Long noncoding RNA HOXC13-AS positively affects cell proliferation and invasion in nasopharyngeal carcinoma via modulating miR-383-3p/HMGA2 axis.


:Long noncoding RNAs have been reported to be important regulators in numerous cancers. In this study, we found that HOXC13 antisense RNA (HOXC13-AS) was highly expressed in head and neck squamous carcinoma (HNSC) tissues in The Cancer Genome Atlas database. Nasopharyngeal carcinoma (NPC) belongs to HNSC. Therefore, we further investigated the potential role of HOXC13-AS in NPC. Quantitative reverse transcription polymerase chain reaction examination revealed that HOXC13-AS was markedly upregulated in NPC tissues and cell lines. Furthermore, HOXC13-AS was identified as an independent prognosis factor by Cox regression analyses. Subsequently, functional assay revealed that knockdown of HOXC13-AS impaired cell proliferation, migration, and invasion. Mechanistically, RIP and luciferase reporter analysis confirmed that miR-383-3p was a target of HOXC13-AS. Besides, high mobility group AT-hook 2 (HMGA2) was proved to be a target of miR-383-3p in NPC. Finally, rescue assays demonstrated that HOXC13-AS functioned as a competing endogenous RNAs to enhance the expression of HMGA2 via sponging miR-383-3p. This study suggested that HOXC13-AS exerted oncogenic function in NPC via regulating miR-383-3p/HMGA2 axis, indicating HOXC13-AS may be a potential therapeutic target for patients with NPC.


J Cell Physiol


Gao C,Lu W,Lou W,Wang L,Xu Q




Has Abstract


2019-08-01 00:00:00












  • Regulation of cellular growth by sodium pump activity.

    abstract::Cellular growth has been found to be directly related to the amount of sodium pumping activity in mouse lymphoblasts (L5178-Y) cultured in varying concentrations of the cardiac glycoside, ouabain. No short-term adaptation (within one generation) occured; i.e., neither growth rate nor (Na+ + K+)-ATPase activity increas...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Shank BB,Smith NE

    更新日期:1976-03-01 00:00:00

  • Preparation of superparamagnetic iron oxide/doxorubicin loaded chitosan nanoparticles as a promising glioblastoma theranostic tool.

    abstract::Theranostic nanoparticles (NPs) are promising for opening new windows toward personalized disease management. Using a single particle capable of both diagnosis and drug delivery, is the major benefit of such particles. In the present study, chitosan NPs were used as a dual action carrier for doxorubicin (DOX; chemothe...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Gholami L,Tafaghodi M,Abbasi B,Daroudi M,Kazemi Oskuee R

    更新日期:2019-02-01 00:00:00

  • Age-related differences in cellular and molecular profiles of inflammatory responses after spinal cord injury.

    abstract::Previous experimental and clinical studies have suggested that the behavioral and pathological outcomes of spinal cord injury (SCI) are affected by the individual's age at the time of injury. However, the underlying mechanism responsible for these differences remains elusive because it is difficult to match injuries o...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Kumamaru H,Saiwai H,Ohkawa Y,Yamada H,Iwamoto Y,Okada S

    更新日期:2012-04-01 00:00:00

  • The role of autophagy in bone homeostasis.

    abstract::Autophagy is an evolutionarily conserved intracellular process and is considered one of the main catabolism pathways. In the process of autophagy, cells are digested nonselectively or selectively to recover nutrients and energy, so it is regarded as an antiaging process. In addition to the essential role of autophagy ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Guo YF,Su T,Yang M,Li CJ,Guo Q,Xiao Y,Huang Y,Liu Y,Luo XH

    更新日期:2021-01-16 00:00:00

  • Microtubules and lymphocyte responses: effect of colchicine and taxol on mitogen-induced human lymphocyte activation and proliferation.

    abstract::The role of microtubules in mitogen-induced human lymphocyte activation and proliferation was examined. The effect of colchicine, a microtubule-disrupting agent, was compared with taxol, a microtubule-stabilizing drug, and with isaxonine (N-isopropyl-amino-2-pyrimidine orthophosphate), a proposed microtubular-active d...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Cuthbert JA,Shay JW

