Abstract:
:Cardiac hypertrophy (CH), characterized by the enlargement of cardiomyocytes, fibrosis and apoptosis, is one of the leading causes of death worldwide. Despite the advances in cardiovascular research, there remains a need to further investigate the signaling pathways that mediate CH in order to identify novel therapeutic targets. One of the hallmarks of CH is the remodeling of the extracellular matrix (ECM). Multiple studies have shown an important role of cysteine proteases and matrix metalloproteinases (MMPs) in the remodeled heart. This review focuses on the role of cysteine cathepins and MMPs in cardiac remodeling.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Riaz S,Zeidan A,Mraiche Fdoi
10.1002/jcp.25884subject
Has Abstractpub_date
2017-12-01 00:00:00pages
3244-3250issue
12eissn
0021-9541issn
1097-4652journal_volume
232pub_type
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