Disparate modulation of plasma membrane protein lateral mobility by various cell permeabilizing agents.

abstract：:Intratympanic injection of gentamicin has proven to be an effective therapy for intractable vestibular dysfunction. However, most studies to date have focused on the cochlea, so little is known about the distribution and uptake of gentamicin by the counterpart of the auditory system, specifically vestibular hair cells...

journal_title：Journal of cellular physiology

authors： Qian X,He Z,Wang Y,Chen B,Hetrick A,Dai C,Chi F,Li H,Ren D

更新日期：2020-12-23 00:00:00

abstract：:Comparative studies with rat transferrin (rTf) and asialotransferrin (asialo-rTf) were performed on suspended adult rat hepatocytes with the aim of elucidating the mechanism of enhanced hepatic Fe acquisition from asialo-rTf observed previously in vivo. At low ligand concentrations (0.05-20 micrograms/ml), the cells b...

journal_title：Journal of cellular physiology

authors： Rudolph JR,Regoeczi E

更新日期：1988-06-01 00:00:00

abstract：:The effects of three purified colony-stimulating factors (CSFs) with different specificities for the granulocyte (G) and macrophage (M) lineages (G-CSF, CSF-1 and GM-CSF) were studied in a serum-free clonal assay system. The results were compared with those obtained in similar cultures containing fetal calf serum (FCS...

journal_title：Journal of cellular physiology

authors： Eliason JF

更新日期：1986-08-01 00:00:00

abstract：:Despite a high degree of structural homology and shared exchange factors, effectors and GTPase activating proteins, a large body of evidence suggests functional heterogeneity among Ras isoforms. One aspect of Ras biology that may explain this heterogeneity is the differential subcellular localizations driven by the C-...

journal_title：Journal of cellular physiology

authors： Lynch SJ,Snitkin H,Gumper I,Philips MR,Sabatini D,Pellicer A

更新日期：2015-03-01 00:00:00

abstract：:Interleukin (IL)-4, which exhibits potent anti-inflammatory activities, is of potential therapeutic value in destructive arthropathies. To further define the response of human joint cells to IL-4, we analyzed the ability of this cytokine to modulate the effects of IL-1beta and growth factors. Freshly isolated chondroc...

journal_title：Journal of cellular physiology

authors： Guicheux J,Palmer G,Relic B,Mezin F,Caverzasio J,Apostolides P,Gauchat JF,Gabay C,Guerne PA

更新日期：2002-07-01 00:00:00

abstract：:We have partially purified a mitogenic factor, termed colony stimulating factor, which is secreted from a human T lymphocytic cell line, and which stimulates in vitro formation of colonies of macrophages and granulocytes by human bone marrow cells. Colony stimulating factor (CSF) produced by cells grown in serum suppl...

journal_title：Journal of cellular physiology

authors： Frölich M

更新日期：1981-12-01 00:00:00

abstract：BACKGROUND:Elevated microsatellite alteration at selected tetranucleotide repeats (EMAST) is a type of microsatellite instability that occurs in ∼60% of colorectal cancers (CRCs) and associated with MSH3 dysfunction. A 5-fluorouracil (5-FU)-related cytotoxicity is attenuated in MSH3-deficient colon cancer cells. Report...

journal_title：Journal of cellular physiology

authors： Mohammadpour S,Goodarzi HR,Jafarinia M,Porhoseingholi MA,Nazemalhosseini-Mojarad E

更新日期：2020-04-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS), characterized by acute hypoxic respiratory dysfunction or failure, is a manifestation of multiple organ failure in the lung, and the most common risk factor is sepsis. We previously showed that blocking α2 -adrenoceptor (α2 -AR) could attenuate lung injury induced by endotox...

journal_title：Journal of cellular physiology

authors： Cong Z,Li D,Tao Y,Lv X,Zhu X

更新日期：2020-10-01 00:00:00

abstract：:Properties of the change from asparagine dependence (asn-) to independence (asn+) were investigated in the androgenetic haploid frog cell line ICR 2A. Two types of asn+ variants arose spontaneously during culture. Glutamine-dependent asparagine synthetase (AS) activity, found to be deficient in asn- cells, was repress...

journal_title：Journal of cellular physiology

authors： Hepfer CE,Little WA,Hengst JA,Freed JJ

更新日期：1989-04-01 00:00:00

abstract：:The concentration of ATP in cysts of the brine shrimp, Artemia salina, has been studied as a function of cyst hydration. Cysts dried over CaSO4 contain 0.02 gH2O/g cysts and 0.54 +/- 0.05 (S.D.) mumoles of ATP/g dried cysts. Addition of water up to 0.05 g/g cysts produced no net change in the level of ATP during incub...

