Studies on the mechanism of Ca2+ stimulation of plasminogen activator synthesis/release by Swiss 3T3 cells.

abstract：:We have previously shown that Compound 5 (Cpd 5), an inhibitor of protein phosphatase Cdc25A, inhibits Hep3B human hepatoma cell growth. We now show that hepatocyte growth factor (HGF), a hepatocyte growth stimulant, can strongly enhance Cpd 5-induced growth inhibition in Hep3B cells, and this enhancement in cell grow...

journal_title：Journal of cellular physiology

authors： Wang Z,Wang M,Carr BI

更新日期：2005-06-01 00:00:00

abstract：:Past work has shown that delta-opioid receptor (DOR) activation by [D-Ala(2),D-Leu(5)]-enkephalin (DADLE) attenuated the disruption of K(+) homeostasis induced by hypoxia or oxygen-glucose deprivation (OGD) in the cortex, while naltrindole, a DOR antagonist blocked this effect, suggesting that DOR activity stabilizes ...

journal_title：Journal of cellular physiology

authors： Chao D,Bazzy-Asaad A,Balboni G,Xia Y

更新日期：2007-07-01 00:00:00

abstract：:We have previously reported that the proliferation of cloned MCF-7 and T47D human mammary tumor cells can be inhibited by increasing concentrations of charcoal-dextran stripped female human serum (CDFHS). The maximal proliferation rate was restored by the addition of 3 X 10(-11) M estradiol-17 beta to the culture medi...

journal_title：Journal of cellular physiology

authors： Schatz RW,Soto AM,Sonnenschein C

更新日期：1985-09-01 00:00:00

abstract：:Autophagy is the general term of lysosomal degradation of substances in cells, which is considered the key to maintaining the normal structure and function of the heart. It also has a correlation with several heart diseases, in particular, myocardial ischemia/reperfusion (I/R) injury. At the stage of myocardial ischem...

journal_title：Journal of cellular physiology

authors： Shi B,Ma M,Zheng Y,Pan Y,Lin X

更新日期：2019-08-01 00:00:00

abstract：:The in vitro culture of porcine bone marrow-derived mesenchymal stem cells (MSCs) was used for the investigation of adult stem cell biology. Isolated porcine MSCs possessed the ability to proliferate extensively in an antioxidants-rich medium containing 5% fetal bovine serum (FBS). Greater than 40 serial MSC passages ...

journal_title：Journal of cellular physiology

authors： Vacanti V,Kong E,Suzuki G,Sato K,Canty JM,Lee T

更新日期：2005-11-01 00:00:00

abstract：:Hydatid cyst, the larval stage of the tapeworm Echinococcus granulosus and a causative agent of cystic echinococcosis, possesses a vast number of antigenic peptides that are constantly presented in the host immune system during infection. Here, we sought to provide more information about the cellular/humoral component...

journal_title：Journal of cellular physiology

authors： Vatankhah A,Ghaffari SMR,Vatankhah RG,Piurkó V,Tímár J,Avan A,Jazayeri MH

更新日期：2019-03-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal and disabling neurodegenerative disease characterized by upper and lower motor neurons depletion. In our previous work, comprehensive genomic profiling of 41 motor cortex samples enabled to discriminate controls from sporadic ALS patients, and segregated these latter into...

journal_title：Journal of cellular physiology

authors： Bonaventura G,Iemmolo R,D'Amico AG,La Cognata V,Costanzo E,Zappia M,D'Agata V,Conforti FL,Aronica E,Cavallaro S

更新日期：2018-04-01 00:00:00

abstract：:Incubation of cultured bovine pulmonary artery endothelial cells with 200 microM of 3-isobutyl-1-methylxanthine (IBMX) for 24 hr produced a five- to tenfold increase in cellular angiotensin converting enzyme activity (ACE) above that of untreated control cells. A lesser increase was observed in medium ACE. Other methy...

journal_title：Journal of cellular physiology

authors： Dasarathy Y,Fanburg BL

更新日期：1988-10-01 00:00:00

abstract：:The role of hsp27 as an inhibitor of actin polymerization was considered in the context of the actin cytoskeleton and its relationship with focal adhesion formation. The aim of this study was to evaluate the potential effects of hsp27 on focal adhesion formation as a relevant biological consequence of actin stress fib...

journal_title：Journal of cellular physiology

authors： Schneider GB,Hamano H,Cooper LF

更新日期：1998-12-01 00:00:00

abstract：:We examined the role of superoxide in the increase in intracellular pH (pHi) of human histiocytic leukemia U937 cells treated with 4 beta-phorbol-12,13-didecanoate (4 beta-PDD) or serum. 4 beta-PDD or serum induced a rapid increase in pHi, and antioxidants such as superoxide dismutase (SOD), vitamin E, and butylated h...

