Curcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF-κB signaling pathway.


:Endometriosis is a chronic gynecological inflammatory disorder in which immune system dysregulation is thought to play a role in its initiation and progression. Due to altered sex steroid receptor concentrations and other signaling defects, eutopic endometriotic tissues have an attenuated response to progesterone. This progesterone-resistance contributes to lesion survival, proliferation, pain, and infertility. The current agency-approved hormonal therapies, including synthetic progestins, GnRH agonists, and danazol are often of limited efficacy and counterproductive to fertility and cause systemic side effects due to suppression of endogenous steroid hormone levels. In the current study, we examined the effects of curcumin (CUR, diferuloylmethane), which has long been used as an anti-inflammatory folk medicine in Asian countries for this condition. The basal levels of proinflammatory and proangiogenic chemokines and cytokines expression were higher in primary cultures of stromal cells derived from eutopic endometrium of endometriosis (EESC) subjects compared with normal endometrial stromal cells (NESC). The treatment of EESC and NESC with CUR significantly and dose-dependently reduced chemokine and cytokine secretion over the time course. Notably, CUR treatment significantly decreased phosphorylation of the IKKα/β, NF-κB, STAT3, and JNK signaling pathways under these experimental conditions. Taken together, our findings suggest that CUR has therapeutic potential to abrogate aberrant activation of chemokines and cytokines, and IKKα/β, NF-κB, STAT3, and JNK signaling pathways to reduce inflammation associated with endometriosis.


J Cell Physiol


Chowdhury I,Banerjee S,Driss A,Xu W,Mehrabi S,Nezhat C,Sidell N,Taylor RN,Thompson WE




Has Abstract


2019-05-01 00:00:00












  • Ca(2+)- and protein kinase C-dependent stimulation of mitogen-activated protein kinase in detergent-skinned vascular smooth muscle.

    abstract::Protein kinase C and mitogen-activated protein (MAP) kinase are expressed in all smooth muscle cells and believed to be important in several physiologically relevant properties of this muscle. Our goal was to determine if protein kinase C and MAP kinase are activated by a simple increase in cellular Ca(2+) and to dete...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Katoch SS,Su X,Moreland RS

    更新日期:1999-05-01 00:00:00

  • In vivo growth stimulation of collagen gel embedded normal human and mouse primary mammary epithelial cells.

    abstract::A new system for studying growth of normal human mammary epithelial cells in an in vivo environment using athymic nude mice is described. Human mammary epithelial cells dissociated from reduction mammoplasty specimens were embedded within collagen gels and subsequently transplanted subcutaneously into nude mice. Histo...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Popnikolov NK,Yang J,Guzman RC,Swanson SM,Thordarson G,Collins G,Talamantes F,Nandi S

    更新日期:1995-04-01 00:00:00

  • Epidermal growth factor upregulates motility of Mat-LyLu rat prostate cancer cells partially via voltage-gated Na+ channel activity.

    abstract::The main aim of this investigation was to determine whether a functional relationship existed between epidermal growth factor (EGF) and voltage-gated sodium channel (VGSC) upregulation, both associated with strongly metastatic prostate cancer cells. Incubation with EGF for 24 h more than doubled VGSC current density. ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Ding Y,Brackenbury WJ,Onganer PU,Montano X,Porter LM,Bates LF,Djamgoz MB

    更新日期:2008-04-01 00:00:00

  • Comparative study between bone marrow mesenchymal stem cell and their conditioned medium in the treatment of rat model of Parkinsonism.

    abstract::Parkinsonism is one of the most common aging neurodegenerative disorders. This study aims to compare the therapeutic effect of stem cell versus its conditioned medium in the Parkinsonism model. Parkinsonism was induced by daily subcutaneous injection of 0.5 mg/kg of rotenone dissolved in dimethyl sulfoxide for 28 days...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Abdelwahab S,Elsebay SAG,Fouli Gaber M,Abdel-Hafez SMN

    更新日期:2021-01-01 00:00:00

  • Codon usage pattern and evolutionary forces of mitochondrial ND genes among orders of class Amphibia.

    abstract::In this study, we used a bioinformatics approach to analyze the nucleotide composition and pattern of synonymous codon usage in mitochondrial ND genes in three amphibian groups, that is, orders Anura, Caudata, and Gymnophiona to identify the commonality and the differences of codon usage as no research work was report...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Barbhuiya PA,Uddin A,Chakraborty S

    更新日期:2020-09-22 00:00:00

  • Insulin producing cells derived from embryonic stem cells: are we there yet?

