Transcription of the pain-related TRPV1 gene requires Runx1 and C/EBPβ factors.


:Transient Receptor Potential Vanilloid type 1 channel (TRPV1) is an important endogenous transducer of noxious heat and chemical stimuli and is required during development of inflammatory hypersensitivity. The transcription factor Runx1 is known to play a relevant role in sensory neuron differentiation as it controls the expression of several sensory nociceptive receptors, including TRPV1. Here, we show that Runx1 up-regulates TRPV1 transcription activity by interacting directly with the proximal TRPV1 gene promoter sequence. Importantly, C/EBPβ a well-established heterodimer partner of Runx1 also binds to the TRPV1 promoter and cooperates with Runx1 to further stimulate TRPV1 transcription. Our results support a mechanism where Runx1-C/EBPβ-containing transcription regulatory complexes are recruited to the TRPV1 gene promoter to modulate TRPV1 expression in dorsal root ganglia neurons.


J Cell Physiol


Ugarte GD,Diaz E,Biscaia M,Stehberg J,Montecino M,van Zundert B




Has Abstract


2013-04-01 00:00:00












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    abstract::Osteogenic differentiation is a complicated process that depends on various regulatory factors and signal pathways. In our research, the osteogenic differentiation capacity was analyzed by alizarin red staining, alkaline phosphatase activity, and protein levels of osteogenic differentiation markers including runt-rela...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Li Z,Sun Y,Cao S,Zhang J,Wei J

    更新日期:2019-05-01 00:00:00

  • Relationship between c-Kit expression and proliferation in acute myeloblastic leukemia cell lines.

    abstract::We have proposed that the transmembrane receptor encoded by the c-Kit protooncogene and its ligand play an important role in regulating the proliferation of blasts cells in acute myeloblastic leukemia (AML). To test this hypothesis, immunobeads were used to separate blasts from three Kit-expression positive cell lines...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Tohda S,Yang GS,Ashman LK,McCulloch EA,Minden MD

    更新日期:1993-02-01 00:00:00

  • Chemically and virally transformed cells able to grow without anchorage in serum-free medium: evidence for an autocrine growth factor.

    abstract::BA10-IR transformed cells, obtained by treating Syrian hamster embryo fibroblasts (HEF) with 7-methylbenz(a)anthracene and cultivated for a long period, are highly tumorigenic and grow in suspension as aggregates (spheroids) (Levy et al., 1976). They also grow in attached form or as spheroids in serum-free (S-) synthe...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Xin LW,Jullien P,Lawrence DA,Pironin M,Vigier P

    更新日期:1987-05-01 00:00:00

  • Protective effects of irisin on hypoxia-reoxygenation injury in hyperglycemia-treated cardiomyocytes: Role of AMPK pathway and mitochondrial protection.

    abstract::Recent evidence has verified the cardioprotective actions of irisin in different diseases models. However, the beneficial action of irisin on hypoxia-reoxygenation (HR) injury under high glucose stress has not been described. Herein our research investigated the influence of irisin on HR-triggered cardiomyocyte death ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Fan J,Zhu Q,Wu Z,Ding J,Qin S,Liu H,Miao P

    更新日期:2020-02-01 00:00:00

  • LINC00261 suppresses human colon cancer progression via sponging miR-324-3p and inactivating the Wnt/β-catenin pathway.

    abstract::Growing evidence indicates long noncoding RNAs (lncRNAs) are significant regulators in the progression of various malignant tumors including colon cancer. Dysregulation of lncRNA LINC00261 has been identified in many cancers. Investigations on LINC00261 function have revealed that LINC00261 could act as a crucial tumo...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Yan D,Liu W,Liu Y,Luo M

    更新日期:2019-12-01 00:00:00

  • Effects of temperature on the degradation and biliary secretion of asialoorosomucoid by the perfused rat liver: evidence for two intracellular pathways.

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Kloppel TM

    更新日期:1989-03-01 00:00:00

  • Regulated localization confers multiple functions on the protease urokinase plasminogen activator.

