Effects of Sex Hormones on Ocular Surface Epithelia: Lessons Learned From Polycystic Ovary Syndrome.


:Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in women of reproductive age. Although its clinical consequences have been known for a long time to extend beyond the reproductive system, with type-2 diabetes and obesity being the most common, the involvement of the ocular surface in PCOS has been described only more recently. The ocular surface is a morphofunctional unit comprising eyelid margin, tear film, cornea, and conjunctiva. Increasing evidence indicates that these structures are under a sex hormone control and relevant diseases such as ocular allergy and dry eye are often caused by alterations in circulating or local steroid hormones levels. Novel treatments targeting sex hormone receptors on ocular surface epithelial cells are also being developed. In this review we aim to describe the current knowledge on the effects of sex hormones at the ocular surface, with a special focus on the effects of androgen imbalance in PCOS.


J Cell Physiol


Mantelli F,Moretti C,Macchi I,Massaro-Giordano G,Cozzupoli GM,Lambiase A,Bonini S




Has Abstract


2016-05-01 00:00:00












  • Transport changes associated with growth control and malignant transformation.

    abstract::We can distinguish two classes of membrane transport changes in cultured cells: (a) growth-rate contingent changes are those which occur in coordination with the onset of density-dependent inhibition of growth; (b) transformation-specific changes are those which occur when cells become transformed, and which can be de...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Weber MJ,Hale AH,Yau TM,Buckman T,Johnson M,Brady TM,LaRossa DD

    更新日期:1976-12-01 00:00:00

  • Effects of reduced cell volume and water content on glycolysis in L-929 cells.

    abstract::Mouse L-929 cells were subjected to increasing concentrations of sorbitol, which remove cell water and reduce volume osmotically. The rate of lactate production from glucose was significantly higher in osmotically perturbed cells than in controls, both in monolayers and in suspensions. L cells can apparently use sorbi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Clegg JS,Jackson SA,Fendl K

    更新日期:1990-02-01 00:00:00

  • Platelet-derived growth factor regulates actin isoform expression and growth state in cultured rat aortic smooth muscle cells.

    abstract::The role of platelet-derived growth factor (PDGF) in the control of smooth muscle cell (SMC) differentiation was explored in vitro by examining its effects on expression of the smooth muscle (SM) specific contractile protein SM alpha actin in cultured rat aortic SMC. Quiescent, postconfluent SMC express maximal levels...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Blank RS,Owens GK

    更新日期:1990-03-01 00:00:00

  • Differential proteomic profiling identifies novel molecular targets of pterostilbene against experimental diabetes.

    abstract::Pterostilbene (PTS), a naturally occurring stilbene, confers protection against oxidative and cytokine stress induced pancreatic β-cell apoptosis in vitro and in vivo. To provide insights into the molecular mechanism, we performed a proteomic study on the pancreas of PTS-treated diabetic mice using electrospray ioniza...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Dornadula S,Thiruppathi S,Palanisamy R,Umapathy D,Suzuki T,K Mohanram R

    更新日期:2019-03-01 00:00:00

  • Effects of glucose supply on myeloma growth and metabolism in chemostat culture.

    abstract::The effects of the glucose supply on growth and metabolism of an SP2/0 derived recombinant myeloma cell line were studied in chemostat culture during growth on IMDM medium at a fixed dilution rate of 0.032 h-1. Lowering of the feed medium glucose concentration from 25.0 to 1.4 mmol/L resulted in a decrease of steady-s...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Meijer JJ,van Dijken JP

    更新日期:1995-02-01 00:00:00

  • Transforming growth factor-β signaling confers hepatic stellate cells progenitor features after partial hepatectomy.

    abstract::Liver regeneration involves not only hepatocyte replication but progenitor aggregation and scarring. Partial hepatectomy (PH), an established model for liver regeneration, reactivates transforming growth factor-β (TGF-β) signaling. Hepatic stellate cells (HSCs) are primarily responding cells for TGF-β and resident in ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Chen Z,Wan L,Jin X,Wang W,Li D

    更新日期:2020-03-01 00:00:00

  • Functional coupling of TRPC2 cation channels and the calcium-activated anion channels in rat thyroid cells: implications for iodide homeostasis.

