Keeping Wnt signalosome in check by vesicular traffic.

abstract：:MicroRNAs (miRNAs or miRs) are small noncoding RNAs that play critical roles in muscle cell proliferation and differentiation via post-transcriptional regulation of gene expression. Here, based on our previous high-throughput sequencing results, we evaluated miRNA-499 (miR-499) functions during myoblast proliferation ...

journal_title：Journal of cellular physiology

authors： Wu J,Yue B,Lan X,Wang Y,Fang X,Ma Y,Bai Y,Qi X,Zhang C,Chen H

更新日期：2019-03-01 00:00:00

abstract：:Osteopontin (OPN) is a major non-collagenous bone matrix protein implicated in the regulation of cell function. Although OPN is rich in the cementum of the tooth, the significance of OPN in this tissue is not understood. Tooth root resorption is the most frequent complication of orthodontic tooth movement (TM). The ob...

journal_title：Journal of cellular physiology

authors： Chung CJ,Soma K,Rittling SR,Denhardt DT,Hayata T,Nakashima K,Ezura Y,Noda M

更新日期：2008-03-01 00:00:00

abstract：:Myeloid Elf-1 like factor (MEF) is a member of the Ets transcription factor family. Ets family proteins control the expression of genes that are critical for biological processes such as proliferation, differentiation, and cell death. Some of Ets factors are also known to regulate bone development. In this study, we i...

journal_title：Journal of cellular physiology

authors： Kim YJ,Kim BG,Lee SJ,Lee HK,Lee SH,Ryoo HM,Cho JY

更新日期：2007-04-01 00:00:00

abstract：:Hypoxia promotes keratinocyte migration on wound bed connective tissues and is a profound biological signal that transforms a basal keratinocyte, destined to differentiate, into a motile cell that is essential for re-epithelialization. In this study, we examined the effect of hypoxia on keratinocyte-derived collagenas...

journal_title：Journal of cellular physiology

authors： O'Toole EA,van Koningsveld R,Chen M,Woodley DT

更新日期：2008-01-01 00:00:00

abstract：:The genetic factors known to be involved in the final realization of beta-glucuronidase activity in mice are considered from the standpoint of structural genes determining the catalytic activity of enzyme molecules as well as the recognition features of enzyme molecules that identify them for subsequent processing by ...

journal_title：Journal of cellular physiology

authors： Paigen K,Swank RT,Tomino S,Ganschow RE

更新日期：1975-04-01 00:00:00

abstract：:Zinc finger E-box binding homeobox 1 (ZEB1), an important transcription factor belonging to the ZEB family, plays a crucial role in regulating gene expression required for both normal physiological and pathological processes. Accumulating evidence has shown that ZEB1 participates in the initiation and progression of a...

journal_title：Journal of cellular physiology

authors： Li H,Zou J,Yu XH,Ou X,Tang CK

更新日期：2020-12-04 00:00:00

abstract：:Breast cancer, as the most common cancer in women which affects patients both mentally and physically, requires great attention in many areas and many levels as this cancer is known to be multifactorial. Single-stranded molecules called microRNAs with near 22 nucleotides are seen to act in central dogma of molecular b...

journal_title：Journal of cellular physiology

authors： Bahreini F,Rayzan E,Rezaei N

更新日期：2021-03-01 00:00:00

abstract：:The study was conducted on human leukemia (K 562) cells to characterize the mechanisms implicated in the regulation of the polyamine spermidine (Spd) transport process. The antagonists of calmodulin, trifluoperazine (TFP), W-7 (N-[6-aminohexyl]-5-chloro-1-naphthelenesulfonamide), or mellitin inhibited significantly po...

journal_title：Journal of cellular physiology

authors： Khan NA,Sezan A,Quemener V,Moulinoux JP

更新日期：1993-12-01 00:00:00

abstract：:Pin1 is a peptidyl prolyl cis-trans isomerase that specifically binds to the phosphoserine-proline or phosphothreonine-proline motifs of numerous proteins. Previously, we reported that Pin1 deficiency resulted in defects in osteoblast differentiation during early bone development. In this study, we found that adult Pi...

journal_title：Journal of cellular physiology

authors： Yoon WJ,Islam R,Cho YD,Ryu KM,Shin HR,Woo KM,Baek JH,Ryoo HM

更新日期：2015-03-01 00:00:00

abstract：:Bcl-2 associated athanogene 5 (Bag5) is a novel endoplasmic reticulum (ER) regulator. However, its role in catecholamine-induced endothelial cells damage has not been fully understood. In our study, catecholamine was used to mimic hypertension-related endothelial cell damage. Then, western blots, enzyme-linked immunos...

