International conference on basic and clinical aspects of cell-cycle control.

abstract：:A variant of the hypoxanthine-guanine phosphoribosyltransferase deficient, and adenine phosphoribosyltransferase deficient mouse resistant to 6-azauridine. These cells are not only resistant to 6-azauridine (5 X 10(-4) M), but also to adenosine (10(-3) M). Resistance persists indefinitely even in the absence of both c...

journal_title：Journal of cellular physiology

authors： Hashmi S,May SR,Krooth RS,Miller OJ

更新日期：1975-10-01 00:00:00

abstract：:B16 mouse melanoma cells are grown inhibited by cyclic AMP or by retinoic acid (RA). However, the combination of these two agents results in less growth inhibition than either agent alone. In order to investigate this interaction, cells were selected for resistance to 8-bromo-cyclic AMP-induced growth inhibition. Two ...

journal_title：Journal of cellular physiology

authors： Niles RM,Loewy B

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:MiR-152 has been reported as a tumor suppressor microRNA that is downregulated in a number of cancers, including colorectal cancer (CRC). A recent study suggested that miR-152 could be one of the key regulators of CRC. The aim of this study is to investigate the role of miR-152 in CRC and its mechanisms. ME...

journal_title：Journal of cellular physiology

authors： Ghazanchaei A,Mansoori B,Mohammadi A,Biglari A,Baradaran B

更新日期：2018-01-01 00:00:00

abstract：:Hepatic expression of the protooncogenes c-fos and c-myc occurs within 2 h after partial hepatectomy, and these immediate early genes are thought to prime the hepatocytes for subsequent proliferation. To examine whether such gene activation occurred in the setting of hepatocyte proliferation after toxic liver injury, ...

journal_title：Journal of cellular physiology

authors： Schmiedeberg P,Biempica L,Czaja MJ

更新日期：1993-02-01 00:00:00

abstract：:We studied the influence of hydrocortisone (HC) on hyaluronan (HA) metabolism in explants of human skin, a model retaining normal three-dimensional architecture of dermal connective tissue and dynamic growth and stratification of epidermal keratinocytes. The synthesis of hyaluronan and proteoglycans (PGs), and DNA, we...

journal_title：Journal of cellular physiology

authors： Agren UM,Tammi M,Tammi R

更新日期：1995-08-01 00:00:00

abstract：:Cancer is a multifaceted disease that involves acquisition of genetic mutations, deletions, and amplifications as well as deregulation of epigenetic mechanisms that fine-tune gene regulation. Key epigenetic mechanisms that include histone modifications, DNA methylation, and non-coding RNA-mediated gene silencing are o...

journal_title：Journal of cellular physiology

authors： Zaidi SK,Van Wijnen AJ,Lian JB,Stein JL,Stein GS

更新日期：2013-11-01 00:00:00

abstract：:In the present study, we have sought to determine whether a given signal transduction pathway can have diverse effects on subpopulations of cells of a lineage depending upon the stage of differentiation. To test this hypothesis, we selected the cyclic adenosine monophosphate (cAMP) signal transduction pathway because ...

journal_title：Journal of cellular physiology

authors： Mohan S,Strong DD,Hilliker S,Malpe R,Lee K,Farley J,Baylink DJ

更新日期：1993-09-01 00:00:00

abstract：:During the development of atherosclerotic and fibromuscular proliferates/lesions, smooth muscle cells (SMC) in the media, particularly near the lumen, are activated to migrate into the intima, where they continue to proliferate to form an intimal thickening. It is to date unclear whether SMCs situated adjacent to the ...

journal_title：Journal of cellular physiology

authors： Betz E,Fallier-Becker P,Wolburg-Buchholz K,Fotev Z

更新日期：1991-06-01 00:00:00

abstract：:We have previously shown that knockout of fibroblast growth factor-2 (FGF-2) and potential compensatory effects of other growth factors result in amelioration of disease symptoms in a transgenic mouse model of amyotrophic lateral sclerosis (ALS). ALS is a rapidly progressive neurological disorder leading to degenerati...

journal_title：Journal of cellular physiology

authors： Kefalakes E,Böselt S,Sarikidi A,Ettcheto M,Bursch F,Naujock M,Stanslowsky N,Schmuck M,Barenys M,Wegner F,Grothe C,Petri S

更新日期：2019-05-01 00:00:00

abstract：:Inhibition of the gap-filling, polymerizing step of excision repair by 1-beta-D-arabinofuranosylcytosine (ara-C) after irradiation with ultraviolet light in human diploid fibroblasts resulted in the formation of persistent DNA strand breaks in G1, G2, and plateau phase cells, but not in S phase cells. Addition of hydr...

