Modulatory effects of statins on the autophagy: A therapeutic perspective.

abstract：:Lipocalin-2 (Lcn2; also termed neutrophil gelatinase-associated lipocalin (NGAL)) levels correlate positively with heart failure (HF) yet mechanisms via which Lcn2 contributes to the pathogenesis of HF remain unclear. In this study, we used coronary artery ligation surgery to induce ischemia in wild-type (wt) mice and...

journal_title：Journal of cellular physiology

authors： Sung HK,Chan YK,Han M,Jahng JWS,Song E,Danielson E,Berger T,Mak TW,Sweeney G

更新日期：2017-08-01 00:00:00

abstract：:Tenascin-C, a six-armed extracellular matrix glycoprotein, is expressed in a temporally and spatially restricted pattern during carcinogenesis and invasion or metastasis of carcinoma cells in association with stromal-epithelial interactions. The human epidermoid carcinoma-derived cell lines, A431 and HEp-2, which do n...

journal_title：Journal of cellular physiology

authors： Sakai T,Ohta M,Furukawa Y,Saga Y,Aizawa S,Kawakatsu H,Saito M

更新日期：1995-10-01 00:00:00

abstract：:Ankylosing spondylitis (AS) is a chronic immune-mediated inflammatory disease that affects both axial and peripheral skeletons as well as soft tissues. Recent investigations offer that disease pathogenesis is ascribed to a complex interplay of genetic, environmental, and immunological factors. Until now, there is no a...

journal_title：Journal of cellular physiology

authors： Mohammadi H,Hemmatzadeh M,Babaie F,Gowhari Shabgah A,Azizi G,Hosseini F,Majidi J,Baradaran B

更新日期：2018-08-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer death worldwide. Although diagnostic methods and targeted drugs have been rapidly developed in recent years, the underlying molecular mechanisms in the pathogenesis of lung cancer remain enigmatic. The N6-methyladenosine (m6 A) modification is the most common modification of ...

journal_title：Journal of cellular physiology

authors： Xu R,Pang G,Zhao Q,Yang L,Chen S,Jiang L,Shen Y,Shao W

更新日期：2020-11-01 00:00:00

abstract：:Cell-extracellular matrix interaction plays a major role in maintaining the structural integrity of connective tissues and sensing changes in the biomechanical environment of cells. Collagen VI is a widely expressed non-fibrillar collagen, which regulates tissues homeostasis. The objective of the present investigation...

journal_title：Journal of cellular physiology

authors： Sardone F,Traina F,Tagliavini F,Pellegrini C,Merlini L,Squarzoni S,Santi S,Neri S,Faldini C,Maraldi N,Sabatelli P

更新日期：2014-07-01 00:00:00

abstract：:Despite the improvements in fracture healing, about 10% of patients undergo abnormal healing. As a tumor suppressor, upregulation of microRNA (miR)-203 has been observed in osteogenic differentiation. Herein, we aimed to explore the functional role of miR-203 in osteoblasts as well as the underlying mechanisms. The ex...

journal_title：Journal of cellular physiology

authors： Liu H,Chen B,Li Y

更新日期：2019-08-01 00:00:00

abstract：:The present study was performed to clarify second messenger signaling in parathyroid hormone (PTH)-induced c-fos gene expression, to characterize the participation of the c-fos gene in the regulation of osteoblast proliferation and function as well as osteoclast-like cell formation by PTH and to compare these effects ...

journal_title：Journal of cellular physiology

authors： Kano J,Sugimoto T,Kanatani M,Kuroki Y,Tsukamoto T,Fukase M,Chihara K

更新日期：1994-11-01 00:00:00

abstract：:The function of microRNA-27a (miR-27a) on synovial angiogenesis and chondrocyte apoptosis in rats with knee osteoarthritis (KOA) by targeting PLK2 is explored in this present study. The rat model of KOA was conducted by anterior cruciate ligament transection. Rats were injected with miR-27a mimics, mimics NC, pcDNA3.1...

journal_title：Journal of cellular physiology

authors： Liu W,Zha Z,Wang H

更新日期：2019-12-01 00:00:00

abstract：:Vascular endothelial cells receive proangiogenic or antiangiogenic signals from components of extracellular matrix (ECM) depending upon the situation and many molecular signals can have opposite effects in different vascular beds. Tissue inhibitor of metalloproteinase 1 is antiangiogenic in several tissues, but promot...

journal_title：Journal of cellular physiology

authors： Lima E Silva R,Kachi S,Akiyama H,Shen J,Aslam S,Yuan Gong Y,Khu NH,Hatara MC,Boutaud A,Peterson R,Campochiaro PA

更新日期：2006-07-01 00:00:00

abstract：:The non-POU-domain-containing octamer binding protein (NONO; also known as p54nrb) has various nuclear functions ranging from transcription, RNA splicing, DNA synthesis and repair. Although tyrosine phosphorylation has been proposed to account for the multi-functional properties of p54nrb, direct evidence on p54nrb as...

