Consequences of aberrant ornithine decarboxylase regulation in rat hepatoma cells.

abstract：:Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in women of reproductive age. Although its clinical consequences have been known for a long time to extend beyond the reproductive system, with type-2 diabetes and obesity being the most common, the involvement of the ocular surface in PCOS has ...

journal_title：Journal of cellular physiology

authors： Mantelli F,Moretti C,Macchi I,Massaro-Giordano G,Cozzupoli GM,Lambiase A,Bonini S

更新日期：2016-05-01 00:00:00

abstract：:Increases in cytoplasmic Ca(2+) are crucial for inducing the initial steps of myoblast differentiation that ultimately lead to fusion; yet the mechanisms that produce this elevated Ca(2+) have not been fully resolved. For example, it is still unclear whether the increase comes exclusively from membrane Ca(2+) influx o...

journal_title：Journal of cellular physiology

authors： Arnaudeau S,Holzer N,König S,Bader CR,Bernheim L

更新日期：2006-08-01 00:00:00

abstract：:The nuclear lamina is a fibrous structure at the nucleoplasmic surface of the inner nuclear membrane. Its assembly state is regulated by phosphorylation of its protein components, the lamins A, B, and C. The isoprenylation of the lamins is essential for their proper membrane anchoring and functionality. The content an...

journal_title：Journal of cellular physiology

authors： Bruscalupi G,Di Croce L,Lamartina S,Zaccaria ML,Luzzatto AC,Trentalance A

更新日期：1997-05-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal and disabling neurodegenerative disease characterized by upper and lower motor neurons depletion. In our previous work, comprehensive genomic profiling of 41 motor cortex samples enabled to discriminate controls from sporadic ALS patients, and segregated these latter into...

journal_title：Journal of cellular physiology

authors： Bonaventura G,Iemmolo R,D'Amico AG,La Cognata V,Costanzo E,Zappia M,D'Agata V,Conforti FL,Aronica E,Cavallaro S

更新日期：2018-04-01 00:00:00

abstract：:A successful aging could be gained by life satisfaction, social functioning, or psychological resources and, definitely, by increasing resistance to diverse age-related pathologies. Nowadays, cancer can be considered an age-related disease since the incidence of most cancers increases with age, rising more rapidly beg...

journal_title：Journal of cellular physiology

authors： Tramontano D,De Amicis F

更新日期：2018-11-01 00:00:00

abstract：:TRPV4 (transient receptor potential vanilloid 4) is a cation channel activated by hypotonicity, moderate heat, or shear stress. We describe the expression of TRPV4 during the differentiation of a corneal epithelial cell model, RCE1(5T5) cells. TRPV4 is a late differentiation feature that is concentrated in the apical ...

journal_title：Journal of cellular physiology

authors： Martínez-Rendón J,Sánchez-Guzmán E,Rueda A,González J,Gulias-Cañizo R,Aquino-Jarquín G,Castro-Muñozledo F,García-Villegas R

更新日期：2017-07-01 00:00:00

abstract：:Osteoclasts are responsible for bone resorption during the process of bone remodeling. Increased osteoclast numbers and bone resorption activity are the main factors contributing to bone loss-related diseases such as osteoporosis. Therefore, modulating the formation and function of osteoclasts is critical for the effe...

journal_title：Journal of cellular physiology

authors： Guo Q,Cao Z,Wu B,Chen F,Tickner J,Wang Z,Qiu H,Wang C,Chen K,Tan R,Gao Q,Xu J

更新日期：2018-01-01 00:00:00

abstract：:Raloxifene (RAL), a selective estrogen receptor (ER) modulator (SERM) seems to induce apoptosis in both androgen-dependent and -independent prostate cell (PC) lines via activation of ERβ and an antagonistic effect on ERα. In this study, we evaluated the effects of RAL on epithelial PC growth using the two following in...

journal_title：Journal of cellular physiology

authors： Rossi V,Bellastella G,De Rosa C,Abbondanza C,Visconti D,Maione L,Chieffi P,Della Ragione F,Prezioso D,De Bellis A,Bellastella A,Sinisi AA

更新日期：2011-05-01 00:00:00

abstract：:Calreticulin is an ER calcium-storage protein, which influences gene expression and cell adhesion. In this study, we analysed the differences in adhesive properties of calreticulin under- and overexpressing fibroblasts in relation to the calmodulin- and calcium/calmodulin-dependent kinase II (CaMK II)-dependent signal...

journal_title：Journal of cellular physiology

authors： Szabo E,Papp S,Opas M

更新日期：2007-10-01 00:00:00

abstract：:The eukaryotic translation initiation factor 5A (eIF5A) contains a special amino acid residue named hypusine that is required for its activity, being produced by a post-translational modification using spermidine as substrate. Stem cells from rat skeletal muscles (satellite cells) were submitted to differentiation and...

journal_title：Journal of cellular physiology

authors： Luchessi AD,Cambiaghi TD,Hirabara SM,Lambertucci RH,Silveira LR,Baptista IL,Moriscot AS,Costa-Neto CM,Curi R

