Control of alkaline phosphatase activity in C3H10T1/2 cells: role of retinoic acid and cell density.

abstract：:The role of diacylglycerol (DAG) in hormonal induction of S phase was investigated in primary cultures of rat hepatocytes. In this model, several agonists that bind to G protein-coupled receptors act as comitogens when added to the cells soon after plating (i.e., in Go/early Gl phase), while the cells are most respons...

journal_title：Journal of cellular physiology

authors： Dajani OF,Sandnes D,Melien O,Rezvani F,Nilssen LS,Thoresen GH,Christoffersen T

更新日期：1999-08-01 00:00:00

abstract：:Neuropathic pain caused by somatosensory nervous system dysfunction is a serious public health problem. Some long noncoding RNAs (lncRNAs) can participate in physiological processes involved in neuropathic pain. However, the effects of lncRNA DGCR5 in neuropathic pain have not been explored. Therefore, in our current ...

journal_title：Journal of cellular physiology

authors： Peng C,Zhang C,Su Z,Lin D

更新日期：2019-05-01 00:00:00

abstract：:Hyperthermia is a clinical sign of inflammation and constitutes in itself an adaptive defense mechanism. The fibrinolytic system, a highly regulated proteolytic system, is involved in inflammatory processes. Plasminogen activator inhibitor 1 (PAI-1) is the principal inhibitor of the two activators of the fibrinolytic ...

journal_title：Journal of cellular physiology

authors： Bergonzelli GE,Kruithof EK

更新日期：1991-08-01 00:00:00

abstract：:Emerging evidence have discovered that circular RNAs (circRNAs) may serve as diagnostic or tumor promising biomarkers. This study aimed to investigate how circular RNA ADAMTS14 (circADAMTS14) regulates microRNA-572/ regulator of calcineurin 1(miR-572/ RCAN1) in hepatocellular carcinoma (HCC). The expression profiles o...

journal_title：Journal of cellular physiology

authors： Song C,Li D,Liu H,Sun H,Liu Z,Zhang L,Hu Y

更新日期：2019-03-01 00:00:00

abstract：:We have previously shown that 24,25-(OH)2D3 plays a major role in resting zone (RC) chondrocyte differentiation and that this vitamin D metabolite regulates protein kinase C (PKC). The aim of the present study was to identify the signal transduction pathway used by 24,25-(OH)2D3 to stimulate PKC activation. Confluent,...

journal_title：Journal of cellular physiology

authors： Helm S,Sylvia VL,Harmon T,Dean DD,Boyan BD,Schwartz Z

更新日期：1996-12-01 00:00:00

abstract：:The existence of cancer stem cells is debatable in numerous solid tumors, yet in leukemia, there is compelling evidence of this cell population. Leukemic stem cells (LSCs) are altered cells in which accumulating genetic and/or epigenetic alterations occur, resulting in the transition between the normal, preleukemic, a...

journal_title：Journal of cellular physiology

authors： Mastelaro de Rezende M,Ferreira AT,Paredes-Gamero EJ

更新日期：2020-06-01 00:00:00

abstract：:Pur-alpha is an essential protein for postnatal brain development which localizes specifically to dendrites where it plays a role in the translation of neuronal RNA. Mice lacking Pur-alpha display decreased neuronogenesis and impaired neuronal differentiation. Here we examined two Rho GTPases, Rac1 and RhoA, which pla...

journal_title：Journal of cellular physiology

authors： Mishra M,Del Valle L,Otte J,Darbinian N,Gordon J

更新日期：2013-01-01 00:00:00

abstract：:Fibroblast growth factors (FGFs) are important regulators of the dynamic development and turnover of tissues. Among FGF receptors, FGFR3 expression is confined in the intestinal crypts. We examined FGFR3-deficient mice and saw increased intestinal crypt depth but no change in villae length or in the distribution of di...

journal_title：Journal of cellular physiology

authors： Arnaud-Dabernat S,Yadav D,Sarvetnick N

更新日期：2008-07-01 00:00:00

abstract：:Active oxygen species are generated in cells during pathophysiologic conditions such as inflammation and postischemic reperfusion. If oxygen radical scavengers are added before reperfusion, then the magnitude of injury is reduced. We investigated whether free radicals generated following exposure to hypoxia and reoxyg...

journal_title：Journal of cellular physiology

authors： Koong AC,Giaccia AJ,Hahn GM,Saad AH

更新日期：1993-08-01 00:00:00

abstract：:Activation of the receptor tyrosine kinase c-kit by the kit-ligand, also known as stem cell factor (SCF), is essential to melanocyte and germ cell development and during the early stages of hematopoiesis. Deregulated expression of c-kit has been reported in malignancies affecting these lineages, i.e., myeloid leukemia...

journal_title：Journal of cellular physiology

authors： Bellone G,Silvestri S,Artusio E,Tibaudi D,Turletti A,Geuna M,Giachino C,Valente G,Emanuelli G,Rodeck U