    更新日期:1983-08-01 00:00:00

  • Identification of microRNAs controlling human ovarian cell steroidogenesis via a genome-scale screen.

    abstract::The aim of our studies was to identify miRNAs affecting the release of the major ovarian steroid hormones progestagen, androgen and estrogen by human ovarian cells. The effect of transfection of cultured primary ovarian granulosa cells with 80 different gene constructs encoding human pre-miRNAs on release of progester...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Sirotkin AV,Ovcharenko D,Grossmann R,Lauková M,Mlyncek M

    更新日期:2009-05-01 00:00:00

  • BDNF Val66Met polymorphism alters food intake and hypothalamic BDNF expression in mice.

    abstract::Obesity, a rising public health burden, is a multifactorial disease with an increased risk for patients to develop several pathological conditions including type 2 diabetes mellitus, hypertension, and cardiovascular disease. Increasing evidence suggests a relationship between the human brain-derived neurotrophic facto...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Ieraci A,Barbieri SS,Macchi C,Amadio P,Sandrini L,Magni P,Popoli M,Ruscica M

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    abstract::Terminal deoxynucleotidyl transferase (TdT) is a template-independent DNA polymerase that is transiently expressed during the normal development of T and B lymphocytes. Phorbol 12-myristate 13-acetate (PMA) has been reported to induce maturation-like changes, including the loss of TdT, in many leukemic cell lines. We ...

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    pub_type: 杂志文章


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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


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  • Uptake of alpha-aminoisobutyric acid and phosphate by membrane vesicles derived from growing and quiescent fibroblasts.

    abstract::Membrane vesicles derived principally from the plasma membrane and endoplasmic reticulum of mouse 3T3 cells transformed by Simian virus 40 take up alpha-aminoisobutyric acid (AIB) and phosphate (Pi). When NaCl is added simultaneously with AIB or Pi, uptake rises two- to three-times above the equilibrium to accumulate ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


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  • Restoration of microRNA-30b expression alleviates vascular calcification through the mTOR signaling pathway and autophagy.

    abstract::Pathological calcification represents an event that consequently leads to a distinct elevation in the morbidity and mortality of patients with chronic kidney disease (CKD) in addition to strengthening its correlation with hyperphosphatemia. Epigenomic regulation by specific microRNAs (miRNAs) is reported to be involve...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Xu TH,Qiu XB,Sheng ZT,Han YR,Wang J,Tian BY,Yao L

    更新日期:2019-08-01 00:00:00

  • Binding of platelet-derived growth factor and low density lipoproteins to glycosaminoglycan species produced by human arterial smooth muscle cells.

    abstract::The platelet-derived growth factor (PDGF) binds via a defined amino acid sequence to heparin (Fager et al., 1992, In Vitro Cell. Dev. Biol., 28A:176-180) and the protein moiety of low density lipoproteins (LDL; apo B-100) via a similar sequence to chondroitin sulfate (Camejo et al., 1988, Arteriosclerosis Thromb., 8:3...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


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  • Synthesis and distribution of cytoskeletal elements in endothelial cells as a function of cell growth and organization.

    abstract::Confluent cultures of adult bovine aortic endothelial (ABAE), corneal endothelial (BCE), and fetal bovine heart endothelial (FBHE) cells form a monolayer of highly flattened, closely apposed, and nonoverlapping cells. In ABAE and BCE cultures, this is associated with a 50-fold decrease in the rate of DNA sythesis and ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


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  • Second messenger signaling of c-fos gene induction by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells: its role in osteoblast proliferation and osteoclast-like cell formation.

    abstract::The present study was performed to clarify second messenger signaling in parathyroid hormone (PTH)-induced c-fos gene expression, to characterize the participation of the c-fos gene in the regulation of osteoblast proliferation and function as well as osteoclast-like cell formation by PTH and to compare these effects ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


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  • Zinc finger E-box binding homeobox 1 and atherosclerosis: New insights and therapeutic potential.

