Altered methionine metabolism occurs in all members of a set of diverse human tumor cell lines.

abstract：:Ephrin A1 has a role in a variety of biological events, including cell proliferation, differentiation, migration, and angiogenesis. Ephrin A1 expression is abundant in trophoblasts and endometrial cells during the implantation period; however, its intracellular activities have not yet been reported in bovine endometri...

journal_title：Journal of cellular physiology

authors： Lim W,Bae H,Bazer FW,Song G

更新日期：2019-04-01 00:00:00

abstract：:The loss of pancreatic islet β-cell function represents the classical feature in the pathogenesis of type 2 diabetes mellitus (T2DM). Previous evidence has highlighted the involvement of the activated JNK pathway in relation to islet β-cell apoptosis. Hence, during the present study a streptozotocin-induced DM mice mo...

journal_title：Journal of cellular physiology

authors： Wang S,Wen X,Han XR,Wang YJ,Shen M,Fan SH,Zhuang J,Xu W,Zhang ZF,Shan Q,Li MQ,Hu B,Sun CH,Wu DM,Lu J,Zheng YL

更新日期：2018-09-01 00:00:00

abstract：:Shear stress secondary to increased pulmonary blood flow (PBF) is elevated in some children born with congenital cardiac abnormalities. However, the majority of these patients do not develop pulmonary edema, despite high levels of permeability inducing factors. Previous studies have suggested that laminar fluid shear ...

journal_title：Journal of cellular physiology

authors： Gross CM,Aggarwal S,Kumar S,Tian J,Kasa A,Bogatcheva N,Datar SA,Verin AD,Fineman JR,Black SM

更新日期：2014-11-01 00:00:00

abstract：:Gene therapy using biocompatible cationic liposomes is amongst promising approaches that decreases death from cancers. Here an invasive multidrug resistant cell model has been developed by lentiviral transfection. In parallel phospholipids have been covalently conjugated to TAT, MMP2, and Herceptin. The functional lip...

journal_title：Journal of cellular physiology

authors： Gholamian Dehkordi N,Elahian F,Khosravian P,Mirzaei SA

更新日期：2019-11-01 00:00:00

abstract：:The poor prognosis of pancreatic cancer patients using currently available therapies mandates novel therapeutics that combine anti-neoplastic potency with toxicity-minimizing cancer specificity. Employing an overlapping pathway screen to identify genes exhibiting coordinated expression as a consequence of terminal cel...

journal_title：Journal of cellular physiology

authors： Chan I,Lebedeva IV,Su ZZ,Sarkar D,Valerie K,Fisher PB

更新日期：2008-05-01 00:00:00

abstract：:Nowadays, epigenetics covers a crucial role in different fields of science. The enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2), is a big proponent of how epigenetic changes can affect the initiation and progression of several diseases. Through its catalytic activi...

journal_title：Journal of cellular physiology

authors： Sanna L,Marchesi I,Melone MAB,Bagella L

更新日期：2018-09-01 00:00:00

abstract：:Several proteases and their specific inhibitors modulate the interdependent processes of cell migration and matrix proteolysis as part of the global program of trauma repair. Expression of plasminogen activator inhibitor type-1 (PAI-1), a serine protease inhibitor (SERPIN) important in the control of barrier proteolys...

journal_title：Journal of cellular physiology

authors： Providence KM,Higgins PJ

更新日期：2004-08-01 00:00:00

abstract：:Retinoic acid (RA) is known to induce differentiation in many cell systems. This induction is mediated by nuclear RA receptors (RARs), which act as transactivating factors belonging to the superfamily of steroid/thyroid nuclear receptors. In this study, effects of RA were studied in a mouse myogenic C2 cell line and i...

journal_title：Journal of cellular physiology

authors： Halevy O,Lerman O

更新日期：1993-03-01 00:00:00

abstract：:In higher eukaryotes there is a link between time of replication and transcription. It is generally accepted that genes that are actively transcribed are replicated in the first half of S phase while inactive genes replicate in the second half of S phase. We have recently reported that in normal human fibroblasts ther...

journal_title：Journal of cellular physiology

authors： Cohen SM,Cordeiro-Stone M,Kaufman DG

更新日期：2007-11-01 00:00:00

abstract：:To test whether the use of a striatum weighted image may improve registration accuracy and diagnostic outcome in patients with parkinsonian syndromes (PS), weighted images were generated by increasing signal intensity of striatal voxels and used as intermediate dataset for co-registering the brain image onto template....

journal_title：Journal of cellular physiology

authors： Ciarmiello A,Giovacchini G,Guidotti C,Meniconi M,Lazzeri P,Carabelli E,Mansi L,Mariani G,Volterrani D,Del Sette M

