Tenascin-C enhances crosstalk signaling of integrin αvβ3/PDGFR-β complex by SRC recruitment promoting PDGF-induced proliferation and migration in smooth muscle cells.

abstract：:A number of different organs and tissues from untreated or endotoxin-injected mice were surveyed for their ability to produce conditioned medium that could induce differentiation of the myelomonocytic leukemic cell line WEHI-3B. All organs were able to do this but were much more effective from endotoxin-injected anima...

journal_title：Journal of cellular physiology

authors： Nicola NA,Metcalf D

更新日期：1981-11-01 00:00:00

abstract：:Atherothrombotic cardiovascular disease is a major cause of mortality throughout the world. Platelet activation and aggregation play a central role in hemostasis and thrombosis. Herbal medicines have been traditionally used in the management of cardiovascular disease and can help in modifying its progression, particul...

journal_title：Journal of cellular physiology

authors： Keihanian F,Saeidinia A,Bagheri RK,Johnston TP,Sahebkar A

更新日期：2018-06-01 00:00:00

abstract：:Invasion of tumor cells is the primary cause of therapeutic failure in the treatment of malignant chondrosarcomas. Glial cell-derived neurotrophic factor (GDNF) plays a crucial role in migration and metastasis of human cancer cells. Integrins are the major adhesive molecules in mammalian cells. Here we found that GDNF...

journal_title：Journal of cellular physiology

authors： Su CM,Lu DY,Hsu CJ,Chen HT,Huang CY,Yang WH,Su YC,Yang SN,Fong YC,Tseng WP,Tang CH

更新日期：2009-08-01 00:00:00

abstract：:The nuclear lamina is a fibrous structure at the nucleoplasmic surface of the inner nuclear membrane. Its assembly state is regulated by phosphorylation of its protein components, the lamins A, B, and C. The isoprenylation of the lamins is essential for their proper membrane anchoring and functionality. The content an...

journal_title：Journal of cellular physiology

authors： Bruscalupi G,Di Croce L,Lamartina S,Zaccaria ML,Luzzatto AC,Trentalance A

更新日期：1997-05-01 00:00:00

abstract：:Glucose and tumor necrosis factor-alpha (TNFalpha) concentrations are elevated in diabetes. Both of these factors correlate with diabetic vasculopathy and endothelial cell apoptosis, yet their combined effects have not been measured. We have previously shown that the angiogenic growth factor fibroblast growth factor-2...

journal_title：Journal of cellular physiology

authors： Clyne AM,Zhu H,Edelman ER

更新日期：2008-10-01 00:00:00

abstract：:Hepatic expression of the protooncogenes c-fos and c-myc occurs within 2 h after partial hepatectomy, and these immediate early genes are thought to prime the hepatocytes for subsequent proliferation. To examine whether such gene activation occurred in the setting of hepatocyte proliferation after toxic liver injury, ...

journal_title：Journal of cellular physiology

authors： Schmiedeberg P,Biempica L,Czaja MJ

更新日期：1993-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) is a small molecule (19-25 nucleotide) noncoding RNA that inhibits the expression of target messenger RNA (mRNA) at the posttranscriptional level as an endogenous regulator. There is an increasing evidence that miR-199a-3p has a significant effect on the development of multiple tumors. However, the ...

journal_title：Journal of cellular physiology

authors： Chen HP,Wen J,Tan SR,Kang LM,Zhu GC

更新日期：2019-12-01 00:00:00

abstract：:Endothelial-mesenchymal transition (EndMT) plays a pivotal role in organ fibrosis. This study examined the effect of SIRT1 on transforming growth factor beta (TGF-β)-induced EndMT in human endothelial cells (ECs) and its probable molecular mechanism. We assessed EndMT by immunofluorescence staining, quantitative real-...

journal_title：Journal of cellular physiology

authors： Li Z,Wang F,Zha S,Cao Q,Sheng J,Chen S

更新日期：2018-11-01 00:00:00

abstract：:The transport of L-alanine in human diploid fibroblasts was investigated. Transport measurements were performed on subcultures between the third and eighth passages with subconfluent cells growing on glass coverslips. Kinetic analysis of approximate initial rates of transport at substrate concentrations from 0.05 to 1...

journal_title：Journal of cellular physiology

authors： Feneant M,Moatti N,Lemonnier F,Lemonnier A

更新日期：1981-10-01 00:00:00

abstract：:This study aimed at investigating the expression and function of uracil nucleotide-sensitive receptors (P2Y(2), P2Y(4), and P2Y(6)) on osteogenic differentiation of human bone marrow stromal cells (BMSCs) in culture. Bone marrow specimens were obtained from postmenopausal female patients (68 ± 5 years old, n = 18) und...

journal_title：Journal of cellular physiology

authors： Noronha-Matos JB,Costa MA,Magalhães-Cardoso MT,Ferreirinha F,Pelletier J,Freitas R,Neves JM,Sévigny J,Correia-de-Sá P

