Scutellarein inhibits RANKL-induced osteoclast formation in vitro and prevents LPS-induced bone loss in vivo.

abstract：:Increased neovascularization is commonly observed in hemorrhagic plaques and associated with rupture of atherosclerotic lesions. This study aims to investigate whether hemin accumulated at the site of hematoma promotes neovascularization through affecting the growth and function of endothelial progenitor cells (EPCs) ...

journal_title：Journal of cellular physiology

authors： Wang JY,Lee YT,Chang PF,Chau LY

更新日期：2009-06-01 00:00:00

abstract：:Two transport systems for neutral amino acids have been characterised in LLC-PK, cells. The first, which transports alanine in a sodium-dependent manner, also mediates alanine exchange and is perferentially inhibited by serine, cysteine, and alpha-amino-n-butyric acid. This system resembles the ASC system in Ehrlich a...

journal_title：Journal of cellular physiology

authors： Sepúlveda FV,Pearson JD

更新日期：1982-08-01 00:00:00

abstract：:The mobility of a cell surface protein on cells osmotically swollen by treatment with several different cell permeabilizing agents retains specific restraints despite detachment of the plasma membrane from the cortical cytoskeleton. Fluorescence photobleaching recovery experiments indicate that the lateral diffusion c...

journal_title：Journal of cellular physiology

authors： Feder TJ,Chang EY,Holowka D,Webb WW

更新日期：1994-01-01 00:00:00

abstract：:Hyaluronan (HA) accumulates in vascular disease but its functional role is not fully understood. To investigate the impact of HA enriched extracellular matrices (ECM) on cell phenotype, arterial smooth muscle cells (ASMCs) were transduced with retroviral constructs (LXSN) encoding murine has-1, has-2, and has-3. HA sy...

journal_title：Journal of cellular physiology

authors： Wilkinson TS,Bressler SL,Evanko SP,Braun KR,Wight TN

更新日期：2006-02-01 00:00:00

abstract：:Cardiac hypertrophy (CH), characterized by the enlargement of cardiomyocytes, fibrosis and apoptosis, is one of the leading causes of death worldwide. Despite the advances in cardiovascular research, there remains a need to further investigate the signaling pathways that mediate CH in order to identify novel therapeut...

journal_title：Journal of cellular physiology

authors： Riaz S,Zeidan A,Mraiche F

更新日期：2017-12-01 00:00:00

abstract：:The tumor-promoting phorbol ester, 12-0-tetradecanoyl-phorbol-13-acetate (TPA), stimulates starch-elicited mouse peritoneal macrophages to undergo DNA synthesis in vitro, apparently without the generation of an endogenous macrophage growth factor (MGF). No evidence was found for any synergistic interaction between TPA...

journal_title：Journal of cellular physiology

authors： Hamilton JA

更新日期：1983-04-01 00:00:00

abstract：:The phenotype of a ouabain-resistant Aedes albopictus cell line has been partially characterized. Treatment of ouabain-sensitive cells with 0.005-1.0 mM ouabain resulted in an 80% reduction in the uptake of 86rubidium (86Rb+), an ion with an affinity for the K+ pump binding site; ouabain-resistant cells showed only a ...

journal_title：Journal of cellular physiology

authors： Mento SJ,Malinoski F,Stollar V

更新日期：1979-12-01 00:00:00

abstract：:We have previously identified two stimulatory activities affecting blood cell maturation in PHA-stimulated human lymphocytes conditioned medium (PHA-LyCM). One was granulocyte-macrophage colony stimulatory activity (GM-CSA), and the other was T lymphocyte growth stimulatory activity (TL-GSA) in suspension culture. In ...

journal_title：Journal of cellular physiology

authors： Wu AM

更新日期：1979-11-01 00:00:00

abstract：:Genomic imprinting in gametogenesis marks a subset of mammalian genes for parent-of-origin-dependent monoallelic expression in the offspring. Embryological and classical genetic experiments in mice that uncovered the existence of genomic imprinting nearly two decades ago produced abnormalities of growth or behavior, w...

journal_title：Journal of cellular physiology

authors： Tycko B,Morison IM

更新日期：2002-09-01 00:00:00

abstract：:Hepatocyte growth factor (HGF)-induced tubulogenesis has been demonstrated with renal epithelial cell lines grown in collagen gels but not with primary cultured renal proximal tubular epithelial cells (RPTEs). We show that HGF selectively induces proliferation and branching morphogenesis of primary cultured rat RPTEs....

journal_title：Journal of cellular physiology

authors： Bowes RC 3rd,Lightfoot RT,Van De Water B,Stevens JL

更新日期：1999-07-01 00:00:00

abstract：:The main aim of this investigation was to determine whether a functional relationship existed between epidermal growth factor (EGF) and voltage-gated sodium channel (VGSC) upregulation, both associated with strongly metastatic prostate cancer cells. Incubation with EGF for 24 h more than doubled VGSC current density. ...

