Upregulation of SOX11 enhances tamoxifen resistance and promotes epithelial-to-mesenchymal transition via slug in MCF-7 breast cancer cells.


:Resistance to tamoxifen remains a prominent conundrum in the therapy of hormone-sensitive breast cancer. Also, the molecular underpinnings leading to tamoxifen resistance remain unclear. In the present study, we utilized the Gene Expression Omnibus database to identify that SOX11 might exert a pivotal function in conferring tamoxifen resistance of breast cancer. SOX11 was found to be markedly upregulated at both the messenger RNA and protein levels in established MCF-7-Tam-R cells compared to the parental counterparts. Moreover, SOX11 was able to activate the transcription of slug via binding to its promoter, resulting in promoting the progress of epithelial-to-mesenchymal transition and suppressing the expression of ESR1. Downregulating SOX11 expression can restore the sensitivity to 4-hydroxytamoxifen in MCF-7-Tam-R cells. Survival analysis from large sample datasets indicated that SOX11 was closely related to poorer survival in patients with breast cancer. These findings suggest a novel feature of SOX11 in contributing to tamoxifen resistance. Hence, targeting SOX11 could be a potential therapeutic strategy to tackle tamoxifen resistance in breast cancer.


J Cell Physiol


Xiao Y,Xie Q,Qin Q,Liang Y,Lin H,Zeng




Has Abstract


2020-10-01 00:00:00












  • Effects of IGFBP3 gene silencing mediated inhibition of ERK/MAPK signaling pathway on proliferation, apoptosis, autophagy, and cell senescence in rats nucleus pulposus cells.

    abstract:OBJECTIVE:Disc degeneration is the common life-threatening disease characterized by flank pain. The gene expression of insulin-like growth factor binding protein 3 (IGFBP3) is increased in patients with disc degeneration, however, its mechanism is still unknown. This study aimed to investigate the influence of IGFBP3 g...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Chen G,Zhou X,Xu Z

    更新日期:2019-06-01 00:00:00

  • Interleukin 1 stimulates prostaglandin synthesis and cyclic AMP accumulation in Swiss 3T3 fibroblasts: interactions between two second messenger systems.

    abstract::Biochemical events elicited by interleukin 1 (IL-1) were studied in Swiss 3T3 fibroblasts. One hour after its addition, IL-1 stimulated synthesis of prostaglandin E2 (PGE2), which continued to accumulate for 4 days. IL-1 also stimulated cAMP accumulation. Indomethacin blocked cAMP accumulation in response to IL-1, sug...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Burch RM,White MF,Connor JR

    更新日期:1989-04-01 00:00:00

  • Ascorbic Acid Induces Necrosis in Human Laryngeal Squamous Cell Carcinoma via ROS, PKC, and Calcium Signaling.

    abstract::Ascorbic acid induces apoptosis, autophagy, and necrotic cell death in cancer cells. We investigated the mechanisms by which ascorbic acid induces death in laryngeal squamous cell carcinoma Hep2 cells. Ascorbic acid markedly reduced cell viability and induced death without caspase activation and an increase in cytochr...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Baek MW,Cho HS,Kim SH,Kim WJ,Jung JY

    更新日期:2017-02-01 00:00:00

  • Involvement of protein phosphatase 2A in the maintenance of E-cadherin-mediated cell-cell adhesion through recruitment of IQGAP1.

    abstract::Serine/threonine protein phosphatase (PP) 2A regulates many biological processes, however it remains unclear whether PP2A participates in cadherin-mediated cell-cell adhesion. We show here that the core enzyme of PP2A (PP2A-AC) is localized in the cell-cell adhesion sites between adjacent cells and associated with the...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Takahashi K,Nakajima E,Suzuki K

    更新日期:2006-03-01 00:00:00

  • Density-dependent regulation of cell surface gamma-glutamyl transpeptidase in cultured glial cells.

    abstract::A decline in cell surface gamma-glutamyl transpeptidase specific activity was previously observed to be concomitant with C6 glial cell proliferation. To elucidate the underlying factor(s) mediating gamma-glutamyl transpeptidase down-regulation, the effects of C6 cell density and culture conditions on cell surface tran...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Morgenstern K,Hanson-Painton O,Wang BL,De Bault L

    更新日期:1992-01-01 00:00:00

  • Molecular and clinical characterization of Galectin-9 in glioma through 1,027 samples.

    abstract::In recent years, research on glioma immunotherapy have grown rapidly. However, the autoimmune-like side effects that are caused by blocking immunological checkpoints hinder their clinical application in gliomas currently. Galectin-9, a ligand for T-cell immunoglobulin mucin 3, has shed a new light on the treatment of ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Yuan F,Ming H,Wang Y,Yang Y,Yi L,Li T,Ma H,Tong L,Zhang L,Liu P,Li J,Lin Y,Yu S,Ren B,Yang X

