Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress.

abstract：:The frequencies of 6-thioguanine-resistant primary clones from the kidneys and skeletal muscles of aging male cohorts of two F1 hybrid strains of Mus musculus varied from 0.59 to 10.96 X 10(-5) and did not increase as a function of donor age (up to 40 months). Resistant clones were shown to be severely deficient in th...

journal_title：Journal of cellular physiology

authors： Horn PL,Turker MS,Ogburn CE,Disteche CM,Martin GM

更新日期：1984-11-01 00:00:00

abstract：:The urokinase system is involved in a variety of physiological processes, such as fibrinolysis, matrix remodeling, wound healing, and regeneration. Upon binding to its cognate receptor urokinase-type plasminogen activator receptor (uPAR), urokinase-type plasminogen activator (uPA) catalyzes the conversion of plasminog...

journal_title：Journal of cellular physiology

authors： Semina EV,Rubina KA,Shmakova AA,Rysenkova KD,Klimovich PS,Aleksanrushkina NA,Sysoeva VY,Karagyaur MN,Tkachuk VA

更新日期：2020-09-01 00:00:00

abstract：:This study examines the regulation of Swarm rat chondrosarcoma (SRC) cell proliferation in vitro. In serum-free cultures, SRC cells showed only transient DNA synthesis and this was increased by serum. Transforming growth factor-beta (TGF-beta) was identified as an essential serum component, since the mitogenic effect ...

journal_title：Journal of cellular physiology

authors： Guerne PA,Lotz M

更新日期：1991-10-01 00:00:00

abstract：:We have previously shown that extracellular ATP acts as a mitogen via protein kinase C (PKC)-dependent and independent pathways (Wang, D., Huang, N., Gonzalez, F.A., and Heppel, L.A. Multiple signal transduction pathways lead to extracellular ATP-stimulated mitogenesis in mammalian cells. I. Involvement of protein kin...

journal_title：Journal of cellular physiology

authors： Huang NN,Wang DJ,Gonzalez F,Heppel LA

更新日期：1991-03-01 00:00:00

abstract：:Bone tissues reportedly contain considerable amounts of activin A and follistatin, an activin A-binding protein. In the present study, we found that follistatin strongly inhibited osteoclast formation in cocultures of mouse bone marrow cells and primary osteoblasts induced by 1alpha,25 dihydroxyvitamin D(3), prostagla...

journal_title：Journal of cellular physiology

authors： Murase Y,Okahashi N,Koseki T,Itoh K,Udagawa N,Hashimoto O,Sugino H,Noguchi T,Nishihara T

更新日期：2001-08-01 00:00:00

abstract：:Modeling breast cancer in the mouse has helped to better define the heterogeneity of human breast cancer. In the recent past, it has become evident that some limitations have restricted the potential benefits that can be achieved with this approach. In this review, we highlight some key points that should be taken int...

journal_title：Journal of cellular physiology

authors： Caligiuri I,Rizzolio F,Boffo S,Giordano A,Toffoli G

更新日期：2012-08-01 00:00:00

abstract：:The transient nuclear localization of metallothionein during cell growth and differentiation may be related to the increased requirement of zinc for DNA synthesis, activation of metalloenzymes, and transcription factors. Treatment of 3T3-L1 fibroblasts with aphidicolin, an inhibitor of nuclear DNA synthesis, caused a ...

journal_title：Journal of cellular physiology

authors： Apostolova MD,Cherian MG

更新日期：2000-05-01 00:00:00

abstract：:Catecholamines produce mitotic inhibition in primary cell cultures of human keratinocytes probably via a block in the G2 part of the cell cycle. Epinephrine produced significant mitotic inhibition (49%) at a concentration as low as 4.5 X 10(-10) M, while its analog, isoproterenol, produced 47% inhibition at 1 X 10(-10...

journal_title：Journal of cellular physiology

authors： Harper RA,Flaxman BA

更新日期：1975-10-01 00:00:00

abstract：:The aim of our studies was to identify miRNAs affecting the release of the major ovarian steroid hormones progestagen, androgen and estrogen by human ovarian cells. The effect of transfection of cultured primary ovarian granulosa cells with 80 different gene constructs encoding human pre-miRNAs on release of progester...

journal_title：Journal of cellular physiology

authors： Sirotkin AV,Ovcharenko D,Grossmann R,Lauková M,Mlyncek M

更新日期：2009-05-01 00:00:00

abstract：:Generation of reactive oxygen species (ROS) is a common event in the pathogenesis of acute lung injury. Endothelial cells may be both a target and a source of the ROS. Exposure of bovine pulmonary endothelial cells (BPAEC) to lipopolysaccharide (LPS) has been shown to result in intracellular generation of both ROS and...

