Suppression of platelet-derived growth factor alpha- and beta-receptor mRNA levels in human fibroblasts by SV40 T/t antigen.

Abstract:

:It is known that down-regulation of cell surface platelet-derived growth factor (PDGF) receptors accompanies transformation by SV40. In this work human embryonic lung fibroblasts were used as a model system to study the effects of SV 40 on PDGF receptor expression. It is shown that transformation by SV 40 early region leads to a total loss of PDGF alpha-receptor and partial loss of beta-receptor mRNA. Microinjection experiments revealed that receptor down-regulation was a primary effect, and not only secondary to transformation and clonal selection. Total loss of PDGF alpha-receptor expression requires both large T and small t, and down-regulation of the PDGF alpha-receptor occurs independently of p53 and Rb binding to large T.

journal_name

J Cell Physiol

authors

Wang JL,Nistér M,Bongcam-Rudloff E,Pontén J,Westermark B

doi

10.1002/(SICI)1097-4652(199601)166:1<12::AID-JCP2>

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

12-21

issue

1

eissn

0021-9541

issn

1097-4652

pii

10.1002/(SICI)1097-4652(199601)166:1<12::AID-JCP2>

journal_volume

166

pub_type

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