Structural basis of urea-induced unfolding of Fasciola gigantica glutathione S-transferase.

abstract：:Osteosarcoma (OS) is an ultra-rare highly malignant tumor of the skeletal system affecting mainly children and young adults and it is characterized by an extremely aggressive clinical course. OS patients are currently treated with chemotherapy and complete surgical resection of cancer tissue. However, resistance to ch...

journal_title：Journal of cellular physiology

authors： Bernardini G,Geminiani M,Gambassi S,Orlandini M,Petricci E,Marzocchi B,Laschi M,Taddei M,Manetti F,Santucci A

更新日期：2018-06-01 00:00:00

abstract：:Laminin is a basement membrane-specific glycoprotein that promotes cell adhesion, proliferation, differentiation, and tumor cell migration. Synthetic peptides from the amino acid sequence deduced from a cDNA clone of the B1 chain of laminin were tested for their ability to promote the migration of B16F10 melanoma cell...

journal_title：Journal of cellular physiology

authors： Iwamoto Y,Graf J,Sasaki M,Kleinman HK,Greatorex DR,Martin GR,Robey FA,Yamada Y

更新日期：1988-02-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) play pivotal roles in bone and cartilage growth and repair. Through phenotypes of short-ear (se) mice, which have BMP-5 mutations, a role for BMP-5 in some specific aspects of skeletogenesis and cartilage growth is known. This report examines BMP-5 expression in the growth plate and ...

journal_title：Journal of cellular physiology

authors： Mailhot G,Yang M,Mason-Savas A,Mackay CA,Leav I,Odgren PR

更新日期：2008-01-01 00:00:00

abstract：:Core binding factor β (Cbfβ) is a partner protein of Runx family transcription factors with minimally characterized function in cartilage. Here we address the role of Cbfβ in cartilage by generating chondrocyte-specific Cbfβ-deficient mice (Cbfb(Δch/Δch) ) from Cbfb-floxed mice crossed with mice expressing Cre from th...

journal_title：Journal of cellular physiology

authors： Park NR,Lim KE,Han MS,Che X,Park CY,Kim JE,Taniuchi I,Bae SC,Choi JY

更新日期：2016-01-01 00:00:00

abstract：:Cells of confluent cultures of the established pig renal epithelial line, LLC-PK1, accumulate alpha-methyl-D-glucoside against a concentration gradient. This transport system is strongly inhibited by phlorizin and 6-deoxy-D-glucose, moderately inhibited by phloretin, and only weakly inhibited by 3-0-methyl-D-glucose, ...

journal_title：Journal of cellular physiology

authors： Mullin JM,Weibel J,Diamond L,Kleinzeller A

更新日期：1980-09-01 00:00:00

abstract：:This study is carried out to elucidate the role of long noncoding RNAs (lncRNAs) MT1JP in proliferation, invasion, migration, and apoptosis of glioma cells through the regulation of PTEN/Akt signaling pathway. The expression of MT1JP in 80 normal brain tissues and 138 glioma tissues, as well as glioma cell lines, was ...

journal_title：Journal of cellular physiology

authors： Zhang Y,Sui R,Chen Y,Liang H,Shi J,Piao H

更新日期：2019-11-01 00:00:00

abstract：:We studied the clinicopathological significance for Calreticulin (CRT) expression in pancreatic cancer (PC), and its functional relationship with other signaling genes (especially with p53) in regulating the biological behavior of PC cells. IHC, IF, IB, and real-time PCR were used to detect CRT expression in PC, while...

journal_title：Journal of cellular physiology

authors： Sheng W,Chen C,Dong M,Zhou J,Liu Q,Dong Q,Li F

更新日期：2014-07-01 00:00:00

abstract：:The presence of an appropriate number of viable cells is prerequisite for successive differentiation during chondrogenesis. Chondrogenic differentiation has been reported to be influenced by mechanical stimuli. This research aimed to study the effects of cyclic compressive stress on cell viability of rat bone marrow-d...

journal_title：Journal of cellular physiology

authors： Wang Y,Wang J,Bai D,Song J,Ye R,Zhao Z,Lei L,Hao J,Jiang C,Fang S,An S,Cheng Q,Li J

更新日期：2013-09-01 00:00:00

abstract：:We have studied the tissue distribution of interleukin (IL) and hemopoietic colony-stimulating factor (CSF) transcripts in mice by S1-nuclease protection analysis. Accumulation of several of these mRNAs in response to intravenous injection of lipopolysaccharide (LPS) appears to occur in a tissue-specific fashion. IL-1...

journal_title：Journal of cellular physiology

authors： Troutt AB,Lee F

更新日期：1989-01-01 00:00:00

abstract：:Incubation of isolated rat soleus and EDL muscles in the presence of 10 mM leucine resulted in a decreased proteolytic rate as measured by the release of tyrosine into the incubation medium. The effect of this branched-chain amino acid (BCAA) is associated with a decreased activity of the lysosomal proteases and a dec...

