Studies on the regulation of the three enzymes of the Leloir pathway in cultured mammalian cells. II. A search for quantitative interrelationships between the three enzyme activities.

abstract：:The synthesis and turnover of metabolically labeled proteoglycans from medium, cell layer, and substratum-associated compartments were characterized in four cell lines of fibroblastic origin, including a fibrosarcoma line, and in the murine melanoma cell type, B16.F10. Substantial differences were apparent between the...

journal_title：Journal of cellular physiology

authors： Piepkorn M,Hovingh P,Linker A

更新日期：1988-05-01 00:00:00

abstract：:We determined the synthesis and secretion of glycosaminoglycans by three distinct preparations of mouse cultured thymic epithelial cells. These comprised primary cultures of thymic nurse cells (TNCs), which are normally located within the cortex of the thymic lobules, as well as two murine thymic epithelial cells, bea...

journal_title：Journal of cellular physiology

authors： Werneck CC,Cruz MS,Silva LC,Villa-Verde DM,Savino W,Mourão PA

更新日期：2000-10-01 00:00:00

abstract：:Pathological calcification represents an event that consequently leads to a distinct elevation in the morbidity and mortality of patients with chronic kidney disease (CKD) in addition to strengthening its correlation with hyperphosphatemia. Epigenomic regulation by specific microRNAs (miRNAs) is reported to be involve...

journal_title：Journal of cellular physiology

authors： Xu TH,Qiu XB,Sheng ZT,Han YR,Wang J,Tian BY,Yao L

更新日期：2019-08-01 00:00:00

abstract：:When human diploid fibroblasts IMR-90 are cultured in routinely used medium (Eagle's basal medium supplemented with 10% fetal calf serum), sulfhydryl compounds appear in the medium. The major component of these sulfhydryl compounds is cysteine, and it is shown that a part of medium cystine is converted into cysteine b...

journal_title：Journal of cellular physiology

authors： Bannai S,Ishii T

更新日期：1980-08-01 00:00:00

abstract：:Bioinformatics is an interdisciplinary field that blends computer science and biostatistics with biological and biomedical sciences such as biochemistry, cell biology, developmental biology, genetics, genomics, and physiology. An important goal of bioinformatics is to facilitate the management, analysis, and interpret...

journal_title：Journal of cellular physiology

authors： Moore JH

更新日期：2007-11-01 00:00:00

abstract：:Tfcp2l1 is a transcription factor critical for mouse embryonic stem cell (mESC) maintenance. However, its role in human ESCs (hESCs) remains unclear. Here, we investigated the role of Tfcp2l1 in controlling hESC activity and showed that Tfcp2l1 is functionally important in the maintenance of hESC identity. Tfcp2l1 exp...

journal_title：Journal of cellular physiology

authors： Sun H,You Y,Guo M,Wang X,Zhang Y,Ye S

更新日期：2018-09-01 00:00:00

abstract：:Core binding factor β (Cbfβ) is a partner protein of Runx family transcription factors with minimally characterized function in cartilage. Here we address the role of Cbfβ in cartilage by generating chondrocyte-specific Cbfβ-deficient mice (Cbfb(Δch/Δch) ) from Cbfb-floxed mice crossed with mice expressing Cre from th...

journal_title：Journal of cellular physiology

authors： Park NR,Lim KE,Han MS,Che X,Park CY,Kim JE,Taniuchi I,Bae SC,Choi JY

更新日期：2016-01-01 00:00:00

abstract：:Endothelial cell-derived growth factor (ECDGF) is a soluble mitogen secreted in vitro by bovine aortic endothelium. ECDGF is a mixture of at least two distinct heat-stable and trypsin-sensitive mitogens. Large amounts of mitogenic activity were found in lysates prepared from cultured endothelial cells. Other nonmitoge...

journal_title：Journal of cellular physiology

authors： Gajdusek CM,Schwartz SM

更新日期：1984-11-01 00:00:00

abstract：:The tuftelin protein isoforms undergo post-translation modifications, and are ubiquitously expressed in various tissues in embryos, adults, and tumors. Developmental and pathological studies suggested an apparent correlation between oxygen deprivation and tuftelin expression. The aim of the study was therefore to inve...

journal_title：Journal of cellular physiology

authors： Leiser Y,Silverstein N,Blumenfeld A,Shilo D,Haze A,Rosenfeld E,Shay B,Tabakman R,Lecht S,Lazarovici P,Deutsch D

更新日期：2011-01-01 00:00:00

abstract：:Progesterone is an endogenous immunomodulator and can suppress T-cell activation during pregnancy. We have previously shown that the non-genomic effects of progesterone, especially acidification, are exerted via plasma membrane sites and suppress cellular genomic responses to mitogens. This study aimed to show that ac...

