Effects of Sex Hormones on Ocular Surface Epithelia: Lessons Learned From Polycystic Ovary Syndrome.

Abstract:

:Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in women of reproductive age. Although its clinical consequences have been known for a long time to extend beyond the reproductive system, with type-2 diabetes and obesity being the most common, the involvement of the ocular surface in PCOS has been described only more recently. The ocular surface is a morphofunctional unit comprising eyelid margin, tear film, cornea, and conjunctiva. Increasing evidence indicates that these structures are under a sex hormone control and relevant diseases such as ocular allergy and dry eye are often caused by alterations in circulating or local steroid hormones levels. Novel treatments targeting sex hormone receptors on ocular surface epithelial cells are also being developed. In this review we aim to describe the current knowledge on the effects of sex hormones at the ocular surface, with a special focus on the effects of androgen imbalance in PCOS.

journal_name

J Cell Physiol

authors

Mantelli F,Moretti C,Macchi I,Massaro-Giordano G,Cozzupoli GM,Lambiase A,Bonini S

doi

10.1002/jcp.25221

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

971-5

issue

5

eissn

0021-9541

issn

1097-4652

journal_volume

231

pub_type

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