Recombinant non-collagenous domain of alpha2(IV) collagen causes involution of choroidal neovascularization by inducing apoptosis.

abstract：:Tissue expansion, a technique to enlarge the skin surface area with an expandable balloon, has been widely used in reconstructive surgery. Although the effect of tissue expansion on in vivo skin physiology and histology has been well documented, it remains unclear whether keratinocytes or other cell types are responsi...

journal_title：Journal of cellular physiology

authors： Takei T,Rivas-Gotz C,Delling CA,Koo JT,Mills I,McCarthy TL,Centrella M,Sumpio BE

更新日期：1997-10-01 00:00:00

abstract：:The Giemsa banding pattern of the chromosomes has been analyzed in a line of transformed golden hamster cells, revertant and re-revertant cells and their tumors. The transformed and re-revertant cells were malignant in vivo and had gained an additional chromosome 5(7). Revertants with a suppression of malignancy lost ...

journal_title：Journal of cellular physiology

authors： Bloch-Shtacher N,Sachs L

更新日期：1976-01-01 00:00:00

abstract：:Aberrant glycosylation changes on many glycoproteins are often related to cancer progression and metastasis. sp2 -Iminosugar-type castanospermine analogues, inhibitors of α-glucosidases, have been reported to exhibit antitumor activity. However, their effects on cell migration and the underlying molecular mechanism ar...

journal_title：Journal of cellular physiology

authors： Gueder N,Allan G,Telliez MS,Hague F,Fernandez JM,Sanchez-Fernandez EM,Ortiz-Mellet C,Ahidouch A,Ouadid-Ahidouch H

更新日期：2017-12-01 00:00:00

abstract：:Factors inhibiting cell growth have been isolated from different cell types. However, little information is available concerning their mode of action. A novel growth inhibitory factor of 45 kDa (IDF45) was recently purified to homogeneity from medium conditioned by 3T3 cells. This molecule was able to inhibit DNA synt...

journal_title：Journal of cellular physiology

authors： Delbe J,Villaudy J,Blat C,Desauty G,Golde A,Harel L

更新日期：1990-02-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) stimulates expression of plasminogen activator inhibitor type-1 (PAI-1), a serine protease inhibitor (SERPIN) important in the control of stromal barrier proteolysis and cell-to-matrix adhesion. Pharmacologic agents that target MEK (PD98059, U0126) or src family (PP1) kinas...

journal_title：Journal of cellular physiology

authors： Samarakoon R,Higgins CE,Higgins SP,Kutz SM,Higgins PJ

更新日期：2005-07-01 00:00:00

abstract：:The application of the phenomenon of premature chromosome condensation for cell cycle analysis in HeLa and CHO cells has been examined. Random populations of HeLa and CHO cells pulse labelled with H3-TdR were separately fused with mitotic HeLa cells using U.V. inactivated Sendai virus. The resulting prematurely conden...

journal_title：Journal of cellular physiology

authors： Rao PN,Wilson B,Puck TT

更新日期：1977-04-01 00:00:00

abstract：:A basic understanding of the recruitment of quiescent tumor cells into the cell cycle would be an important contribution to tumor biology and therapy. As a first step in pursuing this goal, we have investigated the regrowth kinetics of cells from different regions in multicellular spheroids of rodent and human origin....

journal_title：Journal of cellular physiology

authors： Freyer JP,Schor PL

更新日期：1989-02-01 00:00:00

abstract：:Cell hybrids were formed between human diploid fibroblasts (HDF) and carcinogen-transformed HDF to determine the relationship among: (1) finite proliferative lifespan, which we define as an age-related failure of a population to achieve one population doubling in 4 weeks; (2) arrest in a senescent state, which we defi...

journal_title：Journal of cellular physiology

authors： Stein GH,Namba M,Corsaro CM

更新日期：1985-03-01 00:00:00

abstract：:Growing evidence indicates long noncoding RNAs (lncRNAs) are significant regulators in the progression of various malignant tumors including colon cancer. Dysregulation of lncRNA LINC00261 has been identified in many cancers. Investigations on LINC00261 function have revealed that LINC00261 could act as a crucial tumo...

journal_title：Journal of cellular physiology

authors： Yan D,Liu W,Liu Y,Luo M

更新日期：2019-12-01 00:00:00

abstract：:The unique vascular supply of the retina, the ability to visualize the vasculature in vivo, and the ability to selectively express genes in the retina make the retina an ideal model system to study molecular mechanisms of angiogenesis. In addition, this area of investigation has great clinical significance, because re...

journal_title：Journal of cellular physiology

authors： Campochiaro PA

更新日期：2000-09-01 00:00:00

abstract：:The stromal cell-derived factor-1 (SDF-1)/CXC receptor 4 (CXCR4) axis has been shown to play a role in colorectal cancer progression. In addition, the protease urokinase-type plasminogen activator (uPA) is an important factor in tumor cell invasion and metastasis. However, the mechanism by which SDF-1 mediates uPA exp...