journal_title：Journal of cellular physiology

authors： Shibanuma M,Kuroki T,Nose K

更新日期：1988-08-01 00:00:00

abstract：:Recent studies have suggested that interferons (IFNs) have an antifibrotic effect in the liver independent of their antiviral effect although its detailed mechanism remains largely unknown. Some microRNAs have been reported to regulate pathophysiological activities of hepatic stellate cells (HSCs). We performed analys...

journal_title：Journal of cellular physiology

authors： Sekiya Y,Ogawa T,Iizuka M,Yoshizato K,Ikeda K,Kawada N

更新日期：2011-10-01 00:00:00

abstract：:Conditions have been established under which the antizyme of ornithine decarboxylase (E.C. 4.1.1.17, L-ornithine carboxy-lyase, ODC) a non-competitive protein inhibitor of ODC, can be detected in cells in response to as little as 10(-7) M putrescine. The maintenance of intracellular antizyme activity depends upon the ...

journal_title：Journal of cellular physiology

authors： Heller JS,Canellakis ES

更新日期：1981-05-01 00:00:00

abstract：:To analyze transforming growth factor-beta (TGF-beta) response during MCF-7 cell progression, early passage (MCF-7E, < 200 passage) and late passage (MCF-7L, > 500 passage) cells were compared. MCF-7E cells showed an IC50 of approximately 10 ng/ml of TGF-beta1, whereas MCF-7L cells were insensitive. MCF-7E cells conta...

journal_title：Journal of cellular physiology

authors： Ko Y,Banerji SS,Liu Y,Li W,Liang J,Soule HD,Pauley RJ,Willson JK,Zborowska E,Brattain MG

更新日期：1998-08-01 00:00:00

abstract：:Adult stem cell therapy is being used extensively to rejuvenate damaged tissue. One important tissue source to obtain these cells is adipose, which contains cells called adipose-derived stem cells (ADSCs). These cells have a great therapeutic potential not only for their multipotent properties as well as for immunomod...

journal_title：Journal of cellular physiology

authors： Muñoz MF,Argüelles S,Medina R,Cano M,Ayala A

更新日期：2019-08-01 00:00:00

abstract：:Morphine, a mu-opioid receptor (MOR) agonist, has been extensively used to treat advanced cancer pain. In particular, in patients with cancer metastasis, both morphine and anticancer drugs are given simultaneously. However, evidence showed that morphine might be a risk factor in promoting the tumor's malignant potenti...

journal_title：Journal of cellular physiology

authors： Lu H,Zhang H,Weng ML,Zhang J,Jiang N,Cata JP,Ma D,Chen WK,Miao CH

更新日期：2020-11-13 00:00:00

abstract：:Vero (African green monkey kidney) cells grown in tissue culture monolayer were sensitive to Clostridium perfringens enterotoxin. Within 30 minutes of exposure to the enterotoxin gross morphological damage was observed and within 40 minutes approximately 75% of the cells had detached. Nearly half of the cells were non...

journal_title：Journal of cellular physiology

authors： McClane BA,McDonel JL

更新日期：1979-05-01 00:00:00

abstract：:Glutathione S-transferases (GSTs) are enzymes that are involved in the detoxification of harmful electrophilic endogenous and exogenous compounds by conjugating with glutathione (GSH). The liver fluke GSTs have multifunctional roles in the host-parasite interaction, such as general detoxification and bile acid sequest...

journal_title：Journal of cellular physiology

authors： Kalita J,Shukla R,Tripathi T

更新日期：2019-04-01 00:00:00

abstract：:Kinetic studies of binding and internalization of 125I-platelet-derived growth factor (PDGF) demonstrate that up to 15% of membrane-associated radioactivity is internalized within 2 minutes after warming to 37 degrees C in a variety of cell types. The T 1/2 for internalization is approximately 20 minutes. The T 1/2 fo...

journal_title：Journal of cellular physiology

authors： Rosenfeld ME,Bowen-Pope DF,Ross R

更新日期：1984-11-01 00:00:00

abstract：:Subcellular organellles from livers of rats three days prenatal to 50 weeks postnatal were separated on sucrose gradients. The peroxisomes had a constant density of 1.243 g/ml throughout the life of the animal. The density of the mitochondria changed from about 1.236 g/ml at birth to a constant value of 1.200 g/ml aft...

journal_title：Journal of cellular physiology

authors： Krahling JB,Gee R,Gauger JA,Tolbert NE

更新日期：1979-12-01 00:00:00

abstract：:CD8+ T cells play a vital role in cancer immunotherapy and can be shaped by metabolism. Avasimibe is an acyl coenzyme A-cholesterol acyltransferase (ACAT) inhibitor, which has been clinically verified safe in other phase Ⅲ clinical trials. It can potentiate the killing function of CD8+ T cells by modulating cholestero...