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Wells JM,Strickland S

    更新日期:1997-05-01 00:00:00

  • Human vascular cell responses to the circulating bone hormone osteocalcin.

    abstract::The purpose of this study was to characterize the direct effects of uncarboxylated osteocalcin (ucOCN) on vascular cell biology in vitro, to assess its potential function in pathophysiological conditions such as atherosclerosis. Human aortic endothelial cells (HAECs) and smooth muscle cells (HASMCs) were treated with ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Millar SA,Anderson SI,O'sullivan SE

    更新日期:2019-11-01 00:00:00

  • Fibronectin synthesis by high glucose level mediated proliferation of mouse embryonic stem cells: Involvement of ANG II and TGF-beta1.

    abstract::The role of individual supplements necessary for the long-term self-renewal of embryonic stem (ES) cells is poorly characterized in feeder/serum-free culture systems. This study sought to characterize the relationship between the effects of glucose on ES cell proliferation and fibronectin (FN) synthesis, and to assess...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Kim YH,Ryu JM,Lee YJ,Han HJ

    更新日期:2010-05-01 00:00:00

  • TGF-beta-induced G2/M delay in proliferating rabbit articular chondrocytes is associated with an enhancement of replication rate and a cAMP decrease: possible involvement of pertussis toxin-sensitive pathway.

    abstract::This study was undertaken to gain more insight into the mechanism whereby TGF-beta influences the cell cycle progression of cultured rabbit articular chondrocytes. Using proliferating chondrocytes in fetal calf serum-containing medium, we have previously shown that TGF-beta induced a recruitment of cells at the end of...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Vivien D,Galéra P,Lebrun E,Daireaux M,Loyau G,Pujol JP

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  • Efficacy of different chemotherapy regimens in treatment of advanced or metastatic pancreatic cancer: A network meta-analysis.

    abstract::We performed a network meta-analysis (NMA) to compare the short- and long-term efficacy of Gemcitabine, Gemcitabine + S-1 (tegafur), Gemcitabine + nab-paclitaxel, Gemcitabine + Capecitabine, Gemcitabine + Cisplatin, FOLFIRINOX (oxaliplatin + irinotecan + fluorouracil + leucovorin), Gemcitabine + oxaliplatin, Gemcitabi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,meta分析


    authors: Zhang SH,Liu GF,Li XF,Liu L,Yu SN

    更新日期:2018-04-01 00:00:00

  • Cell cycle changes in transformed cells growing under serum-free conditions.

    abstract::Polyoma transformed hamster cells (PyBHK) and SV40 transformed mouse cells (SV3T3) were transferred in culture using crystalline trypsin followed by neutralisation with soybean trypsin inhibitor. Such cells were able to proliferate freely in defined medium without any serum supplement and without any intervening perio...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Bush H,Shodell M

    更新日期:1977-03-01 00:00:00

  • Variant HeLa cells selected for their resistance to ouabain.

    abstract::The cardiac glyoside, ouabain, normally kills HeLa cells at concentrations of about 10-7 M or greater. By treating a population of HeLa cells with increasingly higher concentrations of the drug, a vaiant population was obtained of HeLa cells capable of growing in medium containing 10-4 M ouabain. Inhibition of volume ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Rosenberg HM

    更新日期:1975-02-01 00:00:00

  • Precursor of mast cells fixed in the skin of mice.

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Matsuda H,Kitamura Y,Sonoda T,Imori T

    更新日期:1981-09-01 00:00:00

  • Effect of aging on the mechanisms of PTH-induced calcium influx in rat intestinal cells.

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Massheimer V,Picotto G,Boland R,De Boland AR

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  • Dysregulated calcium homeostasis and oxidative stress in chronic myeloid leukemia (CML) cells.

    abstract::Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder caused by the oncogenic activity of the Bcr-Abl protein, a deregulated tyrosine kinase. Calcium may act directly on cellular enzymes and in conjunction with other cellular metabolites, such as cyclic nucleotides, to regulate cell functions. Alteratio...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Ciarcia R,d'Angelo D,Pacilio C,Pagnini D,Galdiero M,Fiorito F,Damiano S,Mattioli E,Lucchetti C,Florio S,Giordano A

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  • GP130/OSMR is the only LIF/IL-6 family receptor complex to promote osteoblast differentiation of calvaria progenitors.

