Development of excitability in embryonic chick skeletal muscle cells.


:During embryonic and early postnatal development, the chick leg muscle cells undergo a series of changes in their electrical responses in the following sequence: passive response, plateau response, plateau plus spike response and spike response. This suggests that the electrogenetic mechanism of muscles matures during development; a mechanism producing the plateau may first be induced, and then that producing the spike. The plateau is sensitive to manganese or cobalt ions, while the spike to tetrodotoxin. This suggests that the plateau is related to the increase in permeability to calcium ions, while the spike to sodium ions.


J Cell Physiol


Kano M





Has Abstract


1975-12-01 00:00:00




3 Pt 1








  • A molecular mechanism of regulation for granulocyte macrophage colony stimulating factor from T lymphocytes.

    abstract::We have partially purified a mitogenic factor, termed colony stimulating factor, which is secreted from a human T lymphocytic cell line, and which stimulates in vitro formation of colonies of macrophages and granulocytes by human bone marrow cells. Colony stimulating factor (CSF) produced by cells grown in serum suppl...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Frölich M

    更新日期:1981-12-01 00:00:00

  • TNF-alpha in vivo stimulates apoptosis in fibroblasts through caspase-8 activation and modulates the expression of pro-apoptotic genes.

    abstract::Apoptosis of matrix producing cells is common among many inflammatory diseases. The goal of the present study was to examine the apoptotic effects of tumor necrosis factor-alpha (TNF-alpha) on fibroblastic cells in vivo and to investigate the role of different caspases in this process. This was accomplished in vivo by...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Alikhani M,Alikhani Z,Raptis M,Graves DT

    更新日期:2004-12-01 00:00:00

  • Release of potassium, lipids, and proteins from nonionic detergent treated chicken red blood cells.

    abstract::The plasma membrane of erythrocytes, as of other cells, is thought to act as the barrier responsible for maintaining intracellular gradients of most ions and small molecular species between the cell and its environment. Controlled application of the nonionic detergent Brij 58 effectively opened the erythrocyte plasma ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Kellermayer M,Ludány A,Miseta A,Kŏszegi T,Berta G,Bogner P,Hazlewood CF,Cameron IL,Wheatley DN

    更新日期:1994-05-01 00:00:00

  • Direct conversion of somatic cells towards oligodendroglial lineage cells: A novel strategy for enhancement of myelin repair.

    abstract::Oligodendrocyte precursor cells (OPCs) are considered as the main cell source for myelination in the central nervous system. Following demyelination, proliferation, migration, and differentiation capability of endogenous OPCs remarkably increase leading to remyelination in damaged areas. Despite the beneficial impacts...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Yavarpour-Bali H,Nakhaei-Nejad M,Yazdi A,Ghasemi-Kasman M

    更新日期:2020-03-01 00:00:00

  • ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes.

    abstract::The epithelium-specific ETS (ESE)-1 transcription factor is induced in chondrocytes by interleukin-1beta (IL-1beta). We reported previously that early activation of EGR-1 by IL-1beta results in suppression of the proximal COL2A1 promoter activity by displacement of Sp1 from GC boxes. Here we report that ESE-1 is a pot...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Peng H,Tan L,Osaki M,Zhan Y,Ijiri K,Tsuchimochi K,Otero M,Wang H,Choy BK,Grall FT,Gu X,Libermann TA,Oettgen P,Goldring MB

    更新日期:2008-05-01 00:00:00

  • Induction of Na+ channel voltage sensitivity in Xenopus oocytes depends on Ca2+ mobilization.

    abstract::An unusual inward current which is slowly elicited in the Xenopus oocyte membrane during sustained depolarization is reportedly carried by Na+. It is thought that Na+ selective channels are in some way induced to become voltage-sensitive by the depolarization. Earlier studies report that the induction process involves...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Charpentier G,Kado RT

    更新日期:1999-02-01 00:00:00

  • Animal- and human-based evidence for the protective effects of stem cell therapy against cardiovascular disorders.

    abstract::The increasing rate of mortality and morbidity because of cardiac diseases has called for efficient therapeutic needs. With the advancement in cell-based therapies, stem cells are abundantly studied in this area. Nearly, all sources of stem cells are experimented to treat cardiac injuries. Tissue engineering has also ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Pooria A,Pourya A,Gheini A

