Modulation of the G0 to S phase transit time by insulin: potential involvement of protein phosphorylation.

abstract：:We have investigated the characteristics of a transport system in HeLa cells, which turned out to be very similar to a previously described Na+, K+, 2Cl- -cotransport system. For further understanding about the physiological role of the cotransporter, we have mutagenized HeLa cells and selected progeny cells for growt...

journal_title：Journal of cellular physiology

authors： Kort JJ,Koch G

更新日期：1989-10-01 00:00:00

abstract：:Adipogenesis, a physiological process initiated with the committed preadipocytes expressing adipocyte-specific genes and terminated in mature, differentiated and functional adipocytes, mainly involved with energy homeostasis. Abnormal distribution-changes and dysfunctions in adipogenesis may lead to complex physiopath...

journal_title：Journal of cellular physiology

authors： Yi X,Wu P,Liu J,Gong Y,Xu X,Li W

更新日期：2019-11-01 00:00:00

abstract：:The intracellular Ca2+ content of nontransformed Balb/c3T3 cells is two to three times higher than that of a spontaneously transformed derivative. Depriving either cell type of extracellular Mg2+ causes a 2- to 3-fold increase in their Ca2+ content over a 24-hr period. Restoring Mg2+ to the medium decreases the Ca2+ c...

journal_title：Journal of cellular physiology

authors： Vidair C,Rubin H

更新日期：1982-12-01 00:00:00

abstract：:The involvement of Ras-GTPases in the development of renal fibrosis has been addressed in the last decade. We have previously shown that H- and N-Ras isoforms participate in the regulation of fibrosis. Herein, we assessed the role of K-Ras in cellular processes involved in the development of fibrosis: proliferation, m...

journal_title：Journal of cellular physiology

authors： Muñoz-Félix JM,Fuentes-Calvo I,Cuesta C,Eleno N,Crespo P,López-Novoa JM,Martínez-Salgado C

更新日期：2016-10-01 00:00:00

abstract：:Five-week-old female mice supplemented with estradiol and progesterone are able to respond to epidermal growth factor (EGF) and EGF-like growth factors (alpha-transforming growth factor [alpha-TGF] and crude mammary-derived growth factor) with local lobuloalveolar development when these growth factors are directly int...

journal_title：Journal of cellular physiology

authors： Vonderhaar BK

更新日期：1987-09-01 00:00:00

abstract：:Activation of the epidermal growth factor receptor (EGFR) contributes to the pathogenesis of non-small-cell lung carcinomas (NSCLC) and gefitinib, a selective reversible EGFR inhibitor, is effective in treating patients with NSCLC. However, clinical resistance to gefitinib is a frequent occurrence highlighting the nee...

journal_title：Journal of cellular physiology

authors： Emdad L,Lebedeva IV,Su ZZ,Gupta P,Sarkar D,Settleman J,Fisher PB

更新日期：2007-02-01 00:00:00

abstract：:The p53 protein directly regulates the expression of the WAF1 (wild-type p53-activated fragment 1) protein which is a cyclin-dependent kinase inhibitor (CDK1). DNA damaging agents such as ionizing or UV radiation, and some chemical agents induce WAF1 in wild-type p53 containing cells, thereby halting cell cycle progre...

journal_title：Journal of cellular physiology

authors： Shiohara M,Akashi M,Gombart AF,Yang R,Koeffler HP

更新日期：1996-03-01 00:00:00

abstract：:Breast cancer (BC) is the most prevalent malignant cancer in the world, is the leading cause of cancer-related death female. Recently, there is accumulating evidence that long noncoding RNAs (lncRNAs) might as an important role in the progression of BC. (epithelial-mesenchymal transition (EMT) is considered to play a ...

journal_title：Journal of cellular physiology

authors： Wang YY,Yan L,Yang S,Xu HN,Chen TT,Dong ZY,Chen SL,Wang WR,Yang QL,Chen CJ

更新日期：2019-12-01 00:00:00

abstract：:Migration and proliferation of smooth muscle cells (SMCs) are key events during neointimal formation in pathological conditions of vessels. Tenascin-C (TNC) is upregulated in the developing neointima of lesions. We evaluated the effects of TNC on responses of SMCs against platelet-derived growth factor (PDGF) stimulat...

journal_title：Journal of cellular physiology

authors： Ishigaki T,Imanaka-Yoshida K,Shimojo N,Matsushima S,Taki W,Yoshida T

更新日期：2011-10-01 00:00:00

abstract：:Vero (African green monkey kidney) cells grown in tissue culture monolayer were sensitive to Clostridium perfringens enterotoxin. Within 30 minutes of exposure to the enterotoxin gross morphological damage was observed and within 40 minutes approximately 75% of the cells had detached. Nearly half of the cells were non...

