Modulatory effects of statins on the autophagy: A therapeutic perspective.


:Autophagy is considered as an important mechanism for maintaining homeostasis and responsible for the degradation of superfluous or potentially toxic components and organelles. Autophagy impairment is associated with a number of pathological conditions, such as aging, neurological disorders, cancer, and infection. Autophagy also plays a significant role in cancer chemotherapy. The multiple cancer drugs have been notably developed with the strategy of autophagy modulation. Statins, 3-hydroxy-3-methyl-glutaryl-CoA inhibitors, are known due to their efficacy in decreasing low-density lipoprotein and extensively used for the management of cardiovascular diseases. Statins have other therapeutic and biological activities, such as antioxidant, anti-inflammatory, antitumor, and neuroprotective known as pleiotropic effects. It seems that statins are capable of targeting various signaling pathways in the induction of their great pharmacological effects. At the present study, we demonstrate the therapeutic effects of statins mediated via autophagy regulation.


J Cell Physiol


Ashrafizadeh M,Ahmadi Z,Farkhondeh T,Samarghandian S




Has Abstract


2020-04-01 00:00:00












  • Activation of canonical wnt pathway promotes differentiation of mouse bone marrow-derived MSCs into type II alveolar epithelial cells, confers resistance to oxidative stress, and promotes their migration to injured lung tissue in vitro.

    abstract::The differentiation of mesenchymal stem cells (MSCs) into type II alveolar epithelial (AT II) cells in vivo and in vitro, is critical for reepithelization and recovery in acute lung injury (ALI), but the mechanisms responsible for differentiation are unclear. In the present study, we investigated the role of the canon...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Liu AR,Liu L,Chen S,Yang Y,Zhao HJ,Liu L,Guo FM,Lu XM,Qiu HB

    更新日期:2013-06-01 00:00:00

  • Contribution of response kinetics to the response pattern: studies of responses to thyrotropin-releasing hormone in Xenopus oocytes.

    abstract::In Xenopus oocytes injected with total rat pituitary GH3 cell RNA, thyrotropin-releasing hormone (TRH) causes the activation of the inositol lipid transduction pathway and the induction of chloride conductance via calcium-activated channels (Oron et al., 1987, Mol. Endocrinol., 1:918-925). This response exhibits chara...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Lipinsky D,Gershengorn MC,Oron Y

    更新日期:1995-02-01 00:00:00

  • Dexamethasone interferes with osteoblasts formation during osteogenesis through altering IGF-1-mediated angiogenesis.

    abstract::Dexamethasone (Dex), a synthetic glucocorticoid (GC) with long-lasting treatment effects, has been proved to exert a modulatory effect on osteoblast proliferation and differentiation during embryonic osteogenesis. However, it is still controversial if Dex exposure influences endochondral ossification and the underlyin...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Xu S,Guo R,Li PZ,Li K,Yan Y,Chen J,Wang G,Brand-Saberi B,Yang X,Cheng X

    更新日期:2019-01-22 00:00:00

  • Fibroblasts and mesenchymal stem cells: Two sides of the same coin?

    abstract::Mesenchymal stem/stromal cells (MSCs) have gained considerable popularity owing to the vast possibilities and lack of ethical constraints and risks normally associated with other stem cells, such as embryonic stem cells. However, they are morphologically indistinguishable from fibroblasts. This review aims to assess t...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Soundararajan M,Kannan S

    更新日期:2018-12-01 00:00:00

  • Selective release from cultured mammalian cells of heat-shock (stress) proteins that resemble glia-axon transfer proteins.

    abstract::Cultured rat embryo cells were stimulated to rapidly release a small group of proteins that included several heat-shock proteins (hsp110, hsp71, hscp73) and nonmuscle actin. The extracellular proteins were analyzed by two-dimensional polyacrylamide gel electrophoresis. Heat-shocked cells released the same set of prote...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Hightower LE,Guidon PT Jr

    更新日期:1989-02-01 00:00:00

  • Glutamine synthetase induction by glucocorticoids in the glucocorticoid-sensitive human leukemic cell line CEM-C7.

    abstract::Treatment of CEM-C7 cells with glucocorticoids produces a 2.5-fold increase in the activity of the enzyme glutamine synthetase (GS). This increase is specific for steroids with glucocorticoid activity adn occurs over a range of steroid concentrations consistent with a receptor-mediated mechanism. Half-maximal and maxi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Harmon JM,Thompson EB

