The pur protein family: genetic and structural features in development and disease.

abstract：:Acupuncture needle rotation has been previously shown to cause specific mechanical stimulation of subcutaneous connective tissue. This study uses acupuncture to investigate the role of mechanotransduction-based mechanisms in mechanically-induced cytoskeletal remodeling. The effect of acupuncture needle rotation was qu...

journal_title：Journal of cellular physiology

authors： Langevin HM,Bouffard NA,Badger GJ,Churchill DL,Howe AK

更新日期：2006-06-01 00:00:00

abstract：:Transient Receptor Potential Vanilloid type 1 channel (TRPV1) is an important endogenous transducer of noxious heat and chemical stimuli and is required during development of inflammatory hypersensitivity. The transcription factor Runx1 is known to play a relevant role in sensory neuron differentiation as it controls ...

journal_title：Journal of cellular physiology

authors： Ugarte GD,Diaz E,Biscaia M,Stehberg J,Montecino M,van Zundert B

更新日期：2013-04-01 00:00:00

abstract：:Signal transduction of fibroblast growth factor (FGF) receptors is known to involve tyrosine phosphorylation of several substrates, including Grb2, phospholipase C-gamma, and phosphatidylinositol 3-kinase, whereas the role of G-proteins in FGF receptor signaling is controversial. In the present study we investigated t...

journal_title：Journal of cellular physiology

authors： Piiper A,Stryjek-Kaminska D,Gebhardt R,Zeuzem S

更新日期：1996-04-01 00:00:00

abstract：:Recent studies have suggested that interferons (IFNs) have an antifibrotic effect in the liver independent of their antiviral effect although its detailed mechanism remains largely unknown. Some microRNAs have been reported to regulate pathophysiological activities of hepatic stellate cells (HSCs). We performed analys...

journal_title：Journal of cellular physiology

authors： Sekiya Y,Ogawa T,Iizuka M,Yoshizato K,Ikeda K,Kawada N

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:This study aimed to explore the underlying function of Gubenxiezhuo dialysis on the distribution of gut microflora uremia. METHODS:A uremia rat model was constructed, and the morphology of renal tissue was determined using the hematoxylin-eosin (H&E) staining. Moreover, the blood samples were collected and t...

journal_title：Journal of cellular physiology

authors： He H,Hu P,Tang Y,Xu X

更新日期：2019-07-01 00:00:00

abstract：:The hypothesis that, in the case of clonal or low-density cultures, cells which do not readily proliferate are those that do not produce an extracellular matrix (ECM), while those that proliferate actively are cells that have retained their ability to produce it, has been tested using low-density vascular endothelial ...

journal_title：Journal of cellular physiology

authors： Gospodarowicz D,Lui GM

更新日期：1981-10-01 00:00:00

abstract：:Growing evidence has shown that pulsed electromagnetic fields (PEMF) can modulate bone metabolism in vivo and regulate the activities of osteoblasts and osteoclasts in vitro. Osteocytes, accounting for 95% of bone cells, act as the major mechanosensors in bone for transducing external mechanical signals and producing ...

journal_title：Journal of cellular physiology

authors： Wang P,Tang C,Wu J,Yang Y,Yan Z,Liu X,Shao X,Zhai M,Gao J,Liang S,Luo E,Jing D

更新日期：2019-07-01 00:00:00

abstract：:Tumor necrosis factor-α (TNF-α) is a pluripotent signaling molecule. The biological effect of TNF-α includes slowing down osteogenic differentiation, which can lead to bone dysplasia in long-term inflammatory microenvironments. Signal transducer and activator of transcription 3 (STAT3)-interacting protein 1 (StIP1, al...

journal_title：Journal of cellular physiology

authors： Xu CP,Sun HT,Yang YJ,Cui Z,Wang J,Yu B,Wang FZ,Yang QP,Qi Y

更新日期：2019-08-01 00:00:00

abstract：:Cells of confluent cultures of the established pig renal epithelial line, LLC-PK1, accumulate alpha-methyl-D-glucoside against a concentration gradient. This transport system is strongly inhibited by phlorizin and 6-deoxy-D-glucose, moderately inhibited by phloretin, and only weakly inhibited by 3-0-methyl-D-glucose, ...

journal_title：Journal of cellular physiology

authors： Mullin JM,Weibel J,Diamond L,Kleinzeller A

更新日期：1980-09-01 00:00:00

abstract：:The retinoblastoma protein-interacting zinc-finger (RIZ) gene, also known as PRDM2, encodes two protein products, RIZ1 and RIZ2, differing for the presence of a 202 aa domain, called PR domain, at the N-terminus of the RIZ1 molecule. While the histone H3 K9 methyltransferase activity of RIZ1 is associated with the neg...

journal_title：Journal of cellular physiology

authors： Abbondanza C,De Rosa C,D'Arcangelo A,Pacifico M,Spizuoco C,Piluso G,Di Zazzo E,Gazzerro P,Medici N,Moncharmont B,Puca GA

