Pregnane X receptor as the "sensor and effector" in regulating epigenome.

abstract：BACKGROUND:MiR-152 has been reported as a tumor suppressor microRNA that is downregulated in a number of cancers, including colorectal cancer (CRC). A recent study suggested that miR-152 could be one of the key regulators of CRC. The aim of this study is to investigate the role of miR-152 in CRC and its mechanisms. ME...

journal_title：Journal of cellular physiology

authors： Ghazanchaei A,Mansoori B,Mohammadi A,Biglari A,Baradaran B

更新日期：2018-01-01 00:00:00

abstract：:Cell hybrids were formed between human diploid fibroblasts (HDF) and carcinogen-transformed HDF to determine the relationship among: (1) finite proliferative lifespan, which we define as an age-related failure of a population to achieve one population doubling in 4 weeks; (2) arrest in a senescent state, which we defi...

journal_title：Journal of cellular physiology

authors： Stein GH,Namba M,Corsaro CM

更新日期：1985-03-01 00:00:00

abstract：:Effects of interstitial fluid flow on osteoblasts were investigated. Intracellular cyclic adenosine monophosphate (cAMP) levels were monitored in cultured osteoblasts subjected to shear rates ranging from 10 to 3,500 sec-1. Cyclic AMP levels were significantly increased at all shear rates from 1 pmole/mg protein to 10...

journal_title：Journal of cellular physiology

authors： Reich KM,Gay CV,Frangos JA

更新日期：1990-04-01 00:00:00

abstract：:When calcium is removed from culture medium, motility of cultured cells is decreased. The effect is rapid, reversible and pronounced. Decreased motility is observed with normal mouse Balb/c 3T3 cells, mouse L929 cells, rat kidney fibroblasts and chick embryo fibroblasts. The calcium dependence of movement can be obser...

journal_title：Journal of cellular physiology

authors： Moore L,Pastan I

更新日期：1979-10-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in women of reproductive age. Although its clinical consequences have been known for a long time to extend beyond the reproductive system, with type-2 diabetes and obesity being the most common, the involvement of the ocular surface in PCOS has ...

journal_title：Journal of cellular physiology

authors： Mantelli F,Moretti C,Macchi I,Massaro-Giordano G,Cozzupoli GM,Lambiase A,Bonini S

更新日期：2016-05-01 00:00:00

abstract：:The ubiquitous α-catulin acts as a scaffold for distinct signalosomes including RhoA/ROCK; however, its function is not well understood. While α-catulin has homology to the cytoskeletal linkers α-catenin and vinculin, it appears to be functionally divergent. Here we further investigated α-catulin function in pulmonary...

journal_title：Journal of cellular physiology

authors： Bear MD,Liu T,Abualkhair S,Ghamloush MA,Hill NS,Preston I,Fanburg BL,Kayyali US,Toksoz D

更新日期：2016-04-01 00:00:00

abstract：:Earlier studies in multiple epithelia have shown that cell-cell actin-based adherens junction (AJ) dynamics are regulated, at least in part, by the interplay of kinases and phosphatases that determines the intracellular phosphoprotein content. Yet it is virtually unknown regarding the role of protein kinases in Sertol...

journal_title：Journal of cellular physiology

authors： Lee NP,Cheng CY

更新日期：2005-02-01 00:00:00

abstract：:Dexamethasone (Dex), a synthetic glucocorticoid (GC) with long-lasting treatment effects, has been proved to exert a modulatory effect on osteoblast proliferation and differentiation during embryonic osteogenesis. However, it is still controversial if Dex exposure influences endochondral ossification and the underlyin...

journal_title：Journal of cellular physiology

authors： Xu S,Guo R,Li PZ,Li K,Yan Y,Chen J,Wang G,Brand-Saberi B,Yang X,Cheng X

更新日期：2019-01-22 00:00:00

abstract：:We have reported previously that the production of a tumor cell factor that stimulates synthesis of fibroblast collagenase is influenced by a fibroblast-deposited matrix component, possibly heparan sulfate-proteoglycan. In this study, binding sites for heparin and heparan sulfate on mouse B-16 melanoma cells have been...

journal_title：Journal of cellular physiology

authors： Biswas C

更新日期：1988-07-01 00:00:00

abstract：:Adhesion of calf lens epithelial cells to lens capsule, their natural basement membrane was found to be considerably more rapid than either to plastic or to type I or type IV collagen coated surfaces. No polarity of the basement membrane was observed as the cells were able to attach to either side of the anterior or p...

journal_title：Journal of cellular physiology

authors： Cammarata PR,Spiro RG

更新日期：1982-11-01 00:00:00

abstract：:Nitric oxide triggers cGMP-dependent kinase-mediated phosphorylation of the actin regulator vasodilator-stimulated phosphoprotein (VASP) at residue serine239. The function of this phosphorylation for smooth muscle cell (SMC) adhesion, spreading, matrix contraction, and invasion is not well understood. We reconstituted...

