Sarcolectin and interferon in the regulation of cell growth.

abstract：:We have previously isolated 3T3 cell variants unable to respond to specific mitogens. In this report we analyze the dominant and/or recessive nature of these variants. Two independently isolated EGF nonproliferative variants are unable to bind EGF. Hybrids between 3T3R5 cells (thymidine kinase deficient, ouabain-resis...

journal_title：Journal of cellular physiology

authors： Terwilliger E,Herschman HR

更新日期：1985-06-01 00:00:00

abstract：:The Pur proteins are an ancient family of sequence-specific single-stranded nucleic acid-binding proteins. They bind a G-rich element in either single- or double-stranded nucleic acids and are capable of displacing the complementary C-rich strand. Recently several reports have described Pur family member knockouts, mu...

journal_title：Journal of cellular physiology

authors： Johnson EM,Daniel DC,Gordon J

更新日期：2013-05-01 00:00:00

abstract：:Hydrocortisone and dexamethasone produced a time-dependent increase [125I]epidermal growth factor [( 125I]EGF) binding in primary cultures of isolated rat hepatocytes. Maximally effective doses of glucocorticoids resulted in a 70-100% increase in binding. The effect was similar when hepatocytes were maintained on coll...

journal_title：Journal of cellular physiology

authors： Lin Q,Blaisdell J,O'Keefe E,Earp HS

更新日期：1984-06-01 00:00:00

abstract：:Sepsis, a complex and dynamic syndrome resulting from microbial invasion and immune system dysregulation, is associated with an increased mortality, reaching up to 35% worldwide. Cholesterol metabolism is often disturbed during sepsis, with low plasma cholesterol levels being associated with poor prognosis. Proprotein...

journal_title：Journal of cellular physiology

authors： Paciullo F,Fallarino F,Bianconi V,Mannarino MR,Sahebkar A,Pirro M

更新日期：2017-09-01 00:00:00

abstract：:During wound healing, myofibroblasts play a central role in matrix formation and wound contraction. At the end of healing, there is evidence that myofibroblasts disappear via apoptotic pathways. Hypertrophic scars are a fibroproliferative disorder that leads to considerable morbidity. It has been postulated that a def...

journal_title：Journal of cellular physiology

authors： Moulin V,Larochelle S,Langlois C,Thibault I,Lopez-Vallé CA,Roy M

更新日期：2004-03-01 00:00:00

abstract：:The members of the tumor necrosis factor (TNF) family play pivotal roles in the regulation of the immune system. LIGHT is a type II transmembrane protein belonging to the TNF family that was originally identified as a weak inducer of apoptosis. This cytokine has been extensively studied for its role in T cell regulati...

journal_title：Journal of cellular physiology

authors： Zou GM,Hu WY

更新日期：2005-12-01 00:00:00

abstract：:The pregnane X receptor (PXR, NR1I2) is a ligand-activated nuclear receptor which plays an essential role in organism's metabolic detoxification system by sensing the presence of xenobiotics and triggering detoxification responses. In addition to its role in xenobiotic metabolism, PXR has pleiotropic functions in regu...

journal_title：Journal of cellular physiology

authors： Ma X,Chen J,Tian Y

更新日期：2015-04-01 00:00:00

abstract：:Erythropoietin (EPO) retards DNA breakdown characteristic of programmed cell death (apoptosis) and promotes survival in erythroid progenitor cells. The mechanism by which EPO inhibits programmed death is unknown. In the well-characterized model of glucocorticoid-treated thymocytes, activation of a Ca2+/Mg(2+)-sensitiv...

journal_title：Journal of cellular physiology

authors： Kelley LL,Koury MJ,Bondurant MC

更新日期：1992-06-01 00:00:00

abstract：:A proliferation inducing ligand (APRIL or TALL-2 and TRDL-1) was first discovered as a cytokine over-expressed in many transformed cells and with the capacity to stimulate proliferation. APRIL was shown to bind two different receptors of the TNF receptor superfamily: B cell maturation antigen (BCMA) and transmembrane ...

journal_title：Journal of cellular physiology

authors： Kimberley FC,Hahne M,Medema JP

更新日期：2009-01-01 00:00:00

abstract：:Over-production and activation of osteoclasts is a common feature of osteolytic conditions such as osteoporosis, tumor-associated osteolysis, and inflammatory bone erosion. Cyanidin Chloride, a subclass of anthocyanin, displays antioxidant and anti-carcinogenesis properties, but its role in osteoclastic bone resorptio...

journal_title：Journal of cellular physiology

authors： Cheng J,Zhou L,Liu Q,Tickner J,Tan Z,Li X,Liu M,Lin X,Wang T,Pavlos NJ,Zhao J,Xu J