journal_title：Journal of cellular physiology

authors： Chien EJ,Liao CF,Chang CP,Pu HF,Lu LM,Shie MC,Hsieh DJ,Hsu MT

更新日期：2007-05-01 00:00:00

abstract：:Former studies have linked hepatocyte growth with liver fatty acid binding protein (L-FABP) of rat liver cytosol. In search for the roles of L-FABP in hepatocytes, we previously stably transfected rat L-FABP sense and antisense cDNAs into rat hepatoma HTC cells that do not contain L-FABP RNA or protein, thereby provid...

journal_title：Journal of cellular physiology

authors： Keler T,Sorof S

更新日期：1993-10-01 00:00:00

abstract：:Tight junctions govern the paracellular permeability of endothelial and epithelial cells. Aberrations of tight junction function are an early and key event during the vascular spread of cancer and inflammation. This study sought to determine the role of estrogen in the regulation of tight junctions and expression of m...

journal_title：Journal of cellular physiology

authors： Ye L,Martin TA,Parr C,Harrison GM,Mansel RE,Jiang WG

更新日期：2003-08-01 00:00:00

abstract：:Myeloid cells, including granulocytes and monocyte/macrophages, are important in disease-associated inflammatory reactions. These cells come from a common progenitor, the promyelocyte. The human promyelocytic cell line, HL-60, can be induced to terminally differentiate into granulocytes or monocyte/ macrophages in a c...

journal_title：Journal of cellular physiology

authors： Brent LH,Rubenstein B,Gong QH,Wieland SJ

更新日期：1996-07-01 00:00:00

abstract：:Conditioned medium from Sertoli cells, prepared from testes of 20-day-old rats, contains component(s) that inhibit the incorporation of [3H]-thymidine into DNA of peritubular myoid cells (PMC) and inhibit the proliferation of PMC. These components are trypsin-resistant, heat-stable compounds having a molecular weight ...

journal_title：Journal of cellular physiology

authors： Tung PS,Fritz IB

更新日期：1991-06-01 00:00:00

abstract：:The protease nexins (PN-I, Mr approximately 38,000; PN-II, Mr approximately 95,000; and PN-III, Mr approximately 31,000) are recently described cell-secreted proteins that selectively link to regulatory serine proteases in the extracellular environment and mediate their cellular binding, internalization, and degradati...

journal_title：Journal of cellular physiology

authors： Knauer DJ,Thompson JA,Cunningham DD

更新日期：1983-12-01 00:00:00

abstract：:Besides the liver, it has been difficult to identify which organ(s) and/or cellular component(s) contribute significantly to the production of human FVIII:c (FVIII). Thus far, only endothelial cells have been shown to constitute a robust extrahepatic source of FVIII, possibly explaining both the diverse presence of FV...

journal_title：Journal of cellular physiology

authors： Sanada C,Kuo CJ,Colletti EJ,Soland M,Mokhtari S,Knovich MA,Owen J,Zanjani ED,Porada CD,Almeida-Porada G

更新日期：2013-05-01 00:00:00

abstract：:Cultured preadipose 3T3 cells undergo a process of differentiation in which they convert to adipose cells. Growth hormone promotes this conversion. Since 3T3 sublines vary in their susceptibility to adipose conversion, it was of interest to examine the properties of the growth hormone receptors in relation to that sus...

journal_title：Journal of cellular physiology

authors： Nixon T,Green H

更新日期：1983-06-01 00:00:00

abstract：:Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor that was related to cancer development and metastasis dissemination on several types of tumors. However, it is not known the effect of SLPI on mammary and colon tumors. The aim of this study was to examine the effect of SLPI on mammary and co...

journal_title：Journal of cellular physiology

authors： Amiano NO,Costa MJ,Reiteri RM,Payés C,Guerrieri D,Tateosian NL,Sánchez ML,Maffia PC,Diament M,Karas R,Orqueda A,Rizzo M,Alaniz L,Mazzolini G,Klein S,Sallenave JM,Chuluyan HE

更新日期：2013-02-01 00:00:00

abstract：:Phospholipase A2 (PLA2) is pivotal in the rapid membrane-mediated actions of 1,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3]. Microarray analysis indicated that PLA2 activating protein (PLAA) mRNA is upregulated 6-fold before rat growth plate cells exhibit 1alpha,25(OH)2D3-dependent protein kinase C (PKC) increases, sugge...

journal_title：Journal of cellular physiology

authors： Schwartz Z,Graham EJ,Wang L,Lossdörfer S,Gay I,Johnson-Pais TL,Carnes DL,Sylvia VL,Boyan BD

更新日期：2005-04-01 00:00:00

abstract：:Nerve-evoked contractile activity in skeletal muscle regulates transcript and protein levels of many metabolic genes in a coordinate fashion, including the muscle isozyme of glycogen phosphorylase (MGP). Cellular signaling mechanisms mediating the activity-dependent modulation of MGP transcript levels were investigate...