更新日期：2009-03-01 00:00:00

abstract：:A neuroblastoma cell line was assessed for its capacity to bind tetanus toxin (TT) by using immunofluorescence and flow cytometry to analyze cells on a single cell basis. A clone of Neuro 2a, N2AB-1, was shown to bind variable amounts of TT per cell and this binding could be saturated by increasing doses of the toxin....

journal_title：Journal of cellular physiology

authors： Notter MF,Leary JF

更新日期：1985-12-01 00:00:00

abstract：:Hair follicle stem cells (HFSCs) are able to differentiate into neurons and glial cells. Distinct microRNAs (miRNAs) regulate the proliferation and differentiation of HFSCs. However, the exact role of miR-124 in the neural differentiation of HFSCs has not been elucidated. HFSCs were isolated from mouse whisker follicl...

journal_title：Journal of cellular physiology

authors： Mokabber H,Najafzadeh N,Mohammadzadeh Vardin M

更新日期：2019-06-01 00:00:00

abstract：:Laminin is a basement membrane-specific glycoprotein that promotes cell adhesion, proliferation, differentiation, and tumor cell migration. Synthetic peptides from the amino acid sequence deduced from a cDNA clone of the B1 chain of laminin were tested for their ability to promote the migration of B16F10 melanoma cell...

journal_title：Journal of cellular physiology

authors： Iwamoto Y,Graf J,Sasaki M,Kleinman HK,Greatorex DR,Martin GR,Robey FA,Yamada Y

更新日期：1988-02-01 00:00:00

abstract：:Rho is known as an important regulator of actin microfilament formation. We were led to study it because a dynamic rearrangement of actin filaments occurs during activation of gastric acid secretion. In order to use specific probes, the rabbit gastric gland culture system was employed and the various genes were expres...

journal_title：Journal of cellular physiology

authors： Tashiro K,Nagao T,Kurose H,Ichijo H,Urushidani T

更新日期：2003-12-01 00:00:00

abstract：:We previously revealed that epithelial-to-mesenchymal transition (EMT) was mediated by ΔNp63β, a splicing variant of ΔNp63, in oral squamous cell carcinoma (OSCC). Recent studies have highlighted the involvement of microRNA (miRNA) in EMT of cancer cells, though the mechanism remains unclear. To identify miRNAs respon...

journal_title：Journal of cellular physiology

authors： Hashiguchi Y,Kawano S,Goto Y,Yasuda K,Kaneko N,Sakamoto T,Matsubara R,Jinno T,Maruse Y,Tanaka H,Morioka M,Hattori T,Tanaka S,Kiyoshima T,Nakamura S

更新日期：2018-10-01 00:00:00

abstract：:This study designs a strategy for an adoptive cellular therapy (ACT) protocol based on the ex-vivo selection of autologous peripheral blood-derived CD8-enriched T-cells, stimulated with dendritic cells (DCs) that had been pulsed with apoptotic tumor cells to generate cytotoxic T lymphocytes (CTLs) with anti-tumor acti...

journal_title：Journal of cellular physiology

authors： Carluccio S,Delbue S,Signorini L,Setola E,Bagliani A,Della Valle A,Galli A,Ferrante P,Bregni M

更新日期：2015-07-01 00:00:00

abstract：:The purpose of this study was to investigate the potential mechanism of interleukin-6 (IL-6) on the stimulation of excessive androgen secretion in human NCI-H295R adrenocortical cells. We performed transcriptome sequencing of cancer and paracancerous tissues obtained from functional adrenal cortical adenomas. The secr...

journal_title：Journal of cellular physiology

authors： Wei X,Zhang J,Peng W,Xu H,Wei Z,Pang L,Liu J,Wang T

更新日期：2020-12-01 00:00:00

abstract：:Brain arteriovenous malformations (bAVM) arise as congenital or sporadic focal lesions with a significant risk for intracerebral hemorrhage (ICH). A wide range of interindividual differences is present in the onset, progression, and severity of bAVM. A growing body of gene expression and polymorphism-based research st...

journal_title：Journal of cellular physiology

authors： Krithika S,Sumi S

更新日期：2020-12-20 00:00:00

abstract：:Pleiotropic human KB cell mutants, selected for resistance to a conjugate of epidermal growth factor with Pseudomonas exotoxin (PE-EGF), were characterized genetically. These mutants have a pleiotropic phenotype, which includes reduced number of EGF receptors and reduced growth rate. Hybrid cells between HeLa D98 and ...

journal_title：Journal of cellular physiology

authors： Amano F,Pastan I,Gottesman MM

更新日期：1988-06-01 00:00:00

abstract：:Galectin-1 is reported to be upregulated in various human cancers. However, the relationship between galectin-1 expression and cancer prognosis has not been systematically assessed. In this study, we searched PubMed, Web of Science, and Embase to collect all relevant studies and a meta-analysis was performed. We found...

