Thrombin-induced thromboxane generation by neutrophils and lymphocytes: dependence on enzymic site.

abstract：:Connective tissue growth factor (CTGF) is a secreted, extracellular matrix-associated signaling protein that regulates diverse cellular functions. In vivo, CTGF is expressed in many tissues with highest levels in the kidney and brain. The purpose of this study was twofold; first, to localize CTGF in normal bone in viv...

journal_title：Journal of cellular physiology

authors： Safadi FF,Xu J,Smock SL,Kanaan RA,Selim AH,Odgren PR,Marks SC Jr,Owen TA,Popoff SN

更新日期：2003-07-01 00:00:00

abstract：:To determine if Chinese Hamster Ovary (CHO) cells in culture are able to metabolize steroids, CHO cells were incubated in defined medium with [14C]pregnenolone. As shown, [14C]pregnenolone is metabolized to progesterone and other delta 53 beta steroids; this steroidogenic response is appreciably enhanced upon exposure...

journal_title：Journal of cellular physiology

authors： Evain D,Anderson WB,Saez MJ

更新日期：1981-07-01 00:00:00

abstract：:We examined the behavior of the transcription factor Max during retrograde neuronal degeneration of retinal ganglion cells. Using immunohistochemistry, we found a progressive redistribution of full-length Max from the nucleus to the cytoplasm and dendrites of the ganglion cells following axon damage. Then, the axotomi...

journal_title：Journal of cellular physiology

authors： Petrs-Silva H,de Freitas FG,Linden R,Chiarini LB

更新日期：2004-02-01 00:00:00

abstract：:Hydatid cyst, the larval stage of the tapeworm Echinococcus granulosus and a causative agent of cystic echinococcosis, possesses a vast number of antigenic peptides that are constantly presented in the host immune system during infection. Here, we sought to provide more information about the cellular/humoral component...

journal_title：Journal of cellular physiology

authors： Vatankhah A,Ghaffari SMR,Vatankhah RG,Piurkó V,Tímár J,Avan A,Jazayeri MH

更新日期：2019-03-01 00:00:00

abstract：:Testicular cancer is the most common solid malignancy among young men. We downloaded data of testicular cancer patients from The Cancer Genome Atlas database to find novel genes in the testicular cancer microenviroment based on ESTIMATE algorithm-derived immune scores. A total of 156 cases of testicular cancer were in...

journal_title：Journal of cellular physiology

authors： Ke ZB,Wu YP,Huang P,Hou J,Chen YH,Dong RN,Lin F,Wei Y,Xue XY,Ng CF,Xu N

更新日期：2021-01-01 00:00:00

abstract：:A serum factor which enhances the growth/viability of SV40 transformed 3T3 mouse fibroblasts, but not untransformed 3T3 cells in tissue culture has been partially purified from calf serum. The purification, which involves acidification to pH 2, chromatography on Sephadex G-100 at pH 2 followed by either Sephadex G-25 ...

journal_title：Journal of cellular physiology

authors： Young DV,Nakano ET,Wiggins DS,McElaney MA

更新日期：1978-08-01 00:00:00

abstract：:Topical intranasal application of the antifungal Amphotericin B (AmphoB) has been shown as an effective medical treatment of chronic rhinosinusitis. Because this antibiotic forms channels in lipid membranes, we considered the possibility that it affects the properties and/or cell surface expression of ion channels/pum...

journal_title：Journal of cellular physiology

authors： Jornot L,Rochat T,Caruso A,Lacroix JS

更新日期：2005-09-01 00:00:00

abstract：:Activation of the epidermal growth factor receptor (EGFR) contributes to the pathogenesis of non-small-cell lung carcinomas (NSCLC) and gefitinib, a selective reversible EGFR inhibitor, is effective in treating patients with NSCLC. However, clinical resistance to gefitinib is a frequent occurrence highlighting the nee...

journal_title：Journal of cellular physiology

authors： Emdad L,Lebedeva IV,Su ZZ,Gupta P,Sarkar D,Settleman J,Fisher PB

更新日期：2007-02-01 00:00:00

abstract：:This study was undertaken to gain more insight into the mechanism whereby TGF-beta influences the cell cycle progression of cultured rabbit articular chondrocytes. Using proliferating chondrocytes in fetal calf serum-containing medium, we have previously shown that TGF-beta induced a recruitment of cells at the end of...

journal_title：Journal of cellular physiology

authors： Vivien D,Galéra P,Lebrun E,Daireaux M,Loyau G,Pujol JP

更新日期：1992-02-01 00:00:00

abstract：:Obesity is a risk factor for endometrial cancer in pre- and post-menopausal women. Leptin, an adipocyte-derived hormone, in addition to the control weight homeostasis, is implicated in multiple biological actions. A recent study demonstrated that leptin promotes endometrial cancer growth and invasiveness through STAT/...