journal_title：Journal of cellular physiology

authors： Mitchell J,Jiang H,Berry L,Meyrick B

更新日期：1996-11-01 00:00:00

abstract：:The cells of the bone marrow microenvironment are emerging as important contributors and regulators of normal hematopoiesis. This microenvironment is perturbed during leukemogenesis, and evidence points toward a bidirectional communication between leukemia cells and the normal cells of the bone marrow, mediated by dir...

journal_title：Journal of cellular physiology

authors： Heath JL,Cohn GM,Zaidi SK,Stein GS

更新日期：2019-11-01 00:00:00

abstract：:Versican is a large chondroitin sulfate proteoglycan and belongs to the family of lecticans. Versican possesses two globular domains, G1 and G3 domain, separated by a CS-attachment region. The CS-attachment region present in the middle region is divided into two spliced domains named CSalpha and beta. Alternative spli...

journal_title：Journal of cellular physiology

authors： Sheng W,Dong H,Lee DY,Lu WY,Yang BB

更新日期：2007-04-01 00:00:00

abstract：:The mechanisms of agonist-induced calcium entry (ACE) following depletion of intracellular calcium stores have not been fully established. We report here that calcium-independent phospholipase A (iPLA(2)) is required for robust Ca(2+) entry in HaCaT keratinocytes following ATP or UTP stimulation. Lysophosphatidic acid...

journal_title：Journal of cellular physiology

authors： Ross K,Whitaker M,Reynolds NJ

更新日期：2007-06-01 00:00:00

abstract：:Drug discovery is an onerous, extremely expensive, and time-consuming process. Instead, drug repurposing is an attractive strategy for exploiting novel indications for a drug beyond its original use. The untapped potential of drug repurposing compensates the barriers associated with the drug discovery pipeline. Psoria...

journal_title：Journal of cellular physiology

authors： Thatikonda S,Pooladanda V,Godugu C

更新日期：2020-06-01 00:00:00

abstract：:Comparative studies with rat transferrin (rTf) and asialotransferrin (asialo-rTf) were performed on suspended adult rat hepatocytes with the aim of elucidating the mechanism of enhanced hepatic Fe acquisition from asialo-rTf observed previously in vivo. At low ligand concentrations (0.05-20 micrograms/ml), the cells b...

journal_title：Journal of cellular physiology

authors： Rudolph JR,Regoeczi E

更新日期：1988-06-01 00:00:00

abstract：:Although it is well established that epidermal growth factor receptors (EGFRs) are asymmetrically expressed at the basolateral plasma membrane in polarized epithelial cells, how this process is regulated is not known. The purpose of this study was to address the mechanism of directed EGFR basolateral sorting using the...

journal_title：Journal of cellular physiology

authors： Hobert M,Carlin C

更新日期：1995-03-01 00:00:00

abstract：:Dishevelled-associated activator of morphogenesis 1 (DAAM1) is a formin-family protein involved in nucleation of unbranched actin filaments and in cytoskeletal organization through Wnt-Dishevelled PCP pathway, which participates in essential biological processes, such as cell polarity, movement, and adhesion during mo...

journal_title：Journal of cellular physiology

authors： Pariante P,Dotolo R,Venditti M,Ferrara D,Donizetti A,Aniello F,Minucci S

更新日期：2016-10-01 00:00:00

abstract：:Transient Receptor Potential Vanilloid type 1 channel (TRPV1) is an important endogenous transducer of noxious heat and chemical stimuli and is required during development of inflammatory hypersensitivity. The transcription factor Runx1 is known to play a relevant role in sensory neuron differentiation as it controls ...

journal_title：Journal of cellular physiology

authors： Ugarte GD,Diaz E,Biscaia M,Stehberg J,Montecino M,van Zundert B

更新日期：2013-04-01 00:00:00

abstract：:Mouse epidermal cells can be grown as a proliferating monolayer in medium containing 0.02-0.1 mM calcium. Terminal differentiation of these cells with formation of cornified cells and cell death is induced by elevating calcium in the medium to greater than 0.1 mM. A variety of agents were studied as potential modifier...

journal_title：Journal of cellular physiology

authors： Hennings H,Holbrook KA,Yuspa SH

更新日期：1983-09-01 00:00:00

abstract：:We have previously observed major differences in the phosphorylation of membrane proteins in sparse, proliferating versus confluent, quiescent pig aortic endothelial cells (EC) (Kazlauskas and DiCorleto, 1987). In the present study we examined whether EC growth state can influence the activity of a specific phosphoryl...