journal_title：Journal of cellular physiology

authors： Defawe OD,Kim S,Chen L,Huang D,Kenagy RD,Renné T,Walter U,Daum G,Clowes AW

更新日期：2010-01-01 00:00:00

abstract：:The intracellular Ca2+ content of nontransformed Balb/c3T3 cells is two to three times higher than that of a spontaneously transformed derivative. Depriving either cell type of extracellular Mg2+ causes a 2- to 3-fold increase in their Ca2+ content over a 24-hr period. Restoring Mg2+ to the medium decreases the Ca2+ c...

journal_title：Journal of cellular physiology

authors： Vidair C,Rubin H

更新日期：1982-12-01 00:00:00

abstract：:Thrombin is known to evoke numerous inflammatory and proliferative responses in a wide variety of its target cells. Recent studies have demonstrated morphoregulatory and mitogenic effects of thrombin on astroglial cells (astrocytes). The present study deals with thrombin-induced activation of mitogen-activated protein...

journal_title：Journal of cellular physiology

authors： Bhat NR,Zhang P,Hogan EL

更新日期：1995-11-01 00:00:00

abstract：:Myocardin is a transcriptional co-activator of serum response factor (SRF) and can be degraded through ubiquitin-proteasome system. Our preliminary studies unexpectedly revealed that accumulation of myocardin in response to proteasome inhibition by MG132 or lactacystin resulted in decrease of transcriptional activity ...

journal_title：Journal of cellular physiology

authors： Yin H,Jiang Y,Li H,Li J,Gui Y,Zheng XL

更新日期：2011-07-01 00:00:00

abstract：:B cell activating factor from the TNF family (BAFF) stimulates B-cell proliferation and survival, but excessive BAFF promotes the development of aggressive B cells leading to malignant and autoimmune diseases. Recently, we have reported that rapamycin, a macrocyclic lactone, attenuates human soluble BAFF (hsBAFF)-stim...

journal_title：Journal of cellular physiology

authors： Zeng Q,Qin S,Zhang H,Liu B,Qin J,Wang X,Zhang R,Liu C,Dong X,Zhang S,Huang S,Chen L

更新日期：2018-01-01 00:00:00

abstract：:Preincubation of human neutrophils with phorbol esters or soluble diglycerides enhances subsequent f-Met-Leu-Phe (fMLP)-stimulated arachidonate mobilization and leukotriene B4 (LTB4) synthesis. We have recently reported that 1,3-dioctanoylglycerol (1,3-diC8) is equipotent with 1,2-sn-dioctanoylglycerol (1,2-diC8) as p...

journal_title：Journal of cellular physiology

authors： Rosenthal MD,Franson RC

更新日期：1994-09-01 00:00:00

abstract：:MiR-137 has been identified as potential hepatocellular carcinoma (HCC) prognostic biomarkers. Highly relevant HCC prognostic biomarkers may be derived from combinations of miR-137 with its target genes involved in the regulation of liver microenvironment. This study aimed at the discovery of such a combination with i...

journal_title：Journal of cellular physiology

authors： Wei Q,Zhao L,Jiang L,Bi J,Yu Z,Zhao L,Song X,Sun M,Chen Y,Wei M

更新日期：2019-07-01 00:00:00

abstract：:The extent to which autolytic microbial enzymes are involved in the fate of microorganisms ingested by phagocytes has not been determined. It is known, however, that activation of degradative enzymes occurs during certain microbicidal events. We examined the possible role of the pneumococcal autolytic enzyme (an N-ace...

journal_title：Journal of cellular physiology

authors： Tomasz A,Beckerdite S,McDonnell M,Elsbach P

更新日期：1977-08-01 00:00:00

abstract：:Bethanechol, a muscarinic agonist, inhibits the initial rate of amiloride-sensitive Na uptake by intact mucosa of avian small intestine as well as by isolated chicken villus enterocytes, an effect that is maximal at 90 seconds and reverses by 6 minutes. Bethanechol similarly decreases intracellular pH in isolated cell...

journal_title：Journal of cellular physiology

authors： Musch MW,Drabik-Arvans D,Rao MC,Chang EB

更新日期：1992-08-01 00:00:00

abstract：:There are two known phosphorylation-mediated inactivation mechanisms for TRPC3 channels. Protein kinase G (PKG) inactivates TRPC3 by direct phosphorylation on Thr-11 and Ser-263 of the TRPC3 proteins, and protein kinase C (PKC) inactivates TRPC3 by phosphorylation on Ser-712. In the present study, we explored the rela...