    更新日期:2019-02-27 00:00:00

  • Angiotensin type 1 receptor autoantibody from preeclamptic patients induces human fetoplacental vasoconstriction.

    abstract::Increased vascular resistance in the fetoplacental circulation is a characteristic of preeclampsia. However, the potential molecular mechanisms of this condition remain obscure. The current study aimed to determine the direct effect of the peptide antigen corresponding to the second extracellular loop of the angiotens...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Zhang S,Zheng R,Yang L,Zhang X,Zuo L,Yang X,Bai K,Song L,Tian J,Yang J,Liu H

    更新日期:2013-01-01 00:00:00

  • Modulation of the in vitro angiogenic potential of human mesenchymal stromal cells from different tissue sources.

    abstract::Mesenchymal stromal cells (MSCs) have been widely exploited for the treatment of several conditions due to their intrinsic regenerative and immunomodulatory properties. MSC have demonstrated to be particularly relevant for the treatment of ischemic diseases, where MSC-based therapies can stimulate angiogenesis and ind...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Pinto DS,Ahsan T,Serra J,Fernandes-Platzgummer A,Cabral JMS,da Silva CL

    更新日期:2020-10-01 00:00:00

  • Epithelioid and fibroblastic rat kidney cell clones: epidermal growth factor (EGF) receptors and the effect of mouse sarcoma virus transformation.

    abstract::Fibroblastic and epithelioid clones have been isolated from the normal rat kidney line, NRK. These clones were studied for their ability to bind epidermal growth factor (EGF), susceptibility to transformation by mouse sarcoma virus (MSV), and alteration in EGF binding upon sarcoma virus transformation. The epithelioid...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: de Larco JE,Todaro GJ

    更新日期:1978-03-01 00:00:00

  • Role of protein kinase C in interleukin 1, anti-T3, and mitogenic lectin-induced interleukin 2 secretion.

    abstract::Activation of T-lymphocytes by antigen, mitogenic lectins, or antibodies against the T-cell receptor complex, particularly in the presence of IL1, induces the secretion of the T-cell growth factor IL2. IL2 then has a major role in regulating the duration and magnitude of the immune response. Interaction of antigen, an...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Mills GB,May C,Hill M,Gelfand EW

    更新日期:1989-11-01 00:00:00

  • Tissue distribution of murine hemopoietic growth factor mRNA production.

    abstract::We have studied the tissue distribution of interleukin (IL) and hemopoietic colony-stimulating factor (CSF) transcripts in mice by S1-nuclease protection analysis. Accumulation of several of these mRNAs in response to intravenous injection of lipopolysaccharide (LPS) appears to occur in a tissue-specific fashion. IL-1...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Troutt AB,Lee F

    更新日期:1989-01-01 00:00:00

  • GP130/OSMR is the only LIF/IL-6 family receptor complex to promote osteoblast differentiation of calvaria progenitors.

    abstract::Leukemia inhibitory factor (LIF) and its receptor (LIFR) are "twins" of Oncostatin M (OSM) and OSMR, respectively, likely having arisen through gene duplications. We compared their effects in a bone nodule-forming model of in vitro osteogenesis, rat calvaria (RC) cell cultures. Using a dominant-negative LIF mutant (hL...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Malaval L,Liu F,Vernallis AB,Aubin JE

    更新日期:2005-08-01 00:00:00

  • Elevation of a potassium current in differentiating human leukemic (HL-60) cells.

    abstract::Human promyelocytic leukemia (HL-60) cells display a novel voltage-dependent outward current under voltage clamp. This current is present at low levels in the proliferative state and in granulocytes derived from HL-60 cells which were induced to differentiate with retinoic acid. It is elevated in macrophages derived f...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Wieland SJ,Chou RH,Chen TA

    更新日期:1987-08-01 00:00:00

  • Microarray expression profiles analysis revealed lncRNA OXCT1-AS1 promoted bladder cancer cell aggressiveness via miR-455-5p/JAK1 signaling.

    abstract::Bladder cancer (BCa) is one of the most prevalent cancers of the urinary system worldwide. Accumulating evidence suggests that long noncoding RNAs (lncRNAs) perform a vital function in the pathogenesis and progression of BCa. In the current study, we identified a novel lncRNA OXCT1-AS1 and investigated its role and po...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Chen JB,Zhu YW,Guo X,Yu C,Liu PH,Li C,Hu J,Li HH,Liu LF,Chen MF,Chen HQ,Xiong-Bing Z

