VASP phosphorylation at serine239 regulates the effects of NO on smooth muscle cell invasion and contraction of collagen.

abstract：:Osteoclasts mediate bone resorption by secretion at the site of bone attachment. This process depends on calmodulin concentrated at a specialized acid-secreting membrane. We hypothesized that increased calmodulin and bone attachment were required for acid secretion. We tested this by studying calmodulin, bone attachme...

journal_title：Journal of cellular physiology

authors： Williams JP,Dong SS,Whitaker CH,Jordan SE,Blair HC

更新日期：1996-12-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) cells are characterised by their extreme chemoresistance. The activity of multiple-drug resistance (MDR) transporters that extrude antitumor drugs from cells plays the most important role in this phenomenon. To date, the mechanism controlling the expression and activity of MDR transporter...

journal_title：Journal of cellular physiology

authors： Quezada C,Garrido W,Oyarzún C,Fernández K,Segura R,Melo R,Casanello P,Sobrevia L,San Martín R

更新日期：2013-03-01 00:00:00

abstract：:The Giemsa banding pattern of the chromosomes has been analyzed in a line of transformed golden hamster cells, revertant and re-revertant cells and their tumors. The transformed and re-revertant cells were malignant in vivo and had gained an additional chromosome 5(7). Revertants with a suppression of malignancy lost ...

journal_title：Journal of cellular physiology

authors： Bloch-Shtacher N,Sachs L

更新日期：1976-01-01 00:00:00

abstract：:An association has been proved between high salt consumption and cardiovascular mortality. In vertebrates, the heart is the first functional organ to be formed. However, it is not clear whether high-salt exposure has an adverse impact on cardiogenesis. Here we report high-salt exposure inhibited basement membrane brea...

journal_title：Journal of cellular physiology

authors： Gao LR,Wang G,Zhang J,Li S,Chuai M,Bao Y,Hocher B,Yang X

更新日期：2018-09-01 00:00:00

abstract：:Calreticulin is an ER calcium-storage protein, which influences gene expression and cell adhesion. In this study, we analysed the differences in adhesive properties of calreticulin under- and overexpressing fibroblasts in relation to the calmodulin- and calcium/calmodulin-dependent kinase II (CaMK II)-dependent signal...

journal_title：Journal of cellular physiology

authors： Szabo E,Papp S,Opas M

更新日期：2007-10-01 00:00:00

abstract：:A decline in cell surface gamma-glutamyl transpeptidase specific activity was previously observed to be concomitant with C6 glial cell proliferation. To elucidate the underlying factor(s) mediating gamma-glutamyl transpeptidase down-regulation, the effects of C6 cell density and culture conditions on cell surface tran...

journal_title：Journal of cellular physiology

authors： Morgenstern K,Hanson-Painton O,Wang BL,De Bault L

更新日期：1992-01-01 00:00:00

abstract：:We have investigated the protein phosphorylation systems present in cultured bovine aortic and pulmonary artery endothelial cells. The cells contain cyclic AMP-dependent protein kinase, three calcium/calmodulin-dependent protein kinases, protein kinase C, and at least one tyrosine kinase. No cyclic GMP-dependent prote...

journal_title：Journal of cellular physiology

authors： Mackie K,Lai Y,Nairn AC,Greengard P,Pitt BR,Lazo JS

更新日期：1986-09-01 00:00:00

abstract：:The skeleton has recently emerged as a critical insulin target tissue that regulates whole body glucose metabolism and male reproductive function. While our understanding of these new regulatory axes remains in its infancy, the bone-specific protein, osteocalcin, has been shown to be centrally involved. Undercarboxyla...

journal_title：Journal of cellular physiology

authors： Tangseefa P,Martin SK,Fitter S,Baldock PA,Proud CG,Zannettino ACW

更新日期：2018-05-01 00:00:00

abstract：:We investigated the regulation of Cl- secretion by adrenoceptors in polarized 16HBE14o- human bronchial epithelial cells. Treatment with the nonselective β adrenoceptor agonist isoprenaline stimulated an increase in short-circuit current (ISC ), which was inhibited by the β adrenoceptor blocker propranolol. Treatment ...

journal_title：Journal of cellular physiology

authors： Zhang RG,Yip CY,Pan KW,Cai MY,Ko WH

更新日期：2020-11-01 00:00:00

abstract：:The synthesis and degradation of pectoralis myosin have been investigated in chickens 15-23 days after hatching. An essentially nonreutilizable tracer amino acid was used to demonstrate differences in the rates of synthesis and degradation of myosin isolated from normal and hypertrophied, cystrophic breast tissue. The...