    abstract::Derivation of insulin producing cells (IPCs) from embryonic stem (ES) cells provides a potentially innovative form of treatment for type 1 diabetes. Here, we discuss the current state of the art, unique challenges, and future directions on generating IPCs. ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Raikwar SP,Zavazava N

    更新日期:2009-02-01 00:00:00

  • P2Y2 receptors induced cell surface redistribution of alpha(v) integrin is required for activation of ERK 1/2 in U937 cells.

    abstract::Nucleotides released from cells due to stress, injury or inflammation, induce mitogenic effects in monocytes via activation of P2Y(2) nucleotide receptors (P2Y(2)Rs). Here we show that P2Y(2) nucleotide receptors in U937 monocytic cells regulate the activation of extracellular signal-regulated kinases 1 and 2 (ERK 1/2...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Chorna NE,Chevres M,Santos-Berrios C,Orellano EA,Erb L,González FA

    更新日期:2007-05-01 00:00:00

  • Tumor-suppressive roles of ΔNp63β-miR-205 axis in epithelial-mesenchymal transition of oral squamous cell carcinoma via targeting ZEB1 and ZEB2.

    abstract::We previously revealed that epithelial-to-mesenchymal transition (EMT) was mediated by ΔNp63β, a splicing variant of ΔNp63, in oral squamous cell carcinoma (OSCC). Recent studies have highlighted the involvement of microRNA (miRNA) in EMT of cancer cells, though the mechanism remains unclear. To identify miRNAs respon...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Hashiguchi Y,Kawano S,Goto Y,Yasuda K,Kaneko N,Sakamoto T,Matsubara R,Jinno T,Maruse Y,Tanaka H,Morioka M,Hattori T,Tanaka S,Kiyoshima T,Nakamura S

    更新日期:2018-10-01 00:00:00

  • Down-regulation of proteolytic activity in 12-O-tetradecanoyl-phorbol-13-acetate-induced K562 leukemia cell cultures: depletion of active urokinase by excess type 1 plasminogen activator inhibitor.

    abstract::The human chronic myeloid leukemia cell line K562 acquires several megakaryoblastoid features when cultured in the presence of the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA). We observed strongly increased secretion of several proteins into the culture media of K562 cells within a few hours of TPA trea...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Alitalo R,Andersson LC,Tapiovaara H,Sistonen L,Vaheri A,Stephens R

    更新日期:1989-07-01 00:00:00

  • Isoprenoids and astroglial cell cycling: diminished mevalonate availability and inhibition of dolichol-linked glycoprotein synthesis arrest cycling through distinct mechanisms.

    abstract::Primary astroglial cultures were used to compare the relationships to cell cycling of dolichol-linked glycoprotein synthesis, and of availability of mevalonate, the precursor of dolichol and other isoprenoid lipids. With shift-up to 10% serum (time 0) after 48 h of serum depletion, the proportion of cells in S phase (...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Langan TJ,Slater MC

    更新日期:1991-11-01 00:00:00

  • A promising structural magnetic resonance imaging assessment in patients with preclinical cognitive decline and diabetes mellitus.

    abstract::Subjective cognitive decline (SCD) is frequently reported in diabetic patients. Diabetes mellitus (DM) is associated with changes in the microstructure of the brain arise in diabetic patients, including changes in gray matter volume (GMV). However, the underlying mechanisms of changes in GMV in DM patients with cognit...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Dong Y,Wang Q,Yao H,Xiao Y,Wei J,Xie P,Hu J,Chen W,Tang Y,Zhou H,Liu J

    更新日期:2019-08-01 00:00:00

  • Transforming activity of mutant human p53 alleles.

    abstract::Mutant forms of the p53 gene have been shown to cooperate with an activated ras gene in transforming primary cells in culture. The aberrant proteins encoded by p53 mutants are thought to act in a dominant negative manner in these assays. In vivo data, however, reveal that where p53 has undergone genetic change in tumo...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Slingerland JM,Benchimol S

    更新日期:1991-09-01 00:00:00

  • miR-21-regulated M2 polarization of macrophage is involved in arsenicosis-induced hepatic fibrosis through the activation of hepatic stellate cells.

    abstract::Arsenicosis induced by chronic exposure to arsenic is recognized as one of the main damaging effects on public health. Exposure to arsenic can cause hepatic fibrosis, but the molecular mechanisms by which this occurs are complex and elusive. It is not known if miRNAs are involved in arsenic-induced liver fibrosis. We ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Xue J,Xiao T,Wei S,Sun J,Zou Z,Shi M,Sun Q,Dai X,Wu L,Li J,Xia H,Tang H,Zhang A,Liu Q

    更新日期:2021-01-22 00:00:00

  • LncRNA-MEG3 inhibits cell proliferation and invasion by modulating Bmi1/RNF2 in cholangiocarcinoma.

