Abstract:
:Nowadays, epigenetics covers a crucial role in different fields of science. The enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2), is a big proponent of how epigenetic changes can affect the initiation and progression of several diseases. Through its catalytic activity, responsible for the tri-methylation of lysine 27 of the histone H3 (H3K27me3), EZH2 is a good target for both diagnosis and therapy of different pathologies. A large number of studies have demonstrated its crucial role in cancer initiation and progression. Nevertheless, only recently its function in virus diseases has been uncovered; therefore, EZH2 can be an important promoter of viral carcinogenesis. This review explores the role of EZH2 in viral epigenetics based on recent progress that demonstrated the role of this protein in virus environment. In particular, the review focuses on EZH2 behavior in Hepatitis B Virus, analyzing its role in the rise of Hepatocellular Carcinoma.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Sanna L,Marchesi I,Melone MAB,Bagella Ldoi
10.1002/jcp.26545subject
Has Abstractpub_date
2018-09-01 00:00:00pages
6508-6517issue
9eissn
0021-9541issn
1097-4652journal_volume
233pub_type
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pub_type: 杂志文章
doi:10.1002/jcp.29716
更新日期:2020-11-01 00:00:00
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journal_title:Journal of cellular physiology
pub_type: 杂志文章
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abstract::The zafirlukast has been reported to be anti-inflammatory and widely used to alleviate the symptoms of asthma. However, its influence on insulin secretion in pancreatic β-cells has not been investigated. Herein, we examined the effects of zafirlukast on insulin secretion and the potential underlying mechanisms. Among ...
journal_title:Journal of cellular physiology
pub_type: 杂志文章
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更新日期:2018-11-01 00:00:00
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journal_title:Journal of cellular physiology
pub_type: 杂志文章
doi:10.1002/jcp.1040950110
更新日期:1978-04-01 00:00:00
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