    更新日期:2020-05-01 00:00:00

  • Forskolin has biphasic effects on osteoprogenitor cell differentiation in vitro.

    abstract::Cells isolated from fetal rat calvaria (RC) and maintained in vitro in medium containing ascorbic acid and B-glycerophosphate form three-dimensional, mineralized nodules having the histological, immunohistological, and ultrastructural characteristics of woven bone. We have studied the effects of forskolin (FSK), a dit...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Turksen K,Grigoriadis AE,Heersche JN,Aubin JE

    更新日期:1990-01-01 00:00:00

  • The impact of culture dimensionality on behavioral epigenetic memory contributing to pluripotent state of iPS cells.

    abstract::Three-dimensional (3D) culture platforms have been explored to establish physiologically relevant cell culture environment and permit expansion scalability; however, little is known about the mechanisms underlying the regulation of pluripotency of human induced pluripotent stem cells (hiPSCs). This study elucidated ep...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Thanuthanakhun N,Kino-Oka M,Borwornpinyo S,Ito Y,Kim MH

    更新日期:2020-12-10 00:00:00

  • Chromosome balance and the control of malignancy.

    abstract::The Giemsa banding pattern of the chromosomes has been analyzed in a line of transformed golden hamster cells, revertant and re-revertant cells and their tumors. The transformed and re-revertant cells were malignant in vivo and had gained an additional chromosome 5(7). Revertants with a suppression of malignancy lost ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Bloch-Shtacher N,Sachs L

    更新日期:1976-01-01 00:00:00

  • COMMD7 as a novel NEMO interacting protein involved in the termination of NF-κB signaling.

    abstract::NEMO/IKKγ is the regulatory subunit of the IκB Kinase (IKK) complex, required for the activation of the NF-κB pathway, which is involved in a variety of key processes, including immunity, inflammation, differentiation, and cell survival. Termination of NF-κB activity on specific -κB responsive genes, which is crucial ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Esposito E,Napolitano G,Pescatore A,Calculli G,Incoronato MR,Leonardi A,Ursini MV

    更新日期:2016-01-01 00:00:00

  • Sulfated malto-oligosaccharides bind to basic FGF, inhibit endothelial cell proliferation, and disrupt endothelial cell tube formation.

    abstract::The interaction of basic FGF (bFGF) with heparin, heparan sulfate and related sugars can potentiate or antagonize bFGF activity, depending on the size of the saccharide used. Oligosaccharides based on heparin structures, as small as six sugar residues, have been demonstrated to bind to bFGF and block its activity, whi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Foxall C,Wei Z,Schaefer ME,Casabonne M,Fugedi P,Peto C,Castellot JJ Jr,Brandley BK

    更新日期:1996-09-01 00:00:00

  • Grb10 adapter protein as regulator of insulin-like growth factor receptor signaling.

    abstract::Grb10 is a member of a superfamily of adapter proteins that includes Grb10, 7, 14, and a protein of Caenorhabditis elegans called Mig10. Grb10 proteins are binding partners for several trans-membrane tyrosine-kinase receptors, including the insulin-like growth factor receptor (IGF-IR) and the insulin receptor (IR). Ma...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Morrione A

    更新日期:2003-12-01 00:00:00

  • G Protein γ subunit 7 loss contributes to progression of clear cell renal cell carcinoma.

    abstract::Clear cell renal cell carcinoma (ccRCC) is a common urinary neoplasm, looking for useful candidates to establish scientific foundation for the therapy of ccRCC is urgent. We downloaded genomic profiles of GSE781, GSE6244, GSE53757, and GSE66271 from the Gene Expression Omnibus (GEO) database. GEO2R was used to analyze...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Xu S,Zhang H,Liu T,Chen Y,He D,Li L

    更新日期:2019-11-01 00:00:00

  • Amino acid pools in CHL V79 cells during induction of thermotolerance: reduction in free intracellular glutamine.

    abstract::The amino acid pools in Chinese hamster lung V79 cells were measured as a function of time during hyperthermic exposure at 40.5 degrees and 45.0 degrees C. Sixteen of the 20 protein amino acids were present in sufficient quantity to measure accurately. The total amino acid pool and all individual amino acids, except g...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Goh CJ,Dumbroff EB,Lepock JR

    更新日期:1988-04-01 00:00:00

  • Inflammatory molecules produced by meniscus and synovium in early and end-stage osteoarthritis: a coculture study.