journal_title：Journal of cellular physiology

authors： Lee AR,Hung W,Xie N,Liu L,He L,Dong X

更新日期：2017-04-01 00:00:00

abstract：:It has been established that syndecan-1 is an important modulator of events relevant to acute tissue repair and chronic injury responses. The current studies were designed to examine syndecan-1 expression during atherosclerotic lesion formation and whether angiotensin II influences syndecan-1 expression in macrophages...

journal_title：Journal of cellular physiology

authors： Wang W,Haller CA,Wen J,Wang P,Chaikof EL

更新日期：2008-03-01 00:00:00

abstract：:Growth-contingent alterations in potassium and sodium fluxes, ouabain binding, and potassium ion content were examined following serum stimulation of quiescent, density-inhibited chicken embryo fibroblasts. Serum stimulation resulted in very rapid 1.5- to 1.8-fold increases in ouabain-sensitive potassium influx and le...

journal_title：Journal of cellular physiology

authors： Johnson MA,Weber MJ

更新日期：1980-05-01 00:00:00

abstract：:Islet cell transplantation, as a treatment of type 1 diabetes, has a lot of complexity such as allograft rejections and an insufficient number of donors. The liver can be used as a replacement for endogenous insulin production. Hepatocytes can inherently respond to glucose levels and secrete proteins. Utilization of m...

journal_title：Journal of cellular physiology

authors： Beikmohammadi L,Bandehpour M,Hashemi SM,Kazemi B

更新日期：2019-08-01 00:00:00

abstract：:Methylxantine derivative, caffeine, is known to prevent the p53-dependent apoptosis pathway via inhibition of ATM (ataxia telangiectasia mutated) kinase, which activates p53 by phosphorylation of the Ser-15 residue. In contrast, it has been reported that caffeine induces p53-mediated apoptosis through Bax protein in n...

journal_title：Journal of cellular physiology

authors： Ito K,Nakazato T,Miyakawa Y,Yamato K,Ikeda Y,Kizaki M

更新日期：2003-08-01 00:00:00

abstract：:Glutamine is the most abundant free amino acid in the body and is known to play a regulatory role in several cell specific processes including metabolism (e.g., oxidative fuel, gluconeogenic precursor, and lipogenic precursor), cell integrity (apoptosis, cell proliferation), protein synthesis, and degradation, contrac...

journal_title：Journal of cellular physiology

authors： Curi R,Lagranha CJ,Doi SQ,Sellitti DF,Procopio J,Pithon-Curi TC,Corless M,Newsholme P

更新日期：2005-08-01 00:00:00

abstract：:During tissue repair and development, matrix accumulation is modulated as multiple signals impinge on target cells. We have investigated the effects of combinations of the mitogenic cytokines, basic fibroblast growth factor (bFGF), transforming growth factor alpha (TGF-alpha), and insulin-like growth factor-1 (IGF-1) ...

journal_title：Journal of cellular physiology

authors： Davidson JM,Zoia O,Liu JM

更新日期：1993-04-01 00:00:00

abstract：:Integrins are heterodimeric transmembrane proteins that play important roles in various biological processes. Most integrins serve as adhesion molecules and transmit bidirectional signaling across the cell membrane through global conformational changes from the bent closed to the extended open conformation. However, i...

journal_title：Journal of cellular physiology

authors： Song G,Luo BH

更新日期：2020-12-27 00:00:00

abstract：:Sarcolectin is an endolectin present in a great variety of conjunctival tissues (muscles, cartilage, sarcomas), but also in brain or placental extracts of vertebrates, including primates. When purified to electrophoretical homogeneity as a 65-kd protein, it agglutinates cells and has an affinity for simple sugars. In ...

journal_title：Journal of cellular physiology

authors： Chany-Fournier F,Jiang PH,Chany C

更新日期：1990-10-01 00:00:00

abstract：:The extracellular matrix (ECM) physically supports cells and influences stem cell behaviour, modulating kinase-mediated signalling cascades. Cell-derived ECMs have emerged in bone regeneration as they reproduce physiological tissue-architecture and ameliorate mesenchymal stromal cell (MSC) properties. Titanium scaffol...

journal_title：Journal of cellular physiology

authors： Baroncelli M,Fuhler GM,van de Peppel J,Zambuzzi WF,van Leeuwen JP,van der Eerden BCJ,Peppelenbosch MP

更新日期：2019-03-01 00:00:00

abstract：:Aberrations of DNA methylation are early events in the development of tumors. In this study, we investigated the DNA methylation status of growth hormone secretagogue receptor (GHSR), a promising pan-cancer biomarker, in gastric cancer (GC). Initially, data sets from DNA methylation and gene expression studies availab...

journal_title：Journal of cellular physiology

authors： Amini M,Foroughi K,Talebi F,Aghagolzade Haji H,Kamali F,Jandaghi P,Hoheisel JD,Manoochehri M