journal_title：Journal of cellular physiology

authors： Huang WS,Chin CC,Chen CN,Kuo YH,Chen TC,Yu HR,Tung SY,Shen CH,Hsieh YY,Guo SE,Shi CS,Liu TJ,Kuo HC

更新日期：2012-03-01 00:00:00

abstract：:Hepatocyte spheroids have been proposed for drug metabolism studies and in bioartificial liver devices. However, the optimal conditions required to meet the aerobic demands of mitochondria-rich hepatocyte spheroids is not well studied. We hypothesized that an optimal concentration of oxygen could be identified and tha...

journal_title：Journal of cellular physiology

authors： Lillegard JB,Fisher JE,Nedredal G,Luebke-Wheeler J,Bao J,Wang W,Amoit B,Nyberg SL

更新日期：2011-11-01 00:00:00

abstract：:We investigated gene expression profiles of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) in differentiated and non-differentiated retinal pigment epithelial (RPE) cells during oxidative stress. Human RPE cells were grown in culture on laminin-coated flasks to obtain differenti...

journal_title：Journal of cellular physiology

authors： Ohno-Matsui K,Morita I,Tombran-Tink J,Mrazek D,Onodera M,Uetama T,Hayano M,Murota SI,Mochizuki M

更新日期：2001-12-01 00:00:00

abstract：:The nuclear lamina is a fibrous structure at the nucleoplasmic surface of the inner nuclear membrane. Its assembly state is regulated by phosphorylation of its protein components, the lamins A, B, and C. The isoprenylation of the lamins is essential for their proper membrane anchoring and functionality. The content an...

journal_title：Journal of cellular physiology

authors： Bruscalupi G,Di Croce L,Lamartina S,Zaccaria ML,Luzzatto AC,Trentalance A

更新日期：1997-05-01 00:00:00

abstract：:Chronic hyperglycemia and activation of receptor for advanced glycation end products (RAGE) are known risk factors for microvascular disease development in diabetic retinopathy. Thioredoxin-interacting protein (TXNIP), an endogenous inhibitor of antioxidant thioredoxin (TRX), plays a causative role in diabetes and its...

journal_title：Journal of cellular physiology

authors： Perrone L,Devi TS,Hosoya K,Terasaki T,Singh LP

更新日期：2009-10-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) have been widely exploited for the treatment of several conditions due to their intrinsic regenerative and immunomodulatory properties. MSC have demonstrated to be particularly relevant for the treatment of ischemic diseases, where MSC-based therapies can stimulate angiogenesis and ind...

journal_title：Journal of cellular physiology

authors： Pinto DS,Ahsan T,Serra J,Fernandes-Platzgummer A,Cabral JMS,da Silva CL

更新日期：2020-10-01 00:00:00

abstract：:Skeletal muscle dysfunction contributes to exercise limitation in COPD. In this study cigarette smoke exposure was hypothesized to increase expression of the inflammatory cytokine, TNF-alpha, thereby suppressing PGC-1alpha, and hence affecting down stream molecules that regulate oxygen transport and muscle function. F...

journal_title：Journal of cellular physiology

authors： Tang K,Wagner PD,Breen EC

更新日期：2010-02-01 00:00:00

abstract：:We have previously shown that knockout of fibroblast growth factor-2 (FGF-2) and potential compensatory effects of other growth factors result in amelioration of disease symptoms in a transgenic mouse model of amyotrophic lateral sclerosis (ALS). ALS is a rapidly progressive neurological disorder leading to degenerati...

journal_title：Journal of cellular physiology

authors： Kefalakes E,Böselt S,Sarikidi A,Ettcheto M,Bursch F,Naujock M,Stanslowsky N,Schmuck M,Barenys M,Wegner F,Grothe C,Petri S

更新日期：2019-05-01 00:00:00

abstract：:Myeloid cells, including granulocytes and monocyte/macrophages, are important in disease-associated inflammatory reactions. These cells come from a common progenitor, the promyelocyte. The human promyelocytic cell line, HL-60, can be induced to terminally differentiate into granulocytes or monocyte/ macrophages in a c...

journal_title：Journal of cellular physiology

authors： Brent LH,Rubenstein B,Gong QH,Wieland SJ

更新日期：1996-07-01 00:00:00

abstract：:The C3H/10T 1/2 embryo cell line, which is nontumorigenic when inoculated subcutaneously in saline suspension, produces tumors when implanted subcutaneously attached to 1 X 5 X 10 mm plastic plates. Under these in vivo conditions there is direct selection for "spontaneous" transformants that have undergone the specifi...