    abstract::The initial step in a synthesis of thyroid hormones is the uptake of iodide from the circulation. Iodide (I(-)) is transported into thyroid cells via a Na(+)/I(-) symporter (NIS), which is electrogenic and thus sensitive to alterations in membrane potential (V(m)). I(-) is then released to the lumen of thyroid follicl...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Viitanen TM,Sukumaran P,Löf C,Törnquist K

    更新日期:2013-04-01 00:00:00

  • Timing of protooncogene expression varies in toxin-induced liver regeneration.

    abstract::Hepatic expression of the protooncogenes c-fos and c-myc occurs within 2 h after partial hepatectomy, and these immediate early genes are thought to prime the hepatocytes for subsequent proliferation. To examine whether such gene activation occurred in the setting of hepatocyte proliferation after toxic liver injury, ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Schmiedeberg P,Biempica L,Czaja MJ

    更新日期:1993-02-01 00:00:00

  • De novo expression of pp125FAK in human macrophages regulates CSK distribution and MAP kinase activation but does not affect focal contact structure.

    abstract::The protein tyrosine kinase pp125FAK (focal adhesion kinase, or FAK) is expressed by a variety of cell types and has been implicated in integrin-mediated signaling events. We explored the potential functions of FAK by expressing it de novo in a cell type lacking FAK. We showed previously that cultured human macrophage...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: De Nichilo MO,Katz BZ,O'Connell B,Yamada KM

    更新日期:1999-02-01 00:00:00

  • Proteoglycan biosynthesis is required in BC3H1 myogenic cells for modulation of vascular smooth muscle alpha-actin gene expression in response to microenvironmental signals.

    abstract::Induction of vascular smooth muscle (VSM) alpha-actin mRNA expression during cytodifferentiation of mouse BC3H1 myogenic cells coincides with the accumulation of cell surface- and extracellular matrix-associated sulfated proteoglycans. Inhibition of proteoglycan biosynthesis in myogenic cells using an artificial beta-...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Lee SH,Yan H,Reeser JC,Dillman JM,Strauch AR

    更新日期:1995-07-01 00:00:00

  • Divergence and convergence of TGF-beta/BMP signaling.

    abstract::The transforming growth factor-beta (TGF-beta) superfamily includes more than 30 members which have a broad array of biological activities. TGF-beta superfamily ligands bind to type II and type I serine/threonine kinase receptors and transduce signals via Smad proteins. Receptor-regulated Smads (R-Smads) can be classi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Miyazono K,Kusanagi K,Inoue H

    更新日期:2001-06-01 00:00:00

  • Involvement of protein phosphatase 2A in the maintenance of E-cadherin-mediated cell-cell adhesion through recruitment of IQGAP1.

    abstract::Serine/threonine protein phosphatase (PP) 2A regulates many biological processes, however it remains unclear whether PP2A participates in cadherin-mediated cell-cell adhesion. We show here that the core enzyme of PP2A (PP2A-AC) is localized in the cell-cell adhesion sites between adjacent cells and associated with the...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Takahashi K,Nakajima E,Suzuki K

    更新日期:2006-03-01 00:00:00

  • Ca2+ -dependent and Ca2+ -independent somatic release from trigeminal neurons.

    abstract::Besides the nerve endings, the soma of trigeminal neurons also respond to membrane depolarizations with the release of neurotransmitters and neuromodulators in the extracellular space within the ganglion, a process potentially important for the cross-communication between neighboring sensory neurons. In this study, we...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Sforna L,Franciolini F,Catacuzzeno L

    更新日期:2019-07-01 00:00:00

  • C-C motif chemokine ligand 2 regulates lps-induced inflammation and ER stress to enhance proliferation of bovine endometrial epithelial cells.

    abstract::Chemokines play an important role in regulating the complex immune system at the maternal-fetal interface during pregnancy. Among various chemokines, CC motif chemokine ligand 2 (CCL2) plays a role in the recruitment of immune regulatory cells to implantation sites within the endometrium. In cattle, CCL2 is abundantl...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Lim W,Bae H,Bazer FW,Kim SM,Song G

    更新日期:2018-04-01 00:00:00

  • Insulin-like growth factor-I increases bone sialoprotein (BSP) expression through fibroblast growth factor-2 response element and homeodomain protein-binding site in the proximal promoter of the BSP gene.

