Impairment of the Vascular KATP Channel Imposes Fatal Susceptibility to Experimental Diabetes Due to Multi-Organ Injuries.

abstract：:Studies on a normal human diploid cell strain revealed that the specific activity of the cell protein, for each of the three enzymes of the Leloir pathway, changed significantly as the cells grew. The kinetics of change in specific activity varied according to the enzyme being studied, and the kinetics for each enzyme...

journal_title：Journal of cellular physiology

authors： Stern ES,Krooth RS

更新日期：1975-08-01 00:00:00

abstract：:Catecholamines produce mitotic inhibition in primary cell cultures of human keratinocytes probably via a block in the G2 part of the cell cycle. Epinephrine produced significant mitotic inhibition (49%) at a concentration as low as 4.5 X 10(-10) M, while its analog, isoproterenol, produced 47% inhibition at 1 X 10(-10...

journal_title：Journal of cellular physiology

authors： Harper RA,Flaxman BA

更新日期：1975-10-01 00:00:00

abstract：:Respiratory tract epithelia are one type of tissue targeted by vitamin A. In this study the effects of vitamin A and its analogs (retinoids) on human bronchial epithelial (HBE) cells have been investigated in a serum-free hormone-supplemented medium. This serum-free medium, which was developed for the long-term cultiv...

journal_title：Journal of cellular physiology

authors： Wu R,Wu MM

更新日期：1986-04-01 00:00:00

abstract：:Synovial fibroblasts (SFs) of rheumatoid arthritis (RA) are phenotypically aggressive, typically progressing into arthritic cartilage degradation. Throughout our study, we made explorations into the effects of microRNA-135a (miR-135a) on the SFs involved in RA by mediating the phosphatidylinositol 3-kinase (PI3K)/AKT ...

journal_title：Journal of cellular physiology

authors： Qu Y,Zhang YP,Wu J,Jie LG,Deng JX,Zhao DB,Yu QH

更新日期：2019-08-01 00:00:00

abstract：:We compared the effects of 95% O2 (hyperoxia) alone, endotoxin (20 ng/ml) alone, and 95% O2 plus endotoxin on the release of lactate dehydrogenase (LDH), uptake of 5-hydroxytryptamine (5-HT), and antioxidant enzyme activities in porcine pulmonary arterial and aortic endothelial cells in monolayer culture. Hyperoxia in...

journal_title：Journal of cellular physiology

authors： Block ER,Patel JM,Sheridan NP

更新日期：1985-02-01 00:00:00

abstract：:The zafirlukast has been reported to be anti-inflammatory and widely used to alleviate the symptoms of asthma. However, its influence on insulin secretion in pancreatic β-cells has not been investigated. Herein, we examined the effects of zafirlukast on insulin secretion and the potential underlying mechanisms. Among ...

journal_title：Journal of cellular physiology

authors： Hwang HJ,Park KS,Choi JH,Cocco L,Jang HJ,Suh PG

更新日期：2018-11-01 00:00:00

abstract：:The clonal hematopoiesis when occurring without hematologic abnormalities is defined as clonal hematopoiesis of indeterminate potential (CHIP). Aging causes accumulation of somatic mutations, and hematopoietic stem cells (HSCs) can develop clonal expansion of different lineages by these mutations. CHIP has a correlati...

journal_title：Journal of cellular physiology

authors： Haybar H,Shahrabi S,Ghanavat M,Khodadi E

更新日期：2019-06-01 00:00:00

abstract：:Insulin was employed as a stimulant in our continuing investigations of the molecular mechanisms involved in the coordinate control of cellular metabolism and growth. Incubation of chicken embryo fibroblasts for 16 hours in media containing 0-0.1 U insulin/ml resulted in a 17-fold increase in the rate of 3H-thymidine ...

journal_title：Journal of cellular physiology

authors： Sanui H,Rubin AH

更新日期：1978-09-01 00:00:00

abstract：:Brain ischemia is associated with an acute release of pro-inflammatory cytokines, notably TNF-alpha and IL-6 and failure of the blood-brain barrier. Shear stress, hypoxia-hypoglycemia, and blood leukocytes play a significant role in blood-brain barrier failure during transient or permanent ischemia. However, these mec...

journal_title：Journal of cellular physiology

authors： Krizanac-Bengez L,Mayberg MR,Cunningham E,Hossain M,Ponnampalam S,Parkinson FE,Janigro D

更新日期：2006-01-01 00:00:00

abstract：:Osteogenic differentiation is a complicated process that depends on various regulatory factors and signal pathways. In our research, the osteogenic differentiation capacity was analyzed by alizarin red staining, alkaline phosphatase activity, and protein levels of osteogenic differentiation markers including runt-rela...