journal_title：Journal of cellular physiology

authors： Huang MY,He JP,Zhang WQ,Liu JL

更新日期：2019-08-01 00:00:00

abstract：:The experiments reported were motivated by the observation that in vivo gangliosides promoted angiogenesis when the dose of the angiogenic factor was too low to be effective (Ziche et al.: Laboratory Investigation 61:629-634, 1989). As an approach to understanding the mechanism of this modulatory effect, we analysed t...

journal_title：Journal of cellular physiology

authors： De Cristan G,Morbidelli L,Alessandri G,Ziche M,Cappa AP,Gullino PM

更新日期：1990-09-01 00:00:00

abstract：:Concanavalin A (ConA)-induced hepatitis is an experimental model of human autoimmune hepatitis induced in rodents by i.v. injection of Con A. The disease is characterized by increase in serum levels of transaminases and massive immune infiltration of the livers. Type 1, type 2, and type 17 cytokines play a pathogenic ...

journal_title：Journal of cellular physiology

authors： Mangano K,Cavalli E,Mammana S,Basile MS,Caltabiano R,Pesce A,Puleo S,Atanasov AG,Magro G,Nicoletti F,Fagone P

更新日期：2018-05-01 00:00:00

abstract：:Recently, after the identification of ferritin light chain (L-ferritin) gene and protein over-expression in human metastatic melanoma cells, we engineered, starting from the LM metastatic melanoma cell line, clones in which L-ferritin gene expression was down-regulated by the stable expression of a specific antisense ...

journal_title：Journal of cellular physiology

authors： Maresca V,Flori E,Cardinali G,Briganti S,Lombardi D,Mileo AM,Paggi MG,Picardo M

更新日期：2006-03-01 00:00:00

abstract：:Inhibition of insulin-induced 3T3-L1 preadipocyte differentiation by rapamycin has been attributed to a blockade of the early critical clonal expansion phase of the adipogenic program. Rapamycin binds to, and inhibits, mTOR (mammalian target of rapamycin), leading to diminution of p70 S6 kinase activity and eukaryotic...

journal_title：Journal of cellular physiology

authors： Gagnon A,Lau S,Sorisky A

更新日期：2001-10-01 00:00:00

abstract：:The desert hedgehog (Dhh) is crucial for spermatogenesis and Leydig cell differentiation, but little is known regarding its physiological function in cartilage. In this study, Dhh mRNA was abundant in antler chondrocytes, where it advanced cell proliferation concomitant with accelerated transition from the G1 to the S...

journal_title：Journal of cellular physiology

authors： Ma L,Duan CC,Yang ZQ,Ding JL,Liu S,Yue ZP,Guo B

更新日期：2020-09-01 00:00:00

abstract：:Cancer cell lines have contributed immensely in understanding the complex physiology of cancers. They are excellent material for studies as they offer homogenous samples without individual variations and can be utilised with ease and flexibility. Also, the number of assays and end-points one can study is almost limitl...

journal_title：Journal of cellular physiology

authors： Ravi M,Ramesh A,Pattabhi A

更新日期：2017-10-01 00:00:00

abstract：:The development and progression of hepatocellular carcinoma (HCC) have been associated with abnormal cellular metabolism. Gene Expression Profiling Interactive Analysis RNA sequencing data revealed caveolin-1 (CAV-1) and hexokinase 2 (HK2) messenger RNA (mRNA) were significantly upregulated in human HCC compared with ...

journal_title：Journal of cellular physiology

authors： Chai F,Li Y,Liu K,Li Q,Sun H

更新日期：2019-02-01 00:00:00

abstract：:Membrane vesicles derived principally from the plasma membrane and endoplasmic reticulum of mouse 3T3 cells transformed by Simian virus 40 take up alpha-aminoisobutyric acid (AIB) and phosphate (Pi). When NaCl is added simultaneously with AIB or Pi, uptake rises two- to three-times above the equilibrium to accumulate ...

journal_title：Journal of cellular physiology

authors： Nilsen-Hamilton M,Hamilton RT

更新日期：1976-12-01 00:00:00

abstract：:We determined whether the multi-kinase inhibitor sorafenib or its derivative regorafenib interacted with phosphodiesterase 5 (PDE5) inhibitors such as Viagra (sildenafil) to kill tumor cells. PDE5 and PDGFRα/β were over-expressed in liver tumors compared to normal liver tissue. In multiple cell types in vitro sorafeni...

journal_title：Journal of cellular physiology

authors： Tavallai M,Hamed HA,Roberts JL,Cruickshanks N,Chuckalovcak J,Poklepovic A,Booth L,Dent P

更新日期：2015-09-01 00:00:00

abstract：:Long suspected, recently recognized, and increasingly studied, non protein-coding RNAs (ncRNAs) are emerging as key drivers of biological control and pathology. Since their discovery in 1993, microRNAs (miRNAs) have been the subject of intense research focus and investigations have revealed striking findings, establis...

journal_title：Journal of cellular physiology

authors： Tye CE,Gordon JA,Martin-Buley LA,Stein JL,Lian JB,Stein GS

更新日期：2015-03-01 00:00:00