Modulation of drug resistance in homoharringtonine-resistant C-1300 neuroblastoma cells with cyclosporine A and dipyridamole.

abstract：:Over the past decade, a wide range of scientific investigations have been performed to reveal neuropathological aspects of cognitive disorders; however, only limited therapeutic approaches currently exist. The failures of conventional therapeutic options as well as the predicted dramatic rise in the prevalence of cogn...

journal_title：Journal of cellular physiology

authors： Farzaei MH,Bahramsoltani R,Abbasabadi Z,Braidy N,Nabavi SM

更新日期：2019-03-01 00:00:00

abstract：:Osteopontin (OPN) is a major non-collagenous bone matrix protein implicated in the regulation of cell function. Although OPN is rich in the cementum of the tooth, the significance of OPN in this tissue is not understood. Tooth root resorption is the most frequent complication of orthodontic tooth movement (TM). The ob...

journal_title：Journal of cellular physiology

authors： Chung CJ,Soma K,Rittling SR,Denhardt DT,Hayata T,Nakashima K,Ezura Y,Noda M

更新日期：2008-03-01 00:00:00

abstract：:The effects of pulsatile and steady fluid flow on the mRNA levels of proto-oncogenes c-fos, c-jun, and c-myc in cultured human umbilical vein endothelial cells (HUVEC) were investigated. c-fos mRNA levels in stationary cultures were very low. A 1 Hz pulsatile flow with an average shear stress of 16 dynes/cm2 induced a...

journal_title：Journal of cellular physiology

authors： Hsieh HJ,Li NQ,Frangos JA

更新日期：1993-01-01 00:00:00

abstract：:We recently reported that the growth of normal rat pleural mesothelial cells (RPMCs) is inhibited by conditioned media from either in vivo or in vitro transformed RPMCs. In this study we report that the growth of normal RPMCs is inhibited by epidermal growth factor (EGF). This was demonstrated by using three methods o...

journal_title：Journal of cellular physiology

authors： Van der Meeren A,Levy F,Renier A,Katz A,Jaurand MC

更新日期：1990-07-01 00:00:00

abstract：:Metabolic network modeling of microbial communities provides an in-depth understanding of community-wide metabolic and regulatory processes. Compared to single organism analyses, community metabolic network modeling is more complex because it needs to account for interspecies interactions. To date, most approaches foc...

journal_title：Journal of cellular physiology

authors： Henry CS,Bernstein HC,Weisenhorn P,Taylor RC,Lee JY,Zucker J,Song HS

更新日期：2016-11-01 00:00:00

abstract：:Lung cancer (LC) is the leading cause of cancer-related deaths all over the world, among both men and women, with an incidence of over 200,000 new cases per year coupled with a very high mortality rate. LC comprises of two major clinicopathological categories: small-cell (SCLC) and nonsmall-cell lung carcinoma (NSCLC)...

journal_title：Journal of cellular physiology

authors： Uddin A,Chakraborty S

更新日期：2018-04-20 00:00:00

abstract：:The Pur proteins are an ancient family of sequence-specific single-stranded nucleic acid-binding proteins. They bind a G-rich element in either single- or double-stranded nucleic acids and are capable of displacing the complementary C-rich strand. Recently several reports have described Pur family member knockouts, mu...

journal_title：Journal of cellular physiology

authors： Johnson EM,Daniel DC,Gordon J

更新日期：2013-05-01 00:00:00

abstract：:Experiments were conducted to determine the extent and variability of collagen degradation in human fetal lung fibroblasts. Cells were incubated with [14C]proline, and degradation was measured by determining the hydroxy[14C]proline in a low molecular weight fraction relative to total hydroxy[14C]proline. Average (basa...

journal_title：Journal of cellular physiology

authors： Bienkowski RS

更新日期：1984-10-01 00:00:00

abstract：:Cell division, neurite formation and acetylcholinesterase activity were examined in a clone (NBA2) of mouse neuroblastoma cells maintained for up to 120 hours in medium with pH values between 6.6 and 8.0. Growth rate decreased as pH was reduced from 7.8 to 6.6. Generation time at pH 7.4 was 25 hours, while the rate of...

journal_title：Journal of cellular physiology

authors： Bear MP,Schneider FH

更新日期：1977-04-01 00:00:00

abstract：:Impaired cardiac control of intracellular diastolic Ca(2+) gives rise to arrhythmias. Whereas exercise training corrects abnormal cyclic Ca(2+) handling in heart failure, the effect on diastolic Ca(2+) remains unstudied. Here, we studied the effect of exercise training on the generation and propagation of spontaneous ...

journal_title：Journal of cellular physiology

authors： Kemi OJ,MacQuaide N,Hoydal MA,Ellingsen O,Smith GL,Wisloff U

更新日期：2012-01-01 00:00:00

abstract：:EL 4-6.1 cells, variants of the murine EL4 thymoma cell line, can be activated by interleukin 1 (IL-1) or phorbol 12-myristate-13-acetate (PMA), or PMA+IL-1 to secrete interleukin 2 (IL-2) and interleukin 4 (IL-4) and to express the IL-2 receptor (IL-2R). To compare the different activation pathways, we examined the e...

