Septin 7 is a centrosomal protein that ensures S phase entry and microtubule nucleation by maintaining the abundance of p150glued.


:Septins play important roles in regulating development and differentiation. Septin 7 (SEPT7) is a crucial component in orchestrating the septin core complex into highly ordered filamentous structures. Here, we showed that genetic depletion of SEPT7 or treatment with forchlorfenuron (FCF; a compound known to affect septin filament assembly) led to reduced the S phase entry in cell models and zebrafish embryos. In addition to colocalizing with actin filaments, SEPT7 resided in the centrosome, and SEPT7 depletion led to aberrant mitotic spindle pole formation. This mitotic defect was rescued in SEPT7-deficient cells by wild-type SEPT7, suggesting that SEPT7 maintained mitotic spindle poles. In addition, we observed disorganized microtubule nucleation and reduced cell migration with SEPT7 depletion. Furthermore, SEPT7 formed a complex with and maintained the abundance of p150glued , the component of centriole subdistal appendages. Depletion of p150glued resulted in a phenotype reminiscent of SEPT7-deficient cells, and overexpression of p150glued reversed the defective phenotypes. Thus, SEPT7 is a centrosomal protein that maintains proper cell proliferation and microtubule array formation via maintaining the abundance of p150glued .


J Cell Physiol


Chen TY,Lin TC,Kuo PL,Chen ZR,Cheng HL,Chao YY,Syu JS,Lu FI,Wang CY




Has Abstract


2020-09-01 00:00:00






  • Adipose-derived stem cells decreased microglia activation and protected dopaminergic loss in rat lipopolysaccharide model.

    abstract::Adult stem cell therapy is being used extensively to rejuvenate damaged tissue. One important tissue source to obtain these cells is adipose, which contains cells called adipose-derived stem cells (ADSCs). These cells have a great therapeutic potential not only for their multipotent properties as well as for immunomod...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Muñoz MF,Argüelles S,Medina R,Cano M,Ayala A

    更新日期:2019-08-01 00:00:00

  • The calcineurin-nuclear factor of activated T cells signaling pathway mediates the effect of corticotropin releasing factor and urocortins on catecholamine synthesis.

    abstract::The biological effects of the Corticotropin-releasing factor (CRF) family of neuropeptides are mediated by mobilization of [Ca(2+)]. Aim of the current work was to examine if the calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway is involved in the effect of CRF peptides in catecholamine synthesi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Dermitzaki E,Tsatsanis C,Gravanis A,Margioris AN

    更新日期:2012-05-01 00:00:00

  • MicroRNA-1271 functions as a potential tumor suppressor in hepatitis B virus-associated hepatocellular carcinoma through the AMPK signaling pathway by binding to CCNA1.

    abstract::Hepatocellular carcinoma (HCC) is mainly associated with hepatitis B virus (HBV) infection and characterized by metastasizing and infiltrating adjacent and distant tissues. Notably, microRNA-1271 (miR-1271) is a tumor suppressor in various cancers. Therefore, we evaluate the ability of miR-1271 to influence cell proli...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Chen Y,Zhao ZX,Huang F,Yuan XW,Deng L,Tang D

    更新日期:2019-04-01 00:00:00

  • Evidence suggesting a stimulatory role for interleukin-10 in erythropoiesis in vitro.

    abstract::Interleukin-10 (IL-10) has been shown to exert anti-inflammatory effects by suppressing macrophage proliferation and inhibiting cytokine production. In this study we show that in the presence of erythropoietin (EPO), the addition of IL-10 results in a significant dose-dependent increase in both Burst Forming Unit-Eryt...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Wang CQ,Udupa KB,Lipschitz DA

    更新日期:1996-02-01 00:00:00

  • Synthesis of glycolytic and peroxisomal enzymes in Tetrahymena following a change in culture conditions.

    abstract::The specific activity of a peroxisomal enzyme, lactate oxidase, and of pyruvate kinase and lactate dehydrogenase, which are not peroxisomal, increased rapidly when shaken cultures of Tetrahymena were transferred to conditions of oxygen restriction and supplemented with glucose. Two other peroxisomal enzymes, catalase ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Levy MR

    更新日期:1975-02-01 00:00:00

  • PACAP and PAC1R are differentially expressed in motor cortex of amyotrophic lateral sclerosis patients and support survival of iPSC-derived motor neurons.

    abstract::Amyotrophic lateral sclerosis (ALS) is a fatal and disabling neurodegenerative disease characterized by upper and lower motor neurons depletion. In our previous work, comprehensive genomic profiling of 41 motor cortex samples enabled to discriminate controls from sporadic ALS patients, and segregated these latter into...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Bonaventura G,Iemmolo R,D'Amico AG,La Cognata V,Costanzo E,Zappia M,D'Agata V,Conforti FL,Aronica E,Cavallaro S