journal_title：Journal of cellular physiology

authors： Ding Y,Brackenbury WJ,Onganer PU,Montano X,Porter LM,Bates LF,Djamgoz MB

更新日期：2008-04-01 00:00:00

abstract：:Detailed information regarding the synthesis rates of individual protein components is important in understanding the assembly and dynamics of the cytoskeletal matrix of eukaryotic cells. As an approach to this topic, the dual isotope technique of Clark and Zak (J. Biol. Chem., 256:4863-4870, 1981), was employed to me...

journal_title：Journal of cellular physiology

authors： Mitchell JJ,Low RB,Woodcock-Mitchell JL

更新日期：1990-06-01 00:00:00

abstract：:The roles of Sonic hedgehog (Shh) and Bone morphogenetic protein-2 (Bmp-2) in osteoblast differentiation were investigated using in vitro cell systems. Recombinant amino-terminal portion of SHH (rSHH-N) dose dependently stimulated ALP activity in C3H10T1/2 and MC3T3-E1 cells. rSHH-N induced expression of Osteocalcin m...

journal_title：Journal of cellular physiology

authors： Yuasa T,Kataoka H,Kinto N,Iwamoto M,Enomoto-Iwamoto M,Iemura S,Ueno N,Shibata Y,Kurosawa H,Yamaguchi A

更新日期：2002-11-01 00:00:00

abstract：:This study examines the mechanism by which TGF-beta 1, an important mediator of cell growth and differentiation, blocks the differentiation of normal rat diploid fetal osteoblasts in vitro. We have established that the inability for pre-osteoblasts to differentiate is associated with changes in the expression of cell ...

journal_title：Journal of cellular physiology

authors： Breen EC,Ignotz RA,McCabe L,Stein JL,Stein GS,Lian JB

更新日期：1994-08-01 00:00:00

abstract：:The study was conducted on human leukemia (K 562) cells to characterize the mechanisms implicated in the regulation of the polyamine spermidine (Spd) transport process. The antagonists of calmodulin, trifluoperazine (TFP), W-7 (N-[6-aminohexyl]-5-chloro-1-naphthelenesulfonamide), or mellitin inhibited significantly po...

journal_title：Journal of cellular physiology

authors： Khan NA,Sezan A,Quemener V,Moulinoux JP

更新日期：1993-12-01 00:00:00

abstract：:Spontaneously arising, TGF beta 1-resistant colonies were isolated directly from the soft agarose plates of MOSER human colon carcinoma cells grown in the presence of TGF beta 1 but in the absence of serum. The colonies were cloned by limiting dilution and screened in a monolayer proliferation assay for sensitivity to...

journal_title：Journal of cellular physiology

authors： Zhou GH,Sechrist GL,Brattain MG,Mulder KM

更新日期：1995-12-01 00:00:00

abstract：:An imbalance between matrix synthesis and degradation is the hallmark of intervertebral disc degeneration while inflammatory cytokines contribute to the imbalance. Bromodomain and extra-terminal domain (BET) family is associated with the pathogenesis of inflammation, and inhibition of BRD4, a vital member of BET famil...

journal_title：Journal of cellular physiology

authors： Hong J,Li S,Markova DZ,Liang A,Kepler CK,Huang Y,Zhou J,Yan J,Chen W,Huang D,Xu K,Ye W

更新日期：2020-07-01 00:00:00

abstract：:Ethanol induces neuronal cell injury and death by dysregulating several signaling events that are controlled, in part, by activation of MAPK/ERK1/2 and/or inactivation of its corresponding phosphatase, PP1. Recently, we have purified a novel protein of 38 kDa in size, p38SJ, from a callus culture of Hypericum perforat...

journal_title：Journal of cellular physiology

authors： Amini S,Merabova N,Khalili K,Darbinian N

更新日期：2009-12-01 00:00:00

abstract：:The members of the tumor necrosis factor (TNF) family play pivotal roles in the regulation of the immune system. LIGHT is a type II transmembrane protein belonging to the TNF family that was originally identified as a weak inducer of apoptosis. This cytokine has been extensively studied for its role in T cell regulati...

journal_title：Journal of cellular physiology

authors： Zou GM,Hu WY

更新日期：2005-12-01 00:00:00

abstract：:Ovarian cancer (OC) is a fatal cancer in women, mainly due to its aggressive nature and poor survival rate. The lncRNA-miRNA-mRNA (long noncoding RNA-microRNA-messenger RNA) interaction is promising biomarkers for the improving prognosis of OC. Therefore, we explored the regulatory mechanism of WDFY3-AS2/miR-18a/RORA ...

journal_title：Journal of cellular physiology

authors： Li W,Ma S,Bai X,Pan W,Ai L,Tan W

更新日期：2020-02-01 00:00:00

abstract：:As a natural metabolite of limonoids from Dictamnus dasycarpus, fraxinellone has been reported to be neuroprotective and anti-inflammatory. However, its influence on cellular metabolism remains largely unknown. In the present study, we investigated the effect of fraxinellone on cellular senescence-induced by oxidative...