journal_title：Journal of cellular physiology

authors： Rourke AW

更新日期：1975-10-01 00:00:00

abstract：:Protein sorting through vesicular compartments is highly regulated to maintain the integrity and signaling of intracellular organelles in eukaryotic cells. Sorting Nexin-2 (SNX2) is involved in protein sorting in the trans-Golgi network, endosome, and/or lysosome compartments, with loss of function leading to defect i...

journal_title：Journal of cellular physiology

authors： Abdul-Ghani M,Hartman KL,Ngsee JK

更新日期：2005-07-01 00:00:00

abstract：:IGF-I and its receptor IGF-IR are seen as critical effectors of muscle hypertrophy, a notion recently questioned. Using MKR transgenic mice that express a dominant negative IGF-IR only in skeletal muscle, we have examined the role of the IGF-IR signaling in differentiation and repair of muscle fibers after damage-indu...

journal_title：Journal of cellular physiology

authors： Heron-Milhavet L,Mamaeva D,LeRoith D,Lamb NJ,Fernandez A

更新日期：2010-10-01 00:00:00

abstract：:Matrix metalloproteinase-2 (MMP-2) is best understood for its biological actions outside the cell. However, MMP-2 also localizes to intracellular compartments and the cytosol where it has several substrates, including troponin I (TnI). Despite a growing list of cytosolic substrates, we currently do not know the mechan...

journal_title：Journal of cellular physiology

authors： Ali MA,Chow AK,Kandasamy AD,Fan X,West LJ,Crawford BD,Simmen T,Schulz R

更新日期：2012-10-01 00:00:00

abstract：:The platelet-derived growth factor (PDGF) binds via a defined amino acid sequence to heparin (Fager et al., 1992, In Vitro Cell. Dev. Biol., 28A:176-180) and the protein moiety of low density lipoproteins (LDL; apo B-100) via a similar sequence to chondroitin sulfate (Camejo et al., 1988, Arteriosclerosis Thromb., 8:3...

journal_title：Journal of cellular physiology

authors： Fager G,Camejo G,Olsson U,Ostergren-Lundén G,Lustig F,Bondjers G

更新日期：1995-05-01 00:00:00

abstract：:Sirtuin 3 (SIRT3) a mitochondrial enzyme that plays an important role in energy homeostasis, cardiac remodeling, and heart failure (HF). The expression of SIRT3 declines with advanced age, cardiovascular, and metabolic diseases. Accumulating evidence suggests that SIRT3 plays a critical role in protecting the heart fr...

journal_title：Journal of cellular physiology

authors： He X,Zeng H,Chen JX

更新日期：2019-03-01 00:00:00

abstract：:Mesenchymal stem/stromal cells (MSCs) have gained considerable popularity owing to the vast possibilities and lack of ethical constraints and risks normally associated with other stem cells, such as embryonic stem cells. However, they are morphologically indistinguishable from fibroblasts. This review aims to assess t...

journal_title：Journal of cellular physiology

authors： Soundararajan M,Kannan S

更新日期：2018-12-01 00:00:00

abstract：:The biosynthesis and turnover of nicotinamide adenine dinucleotide (NAD) have been examined in mitotic cells of the human culture line, D98/AH2. No significant difference in the incorporation of nicotinic acid or nicotinamide could be detected between mitotic and interphase cells. The distribution of newly-incorporate...

journal_title：Journal of cellular physiology

authors： Elliott G,Rechsteiner M

更新日期：1975-12-01 00:00:00

abstract：:Diabetes mellitus (DM) induces bone deterioration, while mechanical stimulation promotes osteocyte-driven bone formation. We aimed to evaluate the interaction of acute exposure (24 h) to high glucose (HG) with both the pro-survival effect conferred to osteocytic MLO-Y4 cells and osteoblastic MC3T3-E1 cells by mechanic...

journal_title：Journal of cellular physiology

authors： Maycas M,Portolés MT,Matesanz MC,Buendía I,Linares J,Feito MJ,Arcos D,Vallet-Regí M,Plotkin LI,Esbrit P,Gortázar AR

更新日期：2017-12-01 00:00:00

abstract：:Four temperature-sensitive (ts) mutants of rat 3Y1 fibroblasts, representing independent complementation groups, cease to proliferate predominantly with a 2n DNA content, at the restrictive temperature (39.8 degrees C) (temperature arrest) or at the permissive temperature (33.8 degrees C) at a confluent cell density (...

journal_title：Journal of cellular physiology

authors： Mitsudomi T,Kimura G

更新日期：1985-06-01 00:00:00

abstract：:The mobility of a cell surface protein on cells osmotically swollen by treatment with several different cell permeabilizing agents retains specific restraints despite detachment of the plasma membrane from the cortical cytoskeleton. Fluorescence photobleaching recovery experiments indicate that the lateral diffusion c...