    更新日期:2018-04-01 00:00:00

  • Parathyroid hormone-related protein (107-139) increases human osteoblastic cell survival by activation of vascular endothelial growth factor receptor-2.

    abstract::Parathyroid hormone-related protein (PTHrP) (107-139), in contrast to the N-terminal fragment PTHrP (1-36), has been shown to interact with the vascular endothelial growth factor (VEGF) system to modulate human osteoblast differentiation. In this study, we evaluated whether this interaction might affect human osteobla...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Alonso V,de Gortázar AR,Ardura JA,Andrade-Zapata I,Alvarez-Arroyo MV,Esbrit P

    更新日期:2008-12-01 00:00:00

  • Insulin stimulus-secretion coupling is triggered by a novel thiazolidinedione/sulfonylurea hybrid in rat pancreatic islets.

    abstract::New compounds with promising antidiabetic activity were synthesized. For the first time, a portion of the glibenclamide molecule was bound to a part of the core structure of thiazolidinedione to evaluate insulin secretagogue activity. Following studies in our laboratory, 4-{2-[2-(3,4-dichlorophenyl)-4-oxo-1,3-thiazoli...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Mendes CP,Postal BG,Oliveira GTC,Castro AJG,Frederico MJS,Moraes ALL,Neuenfeldt PD,Nunes RJ,Menegaz D,Silva FRMB

    更新日期:2018-01-01 00:00:00

  • Lactoferrin binding sites and nuclear localization in K562(S) cells.

    abstract::Lactoferrin, a single chain cationic glycoprotein, present in the secondary granules of neutrophils, acts as a negative feedback regulator of myelopoiesis. Specific receptors for lactoferrin were detected on the surface of different hematopoietic cell types. The influence of lactoferrin on cell growth in culture has b...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Garré C,Bianchi-Scarrá G,Sirito M,Musso M,Ravazzolo R

    更新日期:1992-12-01 00:00:00

  • Expression of asparagine independence in variants of ICR 2A haploid frog cells.

    abstract::Properties of the change from asparagine dependence (asn-) to independence (asn+) were investigated in the androgenetic haploid frog cell line ICR 2A. Two types of asn+ variants arose spontaneously during culture. Glutamine-dependent asparagine synthetase (AS) activity, found to be deficient in asn- cells, was repress...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Hepfer CE,Little WA,Hengst JA,Freed JJ

    更新日期:1989-04-01 00:00:00

  • Biological roles of glial fibrillary acidic protein as a biomarker in cartilage regenerative medicine.

    abstract::Glial fibrillary acidic protein (GFAP) is an intermediate filament that is expressed in specifically expressed auricular chondrocytes, which are good cell sources of cartilage regenerative medicine. Although our group uses GFAP as a biomarker of matrix production in the cultured auricular chondrocytes, the biological ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Kanazawa S,Nishizawa S,Takato T,Hoshi K

    更新日期:2017-11-01 00:00:00

  • Versatile role of curcumin and its derivatives in lung cancer therapy.

    abstract::Lung cancer is a main cause of death all over the world with a high incidence rate. Metastasis into neighboring and distant tissues as well as resistance of cancer cells to chemotherapy demand novel strategies in lung cancer therapy. Curcumin is a naturally occurring nutraceutical compound derived from Curcuma longa (...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Ashrafizadeh M,Najafi M,Makvandi P,Zarrabi A,Farkhondeh T,Samarghandian S

    更新日期:2020-12-01 00:00:00

  • The non-genomic effects on Na+/H+-exchange 1 by progesterone and 20alpha-hydroxyprogesterone in human T cells.

    abstract::Progesterone is an endogenous immunomodulator and can suppress T-cell activation during pregnancy. We have previously shown that the non-genomic effects of progesterone, especially acidification, are exerted via plasma membrane sites and suppress cellular genomic responses to mitogens. This study aimed to show that ac...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Chien EJ,Liao CF,Chang CP,Pu HF,Lu LM,Shie MC,Hsieh DJ,Hsu MT

    更新日期:2007-05-01 00:00:00

  • Long acting cAMP analogues enhance sulfate incorporation into matrix proteoglycans and suppress cell division of fetal rat chondrocytes in monolayer culture.

    abstract::The relationship between replication and the synthesis of matrix sulfated proteoglycans was investigated with fetal rat chondrocytes grown in monolayer culture. The effect of N6 O2' dibutyryl adenosine 3', 5' cyclic monophosphate (DBcAMP), adenosine 3', 5' cyclic monophosphate (cAMP), 8 Bromo adenosine 3', 5' cyclic m...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Miller RP,Husain M,Lohin S

