinase ...

journal_title：Journal of cellular physiology

authors： Farhat T,Dudakovic A,Chung JH,van Wijnen AJ,St-Arnaud R

更新日期：2021-02-01 00:00:00

abstract：:miR-142a-5p plays critical roles in multiple biological processes and diseases, such as inflammation and tumorigenesis. However, it remains to be explored if and how miR-142a-5p contributes to osteoblast differentiation. In this study, our results showed that miR-142a-5p was highly expressed in bone tissue of mice and...

journal_title：Journal of cellular physiology

authors： Yuan H,Li M,Feng X,Zhu E,Wang B

更新日期：2021-03-01 00:00:00

abstract：:Considering the high rate of osteoclast-related diseases worldwide, research targeting osteoclast formation/function is crucial. In vitro, we demonstrated that chitooligosaccharide (CS) dramatically inhibited osteoclastogenesis as well as osteoclast function dose-dependently. CS suppressed osteoclast-specific genes ex...

journal_title：Journal of cellular physiology

authors： Xu W,Chen X,Wang Y,Fan B,Guo K,Yang C,Yu S,Pang Y,Zhang S

更新日期：2020-03-01 00:00:00

abstract：:Increased oxidative stress contributes to pathogenesis of Parkinson's disease (PD). 8-hydroxy-2'-deoxyguanosine (8-OHdG) is the oxidation product most frequently measured as an indicator of oxidative DNA damage. Several studies have shown increased 8-OHdG in PD patients. There are few basic laboratory data examining 8...

journal_title：Journal of cellular physiology

authors： Kikuchi Y,Yasuhara T,Agari T,Kondo A,Kuramoto S,Kameda M,Kadota T,Baba T,Tajiri N,Wang F,Tayra JT,Liang H,Miyoshi Y,Borlongan CV,Date I

更新日期：2011-05-01 00:00:00

abstract：:We have shown in the present study and in studies reported previously that preneoplastic and neoplastic rat tracheal epithelial (RTE) cell lines express TGF alpha and do so regardless of the mechanism by which they were transformed. In order to determine whether TGF alpha is an autocrine growth regulator of immortaliz...

journal_title：Journal of cellular physiology

authors： Ferriola PC,Earp HS,Di Augustine R,Nettesheim P

更新日期：1991-04-01 00:00:00

abstract：:Glioblastoma multiforme is the most common and aggressive primary brain cancer with only ∼3% of patients surviving more than 3 years from diagnosis. Several mechanisms are involved in drug and radiation resistance to anticancer treatments and among them one of the most important factors is the tumor microenvironment s...

journal_title：Journal of cellular physiology

authors： Barbarisi M,Iaffaioli RV,Armenia E,Schiavo L,De Sena G,Tafuto S,Barbarisi A,Quagliariello V

更新日期：2018-10-01 00:00:00

abstract：:Cellular growth has been found to be directly related to the amount of sodium pumping activity in mouse lymphoblasts (L5178-Y) cultured in varying concentrations of the cardiac glycoside, ouabain. No short-term adaptation (within one generation) occured; i.e., neither growth rate nor (Na+ + K+)-ATPase activity increas...

journal_title：Journal of cellular physiology

authors： Shank BB,Smith NE

更新日期：1976-03-01 00:00:00

abstract：:To date, little is known concerning the promyelocytic leukemia gene (PML) status in tumors of different origin, and its expression has never been evaluated in soft tissue sarcoma. The aim of the present study is focused on the identification of differences in terms of PML protein expression between different types of ...

journal_title：Journal of cellular physiology

authors： Vincenzi B,Perrone G,Santini D,Grosso F,Silletta M,Frezza A,Rossi S,Russo A,Rabitti C,Gebbia N,Badalamenti G,Casali P,Muda AO,Dei Tos AP,Tonini G

更新日期：2010-09-01 00:00:00

abstract：:Insulin was employed as a stimulant in our continuing investigations of the molecular mechanisms involved in the coordinate control of cellular metabolism and growth. Incubation of chicken embryo fibroblasts for 16 hours in media containing 0-0.1 U insulin/ml resulted in a 17-fold increase in the rate of 3H-thymidine ...

journal_title：Journal of cellular physiology

authors： Sanui H,Rubin AH

更新日期：1978-09-01 00:00:00

abstract：:Relative to their normal counterparts, transformed epithelial cells have a distinctive and quantifiable three-dimensional shape. Biophysical and mathematical methods are used to distinguish these extremes in cells from two lines, cultured from rat liver and tracheal epithelium, respectively. Cells adopted a more trans...