journal_title：Journal of cellular physiology

authors： Feder TJ,Chang EY,Holowka D,Webb WW

更新日期：1994-01-01 00:00:00

abstract：:Neurofibromatosis type 1 (NF1) is characterized by the formation of neurofibromas, benign tumors of the peripheral nerve consisting essentially of Schwann cells, which can sometimes turn malignant to form neurofibrosarcomas. The mechanism of progression toward a malignant phenotype remains largely unknown. In this rep...

journal_title：Journal of cellular physiology

authors： Badache A,De Vries GH

更新日期：1998-11-01 00:00:00

abstract：:The biological roles of sphingosine 1-phosphate (S1P) and S1P receptors (S1PRs) have been broadly investigated. However, at present pathophysiological roles of S1P/S1PRs axis in liver fibrosis are not well defined. Here, we investigated the functions of S1P/S1PRs axis in human hepatic stellate cells (HSC) line, LX-2 c...

journal_title：Journal of cellular physiology

authors： Liu X,Yue S,Li C,Yang L,You H,Li L

更新日期：2011-09-01 00:00:00

abstract：:Human polyomaviruses, which include JC virus (JCV) and BK virus (BKV), as well as the simian virus 40 (SV40), have been associated with human tumors and have been shown to be highly tumorigenic in experimental animal models. Although the mechanism by which JCV induces tumorigenesis is not entirely clear, earlier studi...

journal_title：Journal of cellular physiology

authors： Caracciolo V,Reiss K,Crozier-Fitzgerald C,De Pascali F,Macaluso M,Khalili K,Giordano A,Claudio PP

更新日期：2007-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignancies and is a serious threat to people's health worldwide. The prognosis of advanced HCC is dim if left untreated. In the clinic, the treatment options for advanced HCC include surgery, radiotherapy, transcatheter arterial chemoembolization, and so forth...

journal_title：Journal of cellular physiology

authors： Zhu J,Yin T,Xu Y,Lu XJ

更新日期：2019-08-01 00:00:00

abstract：:Mitogen-activated protein (MAP) kinases are serine/threonine kinases that are rapidly activated in response to mitogenic stimuli. Here we examined the enzymatic activity and phosphorylation state of the individual p44mapk and p42mapk isoforms during early G1 and late G1 phase of the mammalian cell cycle. Release of fi...

journal_title：Journal of cellular physiology

authors： Meloche S

更新日期：1995-06-01 00:00:00

abstract：:Fetal brown adipocytes expressed uncoupling protein 1 (UCP1) mRNA, this expression being blunted throughout culture for 24 h in a serum-free medium. At physiological doses, either insulin-like growth factor I (IGF-I) or insulin turned out to be as potent as dibutyryl cAMP (dbcAMP) in increasing UCP1 gene transcription...

journal_title：Journal of cellular physiology

authors： Teruel T,Valverde AM,Navarro P,Benito M,Lorenzo M

更新日期：1998-07-01 00:00:00

abstract：:The human cervical cancer (CC) has been identified as one of the most common tumors in women, and the molecular regulation in CC still remains unclear. The dysregulation of periostin has been found in a variety of cancers, but whether it is involved in the regulation of CC is unknown. The present study aimed to invest...

journal_title：Journal of cellular physiology

authors： Han X,Wang Q,Wang Y,Hu B,Dong X,Zhang H,Wang W

更新日期：2019-08-01 00:00:00

abstract：:Shortly after serum-deprived BALB/c 3T3 fibroblasts are stimulated to grow in medium containing 10% calf serum, the RNA polymerase I activity in permeabilized cells shows a two-fold increase over the values observed in either serum-deprived or density-inhibited resting cells. Inhibition of protein synthesis by pactamy...

journal_title：Journal of cellular physiology

authors： Perrone-Bizzozero N,Iapalucci-Espinoza S,Medrano EE,Franze-Fernández MT

更新日期：1985-07-01 00:00:00

abstract：:Hydatid cyst, the larval stage of the tapeworm Echinococcus granulosus and a causative agent of cystic echinococcosis, possesses a vast number of antigenic peptides that are constantly presented in the host immune system during infection. Here, we sought to provide more information about the cellular/humoral component...

journal_title：Journal of cellular physiology

authors： Vatankhah A,Ghaffari SMR,Vatankhah RG,Piurkó V,Tímár J,Avan A,Jazayeri MH

更新日期：2019-03-01 00:00:00

abstract：:The single-stranded DNA and RNA binding protein, Puralpha, has recently received special attention as this protein, by associating with the specific nucleotide sequence (GGN repeats) and/or several important cellular and viral proteins regulates crucial biological events such as transcription, replication, and cell pr...

journal_title：Journal of cellular physiology

authors： Muralidharan V,Sweet T,Nadraga Y,Amini S,Khalili K

更新日期：2001-03-01 00:00:00