microRNA-related single-nucleotide polymorphisms and breast cancer.

Abstract:

:Breast cancer, as the most common cancer in women which affects patients both mentally and physically, requires great attention in many areas and many levels as this cancer is known to be multifactorial. Single-stranded molecules called microRNAs with near 22 nucleotides are seen to act in central dogma of molecular biology by inhibiting the translation process; it is demonstrated that any alteration in their sequence especially single-nucleotide polymorphisms (SNPs) may lead into increasing the breast cancer risk. miR-SNPs are considered to be the potential biomarkers for early detection of breast cancer. As a result, this review documents the well-known miR-SNPs that are known to be associated with breast cancer. In this regard, two principals were discussed: (a) SNPs in the target genes of microRNAs and the alteration in gene expression due to this phenomenon; (b) changes based on the SNPs in the microRNA coding region and the impact on their interaction with target messenger RNA.

journal_name

J Cell Physiol

authors

Bahreini F,Rayzan E,Rezaei N

doi

10.1002/jcp.29966

subject

Has Abstract

pub_date

2021-03-01 00:00:00

pages

1593-1605

issue

3

eissn

0021-9541

issn

1097-4652

journal_volume

236

pub_type

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