journal_title：Journal of cellular physiology

authors： Busquets S,Alvarez B,Llovera M,Agell N,López-Soriano FJ,Argilés JM

更新日期：2000-09-01 00:00:00

abstract：:Bone is a multifaceted dynamic tissue, involved in mobility, mineral metabolism, and mesenchymal or stromal and hematopoietic progenitor or stem cells breading. Recently, an endocrine role has been attributed to bone due to its ability to produce at least two hormones (osteocalcin and fibroblast growth factor 23) and ...

journal_title：Journal of cellular physiology

authors： Agas D,Lacava G,Sabbieti MG

更新日期：2018-01-01 00:00:00

abstract：:Dishevelled-associated activator of morphogenesis 1 (DAAM1) is a formin-family protein involved in nucleation of unbranched actin filaments and in cytoskeletal organization through Wnt-Dishevelled PCP pathway, which participates in essential biological processes, such as cell polarity, movement, and adhesion during mo...

journal_title：Journal of cellular physiology

authors： Pariante P,Dotolo R,Venditti M,Ferrara D,Donizetti A,Aniello F,Minucci S

更新日期：2016-10-01 00:00:00

abstract：:Data on the biological effects of some overexpressed oncogenes and their cooperation with cellular factors are, at least partially, contradictory. There are reports on the strong pro-apoptotic action of temperature-sensitive (ts) p53(135val) in transformed cells at permissive temperature. However, in our experience ve...

journal_title：Journal of cellular physiology

authors： Schmid G,Kramer MP,Wesierska-Gadek J

更新日期：2009-05-01 00:00:00

abstract：:The coupled action of the Na(+)/H(+) exchanger NHE1 and the HCO3(-)/Cl(-) exchanger AE2 constitutes the principal mechanism for acute correction of decreased cell volume in mammalian somatic cells, while, when acting separately, they regulate intracellular pH. It was previously found that AE2 becomes inactivated durin...

journal_title：Journal of cellular physiology

authors： Zhou C,Fitzharris G,Alper SL,Baltz JM

更新日期：2013-10-01 00:00:00

abstract：:In higher eukaryotes there is a link between time of replication and transcription. It is generally accepted that genes that are actively transcribed are replicated in the first half of S phase while inactive genes replicate in the second half of S phase. We have recently reported that in normal human fibroblasts ther...

journal_title：Journal of cellular physiology

authors： Cohen SM,Cordeiro-Stone M,Kaufman DG

更新日期：2007-11-01 00:00:00

abstract：:We investigated the radiosensitizing effects of Co-NMS, a derivative of nimesulide based on a cobalt carbonyl complex, on malignant glioma cells. In the zebrafish exposed to Co-NMS ranging from 5 to 20 μM, cell death and heat shock protein 70 expression in the brain and neurobehavioral performance were evaluated. Our ...

journal_title：Journal of cellular physiology

authors： Liu Y,Zhang T,Li G,Li S,Li J,Zhao Q,Wu Q,Xu D,Hu X,Zhang L,Li Q,Zhang H,Liu B

更新日期：2020-12-01 00:00:00

abstract：:Dermal fibroblasts exposed to low oxygen tension show upregulated synthesis of transforming growth factor-beta 1 (TGF-beta 1), an established stimulatory peptide in the formation of extracellular matrix proteins. In this report, procollagen synthesis was measured in cultures of confluent adult human dermal fibroblasts...

journal_title：Journal of cellular physiology

authors： Falanga V,Martin TA,Takagi H,Kirsner RS,Helfman T,Pardes J,Ochoa MS

更新日期：1993-11-01 00:00:00

abstract：:A mutant (A204) of Chinese hamster ovary cells (CHO-K1), which is deficient in dihydroorotate (DHO) dehydrogenase (E.C. 1.3,3.1) activity, has been isolated by a replica plating procedure. The mutant does not show a requirement for exogenously added pyrimidines. Examination of intact cells shows that the mutant accumu...

journal_title：Journal of cellular physiology

authors： Stamato TD,Patterson D

更新日期：1979-03-01 00:00:00

abstract：:The extracellular matrix (ECM) is a dynamic component of tissue architecture that physically supports cells and actively influences their behavior. In the context of bone regeneration, cell-secreted ECMs have become of interest as they reproduce tissue-architecture and modulate the promising properties of mesenchymal ...

journal_title：Journal of cellular physiology

authors： Baroncelli M,van der Eerden BC,Kan YY,Alves RD,Demmers JA,van de Peppel J,van Leeuwen JP

更新日期：2018-01-01 00:00:00

abstract：:The prevalence of chronic hyperglycemia and its complications, imposing a critical burden on the worldwide economy and the global healthcare system, is a pressing issue. Mounting evidence indicates that oxidative stress and hypoxia, two noticeable features of hyperglycemia, play a joint crucial role in mediating cellu...

