Bioinformatics.

Abstract:

:Bioinformatics is an interdisciplinary field that blends computer science and biostatistics with biological and biomedical sciences such as biochemistry, cell biology, developmental biology, genetics, genomics, and physiology. An important goal of bioinformatics is to facilitate the management, analysis, and interpretation of data from biological experiments and observational studies. The goal of this review is to introduce some of the important concepts in bioinformatics that must be considered when planning and executing a modern biological research study. We review database resources as well as data mining software tools.

journal_name

J Cell Physiol

authors

Moore JH

doi

10.1002/jcp.21218

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

365-9

issue

2

eissn

0021-9541

issn

1097-4652

journal_volume

213

pub_type

杂志文章,评审
  • A new apoptotic pathway for the complement factor B-derived fragment Bb.

    abstract::Apoptosis is involved in both the cellular and humoral immune system destroying tumors. An apoptosis-inducing factor from HL-60 myeloid leukemia cells was obtained, purified, and sequenced. The protein found has been identified as a human complement factor B-derived fragment Bb, although it is known that factor B is a...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/1097-4652(200011)185:2<280::AID-JCP13>3.0.

    authors: Uwai M,Terui Y,Mishima Y,Tomizuka H,Ikeda M,Itoh T,Mori M,Ueda M,Inoue R,Yamada M,Hayasawa H,Horiuchi T,Niho Y,Matsumoto M,Ishizaka Y,Ikeda K,Ozawa K,Hatake K

    更新日期:2000-11-01 00:00:00

  • Patch-clamp 'mapping' of ion channel activity in human sperm reveals regionalisation and co-localisation into mixed clusters.

    abstract::Ion channels are pivotal to many aspects of sperm physiology and function. We have used the patch clamp technique to investigate the distribution of ion channels in the plasma membrane of the head of human spermatozoa. We report that three types of activity are common in the equatorial and acrosomal regions of the spe...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.21153

    authors: Jiménez-González MC,Gu Y,Kirkman-Brown J,Barratt CL,Publicover S

    更新日期:2007-12-01 00:00:00

  • Septin 7 is a centrosomal protein that ensures S phase entry and microtubule nucleation by maintaining the abundance of p150glued.

    abstract::Septins play important roles in regulating development and differentiation. Septin 7 (SEPT7) is a crucial component in orchestrating the septin core complex into highly ordered filamentous structures. Here, we showed that genetic depletion of SEPT7 or treatment with forchlorfenuron (FCF; a compound known to affect sep...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.30037

    authors: Chen TY,Lin TC,Kuo PL,Chen ZR,Cheng HL,Chao YY,Syu JS,Lu FI,Wang CY

    更新日期:2020-09-01 00:00:00

  • Perlecan Heparan Sulfate Is Required for the Inhibition of Smooth Muscle Cell Proliferation by All-trans-Retinoic Acid.

    abstract::Smooth muscle cell (SMC) proliferation is a key process in stabilization of atherosclerotic plaques, and during restenosis after interventions. A clearer understanding of SMC growth regulation is therefore needed to design specific anti-proliferative therapies. Retinoic acid has been shown to inhibit proliferation of ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.24731

    authors: Tran-Lundmark K,Tannenberg P,Rauch BH,Ekstrand J,Tran PK,Hedin U,Kinsella MG

    更新日期:2015-02-01 00:00:00

  • Cholera toxin and analogues of cyclic AMP stimulate the growth of cultured human mammary epithelial cells.

    abstract::The growth of human epithelial cells is stimulated by cholera toxin and analogues of cyclic AMP, while the growth of breast derived fibroblasts is inhibited. These compounds have little effect on DNA synthesis in the absence of other mitogens but show a synergistic effect with serum and/or EGF. The results suggest tha...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041020306

    authors: Taylor-Papadimitriou J,Purkis P,Fentiman IS

    更新日期:1980-03-01 00:00:00

  • Differential regulation of the lateral mobility of plasma membrane phospholipids by the extracellular matrix and cholesterol.

    abstract::In this study, we compared qualitative and quantitative changes in the lateral mobility of phospholipid molecules in the plasma membrane of intact cells under various conditions of specific interaction of integrins in the cell membrane with two extracellular matrix (ECM) components viz. fibronectin (FN) and laminin (L...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.21339

    authors: Ramprasad OG,Rangaraj N,Srinivas G,Thiery JP,Dufour S,Pande G

    更新日期:2008-05-01 00:00:00

  • Na(+)/K(+) pump expression in the L8 rat myogenic cell line: effects of heterologous alpha subunit transfection.