更新日期：2013-10-01 00:00:00

abstract：:In vitro incubation of hepatocytes acutely isolated from adult male rats leads to a rapid conversion of the adrenergic activation of glycogenolysis from an alpha 1-receptor (alpha 1AR) to a beta 2-receptor (beta 2AR) mediated response within 4 h. In order to understand the underlying mechanism, we examined time-depend...

journal_title：Journal of cellular physiology

authors： Ishac EJ,Lazar-Wesley E,Kunos G

更新日期：1992-07-01 00:00:00

abstract：:The main aim of this investigation was to determine whether a functional relationship existed between epidermal growth factor (EGF) and voltage-gated sodium channel (VGSC) upregulation, both associated with strongly metastatic prostate cancer cells. Incubation with EGF for 24 h more than doubled VGSC current density. ...

journal_title：Journal of cellular physiology

authors： Ding Y,Brackenbury WJ,Onganer PU,Montano X,Porter LM,Bates LF,Djamgoz MB

更新日期：2008-04-01 00:00:00

abstract：:Two transport systems for neutral amino acids have been characterised in LLC-PK, cells. The first, which transports alanine in a sodium-dependent manner, also mediates alanine exchange and is perferentially inhibited by serine, cysteine, and alpha-amino-n-butyric acid. This system resembles the ASC system in Ehrlich a...

journal_title：Journal of cellular physiology

authors： Sepúlveda FV,Pearson JD

更新日期：1982-08-01 00:00:00

abstract：:Extracellular high K(+) (75 mM) increased intracellular Ca(2+) concentrations in cultured rat hippocampal astrocytes, and the Ca(2+) rise was abolished by deleting extracellular Ca(2+) or cadmium, a non-selective inhibitor of voltage-dependent calcium channels (VDCCs). In the reverse transcription-polymerase chain rea...

journal_title：Journal of cellular physiology

authors： Yaguchi T,Nishizaki T

更新日期：2010-11-01 00:00:00

abstract：:The effects of 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) (10(-13)M-10(-8) M) and 24R ,25-dihydroxycholecalciferol ( 24R ,25-(OH)2D3) (10(-12)M-10(-7) M) on cell proliferation and proteoglycan deposition were examined in our newly developed multilayer culture system for rabbit and human articular chondrocytes. The c...

journal_title：Journal of cellular physiology

authors： Harmand MF,Thomasset M,Rouais F,Ducassou D

更新日期：1984-06-01 00:00:00

abstract：:We have analyzed the functional and morphological effects of corticosteroid hormones in a SV40-transformed rabbit cortical-ascending-limb (CAL) cell line (RC.SV2, Vandewalle et al., 1989) having mineralocorticoid (MR) and glucocorticoid (GR) receptors (Rafestin-Oblin et al., 1993). Both aldosterone and dexamethasone (...

journal_title：Journal of cellular physiology

authors： Vandewalle A,Rafestin-Oblin ME,Hagege J,Géniteau-Legendre M,Cassingéna R,Ronco PM

更新日期：1993-08-01 00:00:00

abstract：:Differentiation commitment events are essential for the initiation of hemopoiesis and, in one form or another, occur continuously during adult hemopoiesis. The most studied type of differentiation commitment decision a hemopoietic cell can make involves the alternative choice of self-renewal versus the formation of pr...

journal_title：Journal of cellular physiology

authors： Metcalf D,Nicola NA,Robb L

更新日期：1997-11-01 00:00:00

abstract：:We have examined nucleoside transport (NT) in a cell line derived from primary day 7 murine bone marrow macrophages (S1 macrophages) in response to the macrophage growth factor, colony-stimulating factor 1 (CSF-1). Adenosine and uridine transport in quiescent S1 macrophages occurred primarily by two facilitated diffus...

journal_title：Journal of cellular physiology

authors： Meckling-Gill KA,Guilbert L,Cass CE

更新日期：1993-06-01 00:00:00

abstract：:The snRNAs are abundant and stable components of the interphase nucleus. Aqueous and non-aqueous cell fractionation demonstrate that the snRNAs appear transiently in the cytoplasm shortly after transcription, before returning permanently to the interphase nucleus. In pulse label and chase experiments, the newly synthe...

journal_title：Journal of cellular physiology

authors： Zieve GW

更新日期：1987-05-01 00:00:00

abstract：:Considering the high rate of osteoclast-related diseases worldwide, research targeting osteoclast formation/function is crucial. In vitro, we demonstrated that chitooligosaccharide (CS) dramatically inhibited osteoclastogenesis as well as osteoclast function dose-dependently. CS suppressed osteoclast-specific genes ex...