journal_title：Journal of cellular physiology

authors： Han X,Chen H,Zhou J,Tai H,Gong H,Wang X,Huang N,Qin J,Fang T,Wang F,Xiao H

更新日期：2018-05-01 00:00:00

abstract：:TRPV4 (transient receptor potential vanilloid 4) is a cation channel activated by hypotonicity, moderate heat, or shear stress. We describe the expression of TRPV4 during the differentiation of a corneal epithelial cell model, RCE1(5T5) cells. TRPV4 is a late differentiation feature that is concentrated in the apical ...

journal_title：Journal of cellular physiology

authors： Martínez-Rendón J,Sánchez-Guzmán E,Rueda A,González J,Gulias-Cañizo R,Aquino-Jarquín G,Castro-Muñozledo F,García-Villegas R

更新日期：2017-07-01 00:00:00

abstract：:The vascular isoform of ATP-sensitive K(+) (KATP ) channels regulates blood flow to all organs. The KATP channel is strongly inhibited by reactive oxygen and carbonyl species produced in diabetic tissue inflammation. To address how such channel inhibition impacts vascular regulation as well as tissue viability, we per...

journal_title：Journal of cellular physiology

authors： Li SS,Cui N,Yang Y,Trower TC,Wei YM,Wu Y,Zhang S,Jin X,Jiang C

更新日期：2015-12-01 00:00:00

abstract：:Extracellular ATP and other nucleotides induce autocrine and/or paracrine purinergic signalling via activation of the P2 receptors on the cell surface, which represents one of the most common signalling mechanisms. Mesenchymal stem cells (MSC) are a type of multipotent adult stem cells that have many promising applica...

journal_title：Journal of cellular physiology

authors： Jiang LH,Hao Y,Mousawi F,Peng H,Yang X

更新日期：2017-02-01 00:00:00

abstract：:The cellular proto-oncogene c-myc is an important transcription factor that plays a role in several cellular activities such as proliferation, differentiation, and apoptosis. It follows that regulation of c-myc expression is crucial for maintaining cell integrity. Amplification or translocation can convert this proto-...

journal_title：Journal of cellular physiology

authors： Habel ME,Lemieux R,Jung D

更新日期：2005-04-01 00:00:00

abstract：:This study establishes a causal link between the limitation of myofibre transitions and modulation of calcineurin activity, during different exercise paradigms. We have designed a new swimming-based training protocol in order to draw a comparison between a high frequency and amplitude exercise (swimming) and low frequ...

journal_title：Journal of cellular physiology

authors： Grondard C,Biondi O,Pariset C,Lopes P,Deforges S,Lécolle S,Gaspera BD,Gallien CL,Chanoine C,Charbonnier F

更新日期：2008-01-01 00:00:00

abstract：:Nerve growth factor (NGF) is required for the growth and development of sensory and sympathetic neurons. Incubation of chick dorsal root ganglionic cells without NGF resulted in a decrease of active (Na+,K+-pump-mediated) K+ influx over a period of several hours. Addition of NGF to NGF-deprived cells caused 1) a retur...

journal_title：Journal of cellular physiology

authors： Boonstra J,Skaper SD,Varon S

更新日期：1982-10-01 00:00:00

abstract：:The opossum kidney (OK) cell was used as a model to test the hypothesis that estrogen directly affects proximal renal tubular epithelial cells. To demonstrate the expression of estrogen receptor in OK cells, we developed an approach using reverse transcription and the polymerase chain reaction. Analysis of the DNA amp...

journal_title：Journal of cellular physiology

authors： Stock JL,Coderre JA,Burke EM,Danner DB,Chipman SD,Shapiro JR

更新日期：1992-03-01 00:00:00

abstract：:Studies have been carried out to determine the effect of bacterial infection on CSF production, CFU-C activation, and bacterial clearance by mature granulocytes in mice infected with Escherichia coli. These studies have shown that immediately after bacterial infection (5 minutes), serum colony-stimulating factor (CSF)...

journal_title：Journal of cellular physiology

authors： Hartmann DW,Entringer MA,Robinson WA,Vasil ML,Drebing CJ,Morton NJ,True L

更新日期：1981-10-01 00:00:00

abstract：:The expression of parathyroid hormone-related protein (PTHrP) was studied in a range of cell cultures representative of the osteoblast lineage and in rat calvarial sections. Primary newborn rat calvarial cells, a rat preosteoblastic cell line (UMR 201), a mouse stromal cell line (ST 2), a mouse calvaria-derived osteob...

journal_title：Journal of cellular physiology

authors： Suda N,Gillespie MT,Traianedes K,Zhou H,Ho PW,Hards DK,Allan EH,Martin TJ,Moseley JM

更新日期：1996-01-01 00:00:00