journal_title：Journal of cellular physiology

authors： Paranjpe M,del Ande Eaton S,Boone CW

更新日期：1978-07-01 00:00:00

abstract：:We have examined the ability of epidermal growth factor (EGF) to regulate prostacyclin production by cultured A10 smooth muscle cells. EGF by itself had no effect on prostacyclin production, but it augmented the response to arg8-vasopressin. An AGF stimulation of prostacyclin production was also observed in the presen...

journal_title：Journal of cellular physiology

authors： Blay J,Hollenberg MD

更新日期：1989-06-01 00:00:00

abstract：:BAG3 protein, a member of the BAG co-chaperones family, sustains cell survival in a variety of normal and neoplastic cell types, via its interaction with a variety of partners, such as the heat shock protein (HSP) 70, Bcl-2, Raf-1 and others. Expression of BAG3 is induced by some stressful stimuli, such as heat shock,...

journal_title：Journal of cellular physiology

authors： Du ZX,Zhang HY,Meng X,Gao YY,Zou RL,Liu BQ,Guan Y,Wang HQ

更新日期：2009-03-01 00:00:00

abstract：:Pin1 is a peptidyl prolyl cis-trans isomerase that specifically binds to the phosphoserine-proline or phosphothreonine-proline motifs of numerous proteins. Previously, we reported that Pin1 deficiency resulted in defects in osteoblast differentiation during early bone development. In this study, we found that adult Pi...

journal_title：Journal of cellular physiology

authors： Yoon WJ,Islam R,Cho YD,Ryu KM,Shin HR,Woo KM,Baek JH,Ryoo HM

更新日期：2015-03-01 00:00:00

abstract：:Alkaptonuria (AKU) is a rare disease correlated with deficiency of the enzyme homogentisate 1,2 dioxygenase, which causes homogentisic acid (HGA) accumulation. HGA is subjected to oxidation/polymerization reactions, leading to the production of a peculiar melanin-like pigmentation (ochronosis) after chronic inflammati...

journal_title：Journal of cellular physiology

authors： Schiavone ML,Millucci L,Bernardini G,Giustarini D,Rossi R,Marzocchi B,Santucci A

更新日期：2020-10-01 00:00:00

abstract：:Wound healing is critically affected by age, ischemia, and growth factors such as TGFbeta1. The combined effect of these factors on fibroblast migration, an essential component of wound healing, is poorly understood. To address this deficiency, we examined expression of TGFbeta receptor type I and II (TGFbetaRI and RI...

journal_title：Journal of cellular physiology

authors： Mogford JE,Tawil N,Chen A,Gies D,Xia Y,Mustoe TA

更新日期：2002-02-01 00:00:00

abstract：:An increasing body of evidence suggests that tumors might originate from a few transformed cells that share many properties with normal stem cells. However, it remains unclear how normal stem cells are transformed into cancer stem cells (CSCs). Here, we demonstrated that mutations causing the loss of tumor suppressor ...

journal_title：Journal of cellular physiology

authors： Zeng X,Singh SR,Hou D,Hou SX

更新日期：2010-09-01 00:00:00

abstract：:The effects of P2Y2 purinoceptor activation on c-Fos expression and the signaling pathways evoked by extracellular ATP/UTP in HeLa cells were investigated. We found that P2Y2 activation induced c-Fos protein and phosphorylated the extracellular signal-regulated kinases 1 and 2 (ERK1/2). The P2Y2-stimulated c-Fos induc...

journal_title：Journal of cellular physiology

authors： Muscella A,Elia MG,Greco S,Storelli C,Marsigliante S

更新日期：2003-05-01 00:00:00

abstract：:Hepatocyte growth factor (HGF)-induced tubulogenesis has been demonstrated with renal epithelial cell lines grown in collagen gels but not with primary cultured renal proximal tubular epithelial cells (RPTEs). We show that HGF selectively induces proliferation and branching morphogenesis of primary cultured rat RPTEs....

journal_title：Journal of cellular physiology

authors： Bowes RC 3rd,Lightfoot RT,Van De Water B,Stevens JL

更新日期：1999-07-01 00:00:00

abstract：:Mesenchymal stem cells (MSC) are considered as potential agents for reconstructive and gene-targeting therapies since they differentiate into various cell-lineages, exhibit an extended survival once injected into a host, and can easily be transfected with engineered DNA. MSC are essentially isolated from hematopoietic...

journal_title：Journal of cellular physiology

authors： Suva D,Garavaglia G,Menetrey J,Chapuis B,Hoffmeyer P,Bernheim L,Kindler V

更新日期：2004-01-01 00:00:00

abstract：:Pyroptosis, a type of programmed cell death mediated by gasdermin, is characterized by the swelling and rupture of cells, release of cellular contents and a strong inflammatory response, which is critical for controlling microbial infection. Pattern recognition receptors recognize the intracellular and extracellular p...

journal_title：Journal of cellular physiology

authors： Xia X,Wang X,Zheng Y,Jiang J,Hu J

更新日期：2019-06-01 00:00:00