The STAT3/NFIL3 signaling axis-mediated chemotherapy resistance is reversed by Raddeanin A via inducing apoptosis in choriocarcinoma cells.

abstract：:Previous experimental and clinical studies have suggested that the behavioral and pathological outcomes of spinal cord injury (SCI) are affected by the individual's age at the time of injury. However, the underlying mechanism responsible for these differences remains elusive because it is difficult to match injuries o...

journal_title：Journal of cellular physiology

authors： Kumamaru H,Saiwai H,Ohkawa Y,Yamada H,Iwamoto Y,Okada S

更新日期：2012-04-01 00:00:00

abstract：:Cultured hepatic stellate cells (HSCs), the cell type primarily involved in the progression of liver fibrosis, secrete insulin-like growth factor-I (IGF-I) and IGF binding protein (IGFBP) activity. IGF-I exerts a mitogenic effect on HSCs, thus potentially contributing to the fibrogenic process in an autocrine fashion....

journal_title：Journal of cellular physiology

authors： Gentilini A,Feliers D,Pinzani M,Woodruff K,Abboud S

更新日期：1998-02-01 00:00:00

abstract：:In order to promote cell attachment, fibronectin must first undergo activation by a suitable substrate. In this study, 52 materials have been surveyed for their ability a) to bind fibronectin, b) to activate the cell-adhesive property of fibronectin, and c) to support the growth of cells. Many plastics, polysaccharide...

journal_title：Journal of cellular physiology

authors： Klebe RJ,Bentley KL,Schoen RC

更新日期：1981-12-01 00:00:00

abstract：:Properties of the change from asparagine dependence (asn-) to independence (asn+) were investigated in the androgenetic haploid frog cell line ICR 2A. Two types of asn+ variants arose spontaneously during culture. Glutamine-dependent asparagine synthetase (AS) activity, found to be deficient in asn- cells, was repress...

journal_title：Journal of cellular physiology

authors： Hepfer CE,Little WA,Hengst JA,Freed JJ

更新日期：1989-04-01 00:00:00

abstract：:The role of individual supplements necessary for the long-term self-renewal of embryonic stem (ES) cells is poorly characterized in feeder/serum-free culture systems. This study sought to characterize the relationship between the effects of glucose on ES cell proliferation and fibronectin (FN) synthesis, and to assess...

journal_title：Journal of cellular physiology

authors： Kim YH,Ryu JM,Lee YJ,Han HJ

更新日期：2010-05-01 00:00:00

abstract：:Chronic hyperglycemia and activation of receptor for advanced glycation end products (RAGE) are known risk factors for microvascular disease development in diabetic retinopathy. Thioredoxin-interacting protein (TXNIP), an endogenous inhibitor of antioxidant thioredoxin (TRX), plays a causative role in diabetes and its...

journal_title：Journal of cellular physiology

authors： Perrone L,Devi TS,Hosoya K,Terasaki T,Singh LP

更新日期：2009-10-01 00:00:00

abstract：:Ischemia is a situation occurring in several diseases including myocardial infarction and organ transplantation in which oxygenated blood supply is impaired. Ischemia leads to many cellular and tissue modifications, the most important one being cell death. Several explanations have been proposed to account for these m...

journal_title：Journal of cellular physiology

authors： Arnould T,Michiels C,Alexandre I,Remacle J

更新日期：1992-07-01 00:00:00

abstract：:Patent ductus arteriosus is the third most common congenital heart disease and resulted from the persistence of ductal patency after birth. Ductus arteriosus closure involves functional and structural remodeling, controlled by many factors. The changes in plasma protein levels associated with PDA closure are not known...

journal_title：Journal of cellular physiology

authors： Hou HT,Xi-Zhang,Wang J,Liu LX,Zhang JF,Yang Q,He GW

更新日期：2019-05-01 00:00:00

abstract：:NGF appears to be involved in spermatogenesis. However, mice lacking NGF or TrkA genes do not survive more than a few days whereas p75(NTR) knockout mice are viable and fertile. Therefore, we addressed the effect of betaNGF on spermatogenesis by using the systems of rat germ cell culture we established previously. bet...

journal_title：Journal of cellular physiology

authors： Perrard MH,Vigier M,Damestoy A,Chapat C,Silandre D,Rudkin BB,Durand P

更新日期：2007-01-01 00:00:00

abstract：:Genomic imprinting in gametogenesis marks a subset of mammalian genes for parent-of-origin-dependent monoallelic expression in the offspring. Embryological and classical genetic experiments in mice that uncovered the existence of genomic imprinting nearly two decades ago produced abnormalities of growth or behavior, w...