更新日期：2012-03-01 00:00:00

abstract：:The 10th annual meeting of the Italian Society for Virology (SIV) comprised seven plenary sessions focused on: General virology and viral genetics; Virus-Host interaction and pathogenesis; Viral oncology; Emerging viruses and zoonotic, foodborne and environmental pathways of transmission; Viral immunology and vaccines...

journal_title：Journal of cellular physiology

authors： Salata C,Calistri A,Parolin C,Palù G

更新日期：2012-07-01 00:00:00

abstract：:Oral administration of ajulemic acid (AjA), a cannabinoid acid devoid of psychoactivity, prevents joint tissue injury in rats with adjuvant induced arthritis. Because activation of osteoclasts is central to the pathogenesis of bone erosion in patients with rheumatoid arthritis (RA), we investigated the influence of Aj...

journal_title：Journal of cellular physiology

authors： George KL,Saltman LH,Stein GS,Lian JB,Zurier RB

更新日期：2008-03-01 00:00:00

abstract：:HIV transcription is induced by the HIV-1 Tat protein, in concert with cellular co-factors including CDK9, CDK2, NF-kappaB, and others. The cells of most of the body's organs are exposed to approximately 3-6% oxygen, but most in vitro studies of HIV replication are conducted at 21% oxygen. We hypothesized that activit...

journal_title：Journal of cellular physiology

authors： Charles S,Ammosova T,Cardenas J,Foster A,Rotimi J,Jerebtsova M,Ayodeji AA,Niu X,Ray PE,Gordeuk VR,Kashanchi F,Nekhai S

更新日期：2009-11-01 00:00:00

abstract：:Resistance to tamoxifen remains a prominent conundrum in the therapy of hormone-sensitive breast cancer. Also, the molecular underpinnings leading to tamoxifen resistance remain unclear. In the present study, we utilized the Gene Expression Omnibus database to identify that SOX11 might exert a pivotal function in conf...

journal_title：Journal of cellular physiology

authors： Xiao Y,Xie Q,Qin Q,Liang Y,Lin H,Zeng

更新日期：2020-10-01 00:00:00

abstract：:Monocytes are recruited to the material surface of an implanted biomedical device recognizing it as a foreign body. Differentiation into macrophages subsequently occurs followed by fusion to form foreign body giant cells (FBGCs). Consequently, implants can become degraded, cause chronic inflammation or become isolated...

journal_title：Journal of cellular physiology

authors： Matheson LA,Santerre JP,Labow RS

更新日期：2004-04-01 00:00:00

abstract：:Even though the involvement of intracellular Ca(2+) Ca(i)(2+) in hematopoiesis has been previously demonstrated, the relationship between Ca(i)(2+) signaling and cytokine-induced intracellular pathways remains poorly understood. Herein, the molecular mechanisms integrating Ca(2+) signaling with the extracellular signa...

journal_title：Journal of cellular physiology

authors： Leon CM,Barbosa CM,Justo GZ,Borelli P,Resende JD Jr,de Oliveira JS,Ferreira AT,Paredes-Gamero EJ

更新日期：2011-07-01 00:00:00

abstract：:Using rapid kinetic techniques, we have determined the kinetics of zero-trans influx and equilibrium exchange of adenosine, and its uptake and in situ phosphorylation at 25 degrees C in human erythrocytes which were pretreated with 2'-deoxycoformycin to inhibit deamination of adenosine. Both the Km and Vmax for adenos...

journal_title：Journal of cellular physiology

authors： Plagemann PG,Wohlhueter RM,Kraupp M

更新日期：1985-11-01 00:00:00

abstract：:Cadmium (Cd) is a toxic metal with multiple effects on cell signaling and cell death. We studied the effects of Cd(2+) on quiescent mouse mesangial cells in serum-free conditions. Cadmium induces cell death over 6 h through annexin V+ states without or with causing uptake of propidium iodide, termed apoptotic and apop...

journal_title：Journal of cellular physiology

authors： Liu Y,Templeton DM

更新日期：2008-11-01 00:00:00

abstract：:To evaluate the regulation of endothelial cell Cu,Zn-SOD, we have exposed bovine pulmonary artery endothelial cells in culture to hyperoxia and hypoxia, second messengers or related agonists, hormones, free radical generating systems, endotoxin, and cytokines and have measured Cu,Zn-SOD protein of these cells by an EL...

journal_title：Journal of cellular physiology

authors： Kong XJ,Fanburg BL

更新日期：1992-12-01 00:00:00

abstract：:High potassium concentrations altered the morphology and the ability to grow in soft agar in 6m2 cells, a clone of rat kidney cells infected with a temperature-sensitive mutant of Moloney sarcoma virus. Approximately 60% of cells exhibited normal morphology in the presence of 94.8 mM potassium in isotonic medium at th...

