Abstract:
:Lung diseases are major cause of morbidity and mortality worldwide. The progress in regenerative medicine and stem cell research in the lung are currently a fast-growing research topic that can provide solutions to these major health problems. Under normal conditions, the rate of cellular proliferation is relatively low in the lung in vivo, compared to other major organ systems. Lung injury leads to the activation of stem/progenitor cell populations that re-enter the cell cycle. Yet, little is known about stem cells in the lung, despite common thoughts that these cells could play a critical role in the repair of lung injuries. Nor do we fully understand the cellular and architectural complexity of the respiratory tract, and the diverse stem/progenitor cells that are involved in the lung repair and regeneration. In this review, we discuss the conceptual framework of lung stem/progenitor cell biology, and describe lung diseases, in which stem cell manipulations may be physiologically significant. In addition, we highlight the challenges of lung stem cell-based therapy.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Zhu Y,Chen X,Yang X,El-Hashash Adoi
10.1002/jcp.26414subject
Has Abstractpub_date
2018-10-01 00:00:00pages
6414-6424issue
10eissn
0021-9541issn
1097-4652journal_volume
233pub_type
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