    更新日期:1982-02-01 00:00:00

  • Synthesis of glycolytic and peroxisomal enzymes in Tetrahymena following a change in culture conditions.

    abstract::The specific activity of a peroxisomal enzyme, lactate oxidase, and of pyruvate kinase and lactate dehydrogenase, which are not peroxisomal, increased rapidly when shaken cultures of Tetrahymena were transferred to conditions of oxygen restriction and supplemented with glucose. Two other peroxisomal enzymes, catalase ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Levy MR

    更新日期:1975-02-01 00:00:00

  • Identification of the potential key genes for adipogenesis from human mesenchymal stem cells by RNA-Seq.

    abstract::Adipogenesis, a physiological process initiated with the committed preadipocytes expressing adipocyte-specific genes and terminated in mature, differentiated and functional adipocytes, mainly involved with energy homeostasis. Abnormal distribution-changes and dysfunctions in adipogenesis may lead to complex physiopath...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Yi X,Wu P,Liu J,Gong Y,Xu X,Li W

    更新日期:2019-11-01 00:00:00

  • Laminin decreases PRL and IGFBP-1 expression during in vitro decidualization of human endometrial stromal cells.

    abstract::The expression of laminin, a major constituent of endometrial cell basement membranes, is increased during differentiation of human endometrial stromal cells (decidualization). To determine whether laminin plays a role in decidualization, we studied the effects of laminin substrate on the synthesis and release of prol...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Brar AK,Frank GR,Richards RG,Meyer AJ,Kessler CA,Cedars MI,Klein DJ,Handwerger S

    更新日期:1995-04-01 00:00:00

  • Transcription of the pain-related TRPV1 gene requires Runx1 and C/EBPβ factors.

    abstract::Transient Receptor Potential Vanilloid type 1 channel (TRPV1) is an important endogenous transducer of noxious heat and chemical stimuli and is required during development of inflammatory hypersensitivity. The transcription factor Runx1 is known to play a relevant role in sensory neuron differentiation as it controls ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Ugarte GD,Diaz E,Biscaia M,Stehberg J,Montecino M,van Zundert B

    更新日期:2013-04-01 00:00:00

  • Branched-chain amino acids inhibit proteolysis in rat skeletal muscle: mechanisms involved.

    abstract::Incubation of isolated rat soleus and EDL muscles in the presence of 10 mM leucine resulted in a decreased proteolytic rate as measured by the release of tyrosine into the incubation medium. The effect of this branched-chain amino acid (BCAA) is associated with a decreased activity of the lysosomal proteases and a dec...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Busquets S,Alvarez B,Llovera M,Agell N,López-Soriano FJ,Argilés JM

    更新日期:2000-09-01 00:00:00

  • Abnormal behavior of cultured fibroblasts from nodule and nonaffected aponeurosis of Dupuytren's disease.

    abstract::Vimentin-positive, desmin-negative cells were established in culture from the nodule and from apparently normal palmar aponeurosis of a patient with Dupuytren's disease and compared with normal human embryonic and adult fibroblasts or sarcomatous cells. Cells from the nodule display in vitro biological properties that...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Azzarone B,Failly-Crepin C,Daya-Grosjean L,Chaponnier C,Gabbiani G

    更新日期:1983-12-01 00:00:00

  • Delay of M-phase onset by aphidicolin can retain the nuclear localization of zinc and metallothionein in 3T3-L1 fibroblasts.

    abstract::The transient nuclear localization of metallothionein during cell growth and differentiation may be related to the increased requirement of zinc for DNA synthesis, activation of metalloenzymes, and transcription factors. Treatment of 3T3-L1 fibroblasts with aphidicolin, an inhibitor of nuclear DNA synthesis, caused a ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Apostolova MD,Cherian MG

    更新日期:2000-05-01 00:00:00

  • Regulation of HIV-1 transcription at 3% versus 21% oxygen concentration.

    abstract::HIV transcription is induced by the HIV-1 Tat protein, in concert with cellular co-factors including CDK9, CDK2, NF-kappaB, and others. The cells of most of the body's organs are exposed to approximately 3-6% oxygen, but most in vitro studies of HIV replication are conducted at 21% oxygen. We hypothesized that activit...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Charles S,Ammosova T,Cardenas J,Foster A,Rotimi J,Jerebtsova M,Ayodeji AA,Niu X,Ray PE,Gordeuk VR,Kashanchi F,Nekhai S