journal_title：Journal of cellular physiology

authors： Xu W,Chen X,Wang Y,Fan B,Guo K,Yang C,Yu S,Pang Y,Zhang S

更新日期：2020-03-01 00:00:00

abstract：:A mutant (A204) of Chinese hamster ovary cells (CHO-K1), which is deficient in dihydroorotate (DHO) dehydrogenase (E.C. 1.3,3.1) activity, has been isolated by a replica plating procedure. The mutant does not show a requirement for exogenously added pyrimidines. Examination of intact cells shows that the mutant accumu...

journal_title：Journal of cellular physiology

authors： Stamato TD,Patterson D

更新日期：1979-03-01 00:00:00

abstract：:The actin- and myosin-binding protein, caldesmon (CaD) is an essential component of the cytoskeleton in smooth muscle and non-muscle cells and is involved in the regulation of cell contractility, division, and assembly of actin filaments. CaD is abundantly present in endothelial cells (EC); however, the contribution o...

journal_title：Journal of cellular physiology

authors： Mirzapoiazova T,Kolosova IA,Romer L,Garcia JG,Verin AD

更新日期：2005-06-01 00:00:00

abstract：:The coupled action of the Na(+)/H(+) exchanger NHE1 and the HCO3(-)/Cl(-) exchanger AE2 constitutes the principal mechanism for acute correction of decreased cell volume in mammalian somatic cells, while, when acting separately, they regulate intracellular pH. It was previously found that AE2 becomes inactivated durin...

journal_title：Journal of cellular physiology

authors： Zhou C,Fitzharris G,Alper SL,Baltz JM

更新日期：2013-10-01 00:00:00

abstract：:Heparin and related glycosaminoglycans are potent inhibitors of both in vivo and in vitro smooth muscle cell (SMC) proliferation. We have found that epidermal growth factor (EGF) reverses the antiproliferative effects of heparin. Other known SMC mitogens, including platelet-derived growth factor (PDGF), insulin-like g...

journal_title：Journal of cellular physiology

authors： Reilly CF,Fritze LM,Rosenberg RD

更新日期：1987-05-01 00:00:00

abstract：:Established RAW264.7 cell lines for osteoclastic differentiation has been widely engaged in bone homeostasis research, however, the efficacy of RANKL independently stimulating has rarely been defined, because protocols were usually developed and modified by various laboratories. Otherwise, problematic issues are also ...

journal_title：Journal of cellular physiology

authors： Song C,Yang X,Lei Y,Zhang Z,Smith W,Yan J,Kong L

更新日期：2019-07-01 00:00:00

abstract：:Intramedullary stabilization is frequently used to treat long bone fractures. Since implant removal can become technically very challenging with the potential to cause further tissue damage, biodegradable materials are emerging as alternative options. Magnesium (Mg)-based biodegradable implants have a controllable deg...

journal_title：Journal of cellular physiology

authors： Li D,Yu K,Xiao T,Dai Y,Liu L,Li H,Jiang D,Xiong L

更新日期：2019-11-01 00:00:00

abstract：:Chemokines play an important role in regulating the complex immune system at the maternal-fetal interface during pregnancy. Among various chemokines, CC motif chemokine ligand 2 (CCL2) plays a role in the recruitment of immune regulatory cells to implantation sites within the endometrium. In cattle, CCL2 is abundantl...

journal_title：Journal of cellular physiology

authors： Lim W,Bae H,Bazer FW,Kim SM,Song G

更新日期：2018-04-01 00:00:00

abstract：:The hypothesis that, in the case of clonal or low-density cultures, cells which do not readily proliferate are those that do not produce an extracellular matrix (ECM), while those that proliferate actively are cells that have retained their ability to produce it, has been tested using low-density vascular endothelial ...

journal_title：Journal of cellular physiology

authors： Gospodarowicz D,Lui GM

更新日期：1981-10-01 00:00:00

abstract：:Cultured pig kidney cells designated LLC-PK1, previously shown to acquire Na+-dependent concentrative transport of hexoses as the cells become growth arrested, also show Na+-dependent concentrative uptake of the amino acid analogs alpha-aminoisobutyric acid (AIB) and (methyl) meAIB. This A system-like transport is mos...

journal_title：Journal of cellular physiology

authors： Amsler K,Shaffer C,Cook JS

更新日期：1983-02-01 00:00:00

abstract：:The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is a pleiotropic enzyme involved in DNA repair, cell cycle control, and transcription regulation. A potential role for DNA-PKcs in the regulation of osteoblastogenesis remains to be established. We show that pharmacological inhibition of DNA-PKcs kinase ...

journal_title：Journal of cellular physiology

authors： Farhat T,Dudakovic A,Chung JH,van Wijnen AJ,St-Arnaud R

更新日期：2021-02-01 00:00:00