更新日期：2018-03-01 00:00:00

abstract：:A novel, serum albumin-binding glycoprotein of molecular weight (mw) 43,000 (43K protein) was initially purified from the culture medium of bovine aortic endothelial (BAE) cells (Sage, H., Johnson, C., and Bornstein, P., J. Biol. Chem. 259:3993-4007, 1984). Its secretion by normal mesenchymal cells and by transformed ...

journal_title：Journal of cellular physiology

authors： Sage H,Tupper J,Bramson R

更新日期：1986-06-01 00:00:00

abstract：:Cultivation of human parotid glands in serum-free medium (Ca(2+) concentration, 0.2 mM) with growth supplements resulted in isolation of a homogeneous population of epithelial cells without any mesenchymal cells. The isolated cells showed an undifferentiated phenotype with scant cytoplasmic organelles, and low levels ...

journal_title：Journal of cellular physiology

authors： Hiraki A,Shirasuna K,Ikari T,Shinohara M,Garrod DR

更新日期：2002-10-01 00:00:00

abstract：:Total cellular calcium levels do not change when 3T3-4a cells stop proliferating due to serum depletion, or when serum-arrested quiescent cells are incubated for up to 44 hours in calcium-deficient medium (approximately 10 micrometer Ca++). Upon stimulation with dialyzed serum cells enter S and progress through at lea...

journal_title：Journal of cellular physiology

authors： Paul D,Ristow HJ

更新日期：1979-01-01 00:00:00

abstract：:Toll-like receptors (TLRs) are related to foam cell formation (FCF), key event in the establishment/progression of atherosclerosis. The activation of TLR2 and TLR4 can increase FCF. The aim of this study was to evaluate the role of TLR9 in FCF. Murine macrophages were treated with CpG-ODN, TLR9 agonist, and oxidized p...

journal_title：Journal of cellular physiology

authors： Sorrentino R,Morello S,Chen S,Bonavita E,Pinto A

更新日期：2010-04-01 00:00:00

abstract：:Members of the epidermal growth-factor-receptor tyrosine-kinase (EGFR) family play important roles both in normal growth regulation/cell differentiation and in the genesis and progression of human neoplasia. In the present study, we analysed distinct heregulin (HRG) signals mediated by the HRG receptors HER3 and HER4....

journal_title：Journal of cellular physiology

authors： Weiss FU,Wallasch C,Campiglio M,Issing W,Ullrich A

更新日期：1997-11-01 00:00:00

abstract：:Podocyte injury is a critical factor for the initiation and progression of diabetic kidney disease (DKD). However, the underlying mechanisms of podocyte injury in DKD have not been completely elucidated. Studies suggested that intracellular cholesterol accumulation was correlated with podocyte injury, but the cause of...

journal_title：Journal of cellular physiology

authors： Hu J,Yang Q,Chen Z,Liang W,Feng J,Ding G

更新日期：2019-12-01 00:00:00

abstract：:Male breast cancer (MBC) is an uncommon malignancy. We have previously reported that the expression of the Hippo transducers TAZ/YAP and their target CTGF was associated with inferior survival in MBC patients. Preclinical evidence demonstrated that Axl is a transcriptional target of TAZ/YAP. Thus, we herein assessed A...

journal_title：Journal of cellular physiology

authors： Di Benedetto A,Mottolese M,Sperati F,Ercolani C,Di Lauro L,Pizzuti L,Vici P,Terrenato I,Shaaban AM,Humphries MP,Sundara-Rajan S,Barba M,Speirs V,De Maria R,Maugeri-Saccà M

更新日期：2017-08-01 00:00:00

abstract：:BAG3 protein, a member of the BAG co-chaperones family, sustains cell survival in a variety of normal and neoplastic cell types, via its interaction with a variety of partners, such as the heat shock protein (HSP) 70, Bcl-2, Raf-1 and others. Expression of BAG3 is induced by some stressful stimuli, such as heat shock,...

journal_title：Journal of cellular physiology

authors： Du ZX,Zhang HY,Meng X,Gao YY,Zou RL,Liu BQ,Guan Y,Wang HQ

更新日期：2009-03-01 00:00:00

abstract：:The binding of [3H]tuftsin to normal and in vivo stimulated mouse peritoneal macrophage populations was studied at 22 degrees C. The [3H]tuftsin binding to thioglycollate-stimulated macrophages was shown to be rapid and saturable, with an equilibrium dissociation constant (K(D)) (calculated from a Scatchard plot) of 5...

journal_title：Journal of cellular physiology

authors： Bar-Shavit Z,Stabinsky Y,Fridkin M,Goldman R

更新日期：1979-07-01 00:00:00

abstract：:Non-histone chromosomal proteins are phosphorylated and dephosphorylated within the intact nucleus by two independent sets of reactions, a protein kinase reaction which transfers the terminal phosphate group of a variety of nucleoside and deoxynucleoside triphosphates to serine and threonine residues in the proteins, ...