    更新日期:2009-11-01 00:00:00

  • Spindle pole fragmentation due to proteasome inhibition.

    abstract::During interphase, the centrosome concentrates cell stress response molecules, including chaperones and proteasomes, into a proteolytic center. However, whether the centrosome functions as proteolytic center during mitosis is not known. In this study, cultured mammalian cells were treated with the proteasome inhibitor...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Ehrhardt AG,Sluder G

    更新日期:2005-09-01 00:00:00

  • Splenic erythroblasts in anemia-inducing Friend disease: a source of cells for studies of erythropoietin-mediated differentiation.

    abstract::Splenic erythroblasts obtained from mice during the acute disease caused by either the polycythemia-inducing (FVP) or anemia-inducing (FVA) strain of Friend virus were examined for their degree of terminal differentiation. Morphology, benzidine staining, and heme synthesis kinetics showed that many erythroblasts from ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Koury MJ,Sawyer ST,Bondurant MC

    更新日期:1984-12-01 00:00:00

  • Role of RB and RB2/P130 genes in marrow stromal stem cells plasticity.

    abstract::Marrow stromal cells (MSCs) are stem-like cells having a striking somatic plasticity. In fact, besides differentiating into mesenchymal lineages (bone, cartilage, and fat), they are capable of differentiating into neurons and astrocytes in vitro and in vivo. The RB and RB2/P130 genes, belonging to the retinoblastoma g...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Jori FP,Napolitano MA,Melone MA,Cipollaro M,Cascino A,Giordano A,Galderisi U

    更新日期:2004-08-01 00:00:00

  • Pooling analysis reveals that galectin-1 is a reliable prognostic biomarker in various cancers.

    abstract::Galectin-1 is reported to be upregulated in various human cancers. However, the relationship between galectin-1 expression and cancer prognosis has not been systematically assessed. In this study, we searched PubMed, Web of Science, and Embase to collect all relevant studies and a meta-analysis was performed. We found...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,meta分析


    authors: Huang MY,He JP,Zhang WQ,Liu JL

    更新日期:2019-08-01 00:00:00

  • Extinction of the human insulin gene expression in insulinoma x fibroblast somatic cell hybrids involves cis-acting DNA elements.

    abstract::Insulin gene expression in rat insulinoma (RIN) cells is extinct in RIN x fibroblast hybrids and can reappear upon loss of DNA contributed by the fibroblast parent. (Besnard et al., Exp. Cell Res. 185:101-108, 1989). In the present study, we looked for the role of 5'-flanking sequences of the human insulin gene in the...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Besnard C,Monthioux E,Loràs P,Jami J,Daegelen D

    更新日期:1991-03-01 00:00:00

  • The origin of chicken hematopoietic colonies as assayed in semisolid agar.

    abstract::This investigation was undertaken to determine whether primitive stem cells and/or fully differentiated macrophages were the source of in vitro colonies derived from hematopoietic tissues. The chicken colony-forming cell (CFC) present in uncultured yolk sac was a nonadherent, presumably undifferentiated cell. The effi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Dodge WH,Silva RF,Moscovici C

    更新日期:1975-02-01 00:00:00

  • Bone marrow mesenchymal stem cells-derived conditioned medium protects cardiomyocytes from hypoxia/reoxygenation-induced injury through Notch2/mTOR/autophagy signaling.

    abstract::Bone marrow mesenchymal stem cells (BMSC) can ameliorate ischemic injury of various tissues. However, the molecular mechanisms involved remain to be clarified. In this study, we intend to investigate the effects of BMSC-derived conditioned medium (BMSC-CM) on hypoxia/reoxygenation (H/R)-induced injury of H9c2 myocardi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Li X,Xie X,Yu Z,Chen Y,Qu G,Yu H,Luo B,Lei Y,Li Y

    更新日期:2019-08-01 00:00:00

  • Effect of hypoxia upon intracellular calcium concentration of human endothelial cells.

    abstract::Ischemia is a situation occurring in several diseases including myocardial infarction and organ transplantation in which oxygenated blood supply is impaired. Ischemia leads to many cellular and tissue modifications, the most important one being cell death. Several explanations have been proposed to account for these m...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Arnould T,Michiels C,Alexandre I,Remacle J

