SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity.

abstract：:Fibroblast growth factors (FGFs) are important regulators of the dynamic development and turnover of tissues. Among FGF receptors, FGFR3 expression is confined in the intestinal crypts. We examined FGFR3-deficient mice and saw increased intestinal crypt depth but no change in villae length or in the distribution of di...

journal_title：Journal of cellular physiology

authors： Arnaud-Dabernat S,Yadav D,Sarvetnick N

更新日期：2008-07-01 00:00:00

abstract：:The peroxisome proliferation-activated receptor gamma (PPARgamma) is mainly expressed in the adipose tissue and integrates the control of energy, lipid, and glucose homeostasis. The present study, by means of RT-PCR, Western blot, and immunofluorescence techniques, demonstrates that human sperm express the PPARgamma. ...

journal_title：Journal of cellular physiology

authors： Aquila S,Bonofiglio D,Gentile M,Middea E,Gabriele S,Belmonte M,Catalano S,Pellegrino M,Andò S

更新日期：2006-12-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) signaling in endothelial cells is able to modulate angiogenesis and vascular remodeling, although the underlying molecular mechanisms remain poorly understood. Endoglin and ALK-1 are components of the TGF-beta receptor complex, predominantly expressed in endothelial cells, an...

journal_title：Journal of cellular physiology

authors： Blanco FJ,Santibanez JF,Guerrero-Esteo M,Langa C,Vary CP,Bernabeu C

更新日期：2005-08-01 00:00:00

abstract：:Transforming growth factor beta type 1 (TGF-beta 1) was reacted with NHS-biotin to yield a derivative of TGF-beta 1 which was biotinylated on lysine residues. The biotinylated form of TGF-beta 1 was separated from the unreacted material by reverse phase chromatography. In three separate bioassays, the derivatized pept...

journal_title：Journal of cellular physiology

authors： Newman W,Beall LD,Bertolini DR,Cone JL

更新日期：1989-10-01 00:00:00

abstract：:The purpose of this study was to delineate the traffic patterns of EGF and EGF receptors (EGFR) in primary cultured acinar epithelial cells from rabbit lacrimal glands. Uptake of [(125)I]-EGF exhibited saturable and non-saturable, temperature-dependent components, suggesting both receptor-mediated and fluid phase endo...

journal_title：Journal of cellular physiology

authors： Xie J,Qian L,Wang Y,Rose CM,Yang T,Nakamura T,Hamm-Alvarez SF,Mircheff AK

更新日期：2004-04-01 00:00:00

abstract：:Cancer cells in poorly vascularized solid tumors are constantly or intermittently exposed to stressful microenvironments, including glucose deprivation, hypoxia, and other forms of nutrient starvation. These tumor-specific conditions, especially glucose deprivation, activate a signaling pathway called the unfolded pro...

journal_title：Journal of cellular physiology

authors： Kim JY,Hwang JH,Cha MR,Yoon MY,Son ES,Tomida A,Ko B,Song SW,Shin-ya K,Hwang YI,Park HR

更新日期：2010-07-01 00:00:00

abstract：:An increasing body of evidence suggests that tumors might originate from a few transformed cells that share many properties with normal stem cells. However, it remains unclear how normal stem cells are transformed into cancer stem cells (CSCs). Here, we demonstrated that mutations causing the loss of tumor suppressor ...

journal_title：Journal of cellular physiology

authors： Zeng X,Singh SR,Hou D,Hou SX

更新日期：2010-09-01 00:00:00

abstract：:Ganoderma lucidum immunomodulatory protein (FIP-glu) is an active ingredient with potential immunoregulatory functions. The study was conducted to explore the immunomodulatory activities of recombinant FIP-glu (rFIP-glu) and its possible mechanism in macrophage RAW264.7 cells. In vitro assays of biological activity in...

journal_title：Journal of cellular physiology

authors： Li QZ,Chang YZ,He ZM,Chen L,Zhou XW

更新日期：2019-12-01 00:00:00

abstract：:We have previously observed major differences in the phosphorylation of membrane proteins in sparse, proliferating versus confluent, quiescent pig aortic endothelial cells (EC) (Kazlauskas and DiCorleto, 1987). In the present study we examined whether EC growth state can influence the activity of a specific phosphoryl...

journal_title：Journal of cellular physiology

authors： Uratsuji Y,DiCorleto PE

更新日期：1988-09-01 00:00:00

abstract：:Serum stimulation of quiescent 3T3 cells returns the cells to a proliferative state. Changes in Ca content, transport and distribution during the transition through G1 and S phase have been investigated following serum stimulation of these cells. 45 Ca exchange data indicate at least two kinetically defined cellular c...