journal_title：Journal of cellular physiology

authors： Tycko B,Morison IM

更新日期：2002-09-01 00:00:00

abstract：:Using methods designed for isolation of mutants defective in receptor-mediated endocytosis, a novel L-cell mutant was obtained that exhibits resistance to three different protein toxins as well as alterations in secretion. This mutant, LEFIC, is resistant to modeccin, Pseudomonas exotoxin, and ricin. These toxins, whi...

journal_title：Journal of cellular physiology

authors： Laurie SM,Robbins AR

更新日期：1991-05-01 00:00:00

abstract：:The p21 activated kinases (Paks), an evolutionarily conserved family of serine/threonine kinases, are important for a variety of cellular functions including cell morphogenesis, motility, survival, mitosis, and angiogenesis. Paks are widely expressed in numerous tissues and are activated by growth factors and extracel...

journal_title：Journal of cellular physiology

authors： Kumar R,Vadlamudi RK

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) shows several kinds of disorders, which acutely harm the kidney. However, the current medical methods have limited therapeutic effects. The present study aimed to find out the molecular mechanism of AKI pathogenesis, which may provide new insights for future therapy. METHODS:Bioinf...

journal_title：Journal of cellular physiology

authors： Tian X,Ji Y,Liang Y,Zhang J,Guan L,Wang C

更新日期：2019-08-01 00:00:00

abstract：:BA10-IR transformed cells, obtained by treating Syrian hamster embryo fibroblasts (HEF) with 7-methylbenz(a)anthracene and cultivated for a long period, are highly tumorigenic and grow in suspension as aggregates (spheroids) (Levy et al., 1976). They also grow in attached form or as spheroids in serum-free (S-) synthe...

journal_title：Journal of cellular physiology

authors： Xin LW,Jullien P,Lawrence DA,Pironin M,Vigier P

更新日期：1987-05-01 00:00:00

abstract：:Tumor progression is characterized by loss of cell adhesion and increase of invasion and metastasis. The cell adhesion molecule E-cadherin is frequently down-regulated or mutated in tumors. In addition to down-regulation of cell adhesion, degradation of the extracellular matrix by matrix metalloproteinases is necessar...

journal_title：Journal of cellular physiology

authors： Fuchs M,Hermannstädter C,Specht K,Knyazev P,Ullrich A,Rosivatz E,Busch R,Hutzler P,Höfler H,Luber B

更新日期：2005-03-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) cells are characterised by their extreme chemoresistance. The activity of multiple-drug resistance (MDR) transporters that extrude antitumor drugs from cells plays the most important role in this phenomenon. To date, the mechanism controlling the expression and activity of MDR transporter...

journal_title：Journal of cellular physiology

authors： Quezada C,Garrido W,Oyarzún C,Fernández K,Segura R,Melo R,Casanello P,Sobrevia L,San Martín R

更新日期：2013-03-01 00:00:00

abstract：:The extracellular matrix (ECM) is a dynamic component of tissue architecture that physically supports cells and actively influences their behavior. In the context of bone regeneration, cell-secreted ECMs have become of interest as they reproduce tissue-architecture and modulate the promising properties of mesenchymal ...

journal_title：Journal of cellular physiology

authors： Baroncelli M,van der Eerden BC,Kan YY,Alves RD,Demmers JA,van de Peppel J,van Leeuwen JP

更新日期：2018-01-01 00:00:00

abstract：:Recent findings point to low oxygen tension (hypoxia) as an important mechanism for the expression of several eukaryotic genes. We have previously shown that hypoxia (2% O2), when compared to standard oxygen tension (20% O2), upregulates the mRNA levels of the human alpha1(I) (COL1A1) procollagen gene and transforming...

journal_title：Journal of cellular physiology

authors： Falanga V,Zhou L,Yufit T

更新日期：2002-04-01 00:00:00

abstract：:Cystamine together with colchicine markedly enhanced the uptake of [3H]-thymidine into DNA of quiescent cultures of insulin-stimulated Swiss 3T3 mouse fibroblasts. Flow cytofluorometric analyses showed an increased rate of transition of cells from G0/G1----S + G2 in response to combinations of insulin, colchicine, and...

journal_title：Journal of cellular physiology

authors： Fong S,Friedkin M

更新日期：1984-09-01 00:00:00

abstract：:Heparin-binding epidermal growth factor-like growth factor (HB-EGF) mRNA and protein expression is induced by EGF in MCF-10A nontransformed and Ha-ras transfected human mammary epithelial cells. The anti-EGF receptor (EGFR) blocking monoclonal antibody (MAb) 225 and the EGFR tyrosine kinase inhibitor PD153035 were abl...

journal_title：Journal of cellular physiology

authors： Martínez-Lacaci I,De Santis M,Kannan S,Bianco C,Kim N,Wallace-Jones B,Wechselberger C,Ebert AD,Salomon DS