    更新日期:1979-07-01 00:00:00

  • LINC00520 targeting miR-27b-3p regulates OSMR expression level to promote acute kidney injury development through the PI3K/AKT signaling pathway.

    abstract:BACKGROUND:Acute kidney injury (AKI) shows several kinds of disorders, which acutely harm the kidney. However, the current medical methods have limited therapeutic effects. The present study aimed to find out the molecular mechanism of AKI pathogenesis, which may provide new insights for future therapy. METHODS:Bioinf...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Tian X,Ji Y,Liang Y,Zhang J,Guan L,Wang C

    更新日期:2019-08-01 00:00:00

  • Signal transducer and activator of transcription 3 mediates apoptosis inhibition through reducing mitochondrial ROS and activating Bcl-2 in gemcitabine-resistant lung cancer A549 cells.

    abstract::Lung cancer is a leading cause of cancer-related death worldwide. In this study, we used lung adenocarcinoma cells as a model, as lung adenocarcinoma has the highest mortality rate among all lung cancers. For the past few years, medical treatments or lung cancer have been limited because of chemotherapy resistance. Th...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Liu JS,Yeh CA,Huang IC,Huang GY,Chiu CH,Mahalakshmi B,Wen SY,Huang CY,Kuo WW

    更新日期:2020-12-07 00:00:00

  • Galectin-3 deficiency protects pancreatic islet cells from cytokine-triggered apoptosis in vitro.

    abstract::Beta cell apoptosis is a hallmark of diabetes. Since we have previously shown that galectin-3 deficient (LGALS3(-/-) ) mice are relatively resistant to diabetes induction, the aim of this study was to examine whether beta cell apoptosis depends on the presence of galectin-3 and to delineate the underlying mechanism. D...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Saksida T,Nikolic I,Vujicic M,Nilsson UJ,Leffler H,Lukic ML,Stojanovic I,Stosic-Grujicic S

    更新日期:2013-07-01 00:00:00

  • Additional MDA-MB-231 breast cancer cell matrix metalloproteinases promote invasiveness.

    abstract::We are interested in two aspects of a given type of metastatic breast cancer: which potentially cancer-relevant genes are expressed and which factors determine invasiveness. Using reverse transcription real-time PCR, we detected gene expression of 26 matrix metalloproteinases (MMPs) in MDA-MB-231 breast cancer cells, ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Hegedüs L,Cho H,Xie X,Eliceiri GL

    更新日期:2008-08-01 00:00:00

  • Inhibition of growth and sensitization to cisplatin-mediated killing of ovarian cancer cells by polyphenolic chemopreventive agents.

    abstract::The polyphenolic compounds curcumin and quercetin increased sensitivity of ovarian cancer cells (CAOV3 and SKOV3) to cisplatin. The effect was obtained when the compounds were added simultaneously with cisplatin, as well as when they were added 24 h before. High serum levels of certain cytokines, for example interleuk...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Chan MM,Fong D,Soprano KJ,Holmes WF,Heverling H

    更新日期:2003-01-01 00:00:00

  • Tenascin-C induction by the diffusible factor epidermal growth factor in stromal-epithelial interactions.

    abstract::Tenascin-C, a six-armed extracellular matrix glycoprotein, is expressed in a temporally and spatially restricted pattern during carcinogenesis and invasion or metastasis of carcinoma cells in association with stromal-epithelial interactions. The human epidermoid carcinoma-derived cell lines, A431 and HEp-2, which do n...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Sakai T,Ohta M,Furukawa Y,Saga Y,Aizawa S,Kawakatsu H,Saito M

    更新日期:1995-10-01 00:00:00

  • Identification of a functional estrogen-responsive enhancer element in the promoter 2 of PRDM2 gene in breast cancer cell lines.

    abstract::The retinoblastoma protein-interacting zinc-finger (RIZ) gene, also known as PRDM2, encodes two protein products, RIZ1 and RIZ2, differing for the presence of a 202 aa domain, called PR domain, at the N-terminus of the RIZ1 molecule. While the histone H3 K9 methyltransferase activity of RIZ1 is associated with the neg...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Abbondanza C,De Rosa C,D'Arcangelo A,Pacifico M,Spizuoco C,Piluso G,Di Zazzo E,Gazzerro P,Medici N,Moncharmont B,Puca GA

    更新日期:2012-03-01 00:00:00

  • Ameliorative potential of resveratrol on proinflammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic beta-cell dysfunction in streptozotocin-nicotinamide-induced diabetic rats.