journal_title：Journal of cellular physiology

authors： Dornand J,Bouaboula M,d'Angeac AD,Favero J,Shire D,Casellas P

更新日期：1992-04-01 00:00:00

abstract：:There are two known phosphorylation-mediated inactivation mechanisms for TRPC3 channels. Protein kinase G (PKG) inactivates TRPC3 by direct phosphorylation on Thr-11 and Ser-263 of the TRPC3 proteins, and protein kinase C (PKC) inactivates TRPC3 by phosphorylation on Ser-712. In the present study, we explored the rela...

journal_title：Journal of cellular physiology

authors： Kwan HY,Huang Y,Yao X

更新日期：2006-05-01 00:00:00

abstract：:A decline in cell surface gamma-glutamyl transpeptidase specific activity was previously observed to be concomitant with C6 glial cell proliferation. To elucidate the underlying factor(s) mediating gamma-glutamyl transpeptidase down-regulation, the effects of C6 cell density and culture conditions on cell surface tran...

journal_title：Journal of cellular physiology

authors： Morgenstern K,Hanson-Painton O,Wang BL,De Bault L

更新日期：1992-01-01 00:00:00

abstract：:Tissue expansion, a technique to enlarge the skin surface area with an expandable balloon, has been widely used in reconstructive surgery. Although the effect of tissue expansion on in vivo skin physiology and histology has been well documented, it remains unclear whether keratinocytes or other cell types are responsi...

journal_title：Journal of cellular physiology

authors： Takei T,Rivas-Gotz C,Delling CA,Koo JT,Mills I,McCarthy TL,Centrella M,Sumpio BE

更新日期：1997-10-01 00:00:00

abstract：:Homeostasis of proteins involved in contractility of individual cardiomyocytes and those coupling adjacent cells is of critical importance as any abnormalities in cardiac electrical conduction may result in cardiac irregular activity and heart failure. Bcl2-associated athanogene 3 (BAG3) is a stress-induced protein wh...

journal_title：Journal of cellular physiology

authors： Tahrir FG,Gordon J,Feldman AM,Cheung J,Khalili K,Mohseni Ahooyi T

更新日期：2019-08-01 00:00:00

abstract：:Dauricine, a bioactive component of Asiatic Moonseed Rhizome, has been widely used to treat a large number of inflammatory diseases in traditional Chinese medicine. In our study, we demonstrated that dauricine inhibited colon cancer cell proliferation and invasion, and induced apoptosis by suppressing nuclear factor-k...

journal_title：Journal of cellular physiology

authors： Yang Z,Li C,Wang X,Zhai C,Yi Z,Wang L,Liu B,Du B,Wu H,Guo X,Liu M,Li D,Luo J

更新日期：2010-10-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is one of the main liver diseases today, and may progress to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Some studies have shown the beneficial effects of aerobic exercise on reversing NAFLD. To verify whether chronic aerobic exercise improves the insulin resistan...

journal_title：Journal of cellular physiology

authors： Batatinha HA,Lima EA,Teixeira AA,Souza CO,Biondo LA,Silveira LS,Lira FS,Rosa Neto JC

更新日期：2017-05-01 00:00:00

abstract：:Although the type 1 insulin-like growth factor receptor (IGF-IR) is a potent inhibitor of apoptosis, its C-terminus sequence sends contradictory signals, including a clearly proapoptotic signal. We have synthesized a peptide, peptide 2, having the sequence of the IGF-IR from residue 1282 to residue 1298 (C-terminus of...

journal_title：Journal of cellular physiology

authors： Reiss K,Yumet G,Shan S,Huang Z,Alnemri E,Srinivasula SM,Wang JY,Morrione A,Baserga R

更新日期：1999-10-01 00:00:00

abstract：:Binding of concanavalin A to isolated thymocyte membrane vesicles occurs through (a) numerous (approximately 6 x 106/cell equivalent) low-affinity sites (Ka = 1.3 x 105M-1) anf (b) fewer (approximately 0.4 x 106/cell equipment) specific receptors (Ka = 6.8 x 106 M-1) defined as 55,000 D glycoprotein and its multimers....

journal_title：Journal of cellular physiology

authors： Wallach DF,Schmidt-Ullrich R

更新日期：1976-12-01 00:00:00

abstract：:Membrane vesicles derived principally from the plasma membrane and endoplasmic reticulum of mouse 3T3 cells transformed by Simian virus 40 take up alpha-aminoisobutyric acid (AIB) and phosphate (Pi). When NaCl is added simultaneously with AIB or Pi, uptake rises two- to three-times above the equilibrium to accumulate ...

