Abstract:
:Osteoblasts are terminally differentiated cells with mesenchymal origins, known to possess pivotal roles in sustaining bone microstructure and homeostasis. These cells are implicated in the pathophysiology of various bone disorders, especially osteoporosis. Over the last few decades, strategies to impede bone resorption, principally by bisphosphonates, have been mainstay of treatment of osteoporosis; however, in recent years more attention has been drawn on bone-forming approaches for managing osteoporosis. MicroRNAs (miRNAs) are a broad category of noncoding short sequence RNA fragments that posttranscriptionally regulate the expression of diverse functional and structural genes in a negative manner. An accumulating body of evidence signifies that miRNAs direct mesenchymal stem cells toward osteoblast differentiation and bone formation through bone morphogenic protein, transforming growth factor-β, and Wnt signaling pathways. MiRNAs are regarded as excellent future therapeutic candidates because of their small size and ease of delivery into the cells. Considering their novel therapeutic significance, this review discusses the main miRNAs contributing to the anabolic aspects of bone formation and illustrates their interactions with corresponding signaling pathways involved in osteoblastic differentiation.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Aslani S,Abhari A,Sakhinia E,Sanajou D,Rajabi H,Rahimzadeh Sdoi
10.1002/jcp.27582subject
Has Abstractpub_date
2019-06-01 00:00:00pages
8082-8093issue
6eissn
0021-9541issn
1097-4652journal_volume
234pub_type
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pub_type: 杂志文章
doi:10.1002/jcp.1041450217
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doi:10.1002/jcp.30189
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pub_type: 杂志文章
doi:10.1002/jcp.1041390311
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pub_type: 杂志文章,meta分析,评审
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更新日期:1998-07-01 00:00:00
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