journal_title：Journal of cellular physiology

authors： Catalano S,Giordano C,Rizza P,Gu G,Barone I,Bonofiglio D,Giordano F,Malivindi R,Gaccione D,Lanzino M,De Amicis F,Andò S

更新日期：2009-03-01 00:00:00

abstract：:An association has been proved between high salt consumption and cardiovascular mortality. In vertebrates, the heart is the first functional organ to be formed. However, it is not clear whether high-salt exposure has an adverse impact on cardiogenesis. Here we report high-salt exposure inhibited basement membrane brea...

journal_title：Journal of cellular physiology

authors： Gao LR,Wang G,Zhang J,Li S,Chuai M,Bao Y,Hocher B,Yang X

更新日期：2018-09-01 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) is implicated in the invasion and metastasis of breast cancer cells. We investigated the modulatory effects of nitric oxide (NO) on the 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced MMP-9 expression in MCF-7 cells. Different chemical NO donors inhibited the extracellular content...

journal_title：Journal of cellular physiology

authors： Jespersen C,Doller A,Akool el-S,Bachmann M,Müller R,Gutwein P,Mühl H,Pfeilschifter J,Eberhardt W

更新日期：2009-05-01 00:00:00

abstract：:Cigarettes contain various chemicals with the potential to influence metabolic health. Exposure to cigarette smoke causes a dysfunction in pancreatic β-cells and impairs insulin production. However, the mechanisms for cigarette smoke-induced reduction of insulin remain largely unclear. Data from 558 patients with diab...

journal_title：Journal of cellular physiology

authors： Sun Q,Xu H,Xue J,Yang Q,Chen C,Yang P,Han A,Tu Q,Lu J,Gao X,Xiang Q,Liu Q

更新日期：2018-11-01 00:00:00

abstract：:The cells responsible for the long-term in vitro generation of murine mast cells have been examined. Sequential analysis of all colony types obtained from cultures of spleen or bone marrow cells showed that only colonies derived from multipotential cells (mixed-erythroid colonies) or mast cell progenitors, contained c...

journal_title：Journal of cellular physiology

authors： Li CL,Johnson GR

更新日期：1984-10-01 00:00:00

abstract：:Hydrocortisone and dexamethasone produced a time-dependent increase [125I]epidermal growth factor [( 125I]EGF) binding in primary cultures of isolated rat hepatocytes. Maximally effective doses of glucocorticoids resulted in a 70-100% increase in binding. The effect was similar when hepatocytes were maintained on coll...

journal_title：Journal of cellular physiology

authors： Lin Q,Blaisdell J,O'Keefe E,Earp HS

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND:Despite at the beginning known as a benign disease, endometriosis is defined as a risk factor for developing ovarian carcinoma. The effect of endometriosis on ovarian malignancy is known but its role in granulosa cell tumor is still unclear. METHODS AND MATERIALS:In this study, serum samples were collected ...

journal_title：Journal of cellular physiology

authors： Asghari S,Valizadeh Dizajeykan A,Ahmadi M,Barzegari A,Rikhtegar R,Dolati S,Danaii S,Abdollahi-Fard S,Nouri M,Mahdipour M,Yousefi M

更新日期：2019-07-01 00:00:00

abstract：:A decline in cell surface gamma-glutamyl transpeptidase specific activity was previously observed to be concomitant with C6 glial cell proliferation. To elucidate the underlying factor(s) mediating gamma-glutamyl transpeptidase down-regulation, the effects of C6 cell density and culture conditions on cell surface tran...

journal_title：Journal of cellular physiology

authors： Morgenstern K,Hanson-Painton O,Wang BL,De Bault L

更新日期：1992-01-01 00:00:00

abstract：:Comparative studies with rat transferrin (rTf) and asialotransferrin (asialo-rTf) were performed on suspended adult rat hepatocytes with the aim of elucidating the mechanism of enhanced hepatic Fe acquisition from asialo-rTf observed previously in vivo. At low ligand concentrations (0.05-20 micrograms/ml), the cells b...

journal_title：Journal of cellular physiology

authors： Rudolph JR,Regoeczi E

更新日期：1988-06-01 00:00:00

abstract：:Prostaglandins prevent gastrointestinal mucosal injury and promote healing following mucosal injury by various noxious agents. Preservation or repair of microvascular function appears to be crucial in these processes. The processes involved in prostaglandin-mediated repair and preservation of endothelial function are ...

journal_title：Journal of cellular physiology

authors： Ma TY,Pedram A

更新日期：1996-05-01 00:00:00

abstract：:The transforming growth factor-beta (TGF-beta) superfamily includes more than 30 members which have a broad array of biological activities. TGF-beta superfamily ligands bind to type II and type I serine/threonine kinase receptors and transduce signals via Smad proteins. Receptor-regulated Smads (R-Smads) can be classi...