更新日期：2012-06-01 00:00:00

abstract：:Evolving data suggest that marrow hematopoietic stem cells show reversible changes in homing, engraftment, and differentiation phenotype with cell cycle progression. Furthermore, marrow stem cells are a cycling population. Traditional concepts hold that the system is hierarchical, but the information on the lability o...

journal_title：Journal of cellular physiology

authors： Dooner GJ,Colvin GA,Dooner MS,Johnson KW,Quesenberry PJ

更新日期：2008-03-01 00:00:00

abstract：:Adult bone marrow mesenchymal stromal cells (BMSCs) can easily be differentiated into a variety of cells. In vivo transplantation of BMSCs-differentiated cells has had limited success, suggesting that these cells may not be fully compatible with the cells they are intended to replace in vivo. We investigated the struc...

journal_title：Journal of cellular physiology

authors： Gruia AT,Suciu M,Barbu-Tudoran L,Azghadi SM,Cristea MI,Nica DV,Vaduva A,Muntean D,Mic AA,Mic FA

更新日期：2016-04-01 00:00:00

abstract：:B16 mouse melanoma cells are grown inhibited by cyclic AMP or by retinoic acid (RA). However, the combination of these two agents results in less growth inhibition than either agent alone. In order to investigate this interaction, cells were selected for resistance to 8-bromo-cyclic AMP-induced growth inhibition. Two ...

journal_title：Journal of cellular physiology

authors： Niles RM,Loewy B

更新日期：1991-04-01 00:00:00

abstract：:Osteoarthritis (OA) is a common chronic degenerative disease that affects all joints. At present, the pathological processes and mechanisms of OA are still unclear. Innate immunity, a key player in damage to the structure of the joint and the mechanism by which the host attempts to repair OA, affects all pathological ...

journal_title：Journal of cellular physiology

authors： Wang H,Wang Q,Yang M,Yang L,Wang W,Ding H,Zhang D,Xu J,Tang X,Ding H,Wang Q

更新日期：2018-02-01 00:00:00

abstract：:This study was to explore a potential role of epithelium-derived cytokines in Th17 differentiation. Th17 induction was evaluated by murine CD4(+) T cells treated with different combinations of five inducing cytokines, or conditioned media of human corneal epithelial cells (HCECs) exposed to a variety of stimuli. Th17 ...

journal_title：Journal of cellular physiology

authors： Zheng X,Bian F,Ma P,De Paiva CS,Stern M,Pflugfelder SC,Li DQ

更新日期：2010-01-01 00:00:00

abstract：:Previous studies suggested that the decreased collagen production observed in Kirsten sarcoma virus (Ki-MSV)-transformed BALB 3T3 cells could be reversed by treating cells with Bt2cAMP. We examined the relationship between intracellular cAMP, collagen production, and other properties in NRK and BALB 3T3 cells transfor...

journal_title：Journal of cellular physiology

authors： Majmudar G,Peterkofsky B

更新日期：1985-01-01 00:00:00

abstract：:Oxidized-low density lipoprotein (Ox-LDL) has been shown to play an important role in impaired surfactant metabolism and transforming growth factor-β1 (TGF-β1) is a critical mediator in the pathogenesis of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). In this study, we investigated whether Ox-LDL...

journal_title：Journal of cellular physiology

authors： Guo LL,Chen YJ,Wang T,An J,Wang CN,Shen YC,Yang T,Zhao L,Zuo QN,Zhang XH,Xu D,Wen FQ

更新日期：2012-09-01 00:00:00

abstract：:The Pur proteins are an ancient family of sequence-specific single-stranded nucleic acid-binding proteins. They bind a G-rich element in either single- or double-stranded nucleic acids and are capable of displacing the complementary C-rich strand. Recently several reports have described Pur family member knockouts, mu...

journal_title：Journal of cellular physiology

authors： Johnson EM,Daniel DC,Gordon J

更新日期：2013-05-01 00:00:00

abstract：:Annexin A1 (ANXA1, lipocortin-1) is the first characterized member of the annexin superfamily of proteins, so called since their main property is to bind (i.e., to annex) to cellular membranes in a Ca(2+) -dependent manner. ANXA1 has been involved in a broad range of molecular and cellular processes, including anti-in...

journal_title：Journal of cellular physiology

authors： Bizzarro V,Petrella A,Parente L

更新日期：2012-08-01 00:00:00

abstract：:The mobility of a cell surface protein on cells osmotically swollen by treatment with several different cell permeabilizing agents retains specific restraints despite detachment of the plasma membrane from the cortical cytoskeleton. Fluorescence photobleaching recovery experiments indicate that the lateral diffusion c...