    更新日期:1992-07-01 00:00:00

  • Expression of asparagine independence in variants of ICR 2A haploid frog cells.

    abstract::Properties of the change from asparagine dependence (asn-) to independence (asn+) were investigated in the androgenetic haploid frog cell line ICR 2A. Two types of asn+ variants arose spontaneously during culture. Glutamine-dependent asparagine synthetase (AS) activity, found to be deficient in asn- cells, was repress...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Hepfer CE,Little WA,Hengst JA,Freed JJ

    更新日期:1989-04-01 00:00:00

  • Stress induces an increased hexose uptake in cultured cells.

    abstract::Temperature-sensitive mutants have revealed a region of the herpes simplex virus 1 genome that affects both the uptake of hexose and the synthesis of heat shock proteins. Other inducers of heat-shock proteins, namely heat shock itself and arsenite, likewise induce an increased uptake of hexose. The increased uptake, l...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Warren AP,James MH,Menzies DE,Widnell CC,Whitaker-Dowling PA,Pasternak CA

    更新日期:1986-09-01 00:00:00

  • Extracellular calcium affects the membrane currents of cultured human keratinocytes.

    abstract::Electrophysiologic properties of cultured human keratinocytes were studied using the patch voltage-clamp technique. Undifferentiated, proliferative keratinocytes grown in low Ca2+ medium had an average resting membrane potential of -24 mV. Voltage-clamp experiments showed that these cells had two membrane ionic curren...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Mauro TM,Pappone PA,Isseroff RR

    更新日期:1990-04-01 00:00:00

  • Subcutaneous tissue fibroblast cytoskeletal remodeling induced by acupuncture: evidence for a mechanotransduction-based mechanism.

    abstract::Acupuncture needle rotation has been previously shown to cause specific mechanical stimulation of subcutaneous connective tissue. This study uses acupuncture to investigate the role of mechanotransduction-based mechanisms in mechanically-induced cytoskeletal remodeling. The effect of acupuncture needle rotation was qu...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Langevin HM,Bouffard NA,Badger GJ,Churchill DL,Howe AK

    更新日期:2006-06-01 00:00:00

  • Autophagy, anoikis, ferroptosis, necroptosis, and endoplasmic reticulum stress: Potential applications in melanoma therapy.

    abstract::Melanoma as the most major skin malignancy has attracted much attention, so far. Although a successful therapeutic strategy requires an accurate understanding of the precise mechanisms for the initiation and progression of the melanoma. Several types of cell death mechanisms have recently been identified along with co...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Ashrafizadeh M,Mohammadinejad R,Tavakol S,Ahmadi Z,Roomiani S,Katebi M

    更新日期:2019-11-01 00:00:00

  • Influence of colonic dialysis using Gubenxiezhuo on the distribution of gut microflora in uremia rats.

    abstract:OBJECTIVE:This study aimed to explore the underlying function of Gubenxiezhuo dialysis on the distribution of gut microflora uremia. METHODS:A uremia rat model was constructed, and the morphology of renal tissue was determined using the hematoxylin-eosin (H&E) staining. Moreover, the blood samples were collected and t...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: He H,Hu P,Tang Y,Xu X

    更新日期:2019-07-01 00:00:00

  • MicroRNA-1271 functions as a potential tumor suppressor in hepatitis B virus-associated hepatocellular carcinoma through the AMPK signaling pathway by binding to CCNA1.

    abstract::Hepatocellular carcinoma (HCC) is mainly associated with hepatitis B virus (HBV) infection and characterized by metastasizing and infiltrating adjacent and distant tissues. Notably, microRNA-1271 (miR-1271) is a tumor suppressor in various cancers. Therefore, we evaluate the ability of miR-1271 to influence cell proli...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Chen Y,Zhao ZX,Huang F,Yuan XW,Deng L,Tang D

    更新日期:2019-04-01 00:00:00

  • MiR-145-modulated SOX9-mediated hypospadias through acting on mitogen-activated protein kinase signaling pathway.

    abstract::This study primarily explored how miR-145, mitogen-activated protein kinase (MAPK) signaling and a downstream transcription factor (i.e., SOX9) mediated development of hypospadias. The hypospadias tissues and preputial tissues were isolated from pediatric inpatients postoperatively. Simultaneously, the rat models of h...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Shang Y,Kang Y,Sun J,Wei P,Yang J,Zhang H

    更新日期:2019-07-01 00:00:00