    abstract::We have characterized the physiological and biochemical properties of the Na(+)/K(+) pump and its molecular expression in L8 rat muscle cells. Pump properties were measured by [(3)H]ouabain binding and (86)Rb uptake. Scatchard plot analysis of specific ouabain binding indicated the presence of a single family of bindi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1089

    authors: Sharabani-Yosef O,Bak A,Nir U,Sampson SR

    更新日期:2001-06-01 00:00:00

  • Embryonal carcinoma cells (and their somatic cell hybrids) are resistant to infection by the murine parvovirus MVM, which does infect other teratocarcinoma-derived cell lines.

    abstract::Minute virus of mice (MVM), a non-defective parvovirus, has been shown to infect cultures of non-pluripotent differentiated teratocarcinoma-derived cells, but pluripotent (and "nullipotent") embryonal carcinoma cells derived from the same teratocarcinoma resist MVN infection. Somatic cell hybrids between an embryonal ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1040910309

    authors: Miller RA,Ward DC,Ruddle FH

    更新日期:1977-06-01 00:00:00

  • Synthesis, characterization, and in vitro evaluation of the starch-based α-amylase responsive hydrogels.

    abstract::Controlled-release drug delivery systems are promising platforms in medicine. Among various types of material in drug delivery, hydrogels are interesting ones. They are water-soluble and tissue compatible polymers with a high capacity to carry and release drugs in a controllable manner. In this study, we introduce the...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.30148

    authors: Davoodi-Monfared P,Akbari-Birgani S,Mohammadi S,Kazemi F,Nikfarjam N,Nikbakht M,Mousavi SA

    更新日期:2020-11-05 00:00:00

  • Mechanical stimulation of skeletal muscle generates lipid-related second messengers by phospholipase activation.

    abstract::Repetitive mechanical stimulation of cultured avian skeletal muscle increases the synthesis of prostaglandins (PG) E2 and F2 alpha which regulate protein turnover rates and muscle cell growth. These stretch-induced PG increases are reduced in low extracellular calcium medium and by specific phospholipase inhibitors. M...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041550109

    authors: Vandenburgh HH,Shansky J,Karlisch P,Solerssi RL

    更新日期:1993-04-01 00:00:00

  • SIRT6 deacetylase transcriptionally regulates glucose metabolism in heart.

    abstract::Sirtuins are a family of enzymes, which govern a number of cellular processes essential for maintaining physiological balance. SIRT6, a nuclear sirtuin, is implicated in the development of metabolic disorders. The role of SIRT6 in regulation of cardiac metabolism is unexplored. Although glucose is not the primary ener...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.26434

    authors: Khan D,Sarikhani M,Dasgupta S,Maniyadath B,Pandit AS,Mishra S,Ahamed F,Dubey A,Fathma N,Atreya HS,Kolthur-Seetharam U,Sundaresan NR

    更新日期:2018-07-01 00:00:00

  • A new cell surface marker of aging in human diploid fibroblasts.

    abstract::The relationship of cell surface changes to proliferative decline of human diploid fibroblasts was investigated using the concanavalin A-mediated red blood cell adsorption assay. The amount of the red blood cells adsorbed to human diploid fibroblasts via concanavalin A increased continuously from the early phases of c...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041000219

    authors: Aizawa S,Mitsui Y

    更新日期:1979-08-01 00:00:00

  • High expression of IMPACT protein promotes resistance to indoleamine 2,3-dioxygenase-induced cell death.

    abstract::Indoleamine 2,3-dioxygenase (IDO), a tryptophan degrading enzyme, is a potent immunomodulatory factor. IDO expression in fibroblasts selectively induces apoptosis in immune cells but not in primary skin cells. However, the mechanism(s) of this selective effect of IDO-induced low tryptophan environment is not elucidate...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.22220

    authors: Habibi D,Jalili RB,Forouzandeh F,Ong CJ,Ghahary A

    更新日期:2010-10-01 00:00:00

  • The relationship between purines, pyrimidines, nucleosides, and glutamine for fibroblast cell proliferation.

    abstract::Previous studies indicate that glutamine is a critical requirement for cell proliferation in vitro. We recently showed that depletion of glutamine from the culture medium supporting growing cells significantly reduced the proportion of cells undergoing DNA synthesis. Similarly glutamine depletion significantly reduced...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041200218

    authors: Engström W,Zetterberg A

    更新日期:1984-08-01 00:00:00

  • All-trans retinoic acid blocks the antiproliferative prodifferentiating actions of 1,25-dihydroxyvitamin D3 in normal human keratinocytes.