journal_title：Journal of cellular physiology

authors： Feder TJ,Chang EY,Holowka D,Webb WW

更新日期：1994-01-01 00:00:00

abstract：:Phosphoribosylpyrophosphate synthetase activity was determined in Friend virus-inducted erythroleukemic cells in culture, stimulated to differentiate in the presence of dimethylsulfoxide. The activity of phosphoribosylpyrophosphate synthetase did not decrease in cells which had acquired the specialized function of hem...

journal_title：Journal of cellular physiology

authors： Reem GH,Friend C

更新日期：1976-06-01 00:00:00

abstract：:Homeostasis of proteins involved in contractility of individual cardiomyocytes and those coupling adjacent cells is of critical importance as any abnormalities in cardiac electrical conduction may result in cardiac irregular activity and heart failure. Bcl2-associated athanogene 3 (BAG3) is a stress-induced protein wh...

journal_title：Journal of cellular physiology

authors： Tahrir FG,Gordon J,Feldman AM,Cheung J,Khalili K,Mohseni Ahooyi T

更新日期：2019-08-01 00:00:00

abstract：:Cellular senescence is a growth-arrest program that limits cell proliferation. Low-power laser irradiation (LPLI) has been demonstrated to promote cell proliferation. However, whether LPLI can inhibit cellular senescence remains unknown. In the present study, to investigate the functional role of LPLI against skin agi...

journal_title：Journal of cellular physiology

authors： Ling Q,Meng C,Chen Q,Xing D

更新日期：2014-01-01 00:00:00

abstract：:Members of the transforming growth factor-β (TGF-β) family of cytokines are involved in diverse physiological processes. Although TGF-β is known to play multiple roles in the mammalian central nervous system (CNS), its role in neuronal development has not been explored. We have studied the effects of TGF-β1 on the ele...

journal_title：Journal of cellular physiology

authors： Zhuang JL,Wang CY,Zhou MH,Duan KZ,Mei YA

更新日期：2012-01-01 00:00:00

abstract：:Copper, an essential trace element, can be toxic to some cells when present in excess. But thorough investigations into the cytotoxicity of copper and subsequent molecular mechanisms are rare, although the cytotoxicity of copper has been applied to cancer chemotherapy. The present study demonstrates that Cu(2+) inhibi...

journal_title：Journal of cellular physiology

authors： Zhai Q,Ji H,Zheng Z,Yu X,Sun L,Liu X

更新日期：2000-08-01 00:00:00

abstract：:Beta-arrestins are scaffolding proteins implicated as negative regulators of TLR4 signaling in macrophages and fibroblasts. Unexpectedly, we found that beta-arrestin-1 (beta-arr-1) and -2 knockout (KO) mice are protected from TLR4-mediated endotoxic shock and lethality. To identify the potential mechanisms involved, w...

journal_title：Journal of cellular physiology

authors： Porter KJ,Gonipeta B,Parvataneni S,Appledorn DM,Patial S,Sharma D,Gangur V,Amalfitano A,Parameswaran N

更新日期：2010-11-01 00:00:00

abstract：:Despite remarkable progress in polychemotherapy protocols, pediatric B-cell acute lymphoblastic leukemia (B-ALL) remains fatal in around 20% of cases. Hence, novel targeted therapies are needed for patients with poor prognosis. Glucocorticoids (GCs) are drugs commonly administrated for B-ALL treatment. Activation of t...

journal_title：Journal of cellular physiology

authors： Evangelisti C,Cappellini A,Oliveira M,Fragoso R,Barata JT,Bertaina A,Locatelli F,Simioni C,Neri LM,Chiarini F,Lonetti A,Buontempo F,Orsini E,Pession A,Manzoli L,Martelli AM,Evangelisti C

更新日期：2018-03-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) and the vitamin D receptor (VDR) have been reported to have an important role in the regulation of innate immunity. We earlier reported that the antimicrobial peptide cathelicidin is induced by 1,25(OH)2D3 in normal human bronchial epithelial cells with a resultant increase in an...

journal_title：Journal of cellular physiology

authors： Dhawan P,Wei R,Sun C,Gombart AF,Koeffler HP,Diamond G,Christakos S

更新日期：2015-02-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) stimulates expression of plasminogen activator inhibitor type-1 (PAI-1), a serine protease inhibitor (SERPIN) important in the control of stromal barrier proteolysis and cell-to-matrix adhesion. Pharmacologic agents that target MEK (PD98059, U0126) or src family (PP1) kinas...

journal_title：Journal of cellular physiology

authors： Samarakoon R,Higgins CE,Higgins SP,Kutz SM,Higgins PJ

更新日期：2005-07-01 00:00:00

abstract：:The export of rRNP particles from nuclei isolated from Tetrahymena was investigated after preincubating the nuclei at different temperatures under nonpermissive export-conditions. We observed a new phenomenon: Temperature elevation from the sublethal cells' growth temperature, 8 degrees C, to the optimal temperature, ...

journal_title：Journal of cellular physiology

authors： Wunderlich F,Giese G,Herlan G

更新日期：1984-08-01 00:00:00