Abstract:
:NAD(P) is an indispensable cofactor for all organisms and its biosynthetic pathways are proposed as promising novel antibiotics targets against pathogens such as Mycobacterium tuberculosis. Six NAD(P) biosynthetic pathways were reconstructed by comparative genomics: de novo pathway (Asp), de novo pathway (Try), NmR pathway I (RNK-dependent), NmR pathway II (RNK-independent), Niacin salvage, and Niacin recycling. Three enzymes pivotal to the key reactions of NAD(P) biosynthesis are shared by almost all organisms, that is, NMN/NaMN adenylyltransferase (NMN/NaMNAT), NAD synthetase (NADS), and NAD kinase (NADK). They might serve as ideal broad spectrum antibiotic targets. Studies in M. tuberculosis have in part tested such hypothesis. Three regulatory factors NadR, NiaR, and NrtR, which regulate NAD biosynthesis, have been identified. M. tuberculosis NAD(P) metabolism and regulation thereof, potential drug targets and drug development are summarized in this paper.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Bi J,Wang H,Xie Jdoi
10.1002/jcp.22419subject
Has Abstractpub_date
2011-02-01 00:00:00pages
331-40issue
2eissn
0021-9541issn
1097-4652journal_volume
226pub_type
杂志文章,评审abstract::Myocardium infarction is one of the most deathly cardiovascular diseases. It is characterized by myocardium ischemia as a result of nutrients depletion and hypoxia. The cell can respond to this injury by autophagy or apoptosis, which determines the evolution and possible recovery of the myocardium infarction. Lipids p...
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journal_title:Journal of cellular physiology
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abstract::Embryo implantation is essential for normal pregnancy, and the process of decidualization is critical for embryo implantation. However, the mechanism of decidualization during early pregnancy is still unknown. Forkhead box O3a (FOXO3a) is the most important functional transcription factor of the forkhead box family an...
journal_title:Journal of cellular physiology
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journal_title:Journal of cellular physiology
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更新日期:2001-08-01 00:00:00
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journal_title:Journal of cellular physiology
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更新日期:2007-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1975-06-01 00:00:00
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journal_title:Journal of cellular physiology
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更新日期:2018-04-01 00:00:00
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journal_title:Journal of cellular physiology
pub_type: 杂志文章
doi:10.1002/jcp.1041050116
更新日期:1980-10-01 00:00:00
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journal_title:Journal of cellular physiology
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doi:10.1002/jcp.21005
更新日期:2007-07-01 00:00:00
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journal_title:Journal of cellular physiology
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4652(199901)178:1<51::AID-JCP7>
更新日期:1999-01-01 00:00:00
abstract::Tumor suppressor pRb2/p130 gene belongs to the retinoblastoma (Rb) gene family, which also includes pRb/p105 and pRb/p107. The members of the Rb gene family have attracted a great deal of interest because of their essential role in regulating cell cycle and, consequently, cell proliferation. This mini review discusses...
journal_title:Journal of cellular physiology
pub_type: 杂志文章,评审
doi:10.1002/jcp.21225
更新日期:2007-11-01 00:00:00
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journal_title:Journal of cellular physiology
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doi:10.1002/jcp.21528
更新日期:2008-11-01 00:00:00
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journal_title:Journal of cellular physiology
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abstract::The effect of changes in muscle length on post-tetanic isometric twitch tension potentiation and myosin P-light chain phosphorylation was studied at 23 degrees C in the mouse extensor digitorum longus muscle. The length-tension relationship was determined for the same muscles after a 30 min period of quiescence and be...
journal_title:Journal of cellular physiology
pub_type: 杂志文章
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journal_title:Journal of cellular physiology
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journal_title:Journal of cellular physiology
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