    abstract::Chronic exposure of pancreatic beta-cells to supraphysiologic glucose causes adverse beta-cell dysfunction. Thus, the present study was aimed to investigate the hypothesis that oral administration of resveratrol attenuates hyperglycemia, proinflammatory cytokines and antioxidant competence and protects beta-cell ultra...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Palsamy P,Subramanian S

    更新日期:2010-08-01 00:00:00

  • Lipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion.

    abstract::The profiles of actions of lipoxin A4 (LXA4) and lipoxin B4 (LXB4), two lipoxygenase-derived eicosanoids, were examined with human neutrophils. At nanomolar concentrations, LXA4 and LXB4 each stimulated the release of [1-14C]arachidonic acid from esterified sources in neutrophils. Lipoxin-induced release of [1-14C]ara...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Nigam S,Fiore S,Luscinskas FW,Serhan CN

    更新日期:1990-06-01 00:00:00

  • Cannabinoid receptor 1 mediates palmitic acid-induced apoptosis via endoplasmic reticulum stress in human renal proximal tubular cells.

    abstract::The endocannabinoid system (ECS) is activated at the onset of obesity and diverse metabolic diseases. Endocannabinoids mediate their physiological and behavioral effects by activating specific cannabinoid receptors, mainly cannabinoid receptor 1 (CB(1)R). Diabetic nephropathy (DN) is induced by hyperlipidemia, and ren...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Lim JC,Lim SK,Han HJ,Park SH

    更新日期:2010-11-01 00:00:00

  • Effect of hypoxia upon intracellular calcium concentration of human endothelial cells.

    abstract::Ischemia is a situation occurring in several diseases including myocardial infarction and organ transplantation in which oxygenated blood supply is impaired. Ischemia leads to many cellular and tissue modifications, the most important one being cell death. Several explanations have been proposed to account for these m...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Arnould T,Michiels C,Alexandre I,Remacle J

    更新日期:1992-07-01 00:00:00

  • Agonist-induced calcium entry correlates with STIM1 translocation.

    abstract::The mechanisms of agonist-induced calcium entry (ACE) following depletion of intracellular calcium stores have not been fully established. We report here that calcium-independent phospholipase A (iPLA(2)) is required for robust Ca(2+) entry in HaCaT keratinocytes following ATP or UTP stimulation. Lysophosphatidic acid...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Ross K,Whitaker M,Reynolds NJ

    更新日期:2007-06-01 00:00:00

  • sp2 -Iminosugar α-glucosidase inhibitor 1-C-octyl-2-oxa-3-oxocastanospermine specifically affected breast cancer cell migration through Stim1, β1-integrin, and FAK signaling pathways.

    abstract::Aberrant glycosylation changes on many glycoproteins are often related to cancer progression and metastasis. sp2 -Iminosugar-type castanospermine analogues, inhibitors of α-glucosidases, have been reported to exhibit antitumor activity. However, their effects on cell migration and the underlying molecular mechanism ar...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Gueder N,Allan G,Telliez MS,Hague F,Fernandez JM,Sanchez-Fernandez EM,Ortiz-Mellet C,Ahidouch A,Ouadid-Ahidouch H

    更新日期:2017-12-01 00:00:00

  • Differential calreticulin expression affects focal contacts via the calmodulin/CaMK II pathway.

    abstract::Calreticulin is an ER calcium-storage protein, which influences gene expression and cell adhesion. In this study, we analysed the differences in adhesive properties of calreticulin under- and overexpressing fibroblasts in relation to the calmodulin- and calcium/calmodulin-dependent kinase II (CaMK II)-dependent signal...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Szabo E,Papp S,Opas M

    更新日期:2007-10-01 00:00:00

  • MAPK pathway activation and the origins of pediatric low-grade astrocytomas.

    abstract::Low-grade astrocytomas (LGAs) are the most common type of brain tumor in children. Until recently, very little was known about the underlying biology and molecular genetics of these tumors. However, within the past year a number of studies have shown that the MAPK pathway is constitutively activated in a high proporti...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Tatevossian RG,Lawson AR,Forshew T,Hindley GF,Ellison DW,Sheer D

    更新日期:2010-03-01 00:00:00

  • Gicerin/CD146 is involved in neurite extension of NGF-treated PC12 cells.

    abstract::Gicerin/CD146 is a cell adhesion molecule, which belongs to the immunoglobulin (Ig) superfamily. We have reported that it has a homophilic binding activity, which participates in the neurite extension from embryonic neurons. To elucidate how gicerin is involved in the neurite extension mechanism, we employed PC12 cell...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Taira E,Kohama K,Tsukamoto Y,Okumura S,Miki N

    更新日期:2005-08-01 00:00:00