Thyroid hormones regulate DNA-synthesis and cell-cycle proteins by activation of PKCalpha and p42/44 MAPK in chick embryo hepatocytes.

abstract：:Aberrations of DNA methylation are early events in the development of tumors. In this study, we investigated the DNA methylation status of growth hormone secretagogue receptor (GHSR), a promising pan-cancer biomarker, in gastric cancer (GC). Initially, data sets from DNA methylation and gene expression studies availab...

journal_title：Journal of cellular physiology

authors： Amini M,Foroughi K,Talebi F,Aghagolzade Haji H,Kamali F,Jandaghi P,Hoheisel JD,Manoochehri M

更新日期：2019-01-24 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the most frequently diagnosed cancers and the fourth leading cause of cancer-related death in the United States, suggesting that there is an urgent need to design novel strategies for achieving better treatment outcome of patients diagnosed with PDAC. Our previous stud...

journal_title：Journal of cellular physiology

authors： Wang Z,Ali S,Banerjee S,Bao B,Li Y,Azmi AS,Korc M,Sarkar FH

更新日期：2013-03-01 00:00:00

abstract：:Ascorbic acid induces apoptosis, autophagy, and necrotic cell death in cancer cells. We investigated the mechanisms by which ascorbic acid induces death in laryngeal squamous cell carcinoma Hep2 cells. Ascorbic acid markedly reduced cell viability and induced death without caspase activation and an increase in cytochr...

journal_title：Journal of cellular physiology

authors： Baek MW,Cho HS,Kim SH,Kim WJ,Jung JY

更新日期：2017-02-01 00:00:00

abstract：:Cadmium (Cd) is a toxic metal with multiple effects on cell signaling and cell death. We studied the effects of Cd(2+) on quiescent mouse mesangial cells in serum-free conditions. Cadmium induces cell death over 6 h through annexin V+ states without or with causing uptake of propidium iodide, termed apoptotic and apop...

journal_title：Journal of cellular physiology

authors： Liu Y,Templeton DM

更新日期：2008-11-01 00:00:00

abstract：:Cardiac progenitor cells (CPCs) have the potential to differentiate into several cell lineages with the ability to restore in cardiac tissue. Multipotency and self-renewal activity are the crucial characteristics of CPCs. Also, CPCs have promising therapeutic roles in cardiac diseases such as valvular disease, thrombo...

journal_title：Journal of cellular physiology

authors： Yousefi M,Mamipour M,Sokullu SE,Ghaderi S,Amini H,Rahbarghazi R

更新日期：2019-11-01 00:00:00

abstract：:While dental mesenchymal stem cells are well-studied, the origin of these cells is still unclear. Bone marrow-derived cells (BMDCs) have the potential to engraft into several tissues after injury, but whether they can become dental tissue-specific progenitor cells under normal conditions and the relationship of these ...

journal_title：Journal of cellular physiology

authors： Zhou J,Shi S,Shi Y,Xie H,Chen L,He Y,Guo W,Wen L,Jin Y

更新日期：2011-08-01 00:00:00

abstract：:Stem cells are a unique class of cells that are capable of self-renewal and differentiation into multiple lineages. An increasing number of studies have suggested that both embryonic and adult stem cells possess primary cilia, antenna-like structures protruding from cell surfaces that are critical for sensing and tran...

journal_title：Journal of cellular physiology

authors： Lyu R,Zhou J

更新日期：2017-05-01 00:00:00

abstract：:Osteoblasts are the main functional cells of bone formation, and they are responsible for the synthesis, secretion, and mineralization of the bone matrix. Phosphatidylinositol-3-kinase/Akt is an important signaling pathway involved in the regulation of cell proliferation, death, and survival. Some studies have shown t...

journal_title：Journal of cellular physiology

authors： Bai Y,Zhang Q,Chen Q,Zhou Q,Zhang Y,Shi Z,Nong H,Liu M,Zeng G,Zong S

更新日期：2020-12-30 00:00:00

abstract：:Resistin, secreted by macrophages in tumor microenvironment, has never been investigated in pancreatic cancer models, despite a vibrant tumor microenvironment around pancreatic tumors. We evaluated serum resistin levels in healthy individuals versus pancreatic cancer patients representing different tumor grades. In vi...