journal_title：Journal of cellular physiology

authors： Tupper JT,Del Rosso M,Hazelton B,Zorgniotti F

更新日期：1978-04-01 00:00:00

abstract：:New compounds with promising antidiabetic activity were synthesized. For the first time, a portion of the glibenclamide molecule was bound to a part of the core structure of thiazolidinedione to evaluate insulin secretagogue activity. Following studies in our laboratory, 4-{2-[2-(3,4-dichlorophenyl)-4-oxo-1,3-thiazoli...

journal_title：Journal of cellular physiology

authors： Mendes CP,Postal BG,Oliveira GTC,Castro AJG,Frederico MJS,Moraes ALL,Neuenfeldt PD,Nunes RJ,Menegaz D,Silva FRMB

更新日期：2018-01-01 00:00:00

abstract：:The loss of pancreatic islet β-cell function represents the classical feature in the pathogenesis of type 2 diabetes mellitus (T2DM). Previous evidence has highlighted the involvement of the activated JNK pathway in relation to islet β-cell apoptosis. Hence, during the present study a streptozotocin-induced DM mice mo...

journal_title：Journal of cellular physiology

authors： Wang S,Wen X,Han XR,Wang YJ,Shen M,Fan SH,Zhuang J,Xu W,Zhang ZF,Shan Q,Li MQ,Hu B,Sun CH,Wu DM,Lu J,Zheng YL

更新日期：2018-09-01 00:00:00

abstract：:Resistin, firstly reported as an adipocyte-specific hormone, is suggested to be an important link between obesity and diabetes. Recent studies have suggested an association between resistin and atherogenic processes. The adhesion of circulating monocytes to endothelial cells is a critical step in the early stages of a...

journal_title：Journal of cellular physiology

authors： Hsu WY,Chao YW,Tsai YL,Lien CC,Chang CF,Deng MC,Ho LT,Kwok CF,Juan CC

更新日期：2011-08-01 00:00:00

abstract：:Nuclear factor-κB (NF-κB), a family of master regulated dimeric transcription factors, signaling transduction pathways are active players in the cell signaling that control vital cellular processes, including cell growth, proliferation, differentiation, apoptosis, morphogenesis, angiogenesis, and immune responses. Nev...

journal_title：Journal of cellular physiology

authors： Shokri S,Mahmoudvand S,Taherkhani R,Farshadpour F,Jalalian FA

更新日期：2019-02-11 00:00:00

abstract：:Cardiac hypertrophy (CH) has become a huge threat to human health. Recent years, long noncoding RNAs (lncRNAs) have been studied in human diseases, including CH. According to bioinformatics analysis, 10 lncRNAs possibly involved in the progression of CH were screened out. Among which, lncRNA SYNE1 antisense RNA 1 (SYN...

journal_title：Journal of cellular physiology

authors： Wang Y,Cao R,Yang W,Qi B

更新日期：2019-08-01 00:00:00

abstract：:The progression of T-lymphoma cells (CCRF-CEM) growing in suspension has been monitored during long term (12-28 h) batch experiments using microcalorimetry. In parallel with the calorimetric measurements, changes in cell concentration, pH, p(O2) and concentrations of the main energy sources (glucose and glutamine) wer...

journal_title：Journal of cellular physiology

authors： Bäckman P,Kimura T,Schön A,Wadsö I

更新日期：1992-01-01 00:00:00

abstract：:The Pur proteins are an ancient family of sequence-specific single-stranded nucleic acid-binding proteins. They bind a G-rich element in either single- or double-stranded nucleic acids and are capable of displacing the complementary C-rich strand. Recently several reports have described Pur family member knockouts, mu...

journal_title：Journal of cellular physiology

authors： Johnson EM,Daniel DC,Gordon J

更新日期：2013-05-01 00:00:00

abstract：:Glioblastoma, the most common brain tumor, is characterized by high proliferation rate, invasion, angiogenesis, and chemo- and radio-resistance. One of most remarkable feature of glioblastoma is the switch toward a glycolytic energetic metabolism that leads to high glucose uptake and consumption and a strong productio...

journal_title：Journal of cellular physiology

authors： Cimini A,d'Angelo M,Benedetti E,D'Angelo B,Laurenti G,Antonosante A,Cristiano L,Di Mambro A,Barbarino M,Castelli V,Cinque B,Cifone MG,Ippoliti R,Pentimalli F,Giordano A

更新日期：2017-02-01 00:00:00

abstract：:Endothelin-1 production is increased after liver injury and the subsequent wounding response. Further, endothelin-1 has prominent effects on hepatic stellate cells (key effectors of the hepatic wounding response), including on collagen synthesis, proliferation, and expression of smooth muscle proteins. We tested the h...

journal_title：Journal of cellular physiology

authors： Shao R,Rockey DC

更新日期：2002-06-01 00:00:00

abstract：:To clarify the manner by which erythropoietin (EP), stem cell factor (SCF), or insulin-like growth factor I (IGF-I) regulate erythropoiesis, apoptosis of human erythroid progenitor cells was investigated. Human burst-forming units-erythroid (BFU-E) partially purified from peripheral blood were cultured for 6 days to g...