    abstract::Insulin-like growth factor-I (IGF-I) promotes bone formation by stimulating proliferation and differentiation of osteoblasts. Bone sialoprotein (BSP), is thought to function in the initial mineralization of bone, is selectively expressed by differentiated osteoblast. To determine the molecular mechanism of IGF-I regul...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Nakayama Y,Nakajima Y,Kato N,Takai H,Kim DS,Arai M,Mezawa M,Araki S,Sodek J,Ogata Y

    更新日期:2006-08-01 00:00:00

  • Toll-like receptor 2-mediated peptidoglycan uptake by immature intestinal epithelial cells from apical side and exosome-associated transcellular transcytosis.

    abstract::Peptidoglycan (PGN) is a potent immune adjuvant derived from bacterial cell walls. Previous investigations suggest that intestinal epithelium may absorb PGN from the lumen. Nonetheless, how PGN is taken up and crosses intestinal epithelium remains largely unclear. Here, we first characterized PGN transport in vitro us...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Bu HF,Wang X,Tang Y,Koti V,Tan XD

    更新日期:2010-03-01 00:00:00

  • SIRT1 inhibits gastric cancer proliferation and metastasis via STAT3/MMP-13 signaling.

    abstract::Gastric cancer prognoses are persistently poor due to cancer's penchant to metastasize. As a crucial regulator of signal transducer and activator of transcription (STAT3) signaling, sirtuin 1's (SIRT1) function in gastric cancer has not been well understood. Here, we report upregulated expression of SIRT1 in tissues i...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Zhang S,Yang Y,Huang S,Deng C,Zhou S,Yang J,Cao Y,Xu L,Yuan Y,Yang J,Chen G,Zhou L,Lv Y,Wang L,Zou X

    更新日期:2019-09-01 00:00:00

  • Resveratrol-induced apoptosis is enhanced in low pH environments associated with cancer.

    abstract::Many critical factors such as hypoxia, nutrient deficiency, activation of glycolytic pathway/Warburg effect contribute to the observed low pH in tumors compared to normal tissue. Studies suggest that such tumor specific acidic environment can be exploited for the development of therapeutic strategies against cancer. I...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Shamim U,Hanif S,Albanyan A,Beck FW,Bao B,Wang Z,Banerjee S,Sarkar FH,Mohammad RM,Hadi SM,Azmi AS

    更新日期:2012-04-01 00:00:00

  • Conditional knockout of the PDK-1 gene in osteoblasts affects osteoblast differentiation and bone formation.

    abstract::Osteoblasts are the main functional cells of bone formation, and they are responsible for the synthesis, secretion, and mineralization of the bone matrix. Phosphatidylinositol-3-kinase/Akt is an important signaling pathway involved in the regulation of cell proliferation, death, and survival. Some studies have shown t...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Bai Y,Zhang Q,Chen Q,Zhou Q,Zhang Y,Shi Z,Nong H,Liu M,Zeng G,Zong S

    更新日期:2020-12-30 00:00:00

  • Adipose-derived stem cells for wound healing.

    abstract::Wound healing is a complex but a fine-tuned biological process in which human skin has the ability to regenerate itself following damage. However, in particular conditions such as deep burn or diabetes the process of wound healing is compromised. Despite investigations on the potency of a wide variety of stem cells fo...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Hassanshahi A,Hassanshahi M,Khabbazi S,Hosseini-Khah Z,Peymanfar Y,Ghalamkari S,Su YW,Xian CJ

    更新日期:2019-06-01 00:00:00

  • Local effects of EGF, alpha-TGF, and EGF-like growth factors on lobuloalveolar development of the mouse mammary gland in vivo.

    abstract::Five-week-old female mice supplemented with estradiol and progesterone are able to respond to epidermal growth factor (EGF) and EGF-like growth factors (alpha-transforming growth factor [alpha-TGF] and crude mammary-derived growth factor) with local lobuloalveolar development when these growth factors are directly int...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Vonderhaar BK

    更新日期:1987-09-01 00:00:00

  • Inflammatory cytokines in bladder cancer.

    abstract::The presence of inflammatory cells and their products in the tumor microenvironment plays a crucial role in the pathogenesis of a tumor. Releasing the cytokines from a host in response to infection and inflammation can inhibit tumor growth and progression. However, tumor cells can also respond to the host cytokines wi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Shadpour P,Zamani M,Aghaalikhani N,Rashtchizadeh N

    更新日期:2019-02-18 00:00:00

  • BDNF regulates GLAST and glutamine synthetase in mouse retinal Müller cells.