更新日期：1997-07-01 00:00:00

abstract：:Breast cancer stem cells (BCSCs) are competent to initiate tumor formation and growth and refractory to conventional therapies. Consequently BCSCs are implicated in tumor recurrence. Many signaling cascades associated with BCSCs are critical for epithelial-to-mesenchymal transition (EMT). We developed a model system t...

journal_title：Journal of cellular physiology

authors： Fritz AJ,Hong D,Boyd J,Kost J,Finstaad KH,Fitzgerald MP,Hanna S,Abuarqoub AH,Malik M,Bushweller J,Tye C,Ghule P,Gordon J,Frietze S,Zaidi SK,Lian JB,Stein JL,Stein GS

更新日期：2020-10-01 00:00:00

abstract：:Neuropathic pain (NP) may cause serious brain diseases, but the genes associated with the metabolic pathway and transcript factors of NP remain unclear. This study is aimed to identify the therapy target genes for NP and to investigate the metabolic pathways and transcript factors associated with NP. The differentiall...

journal_title：Journal of cellular physiology

authors： Yan XT,Xu Y,Cheng XL,He XH,Wang Y,Zheng WZ,Zhao Y,Chen H,Wang YL

更新日期：2019-05-01 00:00:00

abstract：:Restitution is a crucial event during the healing of superficial injury of the gastric mucosa involving epithelial cell sheet movement into the damaged area. We demonstrated that growth factors promote the restitution of human gastric epithelial cells. However, the intracellular signaling pathways that transmit extrac...

journal_title：Journal of cellular physiology

authors： Tétreault MP,Chailler P,Beaulieu JF,Rivard N,Ménard D

更新日期：2008-02-01 00:00:00

abstract：:Suppression of PKC activity can selectively induce apoptosis in cells expressing a constitutively activated p21Ras protein. We demonstrate that continued expression of p21Ras activity is required in PKC-mediated apoptosis because farnesyltransferase inhibitors abrogated the loss of viability in p21Ras-transformed cell...

journal_title：Journal of cellular physiology

authors： Liou JS,Chen JS,Faller DV

更新日期：2004-02-01 00:00:00

abstract：:Using methods designed for isolation of mutants defective in receptor-mediated endocytosis, a novel L-cell mutant was obtained that exhibits resistance to three different protein toxins as well as alterations in secretion. This mutant, LEFIC, is resistant to modeccin, Pseudomonas exotoxin, and ricin. These toxins, whi...

journal_title：Journal of cellular physiology

authors： Laurie SM,Robbins AR

更新日期：1991-05-01 00:00:00

abstract：:Cell- and matrix-related parameters, which characterize the aging and differentiation process of cartilage in vivo, were measured in cultured chick epiphyseal chondrocytes during maintenance in a suspension culture for 34 days. A gradual decrease in the rates of proliferation and an increase in the size of the cells w...

journal_title：Journal of cellular physiology

authors： Beit-Or A,Nevo Z,Kalina M,Eilam Y

更新日期：1990-08-01 00:00:00

abstract：:The cholinergic system plays a crucial role in modulating in the central nervous system physiological responses such as neurogenesis, neuronal differentiation, synaptic plasticity, and neuroprotection. In a recent study, we showed that Oxotremorine-M, a non-selective muscarinic acetylcholine receptor agonist, is able ...

journal_title：Journal of cellular physiology

authors： Frinchi M,Scaduto P,Cappello F,Belluardo N,Mudò G

更新日期：2018-08-01 00:00:00

abstract：:Proprotein convertase subtilisin/kexin type-9 (PCSK9), a member of the proprotein convertase family, is an important drug target because of its crucial role in lipid metabolism. Emerging evidence suggests a direct role of localized PCSK9 in the pathogenesis of vascular diseases. With this in our consideration, we revi...

journal_title：Journal of cellular physiology

authors： Guo Y,Yan B,Gui Y,Tang Z,Tai S,Zhou S,Zheng XL

更新日期：2020-09-01 00:00:00

abstract：:Arg8-vasopressin (AVP) is a potent inducer of myogenic differentiation stimulating the expression of myogenic regulatory factors. To understand the mechanism of its effect on myogenesis, we investigated the early signals induced by AVP in myogenic target cells. In the rat skeletal muscle cell line L6, AVP selectively ...

journal_title：Journal of cellular physiology

authors： Naro F,Donchenko V,Minotti S,Zolla L,Molinaro M,Adamo S

更新日期：1997-04-01 00:00:00

abstract：:Responses of rat submandibular acini to intracellular alkalinization were investigated. Intracellular alkalinization was induced by addition of NH4Cl or methyl amines, or by prepulse with Na butyrate. Only partial recovery occurred following Na butyrate prepulse or methylated amine addition, but full recovery was obse...