journal_title：Journal of cellular physiology

authors： Heckman CA,Plummer HK 3rd,Runyeon CS

更新日期：1996-01-01 00:00:00

abstract：:Tumor necrosis factor-α (TNF-α) is a pluripotent signaling molecule. The biological effect of TNF-α includes slowing down osteogenic differentiation, which can lead to bone dysplasia in long-term inflammatory microenvironments. Signal transducer and activator of transcription 3 (STAT3)-interacting protein 1 (StIP1, al...

journal_title：Journal of cellular physiology

authors： Xu CP,Sun HT,Yang YJ,Cui Z,Wang J,Yu B,Wang FZ,Yang QP,Qi Y

更新日期：2019-08-01 00:00:00

abstract：:The actin- and myosin-binding protein, caldesmon (CaD) is an essential component of the cytoskeleton in smooth muscle and non-muscle cells and is involved in the regulation of cell contractility, division, and assembly of actin filaments. CaD is abundantly present in endothelial cells (EC); however, the contribution o...

journal_title：Journal of cellular physiology

authors： Mirzapoiazova T,Kolosova IA,Romer L,Garcia JG,Verin AD

更新日期：2005-06-01 00:00:00

abstract：:Rous sarcoma virus (RSV)-infected chicken embryo cells were used to study the effect of viral transformation on the hormone-stimulated synthesis of cyclic AMP. Transformation by RSV greatly increased the cells' ability to synthesize and accumulate cyclic AMP in response to the beta-adrenergic agonist isoproterenol as ...

journal_title：Journal of cellular physiology

authors： Howard RF,Friis RR,Sheppard JR,Glossmann H

更新日期：1982-06-01 00:00:00

abstract：:Butyrate and acetate are bacterial metabolites present in the large intestine lumen. Although butyrate is well known to inhibit the in vitro proliferation of human colon carcinoma cells in a process involving the hyperacetylation of specific nuclear histones, little is known about the possible link between butyrate me...

journal_title：Journal of cellular physiology

authors： Andriamihaja M,Chaumontet C,Tome D,Blachier F

更新日期：2009-01-01 00:00:00

abstract：:Production of inflammatory cytokines plays important roles in the response against tissue injury and in host defense. Alterations in the production of inflammatory cytokines may cause local or systemic inflammatory imbalance, culminating in organ failure or lethal systemic inflammation. The cholinergic anti-inflammato...

journal_title：Journal of cellular physiology

authors： Pereira MR,Leite PE

更新日期：2016-09-01 00:00:00

abstract：:Breast cancer, as the most common cancer in women which affects patients both mentally and physically, requires great attention in many areas and many levels as this cancer is known to be multifactorial. Single-stranded molecules called microRNAs with near 22 nucleotides are seen to act in central dogma of molecular b...

journal_title：Journal of cellular physiology

authors： Bahreini F,Rayzan E,Rezaei N

更新日期：2021-03-01 00:00:00

abstract：:Spiral artery remodeling at the maternal-fetal interface is crucial for successful pregnancy and requires the interaction between the first trimester trophoblast and the endothelial cells of the maternal vessels. However, the precise mechanism of this dialog has yet to be determined. The current study investigated whe...

journal_title：Journal of cellular physiology

authors： Beltrame JS,Scotti L,Sordelli MS,Cañumil VA,Franchi AM,Parborell F,Ribeiro ML

更新日期：2019-05-01 00:00:00

abstract：:Morphine, a mu-opioid receptor (MOR) agonist, has been extensively used to treat advanced cancer pain. In particular, in patients with cancer metastasis, both morphine and anticancer drugs are given simultaneously. However, evidence showed that morphine might be a risk factor in promoting the tumor's malignant potenti...

journal_title：Journal of cellular physiology

authors： Lu H,Zhang H,Weng ML,Zhang J,Jiang N,Cata JP,Ma D,Chen WK,Miao CH

更新日期：2020-11-13 00:00:00

abstract：:Proteasome inhibitors represent a promising therapy for the treatment of relapsed and/or refractory multiple myeloma, a disease that is concomitant with osteolysis and enhanced osteoclast formation. While blockade of the proteosome pathway has been recently shown to influence osteoclast formation and function, the pre...