journal_title：Journal of cellular physiology

authors： Lei J,Wang H,Zhu D,Wan Y,Yin L

更新日期：2020-05-01 00:00:00

abstract：:Suppression of PKC activity can selectively induce apoptosis in cells expressing a constitutively activated p21Ras protein. We demonstrate that continued expression of p21Ras activity is required in PKC-mediated apoptosis because farnesyltransferase inhibitors abrogated the loss of viability in p21Ras-transformed cell...

journal_title：Journal of cellular physiology

authors： Liou JS,Chen JS,Faller DV

更新日期：2004-02-01 00:00:00

abstract：:Osteosarcoma (OS) is a primary highly malignant tumor of bone, affecting predominately adolescents and young adults between 10 and 20 years of age. OS is characterized by an extremely aggressive clinical course, with a rapid development of metastasis to the lung and distant bones. ...

journal_title：Journal of cellular physiology

authors： Laschi M,Bernardini G,Geminiani M,Ghezzi L,Amato L,Braconi D,Millucci L,Frediani B,Spreafico A,Franchi A,Campanacci D,Capanna R,Santucci A

更新日期：2015-11-01 00:00:00

abstract：:We investigated the actions of human placental lactogen (HPL) and human growth hormone (HGH) on [3H]thymidine incorporation and the release of immunoassayable somatomedin-C (SM-C) by isolated myoblasts, dermal fibroblasts, and costal cartilage explants taken from human fetuses at 11-21 weeks of gestation. The incorpor...

journal_title：Journal of cellular physiology

authors： Hill DJ,Crace CJ,Milner RD

更新日期：1985-11-01 00:00:00

abstract：:Tenascin-C, a six-armed extracellular matrix glycoprotein, is expressed in a temporally and spatially restricted pattern during carcinogenesis and invasion or metastasis of carcinoma cells in association with stromal-epithelial interactions. The human epidermoid carcinoma-derived cell lines, A431 and HEp-2, which do n...

journal_title：Journal of cellular physiology

authors： Sakai T,Ohta M,Furukawa Y,Saga Y,Aizawa S,Kawakatsu H,Saito M

更新日期：1995-10-01 00:00:00

abstract：:An in-depth understanding of circular RNAs (circRNAs) indicates that they are abundant in the eukaryotic transcriptome. Many circRNAs act as microRNA sponges; thus, they represent a new type of regulatory factor. However, the role of circRNA in colorectal cancer (CRC) remains largely unknown. Low circ_0021977 expressi...

journal_title：Journal of cellular physiology

authors： Lu C,Jiang W,Hui B,Rong D,Fu K,Dong C,Tang W,Cao H

更新日期：2020-03-01 00:00:00

abstract：:Optical tweezers were used to scan individual Chronic Myelogenous Leukemia cells to determine if the cell death depends on the scanning conditions. Although increasing the scanning frequency or amplitude means greater force applied to the cells, their effects on cell death are not a simple increasing trend, as observe...

journal_title：Journal of cellular physiology

authors： Ng KS,Zhou ZL,Ngan AH

更新日期：2013-10-01 00:00:00

abstract：:The herbicide 2,4,5 trichlorophenoxy acetic acid (245T) at concentrations from 0.5 to 0.9 mM, was found to inhibit respiration and then growth in exponentially growing cultures of Tetrahymena pyriformis. Cell division was stopped for periods up to 60 minutes after which the cells recovered and division resumed. Recove...

journal_title：Journal of cellular physiology

authors： Silberstein GB,Hooper AB

更新日期：1975-04-01 00:00:00

abstract：:Cancer stem cells (CSCs), also called Tumor Initiating Cells (TICs), can be defined as cancer cells that are present within solid tumors or hematological cancers, which have characteristics associated with normal stem cells, but which can give rise to all cell types found in a particular cancer sample. CSCs, therefore...

journal_title：Journal of cellular physiology

authors： Brinckerhoff CE

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) shows several kinds of disorders, which acutely harm the kidney. However, the current medical methods have limited therapeutic effects. The present study aimed to find out the molecular mechanism of AKI pathogenesis, which may provide new insights for future therapy. METHODS:Bioinf...

journal_title：Journal of cellular physiology

authors： Tian X,Ji Y,Liang Y,Zhang J,Guan L,Wang C

更新日期：2019-08-01 00:00:00

abstract：:A protein carboxyl methyltransferase (PCMT), which specifically modifies atypical protein L-isoaspartyl and D-aspartyl residues, is widely distributed in eucaryotic cells, but the factors that regulate its activity in vivo have not been identified. It has been proposed that the PCMT initiates the repair of structurall...

journal_title：Journal of cellular physiology

authors： Ladino CA,O'Connor CM

更新日期：1992-11-01 00:00:00