Chromosome balance and the control of malignancy.


:The Giemsa banding pattern of the chromosomes has been analyzed in a line of transformed golden hamster cells, revertant and re-revertant cells and their tumors. The transformed and re-revertant cells were malignant in vivo and had gained an additional chromosome 5(7). Revertants with a suppression of malignancy lost this additional chromosome 5(7) and gained an additional chromosome 7(2). The tumors produced by segregants from the revertant cells were malignant, although to a lower degree than transformed and re-revertant cells. These tumors had lost the additional chromosome 7(2) found in revertants and gained one or two 5(12) chromosomes. The results support the hypothesis that the balance between genes for expression and suppression controls malignancy. The data indicate that chromosome 7(2) carries genes for suppression and that chromosomes 5(7) and 5(12) carry genes for expression of malignancy. The genes on chromosome 5(7) seem to result in a greater degree of expression than the genes on chromosome 5(12). The chromosome balance that controlled malignancy in these cells, also controlled the expression and suppression of transformed properties in vitro.


J Cell Physiol


Bloch-Shtacher N,Sachs L





Has Abstract


1976-01-01 00:00:00












  • Multiple signal transduction pathways lead to extracellular ATP-stimulated mitogenesis in mammalian cells: II. A pathway involving arachidonic acid release, prostaglandin synthesis, and cyclic AMP accumulation.

    abstract::We have previously shown that extracellular ATP acts as a mitogen via protein kinase C (PKC)-dependent and independent pathways (Wang, D., Huang, N., Gonzalez, F.A., and Heppel, L.A. Multiple signal transduction pathways lead to extracellular ATP-stimulated mitogenesis in mammalian cells. I. Involvement of protein kin...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Huang NN,Wang DJ,Gonzalez F,Heppel LA

    更新日期:1991-03-01 00:00:00

  • Electrophysiological characterization of voltage-gated Na+ current expressed in the highly metastatic Mat-LyLu cell line of rat prostate cancer.

    abstract::Voltage-gated Na+ channels, classically associated with impulse conduction in excitable tissues, are also found in a variety of epithelial cell types where their possible functions are not known so well. We have previously reported expression of a voltage-gated Na+ channel specifically in the highly metastatic Mat-LyL...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Grimes JA,Djamgoz MB

    更新日期:1998-04-01 00:00:00

  • Reflections on Cellular Physiology as a Catalytic Framework for Medicine.

    abstract::These are the reflections of a retired physician who was introduced to cellular physiology in 1947 at the University of Pennsylvania. I majored in Zoology. I took the required major courses, which were interesting but not exciting. I was a premedical student at the time. Fortunately I was introduced to cellular physio...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Perelman A

    更新日期:2015-11-01 00:00:00

  • Influence of cyclosporine A on growth and extracellular matrix synthesis of human fibroblasts.

    abstract::Cyclosporine A (CyA) is a powerful nonsteroidal immunosuppressive agent used to prevent graft rejection of organ and bone marrow transplants. A major side effect observed can be attributed to the fibroblast and its functions: proliferation of fibroblasts and formation of fibrotic tissue in the gingiva (fibrous hyperpl...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Willershausen-Zönnchen B,Lemmen C,Schumacher U

    更新日期:1992-08-01 00:00:00

  • Effect of PLK1 inhibition on cisplatin-resistant gastric cancer cells.

    abstract:OBJECTIVE:This study aims to investigate the effect of polo-like kinase 1 (PLK1) inhibition on cisplatin (DDP)-resistant gastric cancer (GC) cells. METHODS:The transcriptional level of PLK1 was measured by quantitative reverse-transcription polymerase chain reaction. Expressions of PLK1 and its downstream mediators as...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Chen Z,Chai Y,Zhao T,Li P,Zhao L,He F,Lang Y,Qin J,Ju H

    更新日期:2019-05-01 00:00:00

  • Temporal studies on the tissue compartmentalization of bone sialoprotein (BSP), osteopontin (OPN), and SPARC protein during bone formation in vitro.

    abstract::To study the role of noncollagenous proteins in bone formation, the synthesis and tissue distribution of BSP (bone sialoprotein), OPN (osteopontin) and SPARC (secreted protein acidic and rich in cysteine) were analyzed using pulse-chase and continuous labeling protocols during bone formation by cultures of rat calvari...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Kasugai S,Nagata T,Sodek J

    更新日期:1992-09-01 00:00:00

  • Clinical and prognostic value of the C-Met/HGF signaling pathway in cervical cancer.

