Constitutive expression of parathyroid hormone-related peptide (PTHrP) stimulates growth and inhibits differentiation of CFK2 chondrocytes.

abstract：:Adult bone marrow mesenchymal stromal cells (BMSCs) can easily be differentiated into a variety of cells. In vivo transplantation of BMSCs-differentiated cells has had limited success, suggesting that these cells may not be fully compatible with the cells they are intended to replace in vivo. We investigated the struc...

journal_title：Journal of cellular physiology

authors： Gruia AT,Suciu M,Barbu-Tudoran L,Azghadi SM,Cristea MI,Nica DV,Vaduva A,Muntean D,Mic AA,Mic FA

更新日期：2016-04-01 00:00:00

abstract：:Using rapid kinetic techniques, we have determined the kinetics of zero-trans influx and equilibrium exchange of adenosine, and its uptake and in situ phosphorylation at 25 degrees C in human erythrocytes which were pretreated with 2'-deoxycoformycin to inhibit deamination of adenosine. Both the Km and Vmax for adenos...

journal_title：Journal of cellular physiology

authors： Plagemann PG,Wohlhueter RM,Kraupp M

更新日期：1985-11-01 00:00:00

abstract：:The cardiac glyoside, ouabain, normally kills HeLa cells at concentrations of about 10-7 M or greater. By treating a population of HeLa cells with increasingly higher concentrations of the drug, a vaiant population was obtained of HeLa cells capable of growing in medium containing 10-4 M ouabain. Inhibition of volume ...

journal_title：Journal of cellular physiology

authors： Rosenberg HM

更新日期：1975-02-01 00:00:00

abstract：:Diabetic nephropathy (DN) is one of the most serious and dangerous chronic complications caused by diabetes mellitus, and the identification and development of novel biomarkers could be beneficial for the diagnosis and prognosis of DN patients. This study focused on researching the differently expressed pattern of the...

journal_title：Journal of cellular physiology

authors： Song X,Gong M,Chen Y,Liu H,Zhang J

更新日期：2019-02-01 00:00:00

abstract：:Diabetic nephropathy (DN) is an important factor leading to end-stage kidney disease that affects diabetes mellitus patients globally. Our previous transcriptome sequencing has identified a large group of differentially expressed long noncoding RNA (lncRNA) in early development of DN. On basis of this, we aimed to inv...

journal_title：Journal of cellular physiology

authors： Peng W,Huang S,Shen L,Tang Y,Li H,Shi Y

更新日期：2019-08-01 00:00:00

abstract：:p53-mediated apoptosis involves multiple mechanisms. A number of p53-regulated apoptosis-related genes have been identified. Some of these genes encode proteins that are important in controlling the integrity of mitochondria while the others code for membrane death receptors. p53 may also induce apoptosis by interferi...

journal_title：Journal of cellular physiology

authors： Sheikh MS,Fornace AJ Jr

更新日期：2000-02-01 00:00:00

abstract：:Early biochemical changes associated with adjuvant stimulation of macrophage protein synthesis were studied using two murine macrophage cell lines, PU5-1.8 and J774.1. An induction of ornithine decarboxylase (ODC) was detected 2 hours after exposure of PU5-1.8 and J774.1 cells to two crude immunoadjuvants, BCG cell wa...

journal_title：Journal of cellular physiology

authors： Prosser FH,Schmidt CJ,Nichols SV,Nichols WK

更新日期：1984-07-01 00:00:00

abstract：:Pulmonary fibrosis is a potentially fatal consequence of treatments for malignancy and is an increasing problem in bone marrow transplant patients and in cases of allogenic lung transplant. The fibrotic response is characterized by increases in lung fibroblast number and collagen synthesis. This laboratory previously ...

journal_title：Journal of cellular physiology

authors： Sempowski GD,Derdak S,Phipps RP

更新日期：1996-05-01 00:00:00

abstract：:Lipocalin-2 (Lcn2; also termed neutrophil gelatinase-associated lipocalin (NGAL)) levels correlate positively with heart failure (HF) yet mechanisms via which Lcn2 contributes to the pathogenesis of HF remain unclear. In this study, we used coronary artery ligation surgery to induce ischemia in wild-type (wt) mice and...

journal_title：Journal of cellular physiology

authors： Sung HK,Chan YK,Han M,Jahng JWS,Song E,Danielson E,Berger T,Mak TW,Sweeney G

更新日期：2017-08-01 00:00:00

abstract：:DH23A cells, an alpha-difluoromethylornithine (DFMO)-resistant variant of rat hepatoma tissue culture cells (HTC), contain high levels of very stable ornithine decarboxylase (ODC). In the absence of DFMO, the high ODC activity results in a large accumulation of endogenous putrescine. Concomitant with the putrescine in...

journal_title：Journal of cellular physiology

authors： Tome ME,Fiser SM,Gerner EW

更新日期：1994-02-01 00:00:00

abstract：:The vascular isoform of ATP-sensitive K(+) (KATP ) channels regulates blood flow to all organs. The KATP channel is strongly inhibited by reactive oxygen and carbonyl species produced in diabetic tissue inflammation. To address how such channel inhibition impacts vascular regulation as well as tissue viability, we per...