journal_title：Journal of cellular physiology

authors： Uratsuji Y,DiCorleto PE

更新日期：1988-09-01 00:00:00

abstract：:Impaired cardiac control of intracellular diastolic Ca(2+) gives rise to arrhythmias. Whereas exercise training corrects abnormal cyclic Ca(2+) handling in heart failure, the effect on diastolic Ca(2+) remains unstudied. Here, we studied the effect of exercise training on the generation and propagation of spontaneous ...

journal_title：Journal of cellular physiology

authors： Kemi OJ,MacQuaide N,Hoydal MA,Ellingsen O,Smith GL,Wisloff U

更新日期：2012-01-01 00:00:00

abstract：:Shortly after serum-deprived BALB/c 3T3 fibroblasts are stimulated to grow in medium containing 10% calf serum, the RNA polymerase I activity in permeabilized cells shows a two-fold increase over the values observed in either serum-deprived or density-inhibited resting cells. Inhibition of protein synthesis by pactamy...

journal_title：Journal of cellular physiology

authors： Perrone-Bizzozero N,Iapalucci-Espinoza S,Medrano EE,Franze-Fernández MT

更新日期：1985-07-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) play pivotal roles in bone and cartilage growth and repair. Through phenotypes of short-ear (se) mice, which have BMP-5 mutations, a role for BMP-5 in some specific aspects of skeletogenesis and cartilage growth is known. This report examines BMP-5 expression in the growth plate and ...

journal_title：Journal of cellular physiology

authors： Mailhot G,Yang M,Mason-Savas A,Mackay CA,Leav I,Odgren PR

更新日期：2008-01-01 00:00:00

abstract：:Autophagy is the general term of lysosomal degradation of substances in cells, which is considered the key to maintaining the normal structure and function of the heart. It also has a correlation with several heart diseases, in particular, myocardial ischemia/reperfusion (I/R) injury. At the stage of myocardial ischem...

journal_title：Journal of cellular physiology

authors： Shi B,Ma M,Zheng Y,Pan Y,Lin X

更新日期：2019-08-01 00:00:00

abstract：:The study was conducted on human leukemia (K 562) cells to characterize the mechanisms implicated in the regulation of the polyamine spermidine (Spd) transport process. The antagonists of calmodulin, trifluoperazine (TFP), W-7 (N-[6-aminohexyl]-5-chloro-1-naphthelenesulfonamide), or mellitin inhibited significantly po...

journal_title：Journal of cellular physiology

authors： Khan NA,Sezan A,Quemener V,Moulinoux JP

更新日期：1993-12-01 00:00:00

abstract：:The tumor suppressor p53-related p73 shares significant amino-acid sequence identity with p53. Like p53, p73 recognizes canonical p53 DNA-binding sites and activates p53-responsive target genes and induces apoptosis. Moreover, SIRT1 binds to p53 while repressing the expression of their target genes. Here, we report th...

journal_title：Journal of cellular physiology

authors： Dai JM,Wang ZY,Sun DC,Lin RX,Wang SQ

更新日期：2007-01-01 00:00:00

abstract：:The effect of the glucocorticoids, insulin, and glucose concentration on glycogen deposition in adult rat liver parenchymal cells maintained in a chemically defined, serum-free medium has been studied. Increasing the medium concentration of glucose from 5.6 mM to 30.6 mM in the absence of hormones increased cellular g...

journal_title：Journal of cellular physiology

authors： Weber CA,Kletzien RF

更新日期：1982-03-01 00:00:00

abstract：:The release of vasodilating substances from the vascular endothelium has been postulated to depend on a rise in the level of intracellular free calcium (Cai++). We measured Cai++ in intact monolayers of calf endothelial cells, grown in culture, that were loaded with the fluorescent calcium indicator quin 2. Fluorescen...

journal_title：Journal of cellular physiology

authors： Lückhoff A,Busse R

更新日期：1986-03-01 00:00:00

abstract：:Adsorption of Sendai virus at high multiplicity (500-1,000 HAU/10(6) cells) to HeLa cells grown in monolayers causes immediate changes in the ion barrier of the cell membrane, as well as changes in the morphology of the virus-treated cells. Within minutes of adsorption the cells begin to lose potassium and an extensiv...

journal_title：Journal of cellular physiology

authors： Spiegelstein PF,Haimsohn M,Gitelman J,Kohn A

更新日期：1978-05-01 00:00:00

abstract：:Osteosarcoma (OS) is a primary highly malignant tumor of bone, affecting predominately adolescents and young adults between 10 and 20 years of age. OS is characterized by an extremely aggressive clinical course, with a rapid development of metastasis to the lung and distant bones. ...

journal_title：Journal of cellular physiology

authors： Laschi M,Bernardini G,Geminiani M,Ghezzi L,Amato L,Braconi D,Millucci L,Frediani B,Spreafico A,Franchi A,Campanacci D,Capanna R,Santucci A

更新日期：2015-11-01 00:00:00