journal_title：Journal of cellular physiology

authors： Cleaver JE

更新日期：1981-08-01 00:00:00

abstract：:Proteolytic cleavage of extracellular matrix (ECM) and disruption of tissue architecture are fundamental features of tumor cell invasion. The proteolytic activity is focused in close proximity to the tumor cells. Here, we describe the possibility to quantify local proteolytic activity in the microenvironment of larger...

journal_title：Journal of cellular physiology

authors： Ludwig T,Püttmann S,Bertram H,Tatenhorst L,Paulus W,Oberleithner H,Senner V

更新日期：2005-03-01 00:00:00

abstract：:Vascular endothelial cells (ECs) are constantly subjected to flow-induced shear stress that is crucial for endothelial functions. Laminar shear stress (LSS) exerts atheroprotection to ECs. Mitochondrial homeostasis is essential for cellular survival. However, the effects of LSS on mitochondrial homeostasis in ECs rema...

journal_title：Journal of cellular physiology

authors： Wu LH,Chang HC,Ting PC,Wang DL

更新日期：2018-06-01 00:00:00

abstract：:GAS1 is a pleiotropic protein that has been investigated because of its ability to induce cell proliferation, cell arrest, and apoptosis, depending on the cellular or the physiological context in which it is expressed. At this point, we have information about the molecular mechanisms by which GAS1 induces proliferatio...

journal_title：Journal of cellular physiology

authors： Pérez-Sánchez G,Jiménez A,Quezada-Ramírez MA,Estudillo E,Ayala-Sarmiento AE,Mendoza-Hernández G,Hernández-Soto J,Hernández-Hernández FC,Cázares-Raga FE,Segovia J

更新日期：2018-05-01 00:00:00

abstract：:Differentiation of myofibroblast, as evidenced by alpha-smooth muscle actin (alpha-SMA) expression, is largely mediated by transforming growth factor-beta1 (TGF-beta1). This mechanism often follows inflammatory events such as endothelial damage due to oxidative stress, which can further leads to vascular thickening, s...

journal_title：Journal of cellular physiology

authors： Sen U,Moshal KS,Tyagi N,Kartha GK,Tyagi SC

更新日期：2006-12-01 00:00:00

abstract：:We analyzed the effect of exposure to hypoxic/hypercapnic (HH) gas mixture (5% O2 /9% CO2 ) on the maintenance of functional cord blood CD34(+) hematopoietic stem and progenitor cells in severe hypothermia (4°C) employing the physiological and proteomic approaches. Ten-day exposure to HH maintained the Day 0 (D-0) lev...

journal_title：Journal of cellular physiology

authors： Vlaski M,Negroni L,Kovacevic-Filipovic M,Guibert C,Brunet de la Grange P,Rossignol R,Chevaleyre J,Duchez P,Lafarge X,Praloran V,Schmitter JM,Ivanovic Z

更新日期：2014-12-01 00:00:00

abstract：:This review addresses peptide regions of human tumor liberated protein (TLP) complexes with antigenic activity. The review also deals with antibodies reacting with such proteins, to be used for diagnostic and clinical purposes. We identified peptide sequences of the TLP 100 kDa protein. Lung cancer cells were found po...

journal_title：Journal of cellular physiology

authors： Tarro G

更新日期：2009-10-01 00:00:00

abstract：:Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), are incurable diseases characterized by progressive loss of cognitive or motor function, which construct a serious threat to the life quality of aging populations and their life spans. Apelin is an ...

journal_title：Journal of cellular physiology

authors： Luo H,Han L,Xu J

更新日期：2020-02-01 00:00:00

abstract：:Eukaryotic organisms package DNA into chromatin for compact storage in the cell nucleus. However, this process promotes transcriptional repression of genes. To overcome the transcriptional repression, chromatin remodeling complexes have evolved that alter the configuration of chromatin packaging of DNA into nucleosome...

journal_title：Journal of cellular physiology

authors： Bartlett C,Orvis TJ,Rosson GS,Weissman BE

更新日期：2011-08-01 00:00:00

abstract：:Cancer cell lines have contributed immensely in understanding the complex physiology of cancers. They are excellent material for studies as they offer homogenous samples without individual variations and can be utilised with ease and flexibility. Also, the number of assays and end-points one can study is almost limitl...

journal_title：Journal of cellular physiology

authors： Ravi M,Ramesh A,Pattabhi A

更新日期：2017-10-01 00:00:00

abstract：:Differentiated embryo chondrocyte 1 (DEC1), a member of basic-helix-loop-helix transcription factor Bhlhe40, also called stimulated by retinoic acid 13, STRA13, plays an important role in the regulation of adipogenesis, tumorigenesis, peripheral circadian output, response to hypoxia, and development of metabolic syndr...