    abstract::Aberrant activation of the HGF/c-Met signalling pathway is reported to be associated with cell proliferation, progression, and metastasis features of several tumor types, including cervical cancer, suggesting that it may be of potential value as a novel therapeutic target. Furthermore, HPV-positive patients had a high...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Boromand N,Hasanzadeh M,ShahidSales S,Farazestanian M,Gharib M,Fiuji H,Behboodi N,Ghobadi N,Hassanian SM,Ferns GA,Avan A

    更新日期:2018-06-01 00:00:00

  • Effects of nutritional and hormonal factors on the metabolism of retinol-binding protein by primary cultures of rat hepatocytes.

    abstract::Studies were conducted to explore hormonal and nutritional factors that might be involved in the regulation of retinol-binding protein (RBP) synthesis and secretion by the liver. The studies employed primary cultures of hepatocytes from normal rats. When cells were cultured in Dulbecco's modified Eagle's medium alone,...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Dixon JL,Goodman DS

    更新日期:1987-01-01 00:00:00

  • Functional multimerization of mucolipin channel proteins.

    abstract::MCOLN1 encodes mucolipin-1 (TRPML1), a member of the transient receptor potential TRPML subfamily of channel proteins. Mutations in MCOLN1 cause mucolipidosis-type IV (MLIV), a lysosomal storage disorder characterized by severe neurologic, ophthalmologic, and gastrointestinal abnormalities. Along with TRPML1, there ar...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Curcio-Morelli C,Zhang P,Venugopal B,Charles FA,Browning MF,Cantiello HF,Slaugenhaupt SA

    更新日期:2010-02-01 00:00:00

  • High resolution analysis of cell cycle-correlated vimentin expression in asynchronously grown, TPA-treated MPC-11 cells by the novel flow cytometric multiparameter BrdU-Hoechst/PI and immunolabeling technique.

    abstract::High resolution, multiparameter analysis using the flow cytometric BrdU/Hoechst quenching technique has been applied to study cell cycle kinetics and vimentin expression in individual cells of asynchronously grown MPC-11 mouse plasmacytoma cell cultures treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Giese G,Kubbies M,Traub P

    更新日期:1994-11-01 00:00:00

  • Induction of microvillar hydrolase activities by cell density and exogenous differentiation inducers in an established kidney epithelial cell line (LLC-PK1).

    abstract::Several hydrolase activities characteristic of the apical brush border membrane of renal proximal tubule, leucine aminopeptidase, gamma-glutamyl transpeptidase, alkaline phosphatase, maltase, and trehalase, were identified in cultures of the LLC-PK1 kidney epithelial cell line. A coordinate increase in activities of t...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Yoneyama Y,Lever JE

    更新日期:1984-10-01 00:00:00

  • The anti-apoptosis protein, survivin, mediates gastric epithelial cell cytoprotection against ethanol-induced injury via activation of the p34(cdc2) cyclin-dependent kinase.

    abstract::The anti-apoptosis protein, survivin, promotes cell survival and mitosis. Recent studies have demonstrated that survivin is expressed in normal gastric mucosa. Using an in vitro model, we examined whether survivin plays a role in the cytoprotection produced in gastric mucosa by mild irritant ethanol (ETOH) against sub...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Jones MK,Padilla OR,Webb NA,Norng M

    更新日期:2008-06-01 00:00:00

  • Novel cellular mechanism that mediates the collecting duct formation during postnatal renal development.

    abstract::We have previously demonstrated that kidney embryonic structures are present in rats, and are still developing until postnatal Day 20. Consequently, at postnatal Day 10, the rat renal papilla contains newly formed collecting duct (CD) cells and others in a more mature stage. Performing primary cultures, combined with ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Del Valle Guaytima E,Brandán YR,Favale NO,Sterin-Speziale NB,Márquez MG

    更新日期:2019-08-01 00:00:00

  • Degradation of insulin-like growth factor-I receptor occurs via ubiquitin-proteasome pathway in human lung cancer cells.

    abstract::Insulin-like growth factor-I receptor (IGF-IR) is often overexpressed in malignant tumors, and is involved in the establishment and maintenance of malignant phenotypes. Tyrosine kinase receptor endocytosis is commonly triggered by ligand binding and occurs via clathrin-coated vescicles that transfer the receptor to th...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Carelli S,Di Giulio AM,Paratore S,Bosari S,Gorio A

    更新日期:2006-08-01 00:00:00

  • Contradistinctive growth responses of cultured rat intestinal epithelial cells to epidermal growth factor depending on cell population density.