journal_title：Journal of cellular physiology

authors： Nilsen-Hamilton M,Hamilton RT

更新日期：1976-12-01 00:00:00

abstract：:The caspase recruitment domain (CARD)-containing proteins CARMA1-3 share high degree of sequence, structure and functional homology. Whereas CARMA1 and CARMA3 have been identified as crucial components of signal transduction pathways that lead to activation of NF-κB transcription factor, little is known about the func...

journal_title：Journal of cellular physiology

authors： Scudiero I,Zotti T,Ferravante A,Vessichelli M,Vito P,Stilo R

更新日期：2011-12-01 00:00:00

abstract：:p120-catenin (p120) is an important regulator in the function and stability of E-cadherin. However, the role of p120 in the epidermis is unclear. Previous studies have shown that globally knockout of p120 caused increased epidermal proliferation but little changes in epidermal differentiation and permeability. In the ...

journal_title：Journal of cellular physiology

authors： Xie Z,Tang Y,Man MQ,Shrestha C,Bikle DD

更新日期：2018-01-01 00:00:00

abstract：:In fertilized echinoderm eggs, the male and female pronuclei fuse to form the diploid nucleus even in the presence of aphidicolin, a specific inhibitor of eukaryotic DNA polymerase-alpha. The subsequent first cleavage is independent of chromosomes but dependent on spindle and amphiaster. The fate of DNA originally exi...

journal_title：Journal of cellular physiology

authors： Yamada H,Hirai S,Ikegami S,Kawarada Y,Okuhara E,Nagano H

更新日期：1985-07-01 00:00:00

abstract：:Vitamin D3 metabolites regulate the differentiation of chondrocytes isolated from the growth zone or resting zone of rat costochondral cartilage. Since some of the direct membrane effects of vitamin D metabolites are nongenomic, we hypothesized that protein kinase C (PKC) plays a role in signal transduction for these ...

journal_title：Journal of cellular physiology

authors： Sylvia VL,Schwartz Z,Schuman L,Morgan RT,Mackey S,Gomez R,Boyan BD

更新日期：1993-11-01 00:00:00

abstract：:Tfcp2l1 is a transcription factor critical for mouse embryonic stem cell (mESC) maintenance. However, its role in human ESCs (hESCs) remains unclear. Here, we investigated the role of Tfcp2l1 in controlling hESC activity and showed that Tfcp2l1 is functionally important in the maintenance of hESC identity. Tfcp2l1 exp...

journal_title：Journal of cellular physiology

authors： Sun H,You Y,Guo M,Wang X,Zhang Y,Ye S

更新日期：2018-09-01 00:00:00

abstract：:Pancreatic cancer is a common malignant digestive disease. Epidemiological and clinical studies have demonstrated that pancreatic cancer is closely related to diabetes mellitus. Diabetic patients are more likely to develop pancreatic cancer, which is linked with poor outcomes. Pancreatic cancer is complicated with abn...

journal_title：Journal of cellular physiology

authors： Ma X,Cui Z,Du Z,Lin H

更新日期：2020-09-01 00:00:00

abstract：:Salivary dysfunction commonly occurs in many older adults and is considered a physiological phenomenon. However, the genetic changes in salivary glands during aging have not been characterized. The present study analyzed the gene expression profile in salivary glands from accelerated aging klotho deficient mice (kloth...

journal_title：Journal of cellular physiology

authors： Kwon SM,Kim SA,Yoon JH,Yook JI,Ahn SG

更新日期：2018-04-01 00:00:00

abstract：:In Xenopus oocytes injected with total rat pituitary GH3 cell RNA, thyrotropin-releasing hormone (TRH) causes the activation of the inositol lipid transduction pathway and the induction of chloride conductance via calcium-activated channels (Oron et al., 1987, Mol. Endocrinol., 1:918-925). This response exhibits chara...

journal_title：Journal of cellular physiology

authors： Lipinsky D,Gershengorn MC,Oron Y

更新日期：1995-02-01 00:00:00

abstract：:Over-production and activation of osteoclasts is a common feature of osteolytic conditions such as osteoporosis, tumor-associated osteolysis, and inflammatory bone erosion. Cyanidin Chloride, a subclass of anthocyanin, displays antioxidant and anti-carcinogenesis properties, but its role in osteoclastic bone resorptio...

journal_title：Journal of cellular physiology

authors： Cheng J,Zhou L,Liu Q,Tickner J,Tan Z,Li X,Liu M,Lin X,Wang T,Pavlos NJ,Zhao J,Xu J

更新日期：2018-03-01 00:00:00

abstract：:Lipocalin-2 (LCN2) is a protein largely expressed in many tissues, associated with different biological phenomena such as cellular differentiation, inflammation and cancer acting as a survival/apoptotic signal. We found that LCN2 was expressed during osteoblast differentiation and we generated transgenic (Tg) mice ove...

journal_title：Journal of cellular physiology

authors： Costa D,Lazzarini E,Canciani B,Giuliani A,Spanò R,Marozzi K,Manescu A,Cancedda R,Tavella S

更新日期：2013-11-01 00:00:00