journal_title：Journal of cellular physiology

authors： Huang Y,Lai X,Hu L,Lei C,Lan X,Zhang C,Ma Y,Zheng L,Bai YY,Lin F,Chen H

更新日期：2018-12-01 00:00:00

abstract：:CRM197 is a naturally nontoxic diphtheria toxin mutant that binds and inhibits heparin-binding epidermal growth factor-like growth factor. CRM197 serves as carrier protein for vaccine and other therapeutic agents. CRM197 also inhibits the growth, migration, invasion, and induces apoptosis in various tumors. Vascular c...

journal_title：Journal of cellular physiology

authors： Hu Y,Lin X,Wang P,Xue YX,Li Z,Liu LB,Yu B,Feng TD,Liu YH

更新日期：2015-08-01 00:00:00

abstract：:Histone deacetylase 2 (HDAC2) catalyzes deacetylation of histones at the promoter and coding regions of transcribed genes and regulates chromatin structure and transcription. To explore the role of HDAC2 and phosphorylated HDAC2 in gene regulation, we studied the location along transcribed genes, the mode of recruitme...

journal_title：Journal of cellular physiology

authors： Jahan S,Sun JM,He S,Davie JR

更新日期：2018-02-01 00:00:00

abstract：:BHK fibroblasts can be growth arrested by incubation in low serum (0.1%) medium. Growth is initiated by incubating cells in high serum (10%) medium. We have found that if the quiescent cells in low serum medium are incubated with insulin, the G0 to S transit time is decreased by two to six hours when serum (10%) is ad...

journal_title：Journal of cellular physiology

authors： Kletzien RF,Day P

更新日期：1980-12-01 00:00:00

abstract：:Ascorbic acid induces apoptosis, autophagy, and necrotic cell death in cancer cells. We investigated the mechanisms by which ascorbic acid induces death in laryngeal squamous cell carcinoma Hep2 cells. Ascorbic acid markedly reduced cell viability and induced death without caspase activation and an increase in cytochr...

journal_title：Journal of cellular physiology

authors： Baek MW,Cho HS,Kim SH,Kim WJ,Jung JY

更新日期：2017-02-01 00:00:00

abstract：:Regulation of lipid synthesis from acetate in human diploid fibroblast cultures has been studied at various passage levels and at different stages of cell growth. When cultures were transferred to lipid free medium, a stimulation of [14C]acetate incorporation into lipid occurred within three to six hours after removal...

journal_title：Journal of cellular physiology

authors： Howard BV,Howard WJ,Kefalides NA

更新日期：1976-10-01 00:00:00

abstract：:A temperature-sensitive mutant with a defect in glycoprotein synthesis and a cell cycle (G1)-specific arrest at the nonpermissive temperature (Tenner et al., J. Cell. Physiol., 90:145-160, 1977; Tenner and Scheffler, J. Cell. Physiol., 98:251-266, 1979) was investigated further after a human epidermal growth factor (E...

journal_title：Journal of cellular physiology

authors： Feige JJ,Scheffler IE

更新日期：1987-12-01 00:00:00

abstract：:The S100 protein family comprises more than 20 members of small calcium binding proteins operating as Ca2 +-activated switches that interact and modulate the activity of a large number of targets. S100A1 and S100B, two members of this family, have been recently associated with the differentiation status of human artic...

journal_title：Journal of cellular physiology

authors： Diaz-Romero J,Nesic D

更新日期：2017-08-01 00:00:00

abstract：:NEMO/IKKγ is the regulatory subunit of the IκB Kinase (IKK) complex, required for the activation of the NF-κB pathway, which is involved in a variety of key processes, including immunity, inflammation, differentiation, and cell survival. Termination of NF-κB activity on specific -κB responsive genes, which is crucial ...

journal_title：Journal of cellular physiology

authors： Esposito E,Napolitano G,Pescatore A,Calculli G,Incoronato MR,Leonardi A,Ursini MV

更新日期：2016-01-01 00:00:00

abstract：:The effect of changes in muscle length on post-tetanic isometric twitch tension potentiation and myosin P-light chain phosphorylation was studied at 23 degrees C in the mouse extensor digitorum longus muscle. The length-tension relationship was determined for the same muscles after a 30 min period of quiescence and be...

journal_title：Journal of cellular physiology

authors： Moore RL,Persechini A

更新日期：1990-05-01 00:00:00

abstract：:CRSBP-1 (mammalian LYVE-1) is a membrane glycoprotein highly expressed in lymphatic endothelial cells (LECs). It has multiple ligands, including hyaluronic acid (HA) and growth factors/cytokines (e.g., PDGF-BB and VEGF-A) containing CRS motifs (clusters of basic amino-acid residues). The ligand binding activities are ...

journal_title：Journal of cellular physiology

authors： Huang SS,Li YW,Wu JL,Johnson FE,Huang JS

更新日期：2018-04-01 00:00:00