journal_title：Journal of cellular physiology

authors： Clegg JS,Cavagnaro J

更新日期：1976-06-01 00:00:00

abstract：:The nuclear lamina is a fibrous structure at the nucleoplasmic surface of the inner nuclear membrane. Its assembly state is regulated by phosphorylation of its protein components, the lamins A, B, and C. The isoprenylation of the lamins is essential for their proper membrane anchoring and functionality. The content an...

journal_title：Journal of cellular physiology

authors： Bruscalupi G,Di Croce L,Lamartina S,Zaccaria ML,Luzzatto AC,Trentalance A

更新日期：1997-05-01 00:00:00

abstract：:Theranostic nanoparticles (NPs) are promising for opening new windows toward personalized disease management. Using a single particle capable of both diagnosis and drug delivery, is the major benefit of such particles. In the present study, chitosan NPs were used as a dual action carrier for doxorubicin (DOX; chemothe...

journal_title：Journal of cellular physiology

authors： Gholami L,Tafaghodi M,Abbasi B,Daroudi M,Kazemi Oskuee R

更新日期：2019-02-01 00:00:00

abstract：:The myelin basic protein (MBP) gene contains sequences located upstream of its transcription start site which play a key role in glial-specific transcription of the MBP promoter. Earlier analysis of the 320 bp upstream regulatory sequence of MBP has revealed multiple cis-acting regulatory motifs which differentially r...

journal_title：Journal of cellular physiology

authors： Haque NS,Haas S,Knobler RL,Khalili K

更新日期：1995-05-01 00:00:00

abstract：:While retinoids have been demonstrated to inhibit growth of many tumor cells, including SCC cells, the molecular mechanism by which retinoids suppress growth has not been elucidated. We previously found that the growth of SCC cells was significantly inhibited by all-trans-retinoic acid (all-trans-RA) treatment, and th...

journal_title：Journal of cellular physiology

authors： Le Q,Soprano DR,Soprano KJ

更新日期：2002-03-01 00:00:00

abstract：:We examined the expression of the estrogen and epidermal growth factor (EGF) receptors in a drug-resistant subline of MCF-7 cells in order to study potential alterations in hormone dependence or in the growth factor pathway that could be related to the development of drug resistance in human breast cancer. The drug-re...

journal_title：Journal of cellular physiology

authors： Dickstein B,Valverius EM,Wosikowski K,Saceda M,Pearson JW,Martin MB,Bates SE

更新日期：1993-10-01 00:00:00

abstract：:MiR-137 has been identified as potential hepatocellular carcinoma (HCC) prognostic biomarkers. Highly relevant HCC prognostic biomarkers may be derived from combinations of miR-137 with its target genes involved in the regulation of liver microenvironment. This study aimed at the discovery of such a combination with i...

journal_title：Journal of cellular physiology

authors： Wei Q,Zhao L,Jiang L,Bi J,Yu Z,Zhao L,Song X,Sun M,Chen Y,Wei M

更新日期：2019-07-01 00:00:00

abstract：:Melanoma as the most major skin malignancy has attracted much attention, so far. Although a successful therapeutic strategy requires an accurate understanding of the precise mechanisms for the initiation and progression of the melanoma. Several types of cell death mechanisms have recently been identified along with co...

journal_title：Journal of cellular physiology

authors： Ashrafizadeh M,Mohammadinejad R,Tavakol S,Ahmadi Z,Roomiani S,Katebi M

更新日期：2019-11-01 00:00:00

abstract：:Both the Na+-dependent glucose cotransporter (SGLT1) and the cystic fibrosis transmembrane conductance regulator (CFTR) modulate Na+ and fluid movement, although in opposite directions. Yet few studies have investigated a possible interrelationship between these two transporters. By using the Caco-2 human colon carcin...

journal_title：Journal of cellular physiology

authors： Mailleau C,Capeau J,Brahimi-Horn MC

更新日期：1998-09-01 00:00:00

abstract：AIM:We investigated melanoma-associated antigen A1 (MAGE-A1) expression in lung cancer tissues and its correlation with prognostic factors. MATERIALS AND METHODS:In this cross-sectional study, samples from 101 patients with lung cancer were obtained between 2007 and 2014 and stained for MAGE-A1 by immunohistochemistry...

journal_title：Journal of cellular physiology

authors： Fanipakdel A,Seilanian Toussi M,Rezazadeh F,Mohamadian Roshan N,Javadinia SA

更新日期：2019-07-01 00:00:00

abstract：:Scatchard analysis of binding of 125I-basic fibroblast growth factor (FGF) to baby hamster kidney (BHK) cells revealed the presence of two binding sites: a high affinity site with KD of 20 pM and 80,000 sites per cell and a low affinity site with KD of about 2 nM and 600,000 sites per cell. The binding to the two site...