journal_title：Journal of cellular physiology

authors： McClane BA,McDonel JL

更新日期：1979-05-01 00:00:00

abstract：:During embryonic and early postnatal development, the chick leg muscle cells undergo a series of changes in their electrical responses in the following sequence: passive response, plateau response, plateau plus spike response and spike response. This suggests that the electrogenetic mechanism of muscles matures during...

journal_title：Journal of cellular physiology

authors： Kano M

更新日期：1975-12-01 00:00:00

abstract：:Activation of T-lymphocytes by antigen, mitogenic lectins, or antibodies against the T-cell receptor complex, particularly in the presence of IL1, induces the secretion of the T-cell growth factor IL2. IL2 then has a major role in regulating the duration and magnitude of the immune response. Interaction of antigen, an...

journal_title：Journal of cellular physiology

authors： Mills GB,May C,Hill M,Gelfand EW

更新日期：1989-11-01 00:00:00

abstract：:The non-POU-domain-containing octamer binding protein (NONO; also known as p54nrb) has various nuclear functions ranging from transcription, RNA splicing, DNA synthesis and repair. Although tyrosine phosphorylation has been proposed to account for the multi-functional properties of p54nrb, direct evidence on p54nrb as...

journal_title：Journal of cellular physiology

authors： Lee AR,Hung W,Xie N,Liu L,He L,Dong X

更新日期：2017-04-01 00:00:00

abstract：:Lipocalin-2 (Lcn2; also termed neutrophil gelatinase-associated lipocalin (NGAL)) levels correlate positively with heart failure (HF) yet mechanisms via which Lcn2 contributes to the pathogenesis of HF remain unclear. In this study, we used coronary artery ligation surgery to induce ischemia in wild-type (wt) mice and...

journal_title：Journal of cellular physiology

authors： Sung HK,Chan YK,Han M,Jahng JWS,Song E,Danielson E,Berger T,Mak TW,Sweeney G

更新日期：2017-08-01 00:00:00

abstract：:Using the Madin Darby canine kidney (MDCK) cell "calcium switch," we have previously demonstrated that, as MDCK cells establish contact and ultimately form tight junctions, there are marked global and localized changes in intracellular calcium at the sites of cell-cell contact (Nigam et al., 1992, Proc. Natl. Acad. Sc...

journal_title：Journal of cellular physiology

authors： Stuart RO,Sun A,Panichas M,Hebert SC,Brenner BM,Nigam SK

更新日期：1994-06-01 00:00:00

abstract：:The biological activities of crocin, one of the main bioactive compounds of saffron, include anti-inflammatory, antioxidant, antidepressant, and anticancer effects. Crocin has been shown to trigger the apoptosis of gastric cancer cells, but its effect on the metastasis of gastric cancer cells remains unclear. Krüppel-...

journal_title：Journal of cellular physiology

authors： Zhou Y,Xu Q,Shang J,Lu L,Chen G

更新日期：2019-08-01 00:00:00

abstract：:The role of microtubules in mitogen-induced human lymphocyte activation and proliferation was examined. The effect of colchicine, a microtubule-disrupting agent, was compared with taxol, a microtubule-stabilizing drug, and with isaxonine (N-isopropyl-amino-2-pyrimidine orthophosphate), a proposed microtubular-active d...

journal_title：Journal of cellular physiology

authors： Cuthbert JA,Shay JW

更新日期：1983-08-01 00:00:00

abstract：:Incubation of alveolar macrophages or hepatocytes in media in which Na+ is replaced by K+ ("isotonic-K buffer") inhibited the movement of internalized ligand from late endosomes to lysosomes (Ward et al.: Journal of Cell Biology 110:1013-1022, 1990). In this study we investigate the mechanism responsible for the isoto...

journal_title：Journal of cellular physiology

authors： Ward DM,Hackenyos DP,Davis-Kaplan S,Kaplan J

更新日期：1990-12-01 00:00:00

abstract：:The cell surface phenotype of pluripotent hemopoietic stem cells (CFU-S) and committed progenitors (CFU-C1, CFU-C2, BFU-E) of mouse bone marrow was analyzed with respect to their binding of wheat germ agglutinin (WGA) and two monoclonal antibodies, anti-GM-1.2 and anti-PGP-1. Stained cells were fractionated on the bas...

journal_title：Journal of cellular physiology

authors： Bauman JG,Wagemaker G,Visser JW

更新日期：1986-07-01 00:00:00

abstract：:Hyperthermia is a clinical sign of inflammation and constitutes in itself an adaptive defense mechanism. The fibrinolytic system, a highly regulated proteolytic system, is involved in inflammatory processes. Plasminogen activator inhibitor 1 (PAI-1) is the principal inhibitor of the two activators of the fibrinolytic ...