    abstract::The aim of this study was to identify the molecules and pathways involved in the cross-talk between meniscus and synovium that may play a critical role in osteoarthritis (OA) pathophysiology. Samples of synovium and meniscus were collected from patients with early and end-stage OA and cultured alone or cocultured. Cyt...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Favero M,Belluzzi E,Trisolino G,Goldring MB,Goldring SR,Cigolotti A,Pozzuoli A,Ruggieri P,Ramonda R,Grigolo B,Punzi L,Olivotto E

    更新日期:2019-07-01 00:00:00

  • Increased transcriptional response to mechanical strain in keloid fibroblasts due to increased focal adhesion complex formation.

    abstract::Clinicians have observed that keloids preferentially form in body areas subject to increased skin tension. We hypothesized a difference exists in the transcriptional response of keloid fibroblasts to mechanical strain compared with normal fibroblasts. Normal and keloid fibroblasts were seeded in a device calibrated to...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Wang Z,Fong KD,Phan TT,Lim IJ,Longaker MT,Yang GP

    更新日期:2006-02-01 00:00:00

  • Stem cell factor can overcome inhibition of highly purified human burst-forming units-erythroid by interferon gamma.

    abstract::Highly purified human blood burst-forming units-erythroid (BFU-E) were used to study the effects of interferon gamma (IFN gamma). IFN gamma inhibited erythroid colony formation, cell proliferation, and differentiation of day 3 to day 6 mature BFU-E in a dose-dependent manner. The primitive BFU-E (day 1 and day 2 cells...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Dai CH,Krantz SB,Kollar K,Price JO

    更新日期:1995-11-01 00:00:00

  • Aryl hydrocarbon receptor-mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(a)pyrene.

    abstract::The clinical literature strongly suggests that bone healing in cigarette smokers is impaired. Since cigarette smoke (CS) contains numerous polycyclic aromatic hydrocarbons (PAHs), and since dioxins impair bone formation in vivo via the Aryl Hydrocarbon Receptor (AHR), we investigated the impact of PAH/AHR signaling on...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Kung MH,Yukata K,O'Keefe RJ,Zuscik MJ

    更新日期:2012-03-01 00:00:00

  • The possible role of bacteria, viruses, and parasites in initiation and exacerbation of irritable bowel syndrome.

    abstract::Irritable bowel syndrome (IBS) is a prolonged and disabling functional gastrointestinal disorder with the incidence rate of 18% in the world. IBS could seriously affect lifetime of patients and cause high economic burden on the community. The pathophysiology of the IBS is hardly understood, whereas several possible me...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Shariati A,Fallah F,Pormohammad A,Taghipour A,Safari H,Chirani AS,Sabour S,Alizadeh-Sani M,Azimi T

    更新日期:2019-06-01 00:00:00

  • Cell cycle-related changes in regulatory volume decrease and volume-sensitive chloride conductance in mouse fibroblasts.

    abstract::Cell cycle-related changes in the ability to regulate cell volume following hyposmotic swelling were studied in mouse fibroblasts using videomicroscopy and the whole-cell patch clamp technique. Regulatory volume decrease (RVD) and volume-sensitive Cl- conductance (G(Cl,vol)) were measured: (1) in proliferating cells o...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Doroshenko P,Sabanov V,Doroshenko N

    更新日期:2001-04-01 00:00:00

  • Sarcolectin and interferon in the regulation of cell growth.

    abstract::Sarcolectin is an endolectin present in a great variety of conjunctival tissues (muscles, cartilage, sarcomas), but also in brain or placental extracts of vertebrates, including primates. When purified to electrophoretical homogeneity as a 65-kd protein, it agglutinates cells and has an affinity for simple sugars. In ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Chany-Fournier F,Jiang PH,Chany C

    更新日期:1990-10-01 00:00:00

  • Stress kinase p38 mediates EGFR transactivation by hyperosmolar concentrations of sorbitol.

    abstract::Activation of the epidermal growth factor receptor (EGFR) has been shown to occur by ligand-dependent and ligand-independent mechanisms. Different molecular mechanisms have been found to be responsible for ligand-independent receptor transactivation. Here, we show that hyperosmolar concentrations of sorbitol activate ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Cheng H,Kartenbeck J,Kabsch K,Mao X,Marqués M,Alonso A

    更新日期:2002-08-01 00:00:00

  • Monoclonal antibody that recognizes the carbohydrate portion of cell adhesion molecule L1 influences calcium current in cultured neurons.

    abstract::A monoclonal antibody (mAb), 2E12, against the neural cell adhesion molecule L1 recognized the 200 kDa component of L1. The epitope of L1 reacting with mAb 2E12 was localized in its carbohydrate chain, judging from the results of experiments on glycopeptidase F treatment. The physiological effect of adding mAbL1 (2E12...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Asou H