    更新日期:2019-08-01 00:00:00

  • Effect of epidermal growth factor on rat pleural mesothelial cell growth.

    abstract::We recently reported that the growth of normal rat pleural mesothelial cells (RPMCs) is inhibited by conditioned media from either in vivo or in vitro transformed RPMCs. In this study we report that the growth of normal RPMCs is inhibited by epidermal growth factor (EGF). This was demonstrated by using three methods o...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Van der Meeren A,Levy F,Renier A,Katz A,Jaurand MC

    更新日期:1990-07-01 00:00:00

  • Degradation of insulin-like growth factor-I receptor occurs via ubiquitin-proteasome pathway in human lung cancer cells.

    abstract::Insulin-like growth factor-I receptor (IGF-IR) is often overexpressed in malignant tumors, and is involved in the establishment and maintenance of malignant phenotypes. Tyrosine kinase receptor endocytosis is commonly triggered by ligand binding and occurs via clathrin-coated vescicles that transfer the receptor to th...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Carelli S,Di Giulio AM,Paratore S,Bosari S,Gorio A

    更新日期:2006-08-01 00:00:00

  • Modulation of TGF-beta type 1 receptor: flow cytometric detection with biotinylated TGF-beta.

    abstract::Transforming growth factor beta type 1 (TGF-beta 1) was reacted with NHS-biotin to yield a derivative of TGF-beta 1 which was biotinylated on lysine residues. The biotinylated form of TGF-beta 1 was separated from the unreacted material by reverse phase chromatography. In three separate bioassays, the derivatized pept...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Newman W,Beall LD,Bertolini DR,Cone JL

    更新日期:1989-10-01 00:00:00

  • Relationship of heat labile glucose-6-phosphate dehydrogenase and multiple molecular forms of the enzyme in senescent human fibroblasts.

    abstract::Human fibroblasts derived from newborn foreskin and designated CF-3 were assayed for heat labile glucose-6-phosphate dehydrogenase (G6PD) when they had grown to confluency, as well as when they were arrested in an essentially nonmitotic state. Under both culture conditions there was an increase in heat labile G6PD (up...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Duncan MR,Dell'orco RT,Guthrie PL

    更新日期:1977-10-01 00:00:00

  • A promising structural magnetic resonance imaging assessment in patients with preclinical cognitive decline and diabetes mellitus.

    abstract::Subjective cognitive decline (SCD) is frequently reported in diabetic patients. Diabetes mellitus (DM) is associated with changes in the microstructure of the brain arise in diabetic patients, including changes in gray matter volume (GMV). However, the underlying mechanisms of changes in GMV in DM patients with cognit...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Dong Y,Wang Q,Yao H,Xiao Y,Wei J,Xie P,Hu J,Chen W,Tang Y,Zhou H,Liu J

    更新日期:2019-08-01 00:00:00

  • Model for the regulation of platelet volume and responsiveness by the trans-membrane Na+/K(+)-pump.

    abstract::The correspondence between K+ uptake in platelets to their responsiveness was studied using 86Rb+ as an analogue of K+. An average 86Rb+ uptake rate of 0.73 (+/- 0.140) x 10(-15) mole Rb+/min-plt (n = 20) was observed. By the use of K(+)-influx inhibitors, we were able to distinguish three distinct 86Rb+ uptake pathwa...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Marx G,Blankenfeld A,Panet R,Gorodetsky R

    更新日期:1992-05-01 00:00:00

  • Zinc chelator TPEN induces pancreatic cancer cell death through causing oxidative stress and inhibiting cell autophagy.

    abstract::The essential trace element zinc (Zn) is widely required in cellular functions, and abnormal Zn homeostasis causes a variety of health problems including immunodeficiency and sensory dysfunctions. Previous studies had shown that Zn availability was also important for tumor growth and progression. The aim of the presen...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Yu Z,Yu Z,Chen Z,Yang L,Ma M,Lu S,Wang C,Teng C,Nie Y

    更新日期:2019-11-01 00:00:00

  • Lysophosphatidic acid induces the crosstalk between the endovascular human trophoblast and endothelial cells in vitro.