journal_title：Journal of cellular physiology

authors： Huang YT,Liu CH,Yang YC,Aneja R,Wen SY,Huang CY,Kuo WW

更新日期：2019-08-01 00:00:00

abstract：:Cultured bovine adrenocortical cells were previously shown to be functionally deficient in selenium and vitamin E when grown in medium supplemented with fetal bovine serum. In the present experiments, the lack of significant bioavailable amounts of selenium in the medium was demonstrated by the finding of only low lev...

journal_title：Journal of cellular physiology

authors： Hornsby PJ,Pearson DW,Autor AP,Aldern KA,Harris SE

更新日期：1985-04-01 00:00:00

abstract：:Restenosis after angioplasty or stent is a major clinical problem. While long noncoding RNAs (lncRNAs) are implicated in a variety of diseases, their role in restenosis is not well understood. This study aims to investigate how dysregulated lncRNAs and messenger RNAs (mRNAs) contribute to restenosis. By microarray ana...

journal_title：Journal of cellular physiology

authors： Zhou Y,He X,Liu R,Qin Y,Wang S,Yao X,Li C,Hu Z

更新日期：2019-02-10 00:00:00

abstract：:In vitro incubation of hepatocytes acutely isolated from adult male rats leads to a rapid conversion of the adrenergic activation of glycogenolysis from an alpha 1-receptor (alpha 1AR) to a beta 2-receptor (beta 2AR) mediated response within 4 h. In order to understand the underlying mechanism, we examined time-depend...

journal_title：Journal of cellular physiology

authors： Ishac EJ,Lazar-Wesley E,Kunos G

更新日期：1992-07-01 00:00:00

abstract：:Basic fibroblast growth factor (bFGF, FGF-2) is progressively lost from mammary epithelial cells as they become malignant. To investigate the effects of restoring the expression of bFGF in breast cancer cells, we constructed MCF-7 cells that permanently overexpress 18-kD cytoplasm-localizing bFGF (MCF-7/deltaA(FGF)(18...

journal_title：Journal of cellular physiology

authors： Wieder R,Fenig E,Wang H,Wang Q,Paglin S,Menzel T,Gabrilove J,Fuks Z,Yahalom J

更新日期：1998-12-01 00:00:00

abstract：:Cells are quite sensitive to a change of the extracellular pH and respond to it through detection of the H+/HCO3- level in extracellular fluid. However, little is known about molecular details induced by acidosis, such as intracellular pathways and gene expression. Here we describe properties of gene expression, prote...

journal_title：Journal of cellular physiology

authors： Shimokawa N,Kumaki I,Qiu CH,Ohmiya Y,Takayama K,Koibuchi N

更新日期：2005-10-01 00:00:00

abstract：:B cell activating factor from the TNF family (BAFF) stimulates B-cell proliferation and survival, but excessive BAFF promotes the development of aggressive B cells leading to malignant and autoimmune diseases. Recently, we have reported that rapamycin, a macrocyclic lactone, attenuates human soluble BAFF (hsBAFF)-stim...

journal_title：Journal of cellular physiology

authors： Zeng Q,Qin S,Zhang H,Liu B,Qin J,Wang X,Zhang R,Liu C,Dong X,Zhang S,Huang S,Chen L

更新日期：2018-01-01 00:00:00

abstract：:The protein tyrosine kinase pp125FAK (focal adhesion kinase, or FAK) is expressed by a variety of cell types and has been implicated in integrin-mediated signaling events. We explored the potential functions of FAK by expressing it de novo in a cell type lacking FAK. We showed previously that cultured human macrophage...

journal_title：Journal of cellular physiology

authors： De Nichilo MO,Katz BZ,O'Connell B,Yamada KM

更新日期：1999-02-01 00:00:00

abstract：:Exposure of cultured endothelial cells to endotoxin causes an increase in the amount of cellular heparan sulfate proteoglycan and a depletion of this molecule in the extracellular matrix. Concomitant with the decrease in the extracellular matrix is the appearance of a fraction of proteoglycan bearing altered carbohydr...

journal_title：Journal of cellular physiology

authors： Colburn P,Kobayashi E,Buonassisi V

更新日期：1994-04-01 00:00:00

abstract：:Hyperthermia has long been known as a radio-sensitizing agent that displays anti-tumor effects, and has been developed as a therapeutic application. The mechanisms of hyperthermia-induced radio-sensitization are highly associated with inhibition of DNA repair. Our investigations aimed to show how hyperthermia inactiva...

journal_title：Journal of cellular physiology

authors： Genet SC,Fujii Y,Maeda J,Kaneko M,Genet MD,Miyagawa K,Kato TA

更新日期：2013-07-01 00:00:00

abstract：:Our understanding of the mechanism of cell fate transition during the direct reprogramming of fibroblasts into various central nervous system (CNS) neural cell types has been limited by the lack of a comprehensive analysis on generated cells, independently and in comparison with other CNS neural cell types. Here, we a...

journal_title：Journal of cellular physiology

authors： Khazaei N,Rastegar-Pouyani S,O'Toole N,Wee P,Mohammadnia A,Yaqubi M

更新日期：2018-04-01 00:00:00