journal_title：Journal of cellular physiology

authors： Zhu H,Zhao M,Chen Y,Li D

更新日期：2021-02-01 00:00:00

abstract：:We evaluated the role of CCL20 (MIP-3alpha) chemokine in cells directly involved in the remodeling of bone tissue (osteoblasts and osteoclasts) and we confirmed its expression in the subchondral bone tissue of rheumatoid arthritis (RA) patients. The expression of CCL20 and of its receptor CCR6 was evaluated in osteobl...

journal_title：Journal of cellular physiology

authors： Lisignoli G,Piacentini A,Cristino S,Grassi F,Cavallo C,Cattini L,Tonnarelli B,Manferdini C,Facchini A

更新日期：2007-03-01 00:00:00

abstract：:The tumor microenvironment significantly affects tumor progression, and tumor cells can also remodel the tumor microenvironment through complex interaction. Inflammasomes are innate immune system receptors/sensors that regulate an inflammatory response mainly mediated by the nucleotide-binding oligomerization domain-l...

journal_title：Journal of cellular physiology

authors： Tu CE,Hu Y,Zhou P,Guo X,Gu C,Zhang Y,Li A,Liu S

更新日期：2020-11-23 00:00:00

abstract：:The nuclear lamina is a fibrous structure at the nucleoplasmic surface of the inner nuclear membrane. Its assembly state is regulated by phosphorylation of its protein components, the lamins A, B, and C. The isoprenylation of the lamins is essential for their proper membrane anchoring and functionality. The content an...

journal_title：Journal of cellular physiology

authors： Bruscalupi G,Di Croce L,Lamartina S,Zaccaria ML,Luzzatto AC,Trentalance A

更新日期：1997-05-01 00:00:00

abstract：:Osteosarcoma is the most common bone tumor in children and young adults. Although the microRNAs (miRNA) expression analyses of osteosarcoma have been performed previously, the construction of miRNA-messenger RNA (mRNA) networks for osteosarcoma is needed. This study aimed to identify osteosarcoma-related miRNAs throug...

journal_title：Journal of cellular physiology

authors： Ma G,Zhang C,Luo W,Zhao JL,Wang X,Qian Y

更新日期：2019-08-01 00:00:00

abstract：:There is compelling in vitro and in vivo evidence to implicate mast cells in the development of fibrosis. However, an important question remains as to the mechanisms by which mast cells mediate fibrosis. Recent evidence from our laboratory (Gruber et al., 1997, J. Immunol. , 158:2310-2317) has revealed that tryptase, ...

journal_title：Journal of cellular physiology

authors： Zhang J,Gruber BL,Marchese MJ,Zucker S,Schwartz LB,Kew RR

更新日期：1999-11-01 00:00:00

abstract：:The mobility of a cell surface protein on cells osmotically swollen by treatment with several different cell permeabilizing agents retains specific restraints despite detachment of the plasma membrane from the cortical cytoskeleton. Fluorescence photobleaching recovery experiments indicate that the lateral diffusion c...

journal_title：Journal of cellular physiology

authors： Feder TJ,Chang EY,Holowka D,Webb WW

更新日期：1994-01-01 00:00:00

abstract：:Wnt and TGF-β signaling pathways participate in regulating a variety of cell fates during organogenesis, including tooth development. Despite well-documented, the specific mechanisms, especially how these two pathways act coordinately in regulating enamel development, remain unknown. In this study, we identified Glyco...

journal_title：Journal of cellular physiology

authors： Yang Y,Li Z,Chen G,Li J,Li H,Yu M,Zhang W,Guo W,Tian W

更新日期：2018-07-01 00:00:00

abstract：:Drug discovery is an onerous, extremely expensive, and time-consuming process. Instead, drug repurposing is an attractive strategy for exploiting novel indications for a drug beyond its original use. The untapped potential of drug repurposing compensates the barriers associated with the drug discovery pipeline. Psoria...

journal_title：Journal of cellular physiology

authors： Thatikonda S,Pooladanda V,Godugu C

更新日期：2020-06-01 00:00:00

abstract：:Despite being densely packed with chromatin, nuclear bodies and a nucleoskeletal network, the nucleus is a remarkably dynamic organelle. Chromatin loops form and relax, RNA transcripts and transcription factors move diffusively, and nuclear bodies move. We show here that RNA splicing speckled domains (splicing speckle...

journal_title：Journal of cellular physiology

authors： Zhang Q,Kota KP,Alam SG,Nickerson JA,Dickinson RB,Lele TP

更新日期：2016-06-01 00:00:00

abstract：:HeLa (substrain Ho) grown in serum free medium showed an increase in the specific activity of alkaline phosphatase when fetal calf serum (10%) was added to the medium (9.7 nmoles/sec/mg protein to 86.8). Under the same conditions, eight intracellular enzymes showed no increase in activity. Similar results were obtaine...

journal_title：Journal of cellular physiology

authors： Carlson CW

更新日期：1979-01-01 00:00:00

abstract：:Two genes (MAT1A and MAT2A) encode for the essential enzyme methionine adenosyltransferase (MAT). MAT1A is silenced in hepatocellular carcinoma (HCC), and absence of MAT1A leads to spontaneous development of HCC in mice. Previous report correlated promoter methylation to silencing of MAT1A but definitive proof was lac...