journal_title：Journal of cellular physiology

authors： Lai CN,Becker FF

更新日期：1985-11-01 00:00:00

abstract：:The retinal pigment epithelium is a monolayer of highly specialized pigmented cells located between the neural retina and the Bruch's membrane of the choroid. RPE cells play a crucial role in the maintenance and function of the underlying photoreceptors. This study introduces a spontaneously arising human retinal pigm...

journal_title：Journal of cellular physiology

authors： Shams Najafabadi H,Soheili ZS,Samiei S,Ahmadieh H,Ranaei Pirmardan E,Masoumi M

更新日期：2017-10-01 00:00:00

abstract：:The nuclear Ki-67 protein (pKi-67) has previously been shown to be exclusively expressed in proliferating cells. As a result, antibodies against this protein are widely used as prognostic tools in cancer diagnostics. Here we show, that despite the strong downregulation of pKi-67 expression in non-proliferating cells, ...

journal_title：Journal of cellular physiology

authors： Bullwinkel J,Baron-Lühr B,Lüdemann A,Wohlenberg C,Gerdes J,Scholzen T

更新日期：2006-03-01 00:00:00

abstract：:Incubation of isolated rat soleus and EDL muscles in the presence of 10 mM leucine resulted in a decreased proteolytic rate as measured by the release of tyrosine into the incubation medium. The effect of this branched-chain amino acid (BCAA) is associated with a decreased activity of the lysosomal proteases and a dec...

journal_title：Journal of cellular physiology

authors： Busquets S,Alvarez B,Llovera M,Agell N,López-Soriano FJ,Argilés JM

更新日期：2000-09-01 00:00:00

abstract：:The endogenous thiols (PSH, protein sulfhydryls; NPSH, nonprotein sulfhydryls; and GSH, glutathione) were measured in the 66 and 67 murine carcinoma cells growing under different physiological conditions in vitro (e.g., proliferation, P; nutrient-deprived quiescence QI; and QI cells stimulated by refeeding the monolay...

journal_title：Journal of cellular physiology

authors： Dethlefsen LA,Biaglow JE,Peck VM,Ridinger DN

更新日期：1987-07-01 00:00:00

abstract：:Differentiation of myofibroblast, as evidenced by alpha-smooth muscle actin (alpha-SMA) expression, is largely mediated by transforming growth factor-beta1 (TGF-beta1). This mechanism often follows inflammatory events such as endothelial damage due to oxidative stress, which can further leads to vascular thickening, s...

journal_title：Journal of cellular physiology

authors： Sen U,Moshal KS,Tyagi N,Kartha GK,Tyagi SC

更新日期：2006-12-01 00:00:00

abstract：:Syndecans (SDCs) are a family of heparan sulfate proteoglycans (HSPGs) glycoproteins ubiquitously expressed on the cell surfaces and extracellular matrix of all mammalian tissues. There are four mammalian syndecans, SDC-1 thorough 4, which play a critical role in cell adhesion, migration, proliferation, differentiatio...

journal_title：Journal of cellular physiology

authors： Agere SA,Kim EY,Akhtar N,Ahmed S

更新日期：2018-09-01 00:00:00

abstract：:The antibody-secreting murine hybridoma, CC9C10, was grown in batch culture in a medium containing 20 mM glucose and 2 mM glutamine. After 2 days of exponential growth, the glutamine content of the medium was completely depleted, whereas the glucose content was reduced to 60% of the original concentration. The glucose...

journal_title：Journal of cellular physiology

authors： Petch D,Butler M

更新日期：1994-10-01 00:00:00

abstract：:Autophagy is an evolutionarily conserved intracellular process and is considered one of the main catabolism pathways. In the process of autophagy, cells are digested nonselectively or selectively to recover nutrients and energy, so it is regarded as an antiaging process. In addition to the essential role of autophagy ...

journal_title：Journal of cellular physiology

authors： Guo YF,Su T,Yang M,Li CJ,Guo Q,Xiao Y,Huang Y,Liu Y,Luo XH

更新日期：2021-01-16 00:00:00

abstract：:The highly conserved homeodomains and HMG domains are components of a large number of proteins that play a role in the transcriptional regulation of gene expression during embryogenesis. Both the HMG domain and the homeodomain serve as interfaces for factor interactions with DNA, as well as with other proteins, and it...

journal_title：Journal of cellular physiology

authors： Dailey L,Basilico C

更新日期：2001-03-01 00:00:00

abstract：:In fertilized echinoderm eggs, the male and female pronuclei fuse to form the diploid nucleus even in the presence of aphidicolin, a specific inhibitor of eukaryotic DNA polymerase-alpha. The subsequent first cleavage is independent of chromosomes but dependent on spindle and amphiaster. The fate of DNA originally exi...

journal_title：Journal of cellular physiology

authors： Yamada H,Hirai S,Ikegami S,Kawarada Y,Okuhara E,Nagano H

更新日期：1985-07-01 00:00:00