journal_title：Journal of cellular physiology

authors： Ang E,Pavlos NJ,Rea SL,Qi M,Chai T,Walsh JP,Ratajczak T,Zheng MH,Xu J

更新日期：2009-08-01 00:00:00

abstract：:Nidogen/entactin is a Mr = 150,000 glycoprotein which is present within basement membranes in a noncovalent stable complex with laminin. We have studied the effects of nidogen/entactin complexed or not with laminin on attachment, spreading, and functions of adult rat hepatocytes in primary culture. Freshly isolated he...

journal_title：Journal of cellular physiology

authors： Levavasseur F,Mayer U,Guillouzo A,Clement B

更新日期：1994-11-01 00:00:00

abstract：:We report here that heptanol (3.5 mM) induces in vitro a rapid formation of smooth endoplasmic reticulum aggregates (SERA) within isolated islets of Langerhans. SERA appeared after only 15 min of exposure to the alkanol and increased in number during the first 30 min of incubation. At that time, SERA represented 2% an...

journal_title：Journal of cellular physiology

authors： Knodel S,Meda P,Orci L

更新日期：1987-10-01 00:00:00

abstract：:Our understanding of the mechanism of cell fate transition during the direct reprogramming of fibroblasts into various central nervous system (CNS) neural cell types has been limited by the lack of a comprehensive analysis on generated cells, independently and in comparison with other CNS neural cell types. Here, we a...

journal_title：Journal of cellular physiology

authors： Khazaei N,Rastegar-Pouyani S,O'Toole N,Wee P,Mohammadnia A,Yaqubi M

更新日期：2018-04-01 00:00:00

abstract：:The purpose of this study was to evaluate the possible involvement of the phosphoinositide 3-kinase (PI3K)/Akt survival pathway in determining resistance to arsenic trioxide (As2O3)-induced apoptosis. We employed a HL60 cell clone (HL60AR) with a constitutively active PI3K/Akt survival pathway, as well as U937 and K56...

journal_title：Journal of cellular physiology

authors： Tabellini G,Cappellini A,Tazzari PL,Falà F,Billi AM,Manzoli L,Cocco L,Martelli AM

更新日期：2005-02-01 00:00:00

abstract：:BA10-IR transformed cells, obtained by treating Syrian hamster embryo fibroblasts (HEF) with 7-methylbenz(a)anthracene and cultivated for a long period, are highly tumorigenic and grow in suspension as aggregates (spheroids) (Levy et al., 1976). They also grow in attached form or as spheroids in serum-free (S-) synthe...

journal_title：Journal of cellular physiology

authors： Xin LW,Jullien P,Lawrence DA,Pironin M,Vigier P

更新日期：1987-05-01 00:00:00

abstract：:We have observed that some of the DNA damage or damage product caused by irradiation of interphase cells persisted throughout the cell cycle, and resulted in the expression of gamma-H2AX foci on the mitotic chromosomes. These mitotic expressions of damage after gamma-irradiation of G1 or G2 phase cells were compared i...

journal_title：Journal of cellular physiology

authors： Kato TA,Okayasu R,Bedford JS

更新日期：2009-06-01 00:00:00

abstract：:Long-chain fatty acid (LCFA) movement into skeletal muscle involves a highly mediated process in which lipid rafts are utilized in the cellular membrane, involving numerous putative plasma membrane-associated LCFA transport proteins. The process of LCFA uptake and oxidation is of particular metabolic significance both...

journal_title：Journal of cellular physiology

authors： Jayewardene AF,Mavros Y,Reeves A,Hancock DP,Gwinn T,Rooney KB

更新日期：2016-08-01 00:00:00

abstract：:Migration and proliferation of smooth muscle cells (SMCs) are key events during neointimal formation in pathological conditions of vessels. Tenascin-C (TNC) is upregulated in the developing neointima of lesions. We evaluated the effects of TNC on responses of SMCs against platelet-derived growth factor (PDGF) stimulat...

journal_title：Journal of cellular physiology

authors： Ishigaki T,Imanaka-Yoshida K,Shimojo N,Matsushima S,Taki W,Yoshida T

更新日期：2011-10-01 00:00:00

abstract：:EL 4-6.1 cells, variants of the murine EL4 thymoma cell line, can be activated by interleukin 1 (IL-1) or phorbol 12-myristate-13-acetate (PMA), or PMA+IL-1 to secrete interleukin 2 (IL-2) and interleukin 4 (IL-4) and to express the IL-2 receptor (IL-2R). To compare the different activation pathways, we examined the e...

journal_title：Journal of cellular physiology

authors： Dornand J,Bouaboula M,d'Angeac AD,Favero J,Shire D,Casellas P

更新日期：1992-04-01 00:00:00