journal_title：Journal of cellular physiology

authors： Tomasi ML,Li TW,Li M,Mato JM,Lu SC

更新日期：2012-04-01 00:00:00

abstract：:The basic fibroblast growth factor (FGF) is a potent mitogen that has vascular endothelium as one of its principle target cells. Recent work has provided both the complete amino acid sequence of basic FGF and the nucleotide sequence of the genes for both human and bovine basic FGF. Although capillary endothelial cells...

journal_title：Journal of cellular physiology

authors： Hanneken A,Lutty GA,McLeod DS,Robey F,Harvey AK,Hjelmeland LM

更新日期：1989-01-01 00:00:00

abstract：:Insufficient invasion ability of trophoblasts might be associated with the development of recurrent miscarriage (RM). Ubiquitin-specific protease 25 (USP25) can regulate the processes of invasion and migration in different types of cancer cells. However, the effect of USP25 on trophoblasts and its roles in the develop...

journal_title：Journal of cellular physiology

authors： Ding J,Cheng Y,Zhang Y,Liao S,Yin T,Yang J

更新日期：2019-11-01 00:00:00

abstract：:We tested the expression of genes coding receptors of a cutaneous serotoninergic/melatoninergic system in whole human skin and in normal and pathologic cultured skin cells. Evaluation of serotonin (5HT), melatonin (MT), and melatonin-related receptors (MRR) showed expression of the isoforms 5HT2B, 5HT7, and MT1 genes ...

journal_title：Journal of cellular physiology

authors： Slominski A,Pisarchik A,Zbytek B,Tobin DJ,Kauser S,Wortsman J

更新日期：2003-07-01 00:00:00

abstract：:To analyze transforming growth factor-beta (TGF-beta) response during MCF-7 cell progression, early passage (MCF-7E, < 200 passage) and late passage (MCF-7L, > 500 passage) cells were compared. MCF-7E cells showed an IC50 of approximately 10 ng/ml of TGF-beta1, whereas MCF-7L cells were insensitive. MCF-7E cells conta...

journal_title：Journal of cellular physiology

authors： Ko Y,Banerji SS,Liu Y,Li W,Liang J,Soule HD,Pauley RJ,Willson JK,Zborowska E,Brattain MG

更新日期：1998-08-01 00:00:00

abstract：:We have previously shown that mitochondrial activity is an important regulator of myoblast differentiation, partly through processes targeting myogenin expression. Here, we investigated the possible involvement of c-myc in these processes. Inhibition of mitochondrial activity by chloramphenicol abrogated the decrease ...

journal_title：Journal of cellular physiology

authors： Seyer P,Grandemange S,Busson M,Carazo A,Gamaléri F,Pessemesse L,Casas F,Cabello G,Wrutniak-Cabello C

更新日期：2006-04-01 00:00:00

abstract：:Numerous studies have suggested that urothelial cancer-associated 1 (UCA1) acts as a suppressor gene affecting cell proliferation and migration. However, the biological role and the potential mechanism of UCA1 in the progression of pre-eclampsia (PE) remains unclear. The UCA1 level was markedly upregulated in PE pregn...

journal_title：Journal of cellular physiology

authors： Liu J,Luo C,Zhang C,Cai Q,Lin J,Zhu T,Huang X

更新日期：2020-10-01 00:00:00

abstract：:It has been established that syndecan-1 is an important modulator of events relevant to acute tissue repair and chronic injury responses. The current studies were designed to examine syndecan-1 expression during atherosclerotic lesion formation and whether angiotensin II influences syndecan-1 expression in macrophages...

journal_title：Journal of cellular physiology

authors： Wang W,Haller CA,Wen J,Wang P,Chaikof EL

更新日期：2008-03-01 00:00:00

abstract：:We have analyzed the expression of Na,K-ATPase alpha subunit isoforms in the transporting ciliary processes of the human eye and in cultured cells derived from non-pigmented (NPE) and pigmented (PE) ciliary epithelium. Northern hybridization analysis shows that the mRNAs encoding all the three distinct forms of Na,K-A...

journal_title：Journal of cellular physiology

authors： Martin-Vasallo P,Ghosh S,Coca-Prados M

更新日期：1989-11-01 00:00:00

abstract：:Tumor suppressor pRb2/p130 gene belongs to the retinoblastoma (Rb) gene family, which also includes pRb/p105 and pRb/p107. The members of the Rb gene family have attracted a great deal of interest because of their essential role in regulating cell cycle and, consequently, cell proliferation. This mini review discusses...

journal_title：Journal of cellular physiology

authors： Giordano A,Rossi A,Romano G,Bagella L

更新日期：2007-11-01 00:00:00