journal_title：Journal of cellular physiology

authors： Li SS,Cui N,Yang Y,Trower TC,Wei YM,Wu Y,Zhang S,Jin X,Jiang C

更新日期：2015-12-01 00:00:00

abstract：:The differentiation of human keratinocytes in most culture systems is incomplete; e.g., lamellar bodies, the characteristic lipid-delivery organelles of epidermis, are not present. Moreover, their lipid profile does not reflect the distinctive composition found in cornifying epidermis. In contrast, keratinocytes that ...

journal_title：Journal of cellular physiology

authors： Williams ML,Brown BE,Monger DJ,Grayson S,Elias PM

更新日期：1988-07-01 00:00:00

abstract：:The effects of P2Y2 purinoceptor activation on c-Fos expression and the signaling pathways evoked by extracellular ATP/UTP in HeLa cells were investigated. We found that P2Y2 activation induced c-Fos protein and phosphorylated the extracellular signal-regulated kinases 1 and 2 (ERK1/2). The P2Y2-stimulated c-Fos induc...

journal_title：Journal of cellular physiology

authors： Muscella A,Elia MG,Greco S,Storelli C,Marsigliante S

更新日期：2003-05-01 00:00:00

abstract：:We have analyzed the functional and morphological effects of corticosteroid hormones in a SV40-transformed rabbit cortical-ascending-limb (CAL) cell line (RC.SV2, Vandewalle et al., 1989) having mineralocorticoid (MR) and glucocorticoid (GR) receptors (Rafestin-Oblin et al., 1993). Both aldosterone and dexamethasone (...

journal_title：Journal of cellular physiology

authors： Vandewalle A,Rafestin-Oblin ME,Hagege J,Géniteau-Legendre M,Cassingéna R,Ronco PM

更新日期：1993-08-01 00:00:00

abstract：:MicroRNAs (miRNAs or miRs) are small noncoding RNAs that play critical roles in muscle cell proliferation and differentiation via post-transcriptional regulation of gene expression. Here, based on our previous high-throughput sequencing results, we evaluated miRNA-499 (miR-499) functions during myoblast proliferation ...

journal_title：Journal of cellular physiology

authors： Wu J,Yue B,Lan X,Wang Y,Fang X,Ma Y,Bai Y,Qi X,Zhang C,Chen H

更新日期：2019-03-01 00:00:00

abstract：:In certain epithelial tissues, activation of transient receptor potential (TRP) vanilloid subtype 1 (TRPV1) by noxious stimuli induces pro-inflammatory cytokine release, which helps to mitigate the challenge. While the corneal epithelium elicits such responses to a variety of challenges, it remains unknown whether TRP...

journal_title：Journal of cellular physiology

authors： Zhang F,Yang H,Wang Z,Mergler S,Liu H,Kawakita T,Tachado SD,Pan Z,Capó-Aponte JE,Pleyer U,Koziel H,Kao WW,Reinach PS

更新日期：2007-12-01 00:00:00

abstract：:The addition of anti-laminin IgG to the basal surfaces of rat Sertoli cells in culture in a two-chambered assembly results in a perturbation of F-actin arrangements, including disruption of the pericellular circumferal rings, impairments of the Sertoli cell permeability barrier, and subsequently focal defoliation, fol...

journal_title：Journal of cellular physiology

authors： Tung PS,Fritz IB

更新日期：1993-07-01 00:00:00

abstract：:CRM197 is a naturally nontoxic diphtheria toxin mutant that binds and inhibits heparin-binding epidermal growth factor-like growth factor. CRM197 serves as carrier protein for vaccine and other therapeutic agents. CRM197 also inhibits the growth, migration, invasion, and induces apoptosis in various tumors. Vascular c...

journal_title：Journal of cellular physiology

authors： Hu Y,Lin X,Wang P,Xue YX,Li Z,Liu LB,Yu B,Feng TD,Liu YH

更新日期：2015-08-01 00:00:00

abstract：:Methylglyoxal bis-(guanylhydrazone) (mGBG) blocked the stimulation of DNA synthesis in quiescent, density-inhibited BALB/c-3T3 cells treated with platelet-derived growth factor (PDGF) and platelet-poor plasma (PPP). Competence formation produced by a transient exposure to PDGF was not effected by mGBG. In contrast, mG...

journal_title：Journal of cellular physiology

authors： Wharton W,Van Wyk JJ,Pledger WJ

更新日期：1981-04-01 00:00:00

abstract：:The stromal cell-derived factor-1 (SDF-1)/CXC receptor 4 (CXCR4) axis has been shown to play a role in colorectal cancer progression. In addition, the protease urokinase-type plasminogen activator (uPA) is an important factor in tumor cell invasion and metastasis. However, the mechanism by which SDF-1 mediates uPA exp...

