Tumor suppressors Sav/Scrib and oncogene Ras regulate stem-cell transformation in adult Drosophila malpighian tubules.

abstract：:So far, there were no reports on circular RNA (circRNA) expression profiles in the differentiation of human umbilical cord-derived mesenchymal stem cells (hUCMSCs) into cardiomyocyte-like cells induced by 5-aza. In this study, hUCMSCs were isolated from umbilical cords and induced with 5-aza for 14 days. Immunofluores...

journal_title：Journal of cellular physiology

authors： Ruan ZB,Chen GC,Zhang R,Zhu L

更新日期：2019-02-12 00:00:00

abstract：:These studies describe a liquid suspension culture system for normal myeloid cells derived from human foetal liver. A simple one-step fractionation procedure was employed to obtain a cell population capable of expanding into all stages of myeloid differentiation, including committed myeloid progenitor cells (GM-CFC). ...

journal_title：Journal of cellular physiology

authors： Toksoz D,Brown G

更新日期：1984-05-01 00:00:00

abstract：:Pulmonary fibrosis is a potentially fatal consequence of treatments for malignancy and is an increasing problem in bone marrow transplant patients and in cases of allogenic lung transplant. The fibrotic response is characterized by increases in lung fibroblast number and collagen synthesis. This laboratory previously ...

journal_title：Journal of cellular physiology

authors： Sempowski GD,Derdak S,Phipps RP

更新日期：1996-05-01 00:00:00

abstract：:The loss of pancreatic islet β-cell function represents the classical feature in the pathogenesis of type 2 diabetes mellitus (T2DM). Previous evidence has highlighted the involvement of the activated JNK pathway in relation to islet β-cell apoptosis. Hence, during the present study a streptozotocin-induced DM mice mo...

journal_title：Journal of cellular physiology

authors： Wang S,Wen X,Han XR,Wang YJ,Shen M,Fan SH,Zhuang J,Xu W,Zhang ZF,Shan Q,Li MQ,Hu B,Sun CH,Wu DM,Lu J,Zheng YL

更新日期：2018-09-01 00:00:00

abstract：:The prevalence of chronic hyperglycemia and its complications, imposing a critical burden on the worldwide economy and the global healthcare system, is a pressing issue. Mounting evidence indicates that oxidative stress and hypoxia, two noticeable features of hyperglycemia, play a joint crucial role in mediating cellu...

journal_title：Journal of cellular physiology

authors： Huang YT,Liu CH,Yang YC,Aneja R,Wen SY,Huang CY,Kuo WW

更新日期：2019-08-01 00:00:00

abstract：:Peptidoglycan (PGN) is a potent immune adjuvant derived from bacterial cell walls. Previous investigations suggest that intestinal epithelium may absorb PGN from the lumen. Nonetheless, how PGN is taken up and crosses intestinal epithelium remains largely unclear. Here, we first characterized PGN transport in vitro us...

journal_title：Journal of cellular physiology

authors： Bu HF,Wang X,Tang Y,Koti V,Tan XD

更新日期：2010-03-01 00:00:00

abstract：:Small intestinal crypt cells play a critical role in modulating Cl- secretion during digestion. The types of Cl- channels mediating Cl- secretion in the small intestine was investigated using the intestinal epithelial cell line, IEC-18, which was derived from rat small intestine crypt cells. In initial radioisotope ef...

journal_title：Journal of cellular physiology

authors： Basavappa S,Vulapalli SR,Zhang H,Yule D,Coon S,Sundaram U

更新日期：2005-01-01 00:00:00

abstract：:It is known that down-regulation of cell surface platelet-derived growth factor (PDGF) receptors accompanies transformation by SV40. In this work human embryonic lung fibroblasts were used as a model system to study the effects of SV 40 on PDGF receptor expression. It is shown that transformation by SV 40 early region...

journal_title：Journal of cellular physiology

authors： Wang JL,Nistér M,Bongcam-Rudloff E,Pontén J,Westermark B

更新日期：1996-01-01 00:00:00

abstract：:Multiple modalities for lung cancer therapy have emerged in the past decade, whereas their clinical applications and survival-beneficiary is little known. Vaccination with dendritic cells (DCs) or DCs/cytokine-induced killer (CIK) cells has shown limited success in the treatment of patients with advanced non-small-cel...

journal_title：Journal of cellular physiology

authors： Mohsenzadegan M,Peng RW,Roudi R

更新日期：2020-01-01 00:00:00

abstract：:Glutathione S-transferases (GSTs) are enzymes that are involved in the detoxification of harmful electrophilic endogenous and exogenous compounds by conjugating with glutathione (GSH). The liver fluke GSTs have multifunctional roles in the host-parasite interaction, such as general detoxification and bile acid sequest...