journal_title：Journal of cellular physiology

authors： Li Z,Sun Y,Cao S,Zhang J,Wei J

更新日期：2019-05-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), a potent mediator of endothelial proliferation and migration, has an important role also in brain edema formation during hypoxia and ischemia. VEGF binds to the tyrosine kinase receptors Flt-1 and Flk-1. Yet, their relative importance for hypoxia-induced hyperpermeability is ...

journal_title：Journal of cellular physiology

authors： Vogel C,Bauer A,Wiesnet M,Preissner KT,Schaper W,Marti HH,Fischer S

更新日期：2007-07-01 00:00:00

abstract：:The peroxisome proliferation-activated receptor gamma (PPARgamma) is mainly expressed in the adipose tissue and integrates the control of energy, lipid, and glucose homeostasis. The present study, by means of RT-PCR, Western blot, and immunofluorescence techniques, demonstrates that human sperm express the PPARgamma. ...

journal_title：Journal of cellular physiology

authors： Aquila S,Bonofiglio D,Gentile M,Middea E,Gabriele S,Belmonte M,Catalano S,Pellegrino M,Andò S

更新日期：2006-12-01 00:00:00

abstract：:Poly(ADP-ribosyl)ation is a post-translational modification of protein occurring in the nucleus by poly(ADP-ribose) polymerase enzyme activity. The main role of poly(ADP-ribose) polymerase system as "nick sensor" and DNA breaks repair is based on its activation via DNA strand breaks. Furthermore, poly(ADP-ribose) poly...

journal_title：Journal of cellular physiology

authors： Caldini R,Barletta E,Del Rosso M,Giovannelli L,Chevanne M

更新日期：2005-01-01 00:00:00

abstract：:Serum-free mouse embryo cells, cultured in basal nutrient medium supplemented with insulin, transferrin, epidermal growth factor, fibronectin, and high-density lipoprotein, do not exhibit growth crisis, lack detectable chromosomal aberrations, are nontumorigenic in vivo, are dependent on epidermal growth factor for su...

journal_title：Journal of cellular physiology

authors： Shirahata S,Rawson C,Loo D,Chang YJ,Barnes D

更新日期：1990-07-01 00:00:00

abstract：:Previous studies suggested that the decreased collagen production observed in Kirsten sarcoma virus (Ki-MSV)-transformed BALB 3T3 cells could be reversed by treating cells with Bt2cAMP. We examined the relationship between intracellular cAMP, collagen production, and other properties in NRK and BALB 3T3 cells transfor...

journal_title：Journal of cellular physiology

authors： Majmudar G,Peterkofsky B

更新日期：1985-01-01 00:00:00

abstract：:Male breast cancer (MBC) is an uncommon malignancy. We have previously reported that the expression of the Hippo transducers TAZ/YAP and their target CTGF was associated with inferior survival in MBC patients. Preclinical evidence demonstrated that Axl is a transcriptional target of TAZ/YAP. Thus, we herein assessed A...

journal_title：Journal of cellular physiology

authors： Di Benedetto A,Mottolese M,Sperati F,Ercolani C,Di Lauro L,Pizzuti L,Vici P,Terrenato I,Shaaban AM,Humphries MP,Sundara-Rajan S,Barba M,Speirs V,De Maria R,Maugeri-Saccà M

更新日期：2017-08-01 00:00:00

abstract：:Methionine dependence is a metabolic defect found thus far only in transformed and malignant cells. The defect is manifested as the inability of cells to grow in media in which methionine (Met) is replaced by its immediate precursor homocysteine (Hcy). We have termed this Met- Hcy+ media. We demonstrate here that meth...

journal_title：Journal of cellular physiology

authors： Stern PH,Wallace CD,Hoffman RM

更新日期：1984-04-01 00:00:00

abstract：:The serine protease thrombin has been proposed to be involved in neuromuscular plasticity. Its specific receptor "protease activated receptor-1" (PAR-1), a G protein-coupled receptor, has been shown to be expressed in myoblasts but not after fusion (Suidan et al., 1996 J Biol Chem 271:29162-29169). In the present work...

journal_title：Journal of cellular physiology

authors： Chevessier F,Hantaï D,Verdière-Sahuqué M

更新日期：2001-11-01 00:00:00

abstract：:The Toll and Toll-like receptor signaling pathways are evolutionarily conserved pathways that regulate innate immunity in insects and mammals. While efforts have been made to clarify the signal transduction events that occur during infection, much less is known about the components that maintain immune quiescence. Her...

journal_title：Journal of cellular physiology

authors： Zhou B,Yun EY,Ray L,You J,Ip YT,Lin X

更新日期：2014-04-01 00:00:00

abstract：:In this study, we used a bioinformatics approach to analyze the nucleotide composition and pattern of synonymous codon usage in mitochondrial ND genes in three amphibian groups, that is, orders Anura, Caudata, and Gymnophiona to identify the commonality and the differences of codon usage as no research work was report...