    abstract::Cholangiocarcinoma (CCA) is a mortal cancer with gradually increasing incidences all over the world, whereas effective diagnosis and treatment for this disease are still lacking. As a classical long noncoding RNA (lncRNA), maternally expressed gene 3 (MEG3) has been reported to exhibit pivotal regulatory roles in the ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Li J,Jiang X,Li C,Liu Y,Kang P,Zhong X,Cui Y

    更新日期:2019-12-01 00:00:00

  • Regulation of protein phosphatase 2A-mediated recruitment of IQGAP1 to beta1 integrin by EGF through activation of Ca2+/calmodulin-dependent protein kinase II.

    abstract::Maintenance of beta1 integrin-mediated cell adhesion in quiescent human mammary epithelial (HME) cells requires protein phosphatase (PP) 2A for not only dephosphorylation of beta1 integrin but also recruitment of IQGAP1 to Rac-bound beta1 integrin. However, how PP2A-dependent regulatory machinery of cell adhesion resp...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Takahashi K,Suzuki K

    更新日期:2006-07-01 00:00:00

  • Exercise training corrects control of spontaneous calcium waves in hearts from myocardial infarction heart failure rats.

    abstract::Impaired cardiac control of intracellular diastolic Ca(2+) gives rise to arrhythmias. Whereas exercise training corrects abnormal cyclic Ca(2+) handling in heart failure, the effect on diastolic Ca(2+) remains unstudied. Here, we studied the effect of exercise training on the generation and propagation of spontaneous ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Kemi OJ,MacQuaide N,Hoydal MA,Ellingsen O,Smith GL,Wisloff U

    更新日期:2012-01-01 00:00:00

  • Molecular biology and immunoregulation of human neurotropic JC virus in CNS.

    abstract::The human polyomavirus, JC virus (JCV), provides an excellent model system to investigate the reciprocal interaction of the immune and nervous systems. Infection with JCV occurs during childhood and the virus remains in the latent state with no apparent clinical symptoms. However, under immunosuppressed conditions, th...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Sweet TM,Del Valle L,Khalili K

    更新日期:2002-06-01 00:00:00

  • Neurovascular inflammation in the pathogenesis of brain arteriovenous malformations.

    abstract::Brain arteriovenous malformations (bAVM) arise as congenital or sporadic focal lesions with a significant risk for intracerebral hemorrhage (ICH). A wide range of interindividual differences is present in the onset, progression, and severity of bAVM. A growing body of gene expression and polymorphism-based research st...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Krithika S,Sumi S

    更新日期:2020-12-20 00:00:00

  • Potassium-induced reverse transformation of cells infected with a temperature-sensitive transformation mutant virus.

    abstract::High potassium concentrations altered the morphology and the ability to grow in soft agar in 6m2 cells, a clone of rat kidney cells infected with a temperature-sensitive mutant of Moloney sarcoma virus. Approximately 60% of cells exhibited normal morphology in the presence of 94.8 mM potassium in isotonic medium at th...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Lai CN,Becker FF

    更新日期:1985-11-01 00:00:00

  • Pp60c-src mediates ERK activation/nuclear localization and PAI-1 gene expression in response to cellular deformation.

    abstract::Release of transcellular tension upon disruption of actin stress fibers with cytochalasin D (CD) and associated changes in cell morphology are reflected in the rapid transcription of "deformation-responsive" genes. For certain genes (e.g., urokinase plasminogen activator and its type-1 inhibitor PAI-1), de novo mRNA s...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Samarakoon R,Higgins PJ

    更新日期:2003-06-01 00:00:00

  • Proteasomal degradation of myocardin is required for its transcriptional activity in vascular smooth muscle cells.

    abstract::Myocardin is a transcriptional co-activator of serum response factor (SRF) and can be degraded through ubiquitin-proteasome system. Our preliminary studies unexpectedly revealed that accumulation of myocardin in response to proteasome inhibition by MG132 or lactacystin resulted in decrease of transcriptional activity ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Yin H,Jiang Y,Li H,Li J,Gui Y,Zheng XL

    更新日期:2011-07-01 00:00:00

  • C/EBPα and the Vitamin D Receptor Cooperate in the Regulation of Cathelicidin in Lung Epithelial Cells.

    abstract::1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) and the vitamin D receptor (VDR) have been reported to have an important role in the regulation of innate immunity. We earlier reported that the antimicrobial peptide cathelicidin is induced by 1,25(OH)2D3 in normal human bronchial epithelial cells with a resultant increase in an...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Dhawan P,Wei R,Sun C,Gombart AF,Koeffler HP,Diamond G,Christakos S