更新日期：2019-01-24 00:00:00

abstract：:The enzyme alkaline phosphatase (AP) has been shown to be lost or inappropriately expressed during carcinogenesis in some tissues. Because retinoic acid (RA) appears to play a role in the normal regulation of the enzyme (RA up-regulates AP in a variety of cell types) we have suggested that altered AP expression in som...

journal_title：Journal of cellular physiology

authors： Reese DH,Larsen RA,Hornicek FJ

更新日期：1992-05-01 00:00:00

abstract：:The role of individual supplements necessary for the long-term self-renewal of embryonic stem (ES) cells is poorly characterized in feeder/serum-free culture systems. This study sought to characterize the relationship between the effects of glucose on ES cell proliferation and fibronectin (FN) synthesis, and to assess...

journal_title：Journal of cellular physiology

authors： Kim YH,Ryu JM,Lee YJ,Han HJ

更新日期：2010-05-01 00:00:00

abstract：:Studies on the receptor specificity and dynamics involved in fibroblast phagocytosis of latex beads revealed the following: 1) Ligands other than fibronectin such as concanavalin A (ConA) and serum spreading factor, when coated on latex beads, were found to promote phagocytosis of the beads. This indicates that fibrob...

journal_title：Journal of cellular physiology

authors： McAbee DD,Grinnell F

更新日期：1985-08-01 00:00:00

abstract：:Wg/Wnts are paracrine and autocrine ligands that activate distinct signaling pathways while being internalized through surface receptors. Converging and contrasting views are shaping our understanding of whether, where, and how endocytosis may modulate Wnt signaling. We gather considerable amount of evidences to elabo...

journal_title：Journal of cellular physiology

authors： Feng Q,Gao N

更新日期：2015-06-01 00:00:00

abstract：:We examined the interaction between OSU-03012 (also called AR-12) with phosphodiesterase 5 (PDE5) inhibitors to determine the role of the chaperone glucose-regulated protein (GRP78)/BiP/HSPA5 in the cellular response. Sildenafil (Viagra) interacted in a greater than additive fashion with OSU-03012 to kill stem-like GB...

journal_title：Journal of cellular physiology

authors： Booth L,Roberts JL,Tavallai M,Nourbakhsh A,Chuckalovcak J,Carter J,Poklepovic A,Dent P

更新日期：2015-08-01 00:00:00

abstract：:Small hepatocytes (SHs) are a subpopulation of hepatocytes that have high growth potential in culture and can differentiate into mature hepatocytes (MHs). The activin (Act)/follistatin (Fst) system critically contributes to homeostasis of cell growth in the normal liver. ActA and ActB consist of two disulfide-linked I...

journal_title：Journal of cellular physiology

authors： Ooe H,Chen Q,Kon J,Sasaki K,Miyoshi H,Ichinohe N,Tanimizu N,Mitaka T

更新日期：2012-06-01 00:00:00

abstract：:Characteristic features like self-renewal, multilineage differentiation potential, and immune-modulatory/anti-inflammatory properties, besides the ability to mobilize and home distant tissues make stem cells (SCs) a lifeline for an individual. Stem cells (SCs) if could be harvested and expanded without any abnormal ch...

journal_title：Journal of cellular physiology

authors： Gugjoo MB,Amarpal,Fazili MR,Shah RA,Sharma GT

更新日期：2019-06-01 00:00:00

abstract：:Aberrant activation of the HGF/c-Met signalling pathway is reported to be associated with cell proliferation, progression, and metastasis features of several tumor types, including cervical cancer, suggesting that it may be of potential value as a novel therapeutic target. Furthermore, HPV-positive patients had a high...

journal_title：Journal of cellular physiology

authors： Boromand N,Hasanzadeh M,ShahidSales S,Farazestanian M,Gharib M,Fiuji H,Behboodi N,Ghobadi N,Hassanian SM,Ferns GA,Avan A

更新日期：2018-06-01 00:00:00

abstract：:Cell-based cartilage resurfacing requires ex vivo expansion of autologous articular chondrocytes. Defined culture conditions minimize expansion-dependent phenotypic alterations but maintenance of the cells' differentiation potential must be carefully assessed. Transforming growth factor β-1 (TGF β-1) positively regula...

journal_title：Journal of cellular physiology

authors： Narcisi R,Quarto R,Ulivi V,Muraglia A,Molfetta L,Giannoni P

更新日期：2012-09-01 00:00:00

abstract：:Abnormal glucose handling in the proximal tubule may play an important role in the development of diabetic nephropathy. Thus, the present study was designed to examine the effect of high glucose on alpha-methyl-D-glucopyranoside (alpha-MG) uptake and its signaling pathways in the primary cultured rabbit renal proximal...

journal_title：Journal of cellular physiology

authors： Han HJ,Choi HJ,Park SH

更新日期：2000-06-01 00:00:00