Abstract:
:Glial fibrillary acidic protein (GFAP) is an intermediate filament that is expressed in specifically expressed auricular chondrocytes, which are good cell sources of cartilage regenerative medicine. Although our group uses GFAP as a biomarker of matrix production in the cultured auricular chondrocytes, the biological roles of GFAP in auricular chondrocytes has remained unknown. In this study, we demonstrated the biological functions of GFAP in the human and mouse derived auricles to clarify the significance and role with the chondrocytes of GFAP in order to provide useful information for reliable and safe regenerative medicine. We examined the cell responses to stretch stress for these chondrocytes and completed a nuclear morphological analysis. Based on these results, GFAP seems to support the resistance to severe mechanical stress in the tissue which physiologically suffers from a stretch overload, and plays pivotal roles in the conservation of cell structures and functions through the maintenance of nuclear morphology.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Kanazawa S,Nishizawa S,Takato T,Hoshi Kdoi
10.1002/jcp.25771subject
Has Abstractpub_date
2017-11-01 00:00:00pages
3182-3193issue
11eissn
0021-9541issn
1097-4652journal_volume
232pub_type
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