journal_title：Journal of cellular physiology

authors： Huang WS,Chin CC,Chen CN,Kuo YH,Chen TC,Yu HR,Tung SY,Shen CH,Hsieh YY,Guo SE,Shi CS,Liu TJ,Kuo HC

更新日期：2012-03-01 00:00:00

abstract：:Construction of artificial organs and tissues by tissue engineering is strongly dependent on the availability of viable cells. For that reason, the viability and the physiological status of cells kept in culture must be evaluated before the cells can be used for clinical purposes. In this work, we determined the viabi...

journal_title：Journal of cellular physiology

authors： Alaminos M,Sanchez-Quevedo MC,Muñoz-Avila JI,García JM,Crespo PV,González-Andrades M,Campos A

更新日期：2007-06-01 00:00:00

abstract：:Activation of hepatic progenitor cells (HPCs) is commonly observed in chronic liver disease and Wnt/β-catenin signaling plays a crucial role in the expansion of HPCs. However, the molecular mechanisms that regulate the activation of Wnt/β-catenin signaling in the liver, especially in HPCs, remain largely elusive. Here...

journal_title：Journal of cellular physiology

authors： Ding ZY,Liang HF,Jin GN,Chen WX,Wang W,Datta PK,Zhang MZ,Zhang B,Chen XP

更新日期：2014-05-01 00:00:00

abstract：:There is evidence that cadmium can initiate carcinogenesis. However, the underlying mechanisms remain unknown. There is also evidence that moderate centrosome amplification can initiate tumorigenesis. The present study investigated whether cadmium could trigger cell centrosome amplification, and examined the underlyin...

journal_title：Journal of cellular physiology

authors： Zhang RK,Wang P,Lu YC,Lang L,Wang L,Lee SC

更新日期：2019-08-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in women of reproductive age. Although its clinical consequences have been known for a long time to extend beyond the reproductive system, with type-2 diabetes and obesity being the most common, the involvement of the ocular surface in PCOS has ...

journal_title：Journal of cellular physiology

authors： Mantelli F,Moretti C,Macchi I,Massaro-Giordano G,Cozzupoli GM,Lambiase A,Bonini S

更新日期：2016-05-01 00:00:00

abstract：:To construct a long noncoding RNA (lncRNA)-microRNA (miRNA)-messenger RNA (mRNA) regulatory network related to epithelial ovarian cancer (EOC) cisplatin-resistant, differentially expressed genes (DEGs), differentially expressed lncRNAs (DELs), and differentially expressed miRNAs (DEMs) between MDAH and TOV-112D cells ...

journal_title：Journal of cellular physiology

authors： Zhao X,Tang DY,Zuo X,Zhang TD,Wang C

更新日期：2019-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a newly identified class of small regulatory non-coding endogenous RNAs that are ubiquitous from animals to plants and have pivotal functions in nearly all biological and metabolic processes. Increasing evidence shows that miRNAs are also new players regulating many protein-coding genes and spec...

journal_title：Journal of cellular physiology

authors： Chen D,Farwell MA,Zhang B

更新日期：2010-11-01 00:00:00

abstract：:The beneficial effects of light-emitting diode (LED) irradiation have been reported in various pathologies, including cancer. However, its effect in pancreatic cancer cells remains unclear. Herein, we demonstrated that blue LED of 460 nm regulated pancreatic cancer cell proliferation and apoptosis by suppressing the e...

journal_title：Journal of cellular physiology

authors： Kim YM,Ko SH,Shin YI,Kim Y,Kim T,Jung J,Lee SY,Kim NG,Park KJ,Ryu JH

更新日期：2021-02-01 00:00:00

abstract：:Exposure to D-allose has been demonstrated to lead to decreased 2-deoxy-D-glucose (2-DG) and 3-0-methyl-D-glucose transport in the V79 Chinese hamster lung fibroblast cell line. The effect of D-allose 1) was maximal after 4 hours exposure to the cells; 2) was optimal between 2.77 and 5.55 mM D-allose; and 3) led to a ...

journal_title：Journal of cellular physiology

authors： Germinario RJ,Kristof A,Chang Z,Manuel S

更新日期：1990-11-01 00:00:00

abstract：:Smooth muscle cell (SMC) proliferation is a key process in stabilization of atherosclerotic plaques, and during restenosis after interventions. A clearer understanding of SMC growth regulation is therefore needed to design specific anti-proliferative therapies. Retinoic acid has been shown to inhibit proliferation of ...

journal_title：Journal of cellular physiology

authors： Tran-Lundmark K,Tannenberg P,Rauch BH,Ekstrand J,Tran PK,Hedin U,Kinsella MG

更新日期：2015-02-01 00:00:00

abstract：:Atherothrombotic cardiovascular disease is a major cause of mortality throughout the world. Platelet activation and aggregation play a central role in hemostasis and thrombosis. Herbal medicines have been traditionally used in the management of cardiovascular disease and can help in modifying its progression, particul...

journal_title：Journal of cellular physiology

authors： Keihanian F,Saeidinia A,Bagheri RK,Johnston TP,Sahebkar A

更新日期：2018-06-01 00:00:00