    abstract::1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] and all-trans retinoic acid (RA), the active metabolites of vitamins D and A respectively, regulate the proliferation and differentiation of keratinocytes. Both the vitamin D receptor (VDR) and the retinoic acid receptor family (RAR) bind to DNA response elements as heterodimers ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4652(199801)174:1<1::AID-JCP1>3

    authors: Gibson DF,Bikle DD,Harris J

    更新日期:1998-01-01 00:00:00

  • DNA methylation regulates α-smooth muscle actin expression during cardiac fibroblast differentiation.

    abstract::Cardiac fibroblast (CF) differentiation to myofibroblasts expressing α-smooth muscle actin (α-SMA) plays a key role in cardiac fibrosis. Therefore, a study of the mechanism regulating α-SMA expression is a means to understanding the mechanism of fibroblast differentiation and cardiac fibrosis. Previous studies have sh...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.27471

    authors: He Y,Ling S,Sun Y,Sheng Z,Chen Z,Pan X,Ma G

    更新日期:2019-05-01 00:00:00

  • Regulation of RNA polymerase II activity by CTD phosphorylation and cell cycle control.

    abstract::The carboxyl-terminal domain (CTD) of the largest subunit of mammalian RNA polymerase II (RNAP II) consists of 52 repeats of a consensus heptapeptide and is subject to phosphorylation and dephosphorylation events during each round of transcription. RNAP II activity is regulated during the cell cycle and cell cycle-dep...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审

    doi:10.1002/jcp.10058

    authors: Oelgeschläger T

    更新日期:2002-02-01 00:00:00

  • Tumor necrosis factor alpha: posttranscriptional stabilization of WAF1 mRNA in p53-deficient human leukemic cells.

    abstract::The p53 protein directly regulates the expression of the WAF1 (wild-type p53-activated fragment 1) protein which is a cyclin-dependent kinase inhibitor (CDK1). DNA damaging agents such as ionizing or UV radiation, and some chemical agents induce WAF1 in wild-type p53 containing cells, thereby halting cell cycle progre...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4652(199603)166:3<568::AID-JCP1

    authors: Shiohara M,Akashi M,Gombart AF,Yang R,Koeffler HP

    更新日期:1996-03-01 00:00:00

  • Regulation of cellular growth by sodium pump activity.

    abstract::Cellular growth has been found to be directly related to the amount of sodium pumping activity in mouse lymphoblasts (L5178-Y) cultured in varying concentrations of the cardiac glycoside, ouabain. No short-term adaptation (within one generation) occured; i.e., neither growth rate nor (Na+ + K+)-ATPase activity increas...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1040870313

    authors: Shank BB,Smith NE

    更新日期:1976-03-01 00:00:00

  • Modulation of drug resistance in homoharringtonine-resistant C-1300 neuroblastoma cells with cyclosporine A and dipyridamole.

    abstract::The development of resistance accounts for therapy failure in the majority of advanced cases of neuroblastoma in children. A new transplantable murine C-1300 neuroblastoma cell line was developed in vitro, by repeated exposure of a sensitive cell line to increasing, but sublethal, doses of Homoharringtonine (HHT). The...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041480319

    authors: Tebbi CK,Chervinsky D,Baker RM

    更新日期:1991-09-01 00:00:00

  • TRPM8 in mouse sperm detects temperature changes and may influence the acrosome reaction.

    abstract::Changes in the concentration of intracellular Ca(2+) ([Ca(2+) ]i) trigger and/or regulate principal sperm functions during fertilization, such as motility, capacitation, and the acrosome reaction (AR). Members of the large TRP channel family participate in a variety of Ca(2+) -dependent cell signaling processes. The e...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.22493

    authors: Martínez-López P,Treviño CL,de la Vega-Beltrán JL,De Blas G,Monroy E,Beltrán C,Orta G,Gibbs GM,O'Bryan MK,Darszon A

    更新日期:2011-06-01 00:00:00

  • Induction of ornithine decarboxylase, RNA, and protein synthesis in macrophage cell lines stimulated by immunoadjuvants.

    abstract::Early biochemical changes associated with adjuvant stimulation of macrophage protein synthesis were studied using two murine macrophage cell lines, PU5-1.8 and J774.1. An induction of ornithine decarboxylase (ODC) was detected 2 hours after exposure of PU5-1.8 and J774.1 cells to two crude immunoadjuvants, BCG cell wa...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041200111

    authors: Prosser FH,Schmidt CJ,Nichols SV,Nichols WK

    更新日期:1984-07-01 00:00:00

  • Lactoferrin binding sites and nuclear localization in K562(S) cells.