journal_title：Journal of cellular physiology

authors： Zhang M,Yan L,Wang GJ,Jin R

更新日期：2019-06-01 00:00:00

abstract：:Rap1 is a small GTP-binding protein (SMG) that exists in two 95% homologous isoforms, rap1A and rap1B. The functions of the rap1 proteins are not well understood. In this report we examined expression and function of rap1 in primary (HOKs) and immortalized (IHOKs) human oral keratinocytes under different growth condit...

journal_title：Journal of cellular physiology

authors： D'Silva NJ,Mitra RS,Zhang Z,Kurnit DM,Babcock CR,Polverini PJ,Carey TE

更新日期：2003-09-01 00:00:00

abstract：:Epithelial Cell Adhesion Molecule (EpCAM), or CD326, is a trans-membrane glycoprotein expressed by multiple normal epithelia as well as carcinoma. Human hepatic stem cells and bile duct epithelium of the liver are EpCAM positive. In tumor cell lines, its intracellular domain can be released after cleavage of the extra...

journal_title：Journal of cellular physiology

authors： Gerlach JC,Foka HG,Thompson RL,Gridelli B,Schmelzer E

更新日期：2018-06-01 00:00:00

abstract：:Methylxantine derivative, caffeine, is known to prevent the p53-dependent apoptosis pathway via inhibition of ATM (ataxia telangiectasia mutated) kinase, which activates p53 by phosphorylation of the Ser-15 residue. In contrast, it has been reported that caffeine induces p53-mediated apoptosis through Bax protein in n...

journal_title：Journal of cellular physiology

authors： Ito K,Nakazato T,Miyakawa Y,Yamato K,Ikeda Y,Kizaki M

更新日期：2003-08-01 00:00:00

abstract：:Cell-extracellular matrix interaction plays a major role in maintaining the structural integrity of connective tissues and sensing changes in the biomechanical environment of cells. Collagen VI is a widely expressed non-fibrillar collagen, which regulates tissues homeostasis. The objective of the present investigation...

journal_title：Journal of cellular physiology

authors： Sardone F,Traina F,Tagliavini F,Pellegrini C,Merlini L,Squarzoni S,Santi S,Neri S,Faldini C,Maraldi N,Sabatelli P

更新日期：2014-07-01 00:00:00

abstract：:Nucleotides released during heart injury affect myocardium electrophysiology and remodeling through P2 purinoceptors activation in cardiac myofibroblasts. ATP and UTP endorse [Ca2+ ]i accumulation and growth of DDR-2/α-SMA-expressing myofibroblasts from adult rat ventricles via P2Y4 and P2Y2 receptors activation, resp...

journal_title：Journal of cellular physiology

authors： Certal M,Vinhas A,Barros-Barbosa A,Ferreirinha F,Costa MA,Correia-de-Sá P

更新日期：2017-06-01 00:00:00

abstract：:We have previously reported that the proliferation of cloned MCF-7 and T47D human mammary tumor cells can be inhibited by increasing concentrations of charcoal-dextran stripped female human serum (CDFHS). The maximal proliferation rate was restored by the addition of 3 X 10(-11) M estradiol-17 beta to the culture medi...

journal_title：Journal of cellular physiology

authors： Schatz RW,Soto AM,Sonnenschein C

更新日期：1985-09-01 00:00:00

abstract：:The insulin-like growth factors (IGFs) are potent mitogens for malignant cell proliferation. The majority of secreted IGFs are bound to specific IGF-binding proteins (IGFBPs) that are secreted by a large number of cells. These proteins may either inhibit or enhance IGF actions. Breast carcinoma cells secrete a variety...

journal_title：Journal of cellular physiology

authors： Chen JC,Shao ZM,Sheikh MS,Hussain A,LeRoith D,Roberts CT Jr,Fontana JA

更新日期：1994-01-01 00:00:00

abstract：:Copper, an essential trace element, can be toxic to some cells when present in excess. But thorough investigations into the cytotoxicity of copper and subsequent molecular mechanisms are rare, although the cytotoxicity of copper has been applied to cancer