journal_title：Journal of cellular physiology

authors： Kwan HY,Huang Y,Yao X

更新日期：2006-05-01 00:00:00

abstract：:Using S1 nuclease protection assays, we have examined the representation of cell cycle-dependent H4 histone RNAs in the nuclear matrix and nonmatrix nuclear fractions of human cells. Cytoplasmic and nuclear fractions were prepared from exponentially growing HeLa S3 cells by double detergent (sodium deoxycholate and NP...

journal_title：Journal of cellular physiology

authors： Bandyopadhyay R,Stein G,Stein J

更新日期：1986-08-01 00:00:00

abstract：:Methylglyoxal bis-(guanylhydrazone) (mGBG) blocked the stimulation of DNA synthesis in quiescent, density-inhibited BALB/c-3T3 cells treated with platelet-derived growth factor (PDGF) and platelet-poor plasma (PPP). Competence formation produced by a transient exposure to PDGF was not effected by mGBG. In contrast, mG...

journal_title：Journal of cellular physiology

authors： Wharton W,Van Wyk JJ,Pledger WJ

更新日期：1981-04-01 00:00:00

abstract：:CRSBP-1 (mammalian LYVE-1) is a membrane glycoprotein highly expressed in lymphatic endothelial cells (LECs). It has multiple ligands, including hyaluronic acid (HA) and growth factors/cytokines (e.g., PDGF-BB and VEGF-A) containing CRS motifs (clusters of basic amino-acid residues). The ligand binding activities are ...

journal_title：Journal of cellular physiology

authors： Huang SS,Li YW,Wu JL,Johnson FE,Huang JS

更新日期：2018-04-01 00:00:00

abstract：:The existence of cancer stem cells is debatable in numerous solid tumors, yet in leukemia, there is compelling evidence of this cell population. Leukemic stem cells (LSCs) are altered cells in which accumulating genetic and/or epigenetic alterations occur, resulting in the transition between the normal, preleukemic, a...

journal_title：Journal of cellular physiology

authors： Mastelaro de Rezende M,Ferreira AT,Paredes-Gamero EJ

更新日期：2020-06-01 00:00:00

abstract：:The genetic factors known to be involved in the final realization of beta-glucuronidase activity in mice are considered from the standpoint of structural genes determining the catalytic activity of enzyme molecules as well as the recognition features of enzyme molecules that identify them for subsequent processing by ...

journal_title：Journal of cellular physiology

authors： Paigen K,Swank RT,Tomino S,Ganschow RE

更新日期：1975-04-01 00:00:00

abstract：:Bcl-2 associated athanogene 5 (Bag5) is a novel endoplasmic reticulum (ER) regulator. However, its role in catecholamine-induced endothelial cells damage has not been fully understood. In our study, catecholamine was used to mimic hypertension-related endothelial cell damage. Then, western blots, enzyme-linked immunos...

journal_title：Journal of cellular physiology

authors： Zhu H,Zhao M,Chen Y,Li D

更新日期：2021-02-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the most frequently diagnosed cancers and the fourth leading cause of cancer-related death in the United States, suggesting that there is an urgent need to design novel strategies for achieving better treatment outcome of patients diagnosed with PDAC. Our previous stud...

journal_title：Journal of cellular physiology

authors： Wang Z,Ali S,Banerjee S,Bao B,Li Y,Azmi AS,Korc M,Sarkar FH

更新日期：2013-03-01 00:00:00

abstract：:Vitamin C is an essential micronutrient for the development of male germ cells. In the gonad, the germ cells are isolated from the systemic circulation by the blood-testis barrier, which consists of a basal layer of Sertoli cells that communicate through an extensive array of tight junction complexes. To study the beh...

journal_title：Journal of cellular physiology

authors： Angulo C,Castro MA,Rivas CI,Segretain D,Maldonado R,Yañez AJ,Slebe JC,Vera JC,Concha II

更新日期：2008-12-01 00:00:00

abstract：:The present work reports the beneficial effects of using a microplatform on the development of mouse single blastomeres (SBs) to the blastocyst stage. Development of blastocysts from SBs separated from two- and four-cell stage embryos (two- and four-cell SBs) can provide a valuable supply both for couples who use fert...

journal_title：Journal of cellular physiology

authors： Yekani F,Fazel-Tabar M,Kowsari-Esfahan R,Renaud P,Kavand H,Esfandiari F,Azarnia M,Montazeri L,Baharvand H

更新日期：2018-12-01 00:00:00

abstract：:Endothelial cell-derived growth factor (ECDGF) is a soluble mitogen secreted in vitro by bovine aortic endothelium. ECDGF is a mixture of at least two distinct heat-stable and trypsin-sensitive mitogens. Large amounts of mitogenic activity were found in lysates prepared from cultured endothelial cells. Other nonmitoge...

journal_title：Journal of cellular physiology

authors： Gajdusek CM,Schwartz SM

更新日期：1984-11-01 00:00:00