Lysophosphatidic acid induces the crosstalk between the endovascular human trophoblast and endothelial cells in vitro.

abstract：:Mutant forms of the p53 gene have been shown to cooperate with an activated ras gene in transforming primary cells in culture. The aberrant proteins encoded by p53 mutants are thought to act in a dominant negative manner in these assays. In vivo data, however, reveal that where p53 has undergone genetic change in tumo...

journal_title：Journal of cellular physiology

authors： Slingerland JM,Benchimol S

更新日期：1991-09-01 00:00:00

abstract：:The kinetic properties of partially purified ribonucleotide reductase from Chinese hamster ovary cells have been investigated. Double reciprocal plots of velocity against substrate concentration were found to be linear for three the substrates tested, and yielded apparent Km values of 0.12 mM for CDP, 0.14 mM for ADP ...

journal_title：Journal of cellular physiology

authors： Lewis WH,Wright JA

更新日期：1978-10-01 00:00:00

abstract：:The knowledge of transforming growth factor (TGF)-beta receptors has greatly progressed in the recent years. TGF-beta receptors type I and II have been implicated in the modulation of cell proliferation, whereas type III (betaglycan) may act as a component presenting TGF-beta to its signaling receptors. In addition, f...

journal_title：Journal of cellular physiology

authors： Vivien D,Petitfrère E,Martiny L,Sartelet H,Galéra P,Haye B,Pujol JP

更新日期：1993-06-01 00:00:00

abstract：:Deep vein thrombosis associated with advanced cancer is known as Trousseau's syndrome. We hypothesized that thrombin, an activator of protease-activated receptor (PAR)-1 and PAR-4 contributes to tumor metastasis. In this study, we demonstrated that thrombin and the PAR-1 activating peptide (AP) SFLLRN, but not the PAR...

journal_title：Journal of cellular physiology

authors： Chang LH,Chen CH,Huang DY,Pai HC,Pan SL,Teng CM

更新日期：2011-04-01 00:00:00

abstract：:Cyclosporine A (CyA) is a powerful nonsteroidal immunosuppressive agent used to prevent graft rejection of organ and bone marrow transplants. A major side effect observed can be attributed to the fibroblast and its functions: proliferation of fibroblasts and formation of fibrotic tissue in the gingiva (fibrous hyperpl...

journal_title：Journal of cellular physiology

authors： Willershausen-Zönnchen B,Lemmen C,Schumacher U

更新日期：1992-08-01 00:00:00

abstract：:Three-dimensional (3D) culture platforms have been explored to establish physiologically relevant cell culture environment and permit expansion scalability; however, little is known about the mechanisms underlying the regulation of pluripotency of human induced pluripotent stem cells (hiPSCs). This study elucidated ep...

journal_title：Journal of cellular physiology

authors： Thanuthanakhun N,Kino-Oka M,Borwornpinyo S,Ito Y,Kim MH

更新日期：2020-12-10 00:00:00

abstract：:MicroRNAs (miRNAs) is a small molecule (19-25 nucleotide) noncoding RNA that inhibits the expression of target messenger RNA (mRNA) at the posttranscriptional level as an endogenous regulator. There is an increasing evidence that miR-199a-3p has a significant effect on the development of multiple tumors. However, the ...

journal_title：Journal of cellular physiology

authors： Chen HP,Wen J,Tan SR,Kang LM,Zhu GC

更新日期：2019-12-01 00:00:00

abstract：:Endothelial cells are known to bind to laminin, and two peptides derived from the laminin A (CTFALRGDNP) and B1 (CDPGYIGSR) chains block the capillary-like tube formation on a laminin-rich basement membrane matrix, Matrigel. In the present study, we have used various in vitro and in vivo assays to investigate the angi...

journal_title：Journal of cellular physiology

authors： Grant DS,Kinsella JL,Fridman R,Auerbach R,Piasecki BA,Yamada Y,Zain M,Kleinman HK

更新日期：1992-12-01 00:00:00

abstract：:Vero (African green monkey kidney) cells grown in tissue culture monolayer were sensitive to Clostridium perfringens enterotoxin. Within 30 minutes of exposure to the enterotoxin gross morphological damage was observed and within 40 minutes approximately 75% of the cells had detached. Nearly half of the cells were non...

journal_title：Journal of cellular physiology

authors： McClane BA,McDonel JL

更新日期：1979-05-01 00:00:00

abstract：OBJECTIVE:Disc degeneration is the common life-threatening disease characterized by flank pain. The gene expression of insulin-like growth factor binding protein 3 (IGFBP3) is increased in patients with disc degeneration, however, its mechanism is still unknown. This study aimed to investigate the influence of IGFBP3 g...