journal_title：Journal of cellular physiology

authors： Bergonzelli GE,Kruithof EK

更新日期：1991-08-01 00:00:00

abstract：:The knowledge of transforming growth factor (TGF)-beta receptors has greatly progressed in the recent years. TGF-beta receptors type I and II have been implicated in the modulation of cell proliferation, whereas type III (betaglycan) may act as a component presenting TGF-beta to its signaling receptors. In addition, f...

journal_title：Journal of cellular physiology

authors： Vivien D,Petitfrère E,Martiny L,Sartelet H,Galéra P,Haye B,Pujol JP

更新日期：1993-06-01 00:00:00

abstract：:Wound healing is a complex but a fine-tuned biological process in which human skin has the ability to regenerate itself following damage. However, in particular conditions such as deep burn or diabetes the process of wound healing is compromised. Despite investigations on the potency of a wide variety of stem cells fo...

journal_title：Journal of cellular physiology

authors： Hassanshahi A,Hassanshahi M,Khabbazi S,Hosseini-Khah Z,Peymanfar Y,Ghalamkari S,Su YW,Xian CJ

更新日期：2019-06-01 00:00:00

abstract：:Endothelin (ET)-1 was originally characterized as a potent vasoconstrictor peptide secreted by vascular endothelial cells. It possesses a wide range of biological activities within the cardiovascular system and in other organs, including the brain. Also secreted by endothelial cells, nitric oxide (NO), has recently be...

journal_title：Journal of cellular physiology

authors： Durieu-Trautmann O,Fédérici C,Créminon C,Foignant-Chaverot N,Roux F,Claire M,Strosberg AD,Couraud PO

更新日期：1993-04-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) in the tumor microenvironment play major roles in supporting cancer progression. A previous report showed that SPIN90 downregulation is correlated with CAF activation and that SPIN90-deficient CAFs promote breast cancer progression. However, the mechanisms that mediate cancer-strom...

journal_title：Journal of cellular physiology

authors： Kwon A,Chae IH,You E,Kim SH,Ahn SY,Lee OJ,Park ZY,Rhee S,Huh YH,Song WK

更新日期：2020-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a newly identified class of small regulatory non-coding endogenous RNAs that are ubiquitous from animals to plants and have pivotal functions in nearly all biological and metabolic processes. Increasing evidence shows that miRNAs are also new players regulating many protein-coding genes and spec...

journal_title：Journal of cellular physiology

authors： Chen D,Farwell MA,Zhang B

更新日期：2010-11-01 00:00:00

abstract：:MiR-137 has been identified as potential hepatocellular carcinoma (HCC) prognostic biomarkers. Highly relevant HCC prognostic biomarkers may be derived from combinations of miR-137 with its target genes involved in the regulation of liver microenvironment. This study aimed at the discovery of such a combination with i...

journal_title：Journal of cellular physiology

authors： Wei Q,Zhao L,Jiang L,Bi J,Yu Z,Zhao L,Song X,Sun M,Chen Y,Wei M

更新日期：2019-07-01 00:00:00

abstract：:Despite the improvements in fracture healing, about 10% of patients undergo abnormal healing. As a tumor suppressor, upregulation of microRNA (miR)-203 has been observed in osteogenic differentiation. Herein, we aimed to explore the functional role of miR-203 in osteoblasts as well as the underlying mechanisms. The ex...

journal_title：Journal of cellular physiology

authors： Liu H,Chen B,Li Y

更新日期：2019-08-01 00:00:00

abstract：:Phosphoribosylpyrophosphate synthetase activity was determined in Friend virus-inducted erythroleukemic cells in culture, stimulated to differentiate in the presence of dimethylsulfoxide. The activity of phosphoribosylpyrophosphate synthetase did not decrease in cells which had acquired the specialized function of hem...

journal_title：Journal of cellular physiology

authors： Reem GH,Friend C

更新日期：1976-06-01 00:00:00

abstract：:The unique vascular supply of the retina, the ability to visualize the vasculature in vivo, and the ability to selectively express genes in the retina make the retina an ideal model system to study molecular mechanisms of angiogenesis. In addition, this area of investigation has great clinical significance, because re...

journal_title：Journal of cellular physiology

authors： Campochiaro PA

更新日期：2000-09-01 00:00:00

abstract：:Cell hybrids were formed between human diploid fibroblasts (HDF) and carcinogen-transformed HDF to determine the relationship among: (1) finite proliferative lifespan, which we define as an age-related failure of a population to achieve one population doubling in 4 weeks; (2) arrest in a senescent state, which we defi...

journal_title：Journal of cellular physiology

authors： Stein GH,Namba M,Corsaro CM

更新日期：1985-03-01 00:00:00