    abstract::The growth response of cultured rat intestinal epithelial (RIE-1) cells to epidermal growth factor (EGF) depends on the cell population density. EGF stimulated the proliferation of RIE-1 cells in dense cultures, but inhibited the proliferation of cells growing at low population densities. In contrast, insulin enhanced...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Blay J,Brown KD

    更新日期:1986-12-01 00:00:00

  • Mechanism of zinc uptake by microvilli isolated from human term placenta.

    abstract::The mechanism of zinc (Zn) uptake by microvillous membrane vesicles prepared from human term placenta has been studied. The uptake was complex, with two processes being identified. In the first process, uptake was rapid, reaching equilibrium within 2 min, and was temperature dependent, with a Q10 of 1.5. Equilibrium Z...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Aslam N,McArdle HJ

    更新日期:1992-06-01 00:00:00

  • Heat shock protein (Hsp) regulation by muscarinic acetylcholine receptor (mAChR) activation in the rat hippocampus.

    abstract::The cholinergic system plays a crucial role in modulating in the central nervous system physiological responses such as neurogenesis, neuronal differentiation, synaptic plasticity, and neuroprotection. In a recent study, we showed that Oxotremorine-M, a non-selective muscarinic acetylcholine receptor agonist, is able ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Frinchi M,Scaduto P,Cappello F,Belluardo N,Mudò G

    更新日期:2018-08-01 00:00:00

  • sp2 -Iminosugar α-glucosidase inhibitor 1-C-octyl-2-oxa-3-oxocastanospermine specifically affected breast cancer cell migration through Stim1, β1-integrin, and FAK signaling pathways.

    abstract::Aberrant glycosylation changes on many glycoproteins are often related to cancer progression and metastasis. sp2 -Iminosugar-type castanospermine analogues, inhibitors of α-glucosidases, have been reported to exhibit antitumor activity. However, their effects on cell migration and the underlying molecular mechanism ar...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Gueder N,Allan G,Telliez MS,Hague F,Fernandez JM,Sanchez-Fernandez EM,Ortiz-Mellet C,Ahidouch A,Ouadid-Ahidouch H

    更新日期:2017-12-01 00:00:00

  • Critical role for intracellular calcium in tight junction biogenesis.

    abstract::Using the Madin Darby canine kidney (MDCK) cell "calcium switch," we have previously demonstrated that, as MDCK cells establish contact and ultimately form tight junctions, there are marked global and localized changes in intracellular calcium at the sites of cell-cell contact (Nigam et al., 1992, Proc. Natl. Acad. Sc...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Stuart RO,Sun A,Panichas M,Hebert SC,Brenner BM,Nigam SK

    更新日期:1994-06-01 00:00:00

  • Assembly of the peripheral domain of the bovine vacuolar H(+)-adenosine triphosphatase.

    abstract::The biosynthesis and assembly of the peripheral sector (V1) of the vacuolar proton-translocating adenosine triphosphatase (V-ATPase) was studied in a bovine kidney epithelial cell line. Monolayer cultures of cells were metabolically radiolabeled with Tran35S-label and the V-ATPase subsequently immunoprecipitated using...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Myers M,Forgac M

    更新日期:1993-07-01 00:00:00

  • Expression of connective tissue growth factor in bone: its role in osteoblast proliferation and differentiation in vitro and bone formation in vivo.

    abstract::Connective tissue growth factor (CTGF) is a secreted, extracellular matrix-associated signaling protein that regulates diverse cellular functions. In vivo, CTGF is expressed in many tissues with highest levels in the kidney and brain. The purpose of this study was twofold; first, to localize CTGF in normal bone in viv...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Safadi FF,Xu J,Smock SL,Kanaan RA,Selim AH,Odgren PR,Marks SC Jr,Owen TA,Popoff SN

    更新日期:2003-07-01 00:00:00

  • Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis.

    abstract::Earlier studies in multiple epithelia have shown that cell-cell actin-based adherens junction (AJ) dynamics are regulated, at least in part, by the interplay of kinases and phosphatases that determines the intracellular phosphoprotein content. Yet it is virtually unknown regarding the role of protein kinases in Sertol...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Lee NP,Cheng CY

    更新日期:2005-02-01 00:00:00

  • Influence of colonic dialysis using Gubenxiezhuo on the distribution of gut microflora in uremia rats.

    abstract:OBJECTIVE:This study aimed to explore the underlying function of Gubenxiezhuo dialysis on the distribution of gut microflora uremia. METHODS:A uremia rat model was constructed, and the morphology of renal tissue was determined using the hematoxylin-eosin (H&E) staining. Moreover, the blood samples were collected and t...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: He H,Hu P,Tang Y,Xu X