journal_title：Journal of cellular physiology

authors： Chen G,Zhou X,Xu Z

更新日期：2019-06-01 00:00:00

abstract：:We have previously found progressive diabetic nephropathy in inducible cAMP early repressor (ICER Igamma) transgenic (Tg) mice. The ICER Igamma Tg mouse is an interesting model of sustained hyperglycemia due to its low production of insulin and insulin-producing beta cells. Here in a longitudinal study we further anal...

journal_title：Journal of cellular physiology

authors： Inada A,Kanamori H,Arai H,Akashi T,Araki M,Weir GC,Fukatsu A

更新日期：2008-05-01 00:00:00

abstract：:The increasing rate of mortality and morbidity because of cardiac diseases has called for efficient therapeutic needs. With the advancement in cell-based therapies, stem cells are abundantly studied in this area. Nearly, all sources of stem cells are experimented to treat cardiac injuries. Tissue engineering has also ...

journal_title：Journal of cellular physiology

authors： Pooria A,Pourya A,Gheini A

更新日期：2019-02-27 00:00:00

abstract：:MicroRNAs (miRNAs or miRs) are small noncoding RNAs that play critical roles in muscle cell proliferation and differentiation via post-transcriptional regulation of gene expression. Here, based on our previous high-throughput sequencing results, we evaluated miRNA-499 (miR-499) functions during myoblast proliferation ...

journal_title：Journal of cellular physiology

authors： Wu J,Yue B,Lan X,Wang Y,Fang X,Ma Y,Bai Y,Qi X,Zhang C,Chen H

更新日期：2019-03-01 00:00:00

abstract：:The advent of high throughput gene expression profiling, from microarrays to sequence based assays has yielded vast insight into the biology of tumors. New technologies are constantly being unveiled which promise to generate more accurate maps of tumor gene deregulation, and demand the development of new strategies in...

journal_title：Journal of cellular physiology

authors： Coe BP,Chari R,Lockwood WW,Lam WL

更新日期：2008-12-01 00:00:00

abstract：:Glial fibrillary acidic protein (GFAP) is an intermediate filament that is expressed in specifically expressed auricular chondrocytes, which are good cell sources of cartilage regenerative medicine. Although our group uses GFAP as a biomarker of matrix production in the cultured auricular chondrocytes, the biological ...

journal_title：Journal of cellular physiology

authors： Kanazawa S,Nishizawa S,Takato T,Hoshi K

更新日期：2017-11-01 00:00:00

abstract：:Vimentin-positive, desmin-negative cells were established in culture from the nodule and from apparently normal palmar aponeurosis of a patient with Dupuytren's disease and compared with normal human embryonic and adult fibroblasts or sarcomatous cells. Cells from the nodule display in vitro biological properties that...

journal_title：Journal of cellular physiology

authors： Azzarone B,Failly-Crepin C,Daya-Grosjean L,Chaponnier C,Gabbiani G

更新日期：1983-12-01 00:00:00

abstract：:The effects of kinin B1 receptor (B1 R) deletion were examined on femur bone regeneration in streptozotocin (STZ)-type 1 diabetes. Diabetes induction in wild-type C57/BL6 (WTC57BL6) mice led to decrease in body weight and hyperglycemia, compared to the non-diabetic group of the same strain. The lack of B1 R did not af...

journal_title：Journal of cellular physiology

authors： Cignachi NP,Pesquero JB,Oliveira RB,Etges A,Campos MM

更新日期：2015-12-01 00:00:00

abstract：:In vitro generation of HSCs from pluripotent stem cells (PSCs) can be regarded as novel therapeutic approaches for replacing bone marrow (BM) transplantation without immune rejection or graft versus host disease(GVHD). To date, many differentiation approaches have been evaluated in terms of directing PSCs toward diffe...

journal_title：Journal of cellular physiology

authors： Shan W,Wang B,Xu Y,Li X,Li X,Wang H,Lin Y,Tie R,Zhao Q,Wang J,Zheng W,Hu Y,Shi J,Yu X,Huang H

更新日期：2018-01-31 00:00:00

abstract：:Cells are quite sensitive to a change of the extracellular pH and respond to it through detection of the H+/HCO3- level in extracellular fluid. However, little is known about molecular details induced by acidosis, such as intracellular pathways and gene expression. Here we describe properties of gene expression, prote...

journal_title：Journal of cellular physiology

authors： Shimokawa N,Kumaki I,Qiu CH,Ohmiya Y,Takayama K,Koibuchi N

更新日期：2005-10-01 00:00:00

abstract：:Obesity, a rising public health burden, is a multifactorial disease with an increased risk for patients to develop several pathological conditions including type 2 diabetes mellitus, hypertension, and cardiovascular disease. Increasing evidence suggests a relationship between the human brain-derived neurotrophic facto...

