Abstract:
:Gicerin/CD146 is a cell adhesion molecule, which belongs to the immunoglobulin (Ig) superfamily. We have reported that it has a homophilic binding activity, which participates in the neurite extension from embryonic neurons. To elucidate how gicerin is involved in the neurite extension mechanism, we employed PC12 cells, which expresses gicerin/CD146. PC12 cells extend longer neurites by nerve growth factor (NGF) on gicerin substrate than on without gicerin substrate, which indicates that gicerin participates in neurite extension by NGF. We also found that the expression of gicerin in PC12 cells is induced by NGF. Over-expression of gicerin also promotes neurite extension by gicerin-gicerin homophilic interaction. These findings suggested that increase of gicerin expression by NGF promotes the gicerin-gicerin homophilic interaction resulting in the neurite extension.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Taira E,Kohama K,Tsukamoto Y,Okumura S,Miki Ndoi
10.1002/jcp.20365keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
632-7issue
2eissn
0021-9541issn
1097-4652journal_volume
204pub_type
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