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Malaval L,Liu F,Vernallis AB,Aubin JE

    更新日期:2005-08-01 00:00:00

  • Age-related differences in cellular and molecular profiles of inflammatory responses after spinal cord injury.

    abstract::Previous experimental and clinical studies have suggested that the behavioral and pathological outcomes of spinal cord injury (SCI) are affected by the individual's age at the time of injury. However, the underlying mechanism responsible for these differences remains elusive because it is difficult to match injuries o...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Kumamaru H,Saiwai H,Ohkawa Y,Yamada H,Iwamoto Y,Okada S

    更新日期:2012-04-01 00:00:00

  • Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post-traumatic osteoarthritis.

    abstract::PI3K/AKT signaling is essential in regulating pathophysiology of osteoarthritis (OA). However, its potential modulatory role in early OA progression has not been investigated yet. Here, a mouse destabilization OA model in the tibia was used to investigate roles of PI3K/AKT signaling in the early subchondral bone chang...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Lin C,Shao Y,Zeng C,Zhao C,Fang H,Wang L,Pan J,Liu L,Qi W,Feng X,Qiu H,Zhang H,Chen Y,Wang H,Cai D,Xian CJ

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  • Effects of retinoic acid on protein synthesis in cultured melanoma cells.

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Lotan R,Fischer I,Meromsky L,Moldave K

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  • Induction of heat-shock response and alterations of protein phosphorylation by a novel topoisomerase II inhibitor, withangulatin A, in 9L rat brain tumor cells.

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Lee WC,Lin KY,Chen CM,Chen ZT,Liu HJ,Lai YK

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Gupta RS,Dudani AK

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  • Microbial Community Metabolic Modeling: A Community Data-Driven Network Reconstruction.

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Henry CS,Bernstein HC,Weisenhorn P,Taylor RC,Lee JY,Zucker J,Song HS

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  • Interference with cellular differentiation by D-serine through antagonism at N-methyl-D-aspartate receptors composed of NR1 and NR3A subunits in chondrocytes.

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Takarada T,Takahata Y,Iemata M,Hinoi E,Uno K,Hirai T,Yamamoto T,Yoneda Y

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  • Properties and separation of T lymphocyte growth stimulatory activity (TL-GSA) and of granulocyte-macrophage colony stimulatory activity (GM-CSA) produced separately from two human T lymphocyte subpopulations.

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Wu AM

    更新日期:1979-11-01 00:00:00

  • Overexpression of hyaluronan synthases alters vascular smooth muscle cell phenotype and promotes monocyte adhesion.

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Wilkinson TS,Bressler SL,Evanko SP,Braun KR,Wight TN

    更新日期:2006-02-01 00:00:00

  • Cyclic AMP can partially restore platelet-derived growth factor-stimulated prostaglandin E2 biosynthesis, and calcium mobilization in EJ-ras-transformed NIH-3T3 cells.

    abstract::NIH-3T3 cells transformed by the EJ-ras oncogene display reduced platelet-derived growth factor (PDGF)-stimulated phospholipase C activity as measured by inositol 1,4,5-triphosphate (IP3) synthesis and Ca2+ mobilization. The lack of PDGF-stimulated Ca2+ mobilization in EJ-ras transformed cells is not due to a loss of ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Olinger PL,Benjamin CW,Gorman RR,Connor JA

    更新日期:1989-05-01 00:00:00

  • Bioinformatics.

    abstract::Bioinformatics is an interdisciplinary field that blends computer science and biostatistics with biological and biomedical sciences such as biochemistry, cell biology, developmental biology, genetics, genomics, and physiology. An important goal of bioinformatics is to facilitate the management, analysis, and interpret...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Moore JH

    更新日期:2007-11-01 00:00:00

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    abstract::Interest in the role of the insulin-like growth factor (IGF) axis in growth control and carcinogenesis has recently been increased by the finding of elevated serum insulin-like growth factor I (IGF-I) levels in association with three of the most prevalent cancers in the United States: prostate cancer, colorectal cance...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Grimberg A,Cohen P

    更新日期:2000-04-01 00:00:00

  • Insulin restores glucose inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endothelium.

    abstract::L-Arginine transport and nitric oxide (NO) synthesis (L-arginine/NO pathway) are stimulated by insulin, adenosine or elevated extracellular D-glucose in human umbilical vein endothelial cells (HUVEC). Adenosine uptake via the human equilibrative nucleoside transporters 1 (hENT1) and 2 (hENT2) has been proposed as a me...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Muñoz G,San Martín R,Farías M,Cea L,Vecchiola A,Casanello P,Sobrevia L

    更新日期:2006-12-01 00:00:00