    更新日期:2015-02-01 00:00:00

  • The fate of DNA originally existing in the zygote nucleus during achromosomal cleavage of fertilized echinoderm eggs in the presence of aphidicolin: microscopic studies with anti-DNA antibody.

    abstract::In fertilized echinoderm eggs, the male and female pronuclei fuse to form the diploid nucleus even in the presence of aphidicolin, a specific inhibitor of eukaryotic DNA polymerase-alpha. The subsequent first cleavage is independent of chromosomes but dependent on spindle and amphiaster. The fate of DNA originally exi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Yamada H,Hirai S,Ikegami S,Kawarada Y,Okuhara E,Nagano H

    更新日期:1985-07-01 00:00:00

  • Nexavar/Stivarga and viagra interact to kill tumor cells.

    abstract::We determined whether the multi-kinase inhibitor sorafenib or its derivative regorafenib interacted with phosphodiesterase 5 (PDE5) inhibitors such as Viagra (sildenafil) to kill tumor cells. PDE5 and PDGFRα/β were over-expressed in liver tumors compared to normal liver tissue. In multiple cell types in vitro sorafeni...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Tavallai M,Hamed HA,Roberts JL,Cruickshanks N,Chuckalovcak J,Poklepovic A,Booth L,Dent P

    更新日期:2015-09-01 00:00:00

  • Effect of tumor-associated mutant E-cadherin variants with defects in exons 8 or 9 on matrix metalloproteinase 3.

    abstract::Tumor progression is characterized by loss of cell adhesion and increase of invasion and metastasis. The cell adhesion molecule E-cadherin is frequently down-regulated or mutated in tumors. In addition to down-regulation of cell adhesion, degradation of the extracellular matrix by matrix metalloproteinases is necessar...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Fuchs M,Hermannstädter C,Specht K,Knyazev P,Ullrich A,Rosivatz E,Busch R,Hutzler P,Höfler H,Luber B

    更新日期:2005-03-01 00:00:00

  • Osteocalcin-dependent regulation of glucose metabolism and fertility: Skeletal implications for the development of insulin resistance.

    abstract::The skeleton has recently emerged as a critical insulin target tissue that regulates whole body glucose metabolism and male reproductive function. While our understanding of these new regulatory axes remains in its infancy, the bone-specific protein, osteocalcin, has been shown to be centrally involved. Undercarboxyla...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Tangseefa P,Martin SK,Fitter S,Baldock PA,Proud CG,Zannettino ACW

    更新日期:2018-05-01 00:00:00

  • Proceedings of the fourth National Congress of the Italian Society of Virology.

    abstract::The aim of the yearly National Congress of the Italian Society of Virology (SIV) is to promote the discussion between senior and younger researchers to improve the knowledge and scientific collaboration among the various areas of Virology. The invited and selected lecturers of the fourth National Congress of SIV cover...

    journal_title:Journal of cellular physiology



    authors: Salata C,Parolin C,Palù G

    更新日期:2005-09-01 00:00:00

  • Dominant and recessive mitogen-nonproliferative variants of 3T3 cells.

    abstract::We have previously isolated 3T3 cell variants unable to respond to specific mitogens. In this report we analyze the dominant and/or recessive nature of these variants. Two independently isolated EGF nonproliferative variants are unable to bind EGF. Hybrids between 3T3R5 cells (thymidine kinase deficient, ouabain-resis...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Terwilliger E,Herschman HR

    更新日期:1985-06-01 00:00:00

  • Aluminum fluoride stimulates inositol phosphate metabolism and inhibits expression of differentiation markers in mouse keratinocytes.

    abstract::Mouse keratinocytes are induced to differentiate in vitro by elevating the level of extracellular calcium from 0.05 mM, where keratinocytes express a basal cell phenotype, to greater than 0.10 mM, where they express the differentiated phenotype. This process has been associated with a rapid, sustained increase in inos...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Lee E,Yuspa SH

    更新日期:1991-07-01 00:00:00

  • ROS- and HIF1α-dependent IGFBP3 upregulation blocks IGF1 survival signaling and thereby mediates high-glucose-induced cardiomyocyte apoptosis.

    abstract::The prevalence of chronic hyperglycemia and its complications, imposing a critical burden on the worldwide economy and the global healthcare system, is a pressing issue. Mounting evidence indicates that oxidative stress and hypoxia, two noticeable features of hyperglycemia, play a joint crucial role in mediating cellu...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Huang YT,Liu CH,Yang YC,Aneja R,Wen SY,Huang CY,Kuo WW

    更新日期:2019-08-01 00:00:00