journal_title：Journal of cellular physiology

authors： Barbhuiya PA,Uddin A,Chakraborty S

更新日期：2020-09-22 00:00:00

abstract：:COVID-19, a new disease caused by the 2019-novel coronavirus (SARS-CoV-2), has swept the world and challenged its culture, economy, and health infrastructure. Forced emergence to find an effective vaccine to immunize people has led scientists to design and examine vaccine candidates all over the world. Until a vaccine...

journal_title：Journal of cellular physiology

authors： Rezaei M,Ziai SA,Fakhri S,Pouriran R

更新日期：2020-09-09 00:00:00

abstract：:The development of efficient and repeatable protocols for biobanking and prolonged storage of cancer stem cells (CSCs), with minimum alterations in biological function, is valuable and desired, particularly for retrospective analysis and clinical applications. In particular, data regarding the effect of cryopreservatio...

journal_title：Journal of cellular physiology

authors： Eini L,Naseri M,Karimi-Busheri F,Bozorgmehr M,Ghods R,Madjd Z

更新日期：2020-03-01 00:00:00

abstract：:Focal adhesion kinase (FAK), MAP kinases and the nuclear transcription factor Elk-1 have been reported to be implicated in the same cellular processes, however, their direct or indirect interaction and potential function(s) has not been documented. Here, we explored the association of FAK with Elk-1, the implication o...

journal_title：Journal of cellular physiology

authors： Mamali I,Kotsantis P,Lampropoulou M,Marmaras VJ

更新日期：2008-07-01 00:00:00

abstract：:Nerve-evoked contractile activity in skeletal muscle regulates transcript and protein levels of many metabolic genes in a coordinate fashion, including the muscle isozyme of glycogen phosphorylase (MGP). Cellular signaling mechanisms mediating the activity-dependent modulation of MGP transcript levels were investigate...

journal_title：Journal of cellular physiology

authors： Vali S,Carlsen R,Pessah I,Gorin F

更新日期：2000-11-01 00:00:00

abstract：:1,7-Bis(4-hydroxyphenyl)-1,4-heptadien-3-one (EB30) is a diarylheptanoid-like compound isolated from Viscum coloratum. This curcumin analog exhibits significant cytotoxic activity against HeLa, SGC-7901, and MCF-7 cells. However, little is known about the anticancer effects and mechanisms of EB30 in human lung cancer....

journal_title：Journal of cellular physiology

authors： Fan J,Wu M,Wang J,Ren D,Zhao J,Yang G

更新日期：2019-05-01 00:00:00

abstract：:Podocyte injury is a critical factor for the initiation and progression of diabetic kidney disease (DKD). However, the underlying mechanisms of podocyte injury in DKD have not been completely elucidated. Studies suggested that intracellular cholesterol accumulation was correlated with podocyte injury, but the cause of...

journal_title：Journal of cellular physiology

authors： Hu J,Yang Q,Chen Z,Liang W,Feng J,Ding G

更新日期：2019-12-01 00:00:00

abstract：:Marrow stromal cells (MSCs) are stem-like cells having a striking somatic plasticity. In fact, besides differentiating into mesenchymal lineages (bone, cartilage, and fat), they are capable of differentiating into neurons and astrocytes in vitro and in vivo. The RB and RB2/P130 genes, belonging to the retinoblastoma g...

journal_title：Journal of cellular physiology

authors： Jori FP,Napolitano MA,Melone MA,Cipollaro M,Cascino A,Giordano A,Galderisi U

更新日期：2004-08-01 00:00:00

abstract：:Serine/threonine protein phosphatase (PP) 2A regulates many biological processes, however it remains unclear whether PP2A participates in cadherin-mediated cell-cell adhesion. We show here that the core enzyme of PP2A (PP2A-AC) is localized in the cell-cell adhesion sites between adjacent cells and associated with the...

journal_title：Journal of cellular physiology

authors： Takahashi K,Nakajima E,Suzuki K

更新日期：2006-03-01 00:00:00

abstract：:Retinoic acid reduces the growth rate of mouse S91 melanoma cells in culture and increases the proportion of cells in the G1 phase of the cell cycle. Because of the integral role protein synthesis has been shown to play in growth control we studied the effect of retinoic acid on the protein synthesis machinery with a ...

journal_title：Journal of cellular physiology

authors： Lotan R,Fischer I,Meromsky L,Moldave K

更新日期：1982-10-01 00:00:00

abstract：:The non-POU-domain-containing octamer binding protein (NONO; also known as p54nrb) has various nuclear functions ranging from transcription, RNA splicing, DNA synthesis and repair. Although tyrosine phosphorylation has been proposed to account for the multi-functional properties of p54nrb, direct evidence on p54nrb as...

journal_title：Journal of cellular physiology

authors： Lee AR,Hung W,Xie N,Liu L,He L,Dong X

更新日期：2017-04-01 00:00:00