journal_title：Journal of cellular physiology

authors： Ieraci A,Barbieri SS,Macchi C,Amadio P,Sandrini L,Magni P,Popoli M,Ruscica M

更新日期：2020-12-01 00:00:00

abstract：:RB loss has long been recognized as the causative genetic alteration underlying retinoblastoma but it is increasingly evident that other alterations are required for the tumor to develop. Therefore, we set out to identify additional inheritable susceptibility markers and new potential preventive and therapeutic target...

journal_title：Journal of cellular physiology

authors： Indovina P,Acquaviva A,De Falco G,Rizzo V,Onnis A,Luzzi A,Giorgi F,Hadjistilianou T,Toti P,Tomei V,Pentimalli F,Carugi A,Giordano A

更新日期：2010-04-01 00:00:00

abstract：:Resistance to conventional chemotherapy remains a major cause of cancer relapse and cancer-related deaths. Therefore, there is an urgent need to overcome resistance barriers. To improve cancer treatment approaches, it is critical to elucidate the basic mechanisms underlying drug resistance. Increasingly, the mechanism...

journal_title：Journal of cellular physiology

authors： Naghizadeh S,Mohammadi A,Duijf PHG,Baradaran B,Safarzadeh E,Cho WC,Mansoori B

更新日期：2020-10-01 00:00:00

abstract：:Adipogenesis plays a key role in the pathogenesis of obesity. It begins with the commitment of mesenchymal stem cells (MSCs) to the adipocyte lineage, followed by terminal differentiation of preadipocytes to mature adipocytes. A critical, but poorly understood, component of adipogenesis involves proliferation of MSCs ...

journal_title：Journal of cellular physiology

authors： Stewart A,Guan H,Yang K

更新日期：2010-06-01 00:00:00

abstract：:Macrophages are central mediators of the immune, contributing both to the initiation and the resolution of inflammation. The concept of macrophage activation and program has stimulated interest in its definition, and functional significance in homeostasis and diseases. It has been known that macrophages could be diffe...

journal_title：Journal of cellular physiology

authors： Liu G,Yang H

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is characterized by the apoptosis resistance and hyperproliferation of pulmonary artery smooth muscle cells (PASMCs). Its pathogenesis has not been revealed. Here, we carried out experiments to investigate the functions of miR-140-5p and tumor necrosis factor-α (TNF-α). ...

journal_title：Journal of cellular physiology

authors： Zhu TT,Zhang WF,Yin YL,Liu YH,Song P,Xu J,Zhang MX,Li P

更新日期：2019-06-01 00:00:00

abstract：:Theranostic nanoparticles (NPs) are promising for opening new windows toward personalized disease management. Using a single particle capable of both diagnosis and drug delivery, is the major benefit of such particles. In the present study, chitosan NPs were used as a dual action carrier for doxorubicin (DOX; chemothe...

journal_title：Journal of cellular physiology

authors： Gholami L,Tafaghodi M,Abbasi B,Daroudi M,Kazemi Oskuee R

更新日期：2019-02-01 00:00:00

abstract：:Progenitor cells for the endothelial lineage have been widely investigated for more than a decade, but continue to be controversial since no unique identifying marker has yet been identified. This review will begin with a discussion of the basic tenets originally proposed for proof that a cell displays properties of a...

journal_title：Journal of cellular physiology

authors： Basile DP,Yoder MC

更新日期：2014-01-01 00:00:00

abstract：:Bradykinin (BK) is a potent short-lived effector belonging to a class of peptides known as kinins. It participates in inflammatory and vascular regulation and processes including angioedema, tissue permeability, vascular dilation, and smooth muscle contraction. BK exerts its biological effects through the activation o...

journal_title：Journal of cellular physiology

authors： Prado GN,Taylor L,Zhou X,Ricupero D,Mierke DF,Polgar P

更新日期：2002-12-01 00:00:00

abstract：:Protease nexin-I (PN-I, Mr approximately 43,000) is representative of a newly described class of cell-secreted protease inhibitors. PN-I has been purified to apparent homogeneity, partially sequenced, and monospecific antibodies have been raised against it. PN-I is a potent inhibitor of urokinase, thrombin, plasmin, a...

journal_title：Journal of cellular physiology

authors： Knauer DJ,Orlando RA,Rosenblatt D

更新日期：1987-08-01 00:00:00

abstract：:Cholesterol is an important component for cell physiology. It regulates the fluidity of cell membranes and determines the physical and biochemical properties of proteins. In the central nervous system, cholesterol controls synapse formation and function and supports the saltatory conduction of action potential. In rec...

journal_title：Journal of cellular physiology

authors： Cartocci V,Servadio M,Trezza V,Pallottini V

更新日期：2017-02-01 00:00:00