    abstract::This study investigated whether brain-derived neurotrophic factor (BDNF) regulates the L-glutamate/L-aspartate transporter (GLAST) and glutamine synthetase (GS) in mouse retinal Müller cells (RMCs) under normal and hypoxic conditions. Mouse RMCs were treated with recombinant human BDNF (50, 75, 100, 125, or 150  ng/ml...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Dai M,Xia XB,Xiong SQ

    更新日期:2012-02-01 00:00:00

  • The mechanism of interaction between high-affinity probes and the uridine transport system of mammalian cells.

    abstract::The carrier of uridine transport in hamster cells in culture is highly susceptible to the inhibitory effect of probes like S-benzylated derivatives of mercaptopurine nucleosides. The interaction between the probes and the carrier is competitive and reversible and it takes place at a site different from the substrate b...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Eilam Y,Carbantchik I

    更新日期:1976-12-01 00:00:00

  • The in vitro cell culture age and cell density of articular chondrocytes alter sulfated-proteoglycan biosynthesis.

    abstract::The effect of cell culture age and concomitant changes in cell density on the biosynthesis of sulfated-proteoglycan by rabbit articular chondrocytes in secondary monolayer culture was studied. Low density (LD, 2 d), middle density (MD, 5-7 d), and high density (HD, 12-15 d) cultures demonstrated changes in cellular mo...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Malemud CJ,Papay RS

    更新日期:1984-12-01 00:00:00

  • Epoxyeicosatrienoic acids activate Na+/H+ exchange and are mitogenic in cultured rat glomerular mesangial cells.

    abstract::The present study examined responses of cultured rat glomerular mesangial cells to exogenous exposure of epoxyeicosatrienoic acids (EET's), products of cytochrome P450 epoxygenase. One day after administration of 8,9- or 14,15-EET, cultured rat mesangial cells demonstrated significant increases in [3H]thymidine incorp...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Harris RC,Homma T,Jacobson HR,Capdevila J

    更新日期:1990-09-01 00:00:00

  • Role of polyamines in the stimulation of synthesis and secretion of plasminogen activator from bovine aortic endothelial cells.

    abstract::The effects of the polyamines putrescine (PUT), spermidine (SPD), and spermidine (SPM) on the secretion of plasminogen activator (PA) and plasminogen activator inhibitor (PAI) were evaluated using cultured bovine aortic endothelial cells. All three polyamines enhanced PA secretion in a time- and dose-dependent manner,...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Kuo BS,Korner G,Dryjski M,Bjornsson TD

    更新日期:1988-10-01 00:00:00

  • Second messenger signaling of c-fos gene induction by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells: its role in osteoblast proliferation and osteoclast-like cell formation.

    abstract::The present study was performed to clarify second messenger signaling in parathyroid hormone (PTH)-induced c-fos gene expression, to characterize the participation of the c-fos gene in the regulation of osteoblast proliferation and function as well as osteoclast-like cell formation by PTH and to compare these effects ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Kano J,Sugimoto T,Kanatani M,Kuroki Y,Tsukamoto T,Fukase M,Chihara K

    更新日期:1994-11-01 00:00:00

  • Sensitivity of excision repair in normal human, xeroderma pigmentosum variant and Cockayne's syndrome fibroblasts to inhibition by cytosine arabinoside.

    abstract::Inhibition of the gap-filling, polymerizing step of excision repair by 1-beta-D-arabinofuranosylcytosine (ara-C) after irradiation with ultraviolet light in human diploid fibroblasts resulted in the formation of persistent DNA strand breaks in G1, G2, and plateau phase cells, but not in S phase cells. Addition of hydr...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Cleaver JE

    更新日期:1981-08-01 00:00:00

  • Normal atmospheric oxygen tension and the use of antioxidants improve hepatocyte spheroid viability and function.

    abstract::Hepatocyte spheroids have been proposed for drug metabolism studies and in bioartificial liver devices. However, the optimal conditions required to meet the aerobic demands of mitochondria-rich hepatocyte spheroids is not well studied. We hypothesized that an optimal concentration of oxygen could be identified and tha...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Lillegard JB,Fisher JE,Nedredal G,Luebke-Wheeler J,Bao J,Wang W,Amoit B,Nyberg SL

    更新日期:2011-11-01 00:00:00