    更新日期:2019-07-01 00:00:00

  • Phenotypic effects of aldosterone and dexamethasone in a SV40-transformed mammalian cortical ascending limb cell line exhibiting mineralocorticoid receptors.

    abstract::We have analyzed the functional and morphological effects of corticosteroid hormones in a SV40-transformed rabbit cortical-ascending-limb (CAL) cell line (RC.SV2, Vandewalle et al., 1989) having mineralocorticoid (MR) and glucocorticoid (GR) receptors (Rafestin-Oblin et al., 1993). Both aldosterone and dexamethasone (...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Vandewalle A,Rafestin-Oblin ME,Hagege J,Géniteau-Legendre M,Cassingéna R,Ronco PM

    更新日期:1993-08-01 00:00:00

  • Impaired secretion and increased insolubilization of IgE-receptor complexes in mycophenolic acid-treated (guanine nucleotide-depleted) RBL-2H3 mast cells.

    abstract::In RBL-2H3 rat leukemic mast cells, cross-linking anti-DNP IgE-receptor complexes with multivalent antigen (DNP-BSA) activates a signal transduction pathway leading to Ca2+ influx and secretion. Cross-linking IgE-receptor complexes also stimulates a pathway that inactivates (desensitizes) receptors; this pathway becom...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Wilson BS,Seagrave J,Oliver JM

    更新日期:1991-12-01 00:00:00

  • Establishment and characterization of a telomerase-immortalized porcine bronchial epithelial cell line.

    abstract::Primary porcine bronchial epithelial cells (PBECs) are an ideal model to study the molecular and pathogenic mechanisms of various porcine respiratory pathogens. However, the short lifespan of primary PBECs greatly limit their application. Here, we isolated and cultured primary PBECs and established immortalized PBECs ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Xie X,Gan Y,Pang M,Shao G,Zhang L,Liu B,Xu Q,Wang H,Feng Y,Yu Y,Chen R,Wu M,Zhang Z,Hua L,Xiong Q,Liu M,Feng Z

    更新日期:2018-12-01 00:00:00

  • Comparison of bone morphogenetic protein-2 and osteoactivin for mesenchymal cell differentiation: effects of bolus and continuous administration.

    abstract::Current osteoinductive protein therapy utilizes bolus administration of large doses of bone morphogenetic proteins (BMPs), which is costly, and may not replicate normal bone healing. The limited in vivo biologic activity of BMPs requires the investigation of growth factors that may enhance this activity. In this study...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Arosarena OA,Del Carpio-Cano FE,Dela Cadena RA,Rico MC,Nwodim E,Safadi FF

    更新日期:2011-11-01 00:00:00

  • Transforming growth factor beta inhibits plasminogen activator (PA) activity and stimulates production of urokinase-type PA, PA inhibitor-1 mRNA, and protein in rat osteoblast-like cells.

    abstract::Transforming growth factor beta (TGF beta) treatment of rat osteoblast-rich calvarial cells or of the clonal osteogenic sarcoma cells, UMR 106-01, resulted in dose-dependent inhibition of plasminogen activator (PA) activity, and increased production of 3.2 kb mRNA and protein for PA inhibitor -1 (PAI-1). Although tiss...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Allan EH,Zeheb R,Gelehrter TD,Heaton JH,Fukumoto S,Yee JA,Martin TJ

    更新日期:1991-10-01 00:00:00

  • BMP-2 increases migration of human chondrosarcoma cells via PI3K/Akt pathway.

    abstract::Bone morphogenetic protein-2 (BMP-2), a member of transforming growth factor-beta superfamily, plays a crucial role in migration and metastasis of human cancer cells. Integrins are the major adhesive molecules in mammalian cells. Here we found that BMP-2 directed the migration and increased cell surface and mRNA expre...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Fong YC,Li TM,Wu CM,Hsu SF,Kao ST,Chen RJ,Lin CC,Liu SC,Wu CL,Tang CH

    更新日期:2008-12-01 00:00:00

  • Gap junctions in human synovial cells and tissue.

    abstract::Our objective was to establish the existence of intercellular communication through gap junctions in synovial lining cells and in primary and passaged cultures of human synovial cells. Communication between cells was assessed using the nystatin perforated-patch method, fluorescent dye transfer, immunochemistry, transm...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Kolomytkin OV,Marino AA,Sadasivan KK,Meek WD,Wolf RE,Hall V,McCarthy KJ,Albright JA

    更新日期:2000-07-01 00:00:00