journal_title：Journal of cellular physiology

authors： Vali S,Carlsen R,Pessah I,Gorin F

更新日期：2000-11-01 00:00:00

abstract：:The mammalian olfactory system is a physiologically plastic region of the brain with the potential to support implanted stem cells. We performed direct injection of lineage-negative (lin-neg), green fluorescent protein-positive (GFP+) bone marrow cells into the olfactory bulb to assess cell survival and motility withi...

journal_title：Journal of cellular physiology

authors： Moore BE,Colvin GA,Dooner MS,Quesenberry PJ

更新日期：2005-01-01 00:00:00

abstract：:Therapeutic application of stem cells and oncolytic viruses in cancer treatment has rapidly increased in the last decade. Oncolytic viruses are considered as a new class of anticancer agents because of their ability to selectively infect and destroy cancer cells. Furthermore, regarding the specific migratory capacity ...

journal_title：Journal of cellular physiology

authors： Zendedel E,Atkin SL,Sahebkar A

更新日期：2019-02-15 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) promotes bone formation by stimulating proliferation and differentiation of osteoblasts. Bone sialoprotein (BSP), is thought to function in the initial mineralization of bone, is selectively expressed by differentiated osteoblast. To determine the molecular mechanism of IGF-I regul...

journal_title：Journal of cellular physiology

authors： Nakayama Y,Nakajima Y,Kato N,Takai H,Kim DS,Arai M,Mezawa M,Araki S,Sodek J,Ogata Y

更新日期：2006-08-01 00:00:00

abstract：:miR-222 participates in many cardiovascular diseases, but its effect on cardiac remodeling induced by diabetes is unclear. This study evaluated the functional role of miR-222 in cardiac fibrosis in diabetic mice. Streptozotocin (STZ) was used to establish a type 1 diabetic mouse model. After 10 weeks of STZ injection,...

journal_title：Journal of cellular physiology

authors： Wang Z,Wang Z,Gao L,Xiao L,Yao R,Du B,Li Y,Wu L,Liang C,Huang Z,Li P,Zhang Y

更新日期：2020-03-01 00:00:00

abstract：:We previously demonstrated that, in the MC615 cartilage cell line, the p38/NF-kB pathway is activated both during differentiation and in response to an inflammatory stimulus. In both cases, the p38/NF-kB pathway activation leads to the expression of the lipocalin SIP24 and of COX-2. Given the fact that, in the same ce...

journal_title：Journal of cellular physiology

authors： Ulivi V,Cancedda R,Cancedda FD

更新日期：2008-11-01 00:00:00

abstract：:Previous studies have indicated that intracellular Ca2+ is involved in fetal bovine serum (FBS)- or growth factor (GF)-stimulated Na+ influx in human foreskin fibroblasts (HSWP). In the present study, 45Ca2+ efflux from serum-deprived HSWP cells was measured in response to 10% FBS or GF [lys-bradykinin, vasopressin, e...

journal_title：Journal of cellular physiology

authors： Owen NE,Villereal ML

更新日期：1983-10-01 00:00:00

abstract：:Liver fibrosis (LF) is the result of a vicious cycle between inflammation-induced chronic hepatocyte injury and persistent activation of hepatic stellate cells (HSCs). Mesenchymal stem cell (MSC)-based therapy may represent a potential remedy for treatment of LF. However, the fate of transplanted MSCs in LF remains la...

journal_title：Journal of cellular physiology

authors： Wang HY,Li C,Liu WH,Deng FM,Ma Y,Guo LN,Kong H,Hu KA,Liu Q,Wu J,Sun J,Liu YL

更新日期：2020-03-01 00:00:00

abstract：:Although prostate carcinoma is an aggressive cancer preferentially metastasizing to the bones, many prostate tumors remain localized and confined to the prostate indefinitely. Prediction of the behavior of anatomically localized and moderately differentiated prostate tumors remains difficult because of lack of prognos...

journal_title：Journal of cellular physiology

authors： de Amicis F,Lanzino M,Kisslinger A,Calì G,Chieffi P,Andò S,Mancini FP,Tramontano D

更新日期：2006-10-01 00:00:00

abstract：:Myocardial ischemia is accompanied with hypoxia injury in myocardial cells. Long noncoding RNAs (lncRNA) CAMK2D-associated transcript 1 (C2dat1) C2dat1) has been linked with several ischemic diseases. However, the investigation regarding its role in myocardial ischemia is relatively rare. The aim of this study was to ...

journal_title：Journal of cellular physiology

authors： Sun H,Shi K,Xie D,Zhang H,Yu B

更新日期：2019-11-01 00:00:00

abstract：:Entry of certain free amino acids (alpha aminoisobutyric acid (AIB), alanine and proline), but not of leucine into rat thymic lymphocytes increased progressively when the cells were incubated in amino acid deficient medium. Actinomycin D, cycloheximide, or a high concentration of AIB abolished the time-related increas...

journal_title：Journal of cellular physiology

authors： Peck WA,Rockwell LH,Lichtman MA

更新日期：1976-11-01 00:00:00