journal_title：Journal of cellular physiology

authors： Miyazono K,Kusanagi K,Inoue H

更新日期：2001-06-01 00:00:00

abstract：:The phenotype of a ouabain-resistant Aedes albopictus cell line has been partially characterized. Treatment of ouabain-sensitive cells with 0.005-1.0 mM ouabain resulted in an 80% reduction in the uptake of 86rubidium (86Rb+), an ion with an affinity for the K+ pump binding site; ouabain-resistant cells showed only a ...

journal_title：Journal of cellular physiology

authors： Mento SJ,Malinoski F,Stollar V

更新日期：1979-12-01 00:00:00

abstract：:Skeletal muscle atrophy/wasting is associated with impaired protein metabolism in diverse physiological and pathophysiological conditions. Elevated levels of reactive oxygen species (ROS), disturbed redox status, and weakened antioxidant defense system are the major contributing factors toward atrophy. Regulation of p...

journal_title：Journal of cellular physiology

authors： Kaur N,Gupta P,Saini V,Sherawat S,Gupta S,Dua A,Kumar V,Injeti E,Mittal A

更新日期：2019-05-01 00:00:00

abstract：:Dental follicle cells (DFCs) activate and recruit osteoclasts for tooth development and tooth eruption, whereas DFCs themselves differentiate into osteoblasts to form alveolar bone surrounding tooth roots through the interaction with Hertwig's epithelial root sheath (HERS). Also during tooth development, parathyroid h...

journal_title：Journal of cellular physiology

authors： Zhang J,Liao L,Li Y,Xu Y,Guo W,Tian W,Zou S

更新日期：2019-07-01 00:00:00

abstract：:The role of platelet-derived growth factor (PDGF) in the control of smooth muscle cell (SMC) differentiation was explored in vitro by examining its effects on expression of the smooth muscle (SM) specific contractile protein SM alpha actin in cultured rat aortic SMC. Quiescent, postconfluent SMC express maximal levels...

journal_title：Journal of cellular physiology

authors： Blank RS,Owens GK

更新日期：1990-03-01 00:00:00

abstract：:Cell hybrids were formed between human diploid fibroblasts (HDF) and carcinogen-transformed HDF to determine the relationship among: (1) finite proliferative lifespan, which we define as an age-related failure of a population to achieve one population doubling in 4 weeks; (2) arrest in a senescent state, which we defi...

journal_title：Journal of cellular physiology

authors： Stein GH,Namba M,Corsaro CM

更新日期：1985-03-01 00:00:00

abstract：:Tobacco smoking is associated with many diseases. Addiction is of the most notorious tobacco-related syndrome and is mainly attributed to nicotine. In this study, we employed Caenorhabditis elegans as a biological model to systemically investigate the effect of chronic nicotine exposure on microRNA (miRNA) expression ...

journal_title：Journal of cellular physiology

authors： Taki FA,Pan X,Zhang B

更新日期：2014-01-01 00:00:00

abstract：:Normal FBAE AG 7680 cells and chemically transformed FBAE GM 7373 cells were compared for their capacity to produce and to respond to bFGF. Normal FBAE cells showed higher levels of bFGF protein and of poly(A)+ bFGF mRNA than transformed GM 7373 cells, indicating that chemical transformation in FBAE cells is parallele...

journal_title：Journal of cellular physiology

authors： Presta M,Maier JA,Rusnati M,Ragnotti G

更新日期：1989-12-01 00:00:00

abstract：:Fas, which functions to initiate a signal causing apoptosis, is expressed in epithelia, thus, suggesting a role in controlling cell number during states of cell and matrix turnover. In view of this, we hypothesized that cell-matrix interactions may be an important determinant of Fas expression in epithelial cells. To ...

journal_title：Journal of cellular physiology

authors： Fine A,Miranda K,Farmer SR,Anderson NL

更新日期：1998-03-01 00:00:00

abstract：:The molecular mechanism by which thyroid hormones exert their effects on cell growth is still unknown. In this study, we used chick embryo hepatocytes at different stages of development as a model to investigate the effect of the two thyroid hormones, T3 and T4, and of their metabolite T2, on the control of cell proli...

journal_title：Journal of cellular physiology

authors： Alisi A,Spagnuolo S,Napoletano S,Spaziani A,Leoni S

更新日期：2004-11-01 00:00:00

abstract：:Integrin α2β1 plays an important role in cellular migration and metastasis processes associated with prostate cancer. The aim of this study was to assess whether selective inhibition of integrin α2β1 is an effective strategy to target metastatic prostate cancer cells. In this regard, we examined the effects of the inh...

journal_title：Journal of cellular physiology

authors： Salemi Z,Azizi R,Fallahian F,Aghaei M

更新日期：2020-12-10 00:00:00