Upregulation of SOX11 enhances tamoxifen resistance and promotes epithelial-to-mesenchymal transition via slug in MCF-7 breast cancer cells.


:Resistance to tamoxifen remains a prominent conundrum in the therapy of hormone-sensitive breast cancer. Also, the molecular underpinnings leading to tamoxifen resistance remain unclear. In the present study, we utilized the Gene Expression Omnibus database to identify that SOX11 might exert a pivotal function in conferring tamoxifen resistance of breast cancer. SOX11 was found to be markedly upregulated at both the messenger RNA and protein levels in established MCF-7-Tam-R cells compared to the parental counterparts. Moreover, SOX11 was able to activate the transcription of slug via binding to its promoter, resulting in promoting the progress of epithelial-to-mesenchymal transition and suppressing the expression of ESR1. Downregulating SOX11 expression can restore the sensitivity to 4-hydroxytamoxifen in MCF-7-Tam-R cells. Survival analysis from large sample datasets indicated that SOX11 was closely related to poorer survival in patients with breast cancer. These findings suggest a novel feature of SOX11 in contributing to tamoxifen resistance. Hence, targeting SOX11 could be a potential therapeutic strategy to tackle tamoxifen resistance in breast cancer.


J Cell Physiol


Xiao Y,Xie Q,Qin Q,Liang Y,Lin H,Zeng




Has Abstract


2020-10-01 00:00:00












  • Heat shock proteins within the mammalian cell cycle: relationship to thermal sensitivity, thermal tolerance, and cell cycle progression.

    abstract::We have measured endogenous and induced rates of 70-kD, 89-kD, and 110-kD heat shock proteins in highly pure G1-, S-, or G2-M phase fractions of Chinese hamster fibroblasts (CHO) separated by fluorescence-activated cell sorting (FACS). Relative rates of synthesis of all three polypeptides as measured by two-dimensiona...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Rice G,Laszlo A,Li G,Gray J,Dewey W

    更新日期:1986-02-01 00:00:00

  • LINC00261 suppresses human colon cancer progression via sponging miR-324-3p and inactivating the Wnt/β-catenin pathway.

    abstract::Growing evidence indicates long noncoding RNAs (lncRNAs) are significant regulators in the progression of various malignant tumors including colon cancer. Dysregulation of lncRNA LINC00261 has been identified in many cancers. Investigations on LINC00261 function have revealed that LINC00261 could act as a crucial tumo...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Yan D,Liu W,Liu Y,Luo M

    更新日期:2019-12-01 00:00:00

  • The potential role of senescence in limiting fibrosis caused by aging.

    abstract::Fibrosis-related diseases carry with them a high mortality rate and their morbidity increases with age. Recent findings indicate that induced senescence in myofibroblasts can limit or reduce myocardial fibrosis, cirrhosis, and idiopathic pulmonary fibrosis, while also accelerating wound healing. However, more senescen...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Meng X,Wang H,Song X,Clifton AC,Xiao J

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  • Regulation of basement membrane heparan sulfate proteoglycan, perlecan, gene expression in glomerular epithelial cells by high glucose medium.

    abstract::Proteinuria in diabetic nephropathy has been correlated with reduction in heparan sulfate proteoglycan (HSPG) content of the glomerular basement membrane. We have previously shown that the underlying mechanism probably involves reduction in the synthesis by glomerular epithelial cells. In this study we explored whethe...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


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    更新日期:1996-04-01 00:00:00

  • Biochemical genetic analysis of pyrimidine biosynthesis in mammalian cells. II. Isolation and characterization of a mutant of Chinese hamster ovary cells with defective dihydroorotate dehydrogenase (E.C. activity.

    abstract::A mutant (A204) of Chinese hamster ovary cells (CHO-K1), which is deficient in dihydroorotate (DHO) dehydrogenase (E.C. 1.3,3.1) activity, has been isolated by a replica plating procedure. The mutant does not show a requirement for exogenously added pyrimidines. Examination of intact cells shows that the mutant accumu...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


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  • Adaptive responses of human monocytes infected by bordetella pertussis: the role of adenylate cyclase hemolysin.