journal_title：Journal of cellular physiology

authors： Seagrave JC,Curry M,Martinez JR

更新日期：1994-06-01 00:00:00

abstract：:The effects of src oncogene expression on epidermal growth factor (EGF) receptors have been investigated in mouse 3T3 and rat-1 fibroblasts. Transformation of both cell types with src resulted in marked reductions in cellular EGF receptor levels, as assayed by either 125I-EGF binding or immunoprecipitation of receptor...

journal_title：Journal of cellular physiology

authors： Wasilenko WJ,Shawver LK,Weber MJ

更新日期：1987-06-01 00:00:00

abstract：:Amylin is a 37 amino acid peptide produced mainly by beta-cells of the endocrine pancreas. Human amylin has 43% homology with human calcitonin gene-related peptide (CGRP) and 13% homology with human calcitonin (CT). Amylin and CGRP have been reported to have CT-like hypocalcemic activity in vivo. To investigate the ro...

journal_title：Journal of cellular physiology

authors： Tamura T,Miyaura C,Owan I,Suda T

更新日期：1992-10-01 00:00:00

abstract：:Ascorbic acid induces apoptosis, autophagy, and necrotic cell death in cancer cells. We investigated the mechanisms by which ascorbic acid induces death in laryngeal squamous cell carcinoma Hep2 cells. Ascorbic acid markedly reduced cell viability and induced death without caspase activation and an increase in cytochr...

journal_title：Journal of cellular physiology

authors： Baek MW,Cho HS,Kim SH,Kim WJ,Jung JY

更新日期：2017-02-01 00:00:00

abstract：:Embryo implantation is essential for normal pregnancy, and the process of decidualization is critical for embryo implantation. However, the mechanism of decidualization during early pregnancy is still unknown. Forkhead box O3a (FOXO3a) is the most important functional transcription factor of the forkhead box family an...

journal_title：Journal of cellular physiology

authors： Long J,Yang CS,He JL,Liu XQ,Ding YB,Chen XM,Tong C,Peng C,Wang YX,Gao RF

更新日期：2019-04-01 00:00:00

abstract：:The protein kinase C stimulator TPA (12-O-tetradecanoyl phorbol-13-acetate) enhanced the responsiveness of adenylate cyclase to IPR (isoproterenol) and PGE1 (prostaglandin E1) in quiescent tsKSV-NRK cells at the nonpermissive 41 degrees C. Reactivating the thermolabile mitogenic/oncogenic K-ras protein in tsKSV-NRK ce...

journal_title：Journal of cellular physiology

authors： Franks DJ,Durkin JP,Whitfield JF

更新日期：1989-09-01 00:00:00

abstract：:Endothelial cells play a wide variety of critical roles in the control of vascular function. Indeed, since the early 1980s, the accumulating knowledge of the endothelial cell structure as well as of the functional properties of the endothelial cells shifted their role from a passive membrane or barrier to a complex ti...

journal_title：Journal of cellular physiology

authors： Michiels C

更新日期：2003-09-01 00:00:00

abstract：:The single-copy gene of human basic fibroblast growth factor (bFGF) encodes four co-expressed isoforms, with an apparent molecular weight (M(r)) of 24 kD, 22.5 kD, 22 kD, and 18 kD, co-translated from a single mRNA. As a tool for the study of the role exerted by the different bFGF isoforms in the biology of endothelia...

journal_title：Journal of cellular physiology

authors： Gualandris A,Urbinati C,Rusnati M,Ziche M,Presta M

更新日期：1994-10-01 00:00:00

abstract：:DH23A cells, an alpha-difluoromethylornithine (DFMO)-resistant variant of rat hepatoma tissue culture cells (HTC), contain high levels of very stable ornithine decarboxylase (ODC). In the absence of DFMO, the high ODC activity results in a large accumulation of endogenous putrescine. Concomitant with the putrescine in...

journal_title：Journal of cellular physiology

authors： Tome ME,Fiser SM,Gerner EW

更新日期：1994-02-01 00:00:00

abstract：:The role of individual supplements necessary for the long-term self-renewal of embryonic stem (ES) cells is poorly characterized in feeder/serum-free culture systems. This study sought to characterize the relationship between the effects of glucose on ES cell proliferation and fibronectin (FN) synthesis, and to assess...

journal_title：Journal of cellular physiology

authors： Kim YH,Ryu JM,Lee YJ,Han HJ

更新日期：2010-05-01 00:00:00

abstract：:Mycoplasmas are bacteria lacking the cell wall, which is the major characteristic of this taxonomic class (Mollicutes). Among bacteria, mycoplasmas possess the smallest genome known for free-living organisms. This feature limits the autonomy of bacteria and makes them increasingly susceptible to changes in the host or...

journal_title：Journal of cellular physiology

authors： Borchsenius SN,Daks A,Fedorova O,Chernova O,Barlev NA

更新日期：2018-01-01 00:00:00