journal_title：Journal of cellular physiology

authors： Moscatelli D

更新日期：1987-04-01 00:00:00

abstract：:Chemotherapy resistance is the major issue of choriocarcinoma. Apoptosis always is the ultimate outcome of chemotherapeutic drugs, which considered one of the reasons of resistance. We investigated the role of STAT3/NFIL3 signaling-inhibited apoptosis in chemotherapy resistance and whether Raddeanin A (RA) could be a ...

journal_title：Journal of cellular physiology

authors： Peng Z,Zhang C,Zhou W,Wu C,Zhang Y

更新日期：2018-07-01 00:00:00

abstract：:Cells transformed by murine sarcoma viruses (MSV) produce and release into their tissue culture media several polypeptide growth stimulating factors. One of these has been partially purified using Bio-Gel P-60 column chromatography followed by DEAE-cellulose chromatography. This growth factor was assigned the name sar...

journal_title：Journal of cellular physiology

authors： De Larco JE,Todaro GJ

更新日期：1980-02-01 00:00:00

abstract：:TRPV4 (transient receptor potential vanilloid 4) is a cation channel activated by hypotonicity, moderate heat, or shear stress. We describe the expression of TRPV4 during the differentiation of a corneal epithelial cell model, RCE1(5T5) cells. TRPV4 is a late differentiation feature that is concentrated in the apical ...

journal_title：Journal of cellular physiology

authors： Martínez-Rendón J,Sánchez-Guzmán E,Rueda A,González J,Gulias-Cañizo R,Aquino-Jarquín G,Castro-Muñozledo F,García-Villegas R

更新日期：2017-07-01 00:00:00

abstract：:Nucleotides released from cells due to stress, injury or inflammation, induce mitogenic effects in monocytes via activation of P2Y(2) nucleotide receptors (P2Y(2)Rs). Here we show that P2Y(2) nucleotide receptors in U937 monocytic cells regulate the activation of extracellular signal-regulated kinases 1 and 2 (ERK 1/2...

journal_title：Journal of cellular physiology

authors： Chorna NE,Chevres M,Santos-Berrios C,Orellano EA,Erb L,González FA

更新日期：2007-05-01 00:00:00

abstract：:Circular RNA TCF25 (circTCF25) has been proven to be upregulated in human malignancy and correlated with tumor process. Our study aimed to unravel whether circTCF25 dictates cellular activities of osteosarcoma cells and address the possible mechanisms associated with microRNA (miR). circTCF25 and miR-206 in clinical s...

journal_title：Journal of cellular physiology

authors： Wang Y,Shi S,Zhang Q,Dong H,Zhang J

更新日期：2020-02-13 00:00:00

abstract：:The polyphenolic compounds curcumin and quercetin increased sensitivity of ovarian cancer cells (CAOV3 and SKOV3) to cisplatin. The effect was obtained when the compounds were added simultaneously with cisplatin, as well as when they were added 24 h before. High serum levels of certain cytokines, for example interleuk...

journal_title：Journal of cellular physiology

authors： Chan MM,Fong D,Soprano KJ,Holmes WF,Heverling H

更新日期：2003-01-01 00:00:00

abstract：:Topical intranasal application of the antifungal Amphotericin B (AmphoB) has been shown as an effective medical treatment of chronic rhinosinusitis. Because this antibiotic forms channels in lipid membranes, we considered the possibility that it affects the properties and/or cell surface expression of ion channels/pum...

journal_title：Journal of cellular physiology

authors： Jornot L,Rochat T,Caruso A,Lacroix JS

更新日期：2005-09-01 00:00:00

abstract：:There is compelling in vitro and in vivo evidence to implicate mast cells in the development of fibrosis. However, an important question remains as to the mechanisms by which mast cells mediate fibrosis. Recent evidence from our laboratory (Gruber et al., 1997, J. Immunol. , 158:2310-2317) has revealed that tryptase, ...

journal_title：Journal of cellular physiology

authors： Zhang J,Gruber BL,Marchese MJ,Zucker S,Schwartz LB,Kew RR

更新日期：1999-11-01 00:00:00

abstract：:Destructive bone diseases caused by osteolysis are increasing in incidence. They are characterized by an excessive imbalance of osteoclast formation and activation. During osteolysis, the activation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways are triggered by receptor ac...

journal_title：Journal of cellular physiology

authors： Liu H,Dong Y,Gao Y,Zhao L,Cai C,Qi D,Zhu M,Zhao L,Liu C,Guo F,Xiao J,Huang H

更新日期：2019-07-01 00:00:00

abstract：:Acidic pH of the Golgi lumen is known to be crucial for correct glycosylation, transport and sorting of proteins and lipids during their transit through the organelle. To better understand why Golgi acidity is important for these processes, we have examined here the most pH sensitive events in N-glycosylation by seque...

journal_title：Journal of cellular physiology

authors： Rivinoja A,Hassinen A,Kokkonen N,Kauppila A,Kellokumpu S

更新日期：2009-07-01 00:00:00