    abstract::Lactoferrin, a single chain cationic glycoprotein, present in the secondary granules of neutrophils, acts as a negative feedback regulator of myelopoiesis. Specific receptors for lactoferrin were detected on the surface of different hematopoietic cell types. The influence of lactoferrin on cell growth in culture has b...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041530306

    authors: Garré C,Bianchi-Scarrá G,Sirito M,Musso M,Ravazzolo R

    更新日期:1992-12-01 00:00:00

  • MiR-145 Regulates Lipogenesis in Goat Mammary Cells Via Targeting INSIG1 and Epigenetic Regulation of Lipid-Related Genes.

    abstract::MicroRNAs (miRNAs) are noncoding RNA molecules that regulate gene expression at the post-transcriptional level to cause translational repression or degradation of targets. The profiles of miRNAs across stages of lactation in small ruminant species such as dairy goats is unknown. A small RNA library was constructed usi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.25499

    authors: Wang H,Shi H,Luo J,Yi Y,Yao D,Zhang X,Ma G,Loor JJ

    更新日期:2017-05-01 00:00:00

  • THP-1 macrophage membrane-bound plasmin activity is up-regulated by transforming growth factor-beta 1 via increased expression of urokinase and the urokinase receptor.

    abstract::Receptors for urokinase (uPA) and plasminogen provide a mechanism to direct the cellular activation of plasminogen. The regulation of these receptors is important for several macrophage functions. In these studies, the effect of transforming growth factor-beta 1 (TGF-beta 1) on uPA, uPA receptor, and plasminogen recep...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041640214

    authors: Falcone DJ,McCaffrey TA,Mathew J,McAdam K,Borth W

    更新日期:1995-08-01 00:00:00

  • Activated ERK/FOXM1 pathway by low-power laser irradiation inhibits UVB-induced senescence through down-regulating p21 expression.

    abstract::Cellular senescence is a growth-arrest program that limits cell proliferation. Low-power laser irradiation (LPLI) has been demonstrated to promote cell proliferation. However, whether LPLI can inhibit cellular senescence remains unknown. In the present study, to investigate the functional role of LPLI against skin agi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.24425

    authors: Ling Q,Meng C,Chen Q,Xing D

    更新日期:2014-01-01 00:00:00

  • Long noncoding RNA HOXC13-AS positively affects cell proliferation and invasion in nasopharyngeal carcinoma via modulating miR-383-3p/HMGA2 axis.

    abstract::Long noncoding RNAs have been reported to be important regulators in numerous cancers. In this study, we found that HOXC13 antisense RNA (HOXC13-AS) was highly expressed in head and neck squamous carcinoma (HNSC) tissues in The Cancer Genome Atlas database. Nasopharyngeal carcinoma (NPC) belongs to HNSC. Therefore, we...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.27915

    authors: Gao C,Lu W,Lou W,Wang L,Xu Q

    更新日期:2019-08-01 00:00:00

  • Autophagy inhibition via Becn1 downregulation improves the mesenchymal stem cells antifibrotic potential in experimental liver fibrosis.

    abstract::Liver fibrosis (LF) is the result of a vicious cycle between inflammation-induced chronic hepatocyte injury and persistent activation of hepatic stellate cells (HSCs). Mesenchymal stem cell (MSC)-based therapy may represent a potential remedy for treatment of LF. However, the fate of transplanted MSCs in LF remains la...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.29176

    authors: Wang HY,Li C,Liu WH,Deng FM,Ma Y,Guo LN,Kong H,Hu KA,Liu Q,Wu J,Sun J,Liu YL

    更新日期:2020-03-01 00:00:00

  • An Innovative Assay for the Analysis of In Vitro Endothelial Remodeling: Experimental and Computational Evidence.

    abstract::The molecular and cellular mechanisms underlying vascular remodeling are currently investigated by experimental strategies which aim to mimic the complex environmental conditions found in vivo. Some of them focus on the tubulogenic activity of dispersed endothelial cell populations, while others evaluate vascular spro...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.25468

    authors: Scianna M,Bassino E,Munaron L

    更新日期:2017-02-01 00:00:00

  • Separation of isolated hamster intestinal epithelial cells by velocity sedimentation on Ficoll Gradients.

    abstract::Isolated hamster intestinal epithelial cells can be separated by velocity sedimentationion on 2-10% Ficoll gradients into three subpopulations of cells which differ in morphology, biochemistry, physiology, and membrane components. These subpopulations are not pure but are enriched in a single cell type to the extent t...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041110111

    authors: Carter JH,Poretz RD,Eichholz A

    更新日期:1982-04-01 00:00:00