    abstract::Spiral artery remodeling at the maternal-fetal interface is crucial for successful pregnancy and requires the interaction between the first trimester trophoblast and the endothelial cells of the maternal vessels. However, the precise mechanism of this dialog has yet to be determined. The current study investigated whe...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Beltrame JS,Scotti L,Sordelli MS,Cañumil VA,Franchi AM,Parborell F,Ribeiro ML

    更新日期:2019-05-01 00:00:00

  • MicroRNA implications in the etiopathogenesis of ankylosing spondylitis.

    abstract::Ankylosing spondylitis (AS) is a chronic immune-mediated inflammatory disease that affects both axial and peripheral skeletons as well as soft tissues. Recent investigations offer that disease pathogenesis is ascribed to a complex interplay of genetic, environmental, and immunological factors. Until now, there is no a...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Mohammadi H,Hemmatzadeh M,Babaie F,Gowhari Shabgah A,Azizi G,Hosseini F,Majidi J,Baradaran B

    更新日期:2018-08-01 00:00:00

  • Regulation of heparin-binding EGF-like growth factor expression in Ha-ras transformed human mammary epithelial cells.

    abstract::Heparin-binding epidermal growth factor-like growth factor (HB-EGF) mRNA and protein expression is induced by EGF in MCF-10A nontransformed and Ha-ras transfected human mammary epithelial cells. The anti-EGF receptor (EGFR) blocking monoclonal antibody (MAb) 225 and the EGFR tyrosine kinase inhibitor PD153035 were abl...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Martínez-Lacaci I,De Santis M,Kannan S,Bianco C,Kim N,Wallace-Jones B,Wechselberger C,Ebert AD,Salomon DS

    更新日期:2001-02-01 00:00:00

  • Ox-LDL-induced TGF-β1 production in human alveolar epithelial cells: involvement of the Ras/ERK/PLTP pathway.

    abstract::Oxidized-low density lipoprotein (Ox-LDL) has been shown to play an important role in impaired surfactant metabolism and transforming growth factor-β1 (TGF-β1) is a critical mediator in the pathogenesis of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). In this study, we investigated whether Ox-LDL...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Guo LL,Chen YJ,Wang T,An J,Wang CN,Shen YC,Yang T,Zhao L,Zuo QN,Zhang XH,Xu D,Wen FQ

    更新日期:2012-09-01 00:00:00

  • BDNF regulates GLAST and glutamine synthetase in mouse retinal Müller cells.

    abstract::This study investigated whether brain-derived neurotrophic factor (BDNF) regulates the L-glutamate/L-aspartate transporter (GLAST) and glutamine synthetase (GS) in mouse retinal Müller cells (RMCs) under normal and hypoxic conditions. Mouse RMCs were treated with recombinant human BDNF (50, 75, 100, 125, or 150  ng/ml...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Dai M,Xia XB,Xiong SQ

    更新日期:2012-02-01 00:00:00

  • Membrane transport by guinea pig peritoneal exudate leukocytes: effect of phagocytosis on hexose and amino acid transport.

    abstract::Short term, carrier mediated transport of D-glucose, L-leucine and L-lysine by guinea pig peritoneal macrophages was characterized. Analysis of the amino acid transport demonstrated two-limbed double reciprocal plots suggesting two transport systems for each amino acid. The low concentration limb of the curves establi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Straus DC,Imhoff JG,Bonventre PF

    更新日期:1977-10-01 00:00:00

  • Induction of heat-shock response and alterations of protein phosphorylation by a novel topoisomerase II inhibitor, withangulatin A, in 9L rat brain tumor cells.

    abstract::Withangulatin A is a newly identified in vitro topoisomerase II inhibitor isolated from the Chinese antitumor herb Physalis angulata. In vivo, it was found to be cytotoxic, capable of suppressing general protein synthesis and of inducing the synthesis of a small set of proteins including those generated by heat-shock ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Lee WC,Lin KY,Chen CM,Chen ZT,Liu HJ,Lai YK

    更新日期:1991-10-01 00:00:00

  • In vivo evaluation of hsp27 as an inhibitor of actin polymerization: hsp27 limits actin stress fiber and focal adhesion formation after heat shock.

    abstract::The role of hsp27 as an inhibitor of actin polymerization was considered in the context of the actin cytoskeleton and its relationship with focal adhesion formation. The aim of this study was to evaluate the potential effects of hsp27 on focal adhesion formation as a relevant biological consequence of actin stress fib...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Schneider GB,Hamano H,Cooper LF

    更新日期:1998-12-01 00:00:00