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Li H,Zou J,Yu XH,Ou X,Tang CK

    更新日期:2020-12-04 00:00:00

  • Novel cellular mechanism that mediates the collecting duct formation during postnatal renal development.

    abstract::We have previously demonstrated that kidney embryonic structures are present in rats, and are still developing until postnatal Day 20. Consequently, at postnatal Day 10, the rat renal papilla contains newly formed collecting duct (CD) cells and others in a more mature stage. Performing primary cultures, combined with ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Del Valle Guaytima E,Brandán YR,Favale NO,Sterin-Speziale NB,Márquez MG

    更新日期:2019-08-01 00:00:00

  • Na+/H+ exchange is inactivated during mouse oocyte meiosis, facilitating glycine accumulation that maintains embryo cell volume.

    abstract::The coupled action of the Na(+)/H(+) exchanger NHE1 and the HCO3(-)/Cl(-) exchanger AE2 constitutes the principal mechanism for acute correction of decreased cell volume in mammalian somatic cells, while, when acting separately, they regulate intracellular pH. It was previously found that AE2 becomes inactivated durin...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Zhou C,Fitzharris G,Alper SL,Baltz JM

    更新日期:2013-10-01 00:00:00

  • Phenotypic characterization of ouabain-resistant Aedes albopictus cells.

    abstract::The phenotype of a ouabain-resistant Aedes albopictus cell line has been partially characterized. Treatment of ouabain-sensitive cells with 0.005-1.0 mM ouabain resulted in an 80% reduction in the uptake of 86rubidium (86Rb+), an ion with an affinity for the K+ pump binding site; ouabain-resistant cells showed only a ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


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    更新日期:1979-12-01 00:00:00

  • Inhibition of chemotactic factor-induced neutrophil responsiveness by arachidonic acid.

    abstract::Arachidonic acid when added simultaneously with the chemotactic peptide formyl-methionyl-leucyl-phenylalanine (f-Met-Leu-Phe) inhibits the ability of the latter to initiate several but not all of its effects on rabbit peritoneal neutrophils. Stimulated neutrophil aggregation, calcium uptake, and increases in the stead...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


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    更新日期:1983-06-01 00:00:00

  • Possible involvement of protein kinases and Smad2 signaling pathways on osteoclast differentiation enhanced by activin A.

    abstract::Bone tissues reportedly contain considerable amounts of activin A and follistatin, an activin A-binding protein. In the present study, we found that follistatin strongly inhibited osteoclast formation in cocultures of mouse bone marrow cells and primary osteoblasts induced by 1alpha,25 dihydroxyvitamin D(3), prostagla...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Murase Y,Okahashi N,Koseki T,Itoh K,Udagawa N,Hashimoto O,Sugino H,Noguchi T,Nishihara T

    更新日期:2001-08-01 00:00:00

  • Mutations in GAS5 affect the transformation from benign prostate proliferation to aggressive prostate cancer by affecting the transcription efficiency of GAS5.

    abstract:BACKGROUND:In this study, we aimed to explore the effects of GAS5 single-nucleotide polymorphisms (SNPs) on GAS5 expression. And the signaling pathways underlying the function of GAS5 during the pathogenesis of prostate cancer (PC) were clarified. MATERIALS AND METHODS:Patients with PC were recruited and grouped accor...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Zhu L,Zhu Q,Wen H,Huang X,Zheng G

    更新日期:2019-06-01 00:00:00

  • Protease nexins: cell-secreted proteins that mediate the binding, internalization, and degradation of regulatory serine proteases.

    abstract::The protease nexins (PN-I, Mr approximately 38,000; PN-II, Mr approximately 95,000; and PN-III, Mr approximately 31,000) are recently described cell-secreted proteins that selectively link to regulatory serine proteases in the extracellular environment and mediate their cellular binding, internalization, and degradati...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Knauer DJ,Thompson JA,Cunningham DD

    更新日期:1983-12-01 00:00:00

  • Interplay between the retinoblastoma related pRb2/p130 and E2F-4 and -5 in relation to JCV-TAg.