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    abstract::Brain-derived neurotrophic factor (BDNF) promotes the regeneration of periodontal tissue. Since angiogenesis is important for tissue regeneration, investigating effect of BDNF on endothelial cell function may help to reveal its mechanism, whereby, BDNF promotes periodontal tissue regeneration. In this study, we examin...

    journal_title:Journal of cellular physiology

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  • Versatile role of curcumin and its derivatives in lung cancer therapy.

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


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  • Lens epithelial cell adhesion to lens capsule: a model system for cell-basement membrane interaction.

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  • Innate-immune responses of tilapia (Oreochromis mossambicus) exposure to acute cold stress.

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  • Interleukin-6 and transforming growth factor-beta synergistically stimulate chondrosarcoma cell proliferation.

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    pub_type: 杂志文章


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  • Molecular mechanisms of nitric oxide-dependent inhibition of TPA-induced matrix metalloproteinase-9 (MMP-9) in MCF-7 cells.

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


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  • The momentous role of N6-methyladenosine in lung cancer.

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


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  • Protein tyrosine phosphorylation and calcium signaling in thyroid FRTL-5 cells.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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  • Reverse transformation of vole cells transformed by avian sarcoma virus containing the src gene.

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    pub_type: 杂志文章


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  • COMMD7 as a novel NEMO interacting protein involved in the termination of NF-κB signaling.

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


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    更新日期:2016-01-01 00:00:00

  • Molecular mechanisms of glutamine action.

    abstract::Glutamine is the most abundant free amino acid in the body and is known to play a regulatory role in several cell specific processes including metabolism (e.g., oxidative fuel, gluconeogenic precursor, and lipogenic precursor), cell integrity (apoptosis, cell proliferation), protein synthesis, and degradation, contrac...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


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  • Expression profile of circular RNA in rat intimal hyperplasia and target gene prediction.

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Li T,Rong ZH,Chang NB,Liu X,Xu JY,Liu D,Shi CC,Zhang WY,Jiang R,Jiang J

    更新日期:2019-01-17 00:00:00

  • Role of protein kinase C in interleukin 1, anti-T3, and mitogenic lectin-induced interleukin 2 secretion.

    abstract::Activation of T-lymphocytes by antigen, mitogenic lectins, or antibodies against the T-cell receptor complex, particularly in the presence of IL1, induces the secretion of the T-cell growth factor IL2. IL2 then has a major role in regulating the duration and magnitude of the immune response. Interaction of antigen, an...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


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    更新日期:1989-11-01 00:00:00

  • Alteration in Phospholipidome Profile of Myoblast H9c2 Cell Line in a Model of Myocardium Starvation and Ischemia.

    abstract::Myocardium infarction is one of the most deathly cardiovascular diseases. It is characterized by myocardium ischemia as a result of nutrients depletion and hypoxia. The cell can respond to this injury by autophagy or apoptosis, which determines the evolution and possible recovery of the myocardium infarction. Lipids p...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Sousa B,Melo T,Campos A,Moreira AS,Maciel E,Domingues P,Carvalho RP,Rodrigues TR,Girão H,Domingues MR

    更新日期:2016-10-01 00:00:00

  • Journal of Cellular Physiology: Volume 230, Number 2, February 2015.

    abstract::Cover: Diagram illustrating the chromatic median analysis. See article by Pliss et al. on pages 427-439. ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章



    更新日期:2015-02-01 00:00:00

  • 1,7-Bis(4-hydroxyphenyl)-1,4-heptadien-3-one induces lung cancer cell apoptosis via the PI3K/Akt and ERK1/2 pathways.

    abstract::1,7-Bis(4-hydroxyphenyl)-1,4-heptadien-3-one (EB30) is a diarylheptanoid-like compound isolated from Viscum coloratum. This curcumin analog exhibits significant cytotoxic activity against HeLa, SGC-7901, and MCF-7 cells. However, little is known about the anticancer effects and mechanisms of EB30 in human lung cancer....

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Fan J,Wu M,Wang J,Ren D,Zhao J,Yang G

    更新日期:2019-05-01 00:00:00