    更新日期:1992-11-01 00:00:00

  • Non-Metabolic Role of PKM2 in Regulation of the HIV-1 LTR.

    abstract::Identification of cellular proteins, in addition to already known transcription factors such as NF-κB, Sp1, C-EBPβ, NFAT, ATF/CREB, and LEF-1, which interact with the HIV-1 LTR, is critical in understanding the mechanism of HIV-1 replication in monocytes/macrophages. Our studies demonstrate upregulation of pyruvate ki...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Sen S,Deshmane SL,Kaminski R,Amini S,Datta PK

    更新日期:2017-03-01 00:00:00

  • Cell cycle dependent gene expression in quiescent stimulated and asynchronously cycling arterial smooth muscle cells in culture.

    abstract::The expression of a set of cell cycle dependent (CCD) genes (c-fos, c-myc, ornithine decarboxylase (ODC), and thymidine kinase (TK)) was comparatively studied in cultured arterial smooth muscle cells (SMC) during exit from quiescence and exponential proliferation. These genes, which were not expressed in quiescent SMC...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Campan M,Desgranges C,Gadeau AP,Millet D,Belloc F

    更新日期:1992-03-01 00:00:00

  • c-Ha-rasEJ transfection of rat aortic smooth muscle cells induces epidermal growth factor responsiveness and characteristics of a malignant phenotype.

    abstract::Although the role of several protooncogenes, including sis, myc, and myb in the regulation of growth and differentiation of vascular cells has been examined in some detail, limited information is available on the contribution of ras genes to these processes. In the present studies the influence of oncogenic ras transf...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Sadhu DN,Lundberg MS,Burghardt RC,Ramos KS

    更新日期:1994-12-01 00:00:00

  • Functional multimerization of mucolipin channel proteins.

    abstract::MCOLN1 encodes mucolipin-1 (TRPML1), a member of the transient receptor potential TRPML subfamily of channel proteins. Mutations in MCOLN1 cause mucolipidosis-type IV (MLIV), a lysosomal storage disorder characterized by severe neurologic, ophthalmologic, and gastrointestinal abnormalities. Along with TRPML1, there ar...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Curcio-Morelli C,Zhang P,Venugopal B,Charles FA,Browning MF,Cantiello HF,Slaugenhaupt SA

    更新日期:2010-02-01 00:00:00

  • ADP-Induced Ca2+ Signaling and Proliferation of Rat Ventricular Myofibroblasts Depend on Phospholipase C-Linked TRP Channels Activation Within Lipid Rafts.

    abstract::Nucleotides released during heart injury affect myocardium electrophysiology and remodeling through P2 purinoceptors activation in cardiac myofibroblasts. ATP and UTP endorse [Ca2+ ]i accumulation and growth of DDR-2/α-SMA-expressing myofibroblasts from adult rat ventricles via P2Y4 and P2Y2 receptors activation, resp...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Certal M,Vinhas A,Barros-Barbosa A,Ferreirinha F,Costa MA,Correia-de-Sá P

    更新日期:2017-06-01 00:00:00

  • PPARα Antagonist AA452 Triggers Metabolic Reprogramming and Increases Sensitivity to Radiation Therapy in Human Glioblastoma Primary Cells.

    abstract::Glioblastoma (GB) is the most common cancer in the brain and with an increasing incidence. Despite major advances in the field, there is no curative therapy for GB to date. Many solid tumors, including GB, experienced metabolic reprogramming in order to sustain uncontrolled proliferation, hypoxic conditions, and angio...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Benedetti E,d'Angelo M,Ammazzalorso A,Gravina GL,Laezza C,Antonosante A,Panella G,Cinque B,Cristiano L,Dhez AC,Astarita C,Galzio R,Cifone MG,Ippoliti R,Amoroso R,Di Cesare E,Giordano A,Cimini A

    更新日期:2017-06-01 00:00:00

  • Novel nanohydrogel of hyaluronic acid loaded with quercetin alone and in combination with temozolomide as new therapeutic tool, CD44 targeted based, of glioblastoma multiforme.

    abstract::Glioblastoma multiforme is the most common and aggressive primary brain cancer with only ∼3% of patients surviving more than 3 years from diagnosis. Several mechanisms are involved in drug and radiation resistance to anticancer treatments and among them one of the most important factors is the tumor microenvironment s...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Barbarisi M,Iaffaioli RV,Armenia E,Schiavo L,De Sena G,Tafuto S,Barbarisi A,Quagliariello V

    更新日期:2018-10-01 00:00:00