journal_title：Journal of cellular physiology

authors： Kleinsmith LJ

更新日期：1975-04-01 00:00:00

abstract：:Deletion of p53, most common genetic alteration, is observed in human tumors and reported to lead to improve in cell radioresistance. Heavy-ion irradiation (IR) could induce p53-/- cancer cells apoptosis. However, little is known regarding the molecular mechanism in this type of cell apoptosis. The present studies hav...

journal_title：Journal of cellular physiology

authors： Xie Y,Si J,Wang YP,Li HY,Di CX,Yan JF,Ye YC,Zhang YS,Zhang H

更新日期：2018-02-01 00:00:00

abstract：:We have proposed that the transmembrane receptor encoded by the c-Kit protooncogene and its ligand play an important role in regulating the proliferation of blasts cells in acute myeloblastic leukemia (AML). To test this hypothesis, immunobeads were used to separate blasts from three Kit-expression positive cell lines...

journal_title：Journal of cellular physiology

authors： Tohda S,Yang GS,Ashman LK,McCulloch EA,Minden MD

更新日期：1993-02-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is the most common malignancy in head and neck cancer and a global cause of cancer-related death. Due to the poor survival rates associated with OSCC, there is a growing need to develop novel technologies and predictive biomarkers to improve disease diagnosis. The identification of ...

journal_title：Journal of cellular physiology

authors： Wang Q,Zhi Y,Ren W,Li S,Dou Z,Xing X,Quan X,Wang Y,Jiang C,Liang X,Gao L,Zhi K

更新日期：2019-01-28 00:00:00

abstract：:The C3H/10T 1/2 embryo cell line, which is nontumorigenic when inoculated subcutaneously in saline suspension, produces tumors when implanted subcutaneously attached to 1 X 5 X 10 mm plastic plates. Under these in vivo conditions there is direct selection for "spontaneous" transformants that have undergone the specifi...

journal_title：Journal of cellular physiology

authors： Paranjpe M,del Ande Eaton S,Boone CW

更新日期：1978-07-01 00:00:00

abstract：:Adipogenesis plays a key role in the pathogenesis of obesity. It begins with the commitment of mesenchymal stem cells (MSCs) to the adipocyte lineage, followed by terminal differentiation of preadipocytes to mature adipocytes. A critical, but poorly understood, component of adipogenesis involves proliferation of MSCs ...

journal_title：Journal of cellular physiology

authors： Stewart A,Guan H,Yang K

更新日期：2010-06-01 00:00:00

abstract：:Osteoarthritis (OA) is a common chronic degenerative disease that affects all joints. At present, the pathological processes and mechanisms of OA are still unclear. Innate immunity, a key player in damage to the structure of the joint and the mechanism by which the host attempts to repair OA, affects all pathological ...

journal_title：Journal of cellular physiology

authors： Wang H,Wang Q,Yang M,Yang L,Wang W,Ding H,Zhang D,Xu J,Tang X,Ding H,Wang Q

更新日期：2018-02-01 00:00:00

abstract：:Exposure of live cells to shear flow induces major changes in cell shape, adhesion to the extracellular matrix, and migration. In the present study, we show that exposure of cultured multiple myeloma (MM) cells to shear flow of 4-36 dynes/cm(2) triggers the extension of long tubular protrusions (denoted flow-induced p...

journal_title：Journal of cellular physiology

authors： Porat Z,Yaron I,Katz BZ,Kam Z,Geiger B

更新日期：2011-12-01 00:00:00

abstract：:Toll-like receptors (TLRs) are usually expressed on immune cells such as macrophages, dendritic cells, mast cells, as well as on eosinophils and some epithelial cells. They play a central role in the recognition of harmful molecules that belong to invading microorganisms or internal damaged tissues, which lead to infl...

journal_title：Journal of cellular physiology

authors： Ayala-Cuellar AP,Cho J,Choi KC

更新日期：2019-12-01 00:00:00

abstract：:Proteinuria in diabetic nephropathy has been correlated with reduction in heparan sulfate proteoglycan (HSPG) content of the glomerular basement membrane. We have previously shown that the underlying mechanism probably involves reduction in the synthesis by glomerular epithelial cells. In this study we explored whethe...

journal_title：Journal of cellular physiology

authors： Kasinath BS,Grellier P,Choudhury GG,Abboud SL

更新日期：1996-04-01 00:00:00

abstract：:Phosphodiesterase 5A (PDE5A) specifically degrades the ubiquitous second messenger cGMP and experimental and clinical data highlight its important role in cardiac diseases. To address PDE5A role in cardiac physiology, three splice variants of the PDE5A were cloned for the first time from mouse cDNA library (mPde5a1, m...

journal_title：Journal of cellular physiology

authors： Campolo F,Zevini A,Cardarelli S,Monaco L,Barbagallo F,Pellegrini M,Cornacchione M,Di Grazia A,De Arcangelis V,Gianfrilli D,Giorgi M,Lenzi A,Isidori AM,Naro F

更新日期：2018-01-01 00:00:00