    abstract::Human polyomaviruses, which include JC virus (JCV) and BK virus (BKV), as well as the simian virus 40 (SV40), have been associated with human tumors and have been shown to be highly tumorigenic in experimental animal models. Although the mechanism by which JCV induces tumorigenesis is not entirely clear, earlier studi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Caracciolo V,Reiss K,Crozier-Fitzgerald C,De Pascali F,Macaluso M,Khalili K,Giordano A,Claudio PP

    更新日期:2007-07-01 00:00:00

  • Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR.

    abstract::Sleep-disordered breathing with recurrent apnea (periodic cessation of breathing) results in chronic intermittent hypoxia (IH), which leads to cardiovascular and respiratory pathology. Molecular mechanisms underlying IH-evoked cardio-respiratory co-morbidities have not been delineated. Mice with heterozygous deficienc...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Yuan G,Nanduri J,Khan S,Semenza GL,Prabhakar NR

    更新日期:2008-12-01 00:00:00

  • Small interfering RNA-mediated gene suppression as a therapeutic intervention in hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is one of the lethal and difficult-to-cure cancers worldwide. Owing to the late diagnosis and drug resistance of malignant hepatocytes, treatment of this cancer by conventional chemotherapy agents is challenging, and researchers are seeking new alternative treatment options to overcome t...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Hajiasgharzadeh K,Somi MH,Shanehbandi D,Mokhtarzadeh A,Baradaran B

    更新日期:2019-04-01 00:00:00

  • Regulation of HIV-1 transcription at 3% versus 21% oxygen concentration.

    abstract::HIV transcription is induced by the HIV-1 Tat protein, in concert with cellular co-factors including CDK9, CDK2, NF-kappaB, and others. The cells of most of the body's organs are exposed to approximately 3-6% oxygen, but most in vitro studies of HIV replication are conducted at 21% oxygen. We hypothesized that activit...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Charles S,Ammosova T,Cardenas J,Foster A,Rotimi J,Jerebtsova M,Ayodeji AA,Niu X,Ray PE,Gordeuk VR,Kashanchi F,Nekhai S

    更新日期:2009-11-01 00:00:00

  • Hypoxia induces epidermal keratinocyte matrix metalloproteinase-9 secretion via the protein kinase C pathway.

    abstract::Hypoxia promotes keratinocyte migration on wound bed connective tissues and is a profound biological signal that transforms a basal keratinocyte, destined to differentiate, into a motile cell that is essential for re-epithelialization. In this study, we examined the effect of hypoxia on keratinocyte-derived collagenas...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: O'Toole EA,van Koningsveld R,Chen M,Woodley DT

    更新日期:2008-01-01 00:00:00

  • Length-dependence of isometric twitch tension potentiation and myosin phosphorylation in mouse skeletal muscle.

    abstract::The effect of changes in muscle length on post-tetanic isometric twitch tension potentiation and myosin P-light chain phosphorylation was studied at 23 degrees C in the mouse extensor digitorum longus muscle. The length-tension relationship was determined for the same muscles after a 30 min period of quiescence and be...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Moore RL,Persechini A

    更新日期:1990-05-01 00:00:00

  • Comparison of intracellular and extracellular mitogenic activity.

    abstract::Endothelial cell-derived growth factor (ECDGF) is a soluble mitogen secreted in vitro by bovine aortic endothelium. ECDGF is a mixture of at least two distinct heat-stable and trypsin-sensitive mitogens. Large amounts of mitogenic activity were found in lysates prepared from cultured endothelial cells. Other nonmitoge...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Gajdusek CM,Schwartz SM

    更新日期:1984-11-01 00:00:00

  • Mechanisms controlling neurite outgrowth in a pheochromocytoma cell line: the role of TRPC channels.

    abstract::Transient Receptor Potential Canonical (TRPC) channels are implicated in modulating neurite outgrowth. The expression pattern of TRPCs changes significantly during brain development, suggesting that fine-tuning TRPC expression may be important for orchestrating neuritogenesis. To study how alterations in the TRPC expr...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Kumar S,Chakraborty S,Barbosa C,Brustovetsky T,Brustovetsky N,Obukhov AG

    更新日期:2012-04-01 00:00:00