journal_title：Journal of cellular physiology

authors： Muta K,Krantz SB

更新日期：1993-08-01 00:00:00

abstract：:We have investigated the kinetics of fluid-phase endocytosis and diacytosis in confluent monolayers of human fibroblasts by comparing the behavior of three markers that have been previously used to study this process: [14C]sucrose, 125I-labeled polyvinylpyrrolidone ([125I]PVP), and Lucifer Yellow. Three distinct kinet...

journal_title：Journal of cellular physiology

authors： McKinley DN,Wiley HS

更新日期：1988-09-01 00:00:00

abstract：:17β-estradiol (E2) regulates diverse physiological effects including cell proliferation through the estrogen receptor α (ERα), which as a transcription factor drives gene transcription and as an extra-nuclear localized receptor triggers the membrane-dependent activation of diverse kinase cascades. E2 also modifies ERα...

journal_title：Journal of cellular physiology

authors： Leone S,Busonero C,Acconcia F

更新日期：2018-05-01 00:00:00

abstract：:We have observed that some of the DNA damage or damage product caused by irradiation of interphase cells persisted throughout the cell cycle, and resulted in the expression of gamma-H2AX foci on the mitotic chromosomes. These mitotic expressions of damage after gamma-irradiation of G1 or G2 phase cells were compared i...

journal_title：Journal of cellular physiology

authors： Kato TA,Okayasu R,Bedford JS

更新日期：2009-06-01 00:00:00

abstract：:Studies have shown that microRNAs (miRNAs) play a vital role in tumor progression and patients' prognosis. Therefore, we aimed to construct a miRNA model for forecasting the survival of hepatocellular carcinoma (HCC) patients. The gene expression data of 433 patients with HCC from The Cancer Genome Atlas (TCGA) and Ge...

journal_title：Journal of cellular physiology

authors： Fang SS,Guo JC,Zhang JH,Liu JN,Hong S,Yu B,Gao Y,Hu SP,Liu HZ,Sun L,Zhao Y

更新日期：2020-04-01 00:00:00

abstract：:To determine if Chinese Hamster Ovary (CHO) cells in culture are able to metabolize steroids, CHO cells were incubated in defined medium with [14C]pregnenolone. As shown, [14C]pregnenolone is metabolized to progesterone and other delta 53 beta steroids; this steroidogenic response is appreciably enhanced upon exposure...

journal_title：Journal of cellular physiology

authors： Evain D,Anderson WB,Saez MJ

更新日期：1981-07-01 00:00:00

abstract：:We report the continuous growth maintenance of untransformed and chemically transformed fibroblasts (AKR-2B, AKR-MCA cells) in low concentrations of serum (0.1% FBS). The cell lines established (AKR-0.1F, MCA-0.1F) proliferated at rates comparable to cells maintained under high serum conditions (10% FBS). Complete rem...

journal_title：Journal of cellular physiology

authors： Mulder KM,Brattain MG

更新日期：1989-03-01 00:00:00

abstract：:Ehrlich ascites tumor cells from the plateau phase of growth were transplanted into new hosts, pulse-labeled with tritiated thymidine and blocked with repeated injections of vinblastine. When unlabeled cells were analyzed for their cellular DNA content utilizing a cytophotometric technique it was found that in relatio...

journal_title：Journal of cellular physiology

authors： Andersson G

更新日期：1977-02-01 00:00:00

abstract：BACKGROUND:Despite at the beginning known as a benign disease, endometriosis is defined as a risk factor for developing ovarian carcinoma. The effect of endometriosis on ovarian malignancy is known but its role in granulosa cell tumor is still unclear. METHODS AND MATERIALS:In this study, serum samples were collected ...

journal_title：Journal of cellular physiology

authors： Asghari S,Valizadeh Dizajeykan A,Ahmadi M,Barzegari A,Rikhtegar R,Dolati S,Danaii S,Abdollahi-Fard S,Nouri M,Mahdipour M,Yousefi M

更新日期：2019-07-01 00:00:00

abstract：:The relationship between replication and the synthesis of matrix sulfated proteoglycans was investigated with fetal rat chondrocytes grown in monolayer culture. The effect of N6 O2' dibutyryl adenosine 3', 5' cyclic monophosphate (DBcAMP), adenosine 3', 5' cyclic monophosphate (cAMP), 8 Bromo adenosine 3', 5' cyclic m...

journal_title：Journal of cellular physiology

authors： Miller RP,Husain M,Lohin S

更新日期：1979-07-01 00:00:00

abstract：:Biosensors are composed of (bio)receptors, transducers, and detection systems and are able to convert the biological stimulus into a measurable signal. This systematic review evaluates the current state of the art of innovation and research in this field, identifying the biosensors that in vitro monitor the musculoske...

journal_title：Journal of cellular physiology

authors： Veronesi F,Tschon M,Visani A,Fini M

更新日期：2019-12-01 00:00:00