更新日期：2001-02-01 00:00:00

abstract：:Urotensin II (UII), a vasoactive peptide modulates renal hemodynamics. However, the physiological functions of UII in glomerular cells are unclear. In particular, whether UII alters mesangial tone remains largely unknown. The present study investigates the physiological effects of UII on glomerular mesangial cells (GM...

journal_title：Journal of cellular physiology

authors： Adebiyi A

更新日期：2014-04-01 00:00:00

abstract：:The human neuroblastoma cell line SK-N-BE, after incubation with 10 microM retinoic acid (RA) or 20 nM phorbol 12-myristate 13-acetate (PMA), underwent biochemical and morphological signs of differentiation within 10-14 days. In parallel, SK-N-BE cells produced significantly higher amounts of nitric oxide (NO) in comp...

journal_title：Journal of cellular physiology

authors： Ghigo D,Priotto C,Migliorino D,Geromin D,Franchino C,Todde R,Costamagna C,Pescarmona G,Bosia A

更新日期：1998-01-01 00:00:00

abstract：:We have previously found progressive diabetic nephropathy in inducible cAMP early repressor (ICER Igamma) transgenic (Tg) mice. The ICER Igamma Tg mouse is an interesting model of sustained hyperglycemia due to its low production of insulin and insulin-producing beta cells. Here in a longitudinal study we further anal...

journal_title：Journal of cellular physiology

authors： Inada A,Kanamori H,Arai H,Akashi T,Araki M,Weir GC,Fukatsu A

更新日期：2008-05-01 00:00:00

abstract：:Mesenchymal stem/stromal cells (MSCs) have gained considerable popularity owing to the vast possibilities and lack of ethical constraints and risks normally associated with other stem cells, such as embryonic stem cells. However, they are morphologically indistinguishable from fibroblasts. This review aims to assess t...

journal_title：Journal of cellular physiology

authors： Soundararajan M,Kannan S

更新日期：2018-12-01 00:00:00

abstract：:Peptidoglycan (PGN) is a potent immune adjuvant derived from bacterial cell walls. Previous investigations suggest that intestinal epithelium may absorb PGN from the lumen. Nonetheless, how PGN is taken up and crosses intestinal epithelium remains largely unclear. Here, we first characterized PGN transport in vitro us...

journal_title：Journal of cellular physiology

authors： Bu HF,Wang X,Tang Y,Koti V,Tan XD

更新日期：2010-03-01 00:00:00

abstract：:Vero M3 cells, a line derived from the kidney of an African Green Monkey, display certain alterations in their protein synthetic apparatus as a function of time during a growth cycle. (Growth cycle here refers to exponential growth of unsynchronized cells in culture and their subsequent passage into the stationary pha...

journal_title：Journal of cellular physiology

authors： Engelhardt DL,Sarnoski J

更新日期：1975-08-01 00:00:00

abstract：:Myofibroblasts mediate normal wound healing and upon chronic activation can contribute to the development of pathological conditions including organ fibrosis and cancer. Myofibroblasts can develop from epithelial cells through an epithelial-mesenchymal transition (EMT) during which epithelial cells exhibit drastic mor...

journal_title：Journal of cellular physiology

authors： O'Connor JW,Riley PN,Nalluri SM,Ashar PK,Gomez EW

更新日期：2015-08-01 00:00:00

abstract：:Release of transcellular tension upon disruption of actin stress fibers with cytochalasin D (CD) and associated changes in cell morphology are reflected in the rapid transcription of "deformation-responsive" genes. For certain genes (e.g., urokinase plasminogen activator and its type-1 inhibitor PAI-1), de novo mRNA s...

journal_title：Journal of cellular physiology

authors： Samarakoon R,Higgins PJ

更新日期：2003-06-01 00:00:00

abstract：:Previous studies suggested that the decreased collagen production observed in Kirsten sarcoma virus (Ki-MSV)-transformed BALB 3T3 cells could be reversed by treating cells with Bt2cAMP. We examined the relationship between intracellular cAMP, collagen production, and other properties in NRK and BALB 3T3 cells transfor...

journal_title：Journal of cellular physiology

authors： Majmudar G,Peterkofsky B

更新日期：1985-01-01 00:00:00

abstract：:The basic fibroblast growth factor (FGF) is a potent mitogen that has vascular endothelium as one of its principle target cells. Recent work has provided both the complete amino acid sequence of basic FGF and the nucleotide sequence of the genes for both human and bovine basic FGF. Although capillary endothelial cells...

journal_title：Journal of cellular physiology

authors： Hanneken A,Lutty GA,McLeod DS,Robey F,Harvey AK,Hjelmeland LM

更新日期：1989-01-01 00:00:00