journal_title：Journal of cellular physiology

authors： Kalita J,Shukla R,Tripathi T

更新日期：2019-04-01 00:00:00

abstract：:Autophagy is considered as an important mechanism for maintaining homeostasis and responsible for the degradation of superfluous or potentially toxic components and organelles. Autophagy impairment is associated with a number of pathological conditions, such as aging, neurological disorders, cancer, and infection. Aut...

journal_title：Journal of cellular physiology

authors： Ashrafizadeh M,Ahmadi Z,Farkhondeh T,Samarghandian S

更新日期：2020-04-01 00:00:00

abstract：:Three-dimensional (3D) culture platforms have been explored to establish physiologically relevant cell culture environment and permit expansion scalability; however, little is known about the mechanisms underlying the regulation of pluripotency of human induced pluripotent stem cells (hiPSCs). This study elucidated ep...

journal_title：Journal of cellular physiology

authors： Thanuthanakhun N,Kino-Oka M,Borwornpinyo S,Ito Y,Kim MH

更新日期：2020-12-10 00:00:00

abstract：:Resistance to tamoxifen remains a prominent conundrum in the therapy of hormone-sensitive breast cancer. Also, the molecular underpinnings leading to tamoxifen resistance remain unclear. In the present study, we utilized the Gene Expression Omnibus database to identify that SOX11 might exert a pivotal function in conf...

journal_title：Journal of cellular physiology

authors： Xiao Y,Xie Q,Qin Q,Liang Y,Lin H,Zeng

更新日期：2020-10-01 00:00:00

abstract：:Two genes (MAT1A and MAT2A) encode for the essential enzyme methionine adenosyltransferase (MAT). MAT1A is silenced in hepatocellular carcinoma (HCC), and absence of MAT1A leads to spontaneous development of HCC in mice. Previous report correlated promoter methylation to silencing of MAT1A but definitive proof was lac...

journal_title：Journal of cellular physiology

authors： Tomasi ML,Li TW,Li M,Mato JM,Lu SC

更新日期：2012-04-01 00:00:00

abstract：:Ubiquitin-specific protease 14 (USP14) is a ubiquitin-specific protease that is associated with the proteasome and plays important roles in cellular functions, viral infection, inflammatory responses, neurodegenerative diseases, and tumorigenesis. USP14 appears to have a dual function in regulating intracellular prote...

journal_title：Journal of cellular physiology

authors： Wang D,Ma H,Zhao Y,Zhao J

更新日期：2020-11-01 00:00:00

abstract：:Keratin intermediate filaments play an important role in maintaining the integrity of the skin structure. Understanding the importance of this subject is possible with the investigation of keratin defects in epidermolysis bullosa simplex (EBS). Nowadays, in addition to clinical criteria, new molecular diagnostic metho...

journal_title：Journal of cellular physiology

authors： Khani P,Ghazi F,Zekri A,Nasri F,Behrangi E,Aghdam AM,Mirzaei H

更新日期：2018-01-01 00:00:00

abstract：:The 94-kDa glucose-regulated protein (GRP94) is a glycoprotein in the endoplasmic reticulum (ER). It has been characterized as a Ca2+-binding protein and a molecular chaperone. In this report we show that highly purified GRP94 exhibits an active Mg2+-dependent serine kinase activity (termed 94-kinase). The 94-kinase c...

journal_title：Journal of cellular physiology

authors： Ramakrishnan M,Schönthal AH,Lee AS

更新日期：1997-02-01 00:00:00

abstract：:Our main objective is probing the effect of methylation of CLEC14A on its expression and lung adenocarcinoma (LUAD) progression. Microarray analysis was utilized to screen out differentially downregulated genes with hypermethylation in LUAD tissues. The CLEC14A expression level was measured by western blot analysis an...

journal_title：Journal of cellular physiology

authors： Su C,Shi K,Cheng X,Han Y,Li Y,Yu D,Liu Z

更新日期：2019-03-01 00:00:00

abstract：:Programmed cell death in mammary tissue was studied during natural weaning in lactating mice and after litter removal or milk stasis. All treatments stimulated mammary apoptosis, indicating that this process is an integral part of the tissue's involution after lactation. Induction of apoptosis was slower in natural we...

journal_title：Journal of cellular physiology

authors： Quarrie LH,Addey CV,Wilde CJ

更新日期：1996-09-01 00:00:00

abstract：:The synthesis and turnover of metabolically labeled proteoglycans from medium, cell layer, and substratum-associated compartments were characterized in four cell lines of fibroblastic origin, including a fibrosarcoma line, and in the murine melanoma cell type, B16.F10. Substantial differences were apparent between the...

journal_title：Journal of cellular physiology

authors： Piepkorn M,Hovingh P,Linker A

更新日期：1988-05-01 00:00:00

abstract：:Selenium (Se) deficiency induces typical clinical and pathological changes and causes various pathological responses at the molecular level in several different chicken organs; the kidney is one of the target organs of Se deficiency. To explore the mechanisms that underlie the effects of microRNA-33-3p (miR-33-3p) on ...

journal_title：Journal of cellular physiology

authors： Wan N,Xu Z,Chi Q,Hu X,Pan T,Liu T,Li S

更新日期：2019-08-01 00:00:00

abstract：:The biosynthesis and turnover of nicotinamide adenine dinucleotide (NAD) have been examined in mitotic cells of the human culture line, D98/AH2. No significant difference in the incorporation of nicotinic acid or nicotinamide could be detected between mitotic and interphase cells. The distribution of newly-incorporate...

journal_title：Journal of cellular physiology

authors： Elliott G,Rechsteiner M

更新日期：1975-12-01 00:00:00

abstract：:Cancer cells in poorly vascularized solid tumors are constantly or intermittently exposed to stressful microenvironments, including glucose deprivation, hypoxia, and other forms of nutrient starvation. These tumor-specific conditions, especially glucose deprivation, activate a signaling pathway called the unfolded pro...

journal_title：Journal of cellular physiology

authors： Kim JY,Hwang JH,Cha MR,Yoon MY,Son ES,Tomida A,Ko B,Song SW,Shin-ya K,Hwang YI,Park HR

更新日期：2010-07-01 00:00:00

abstract：:There are two known phosphorylation-mediated inactivation mechanisms for TRPC3 channels. Protein kinase G (PKG) inactivates TRPC3 by direct phosphorylation on Thr-11 and Ser-263 of the TRPC3 proteins, and protein kinase C (PKC) inactivates TRPC3 by phosphorylation on Ser-712. In the present study, we explored the rela...

journal_title：Journal of cellular physiology

authors： Kwan HY,Huang Y,Yao X

更新日期：2006-05-01 00:00:00

abstract：:An imbalance between matrix synthesis and degradation is the hallmark of intervertebral disc degeneration while inflammatory cytokines contribute to the imbalance. Bromodomain and extra-terminal domain (BET) family is associated with the pathogenesis of inflammation, and inhibition of BRD4, a vital member of BET famil...

journal_title：Journal of cellular physiology

authors： Hong J,Li S,Markova DZ,Liang A,Kepler CK,Huang Y,Zhou J,Yan J,Chen W,Huang D,Xu K,Ye W

更新日期：2020-07-01 00:00:00

abstract：:Considering the high rate of osteoclast-related diseases worldwide, research targeting osteoclast formation/function is crucial. In vitro, we demonstrated that chitooligosaccharide (CS) dramatically inhibited osteoclastogenesis as well as osteoclast function dose-dependently. CS suppressed osteoclast-specific genes ex...

journal_title：Journal of cellular physiology

authors： Xu W,Chen X,Wang Y,Fan B,Guo K,Yang C,Yu S,Pang Y,Zhang S

更新日期：2020-03-01 00:00:00

abstract：:Extracellular glutathione (GSH) is degraded by an external cell-surface enzyme, gamma-glutamyltranspeptidase (gamma-GT). The products are transported into cells to participate in important cellular processes. In the present study, we tested the hypothesis that extracellular GSH is a source of glutamic acid for cells t...

journal_title：Journal of cellular physiology

authors： Kang YJ,Feng Y,Hatcher EL

更新日期：1994-12-01 00:00:00

abstract：:Breast cancer stem cells (BCSCs) are competent to initiate tumor formation and growth and refractory to conventional therapies. Consequently BCSCs are implicated in tumor recurrence. Many signaling cascades associated with BCSCs are critical for epithelial-to-mesenchymal transition (EMT). We developed a model system t...

journal_title：Journal of cellular physiology

authors： Fritz AJ,Hong D,Boyd J,Kost J,Finstaad KH,Fitzgerald MP,Hanna S,Abuarqoub AH,Malik M,Bushweller J,Tye C,Ghule P,Gordon J,Frietze S,Zaidi SK,Lian JB,Stein JL,Stein GS

更新日期：2020-10-01 00:00:00

abstract：:Hyperthermia is a clinical sign of inflammation and constitutes in itself an adaptive defense mechanism. The fibrinolytic system, a highly regulated proteolytic system, is involved in inflammatory processes. Plasminogen activator inhibitor 1 (PAI-1) is the principal inhibitor of the two activators of the fibrinolytic ...

journal_title：Journal of cellular physiology

authors： Bergonzelli GE,Kruithof EK

更新日期：1991-08-01 00:00:00

abstract：:The C3H/10T 1/2 embryo cell line, which is nontumorigenic when inoculated subcutaneously in saline suspension, produces tumors when implanted subcutaneously attached to 1 X 5 X 10 mm plastic plates. Under these in vivo conditions there is direct selection for "spontaneous" transformants that have undergone the specifi...

journal_title：Journal of cellular physiology

authors： Paranjpe M,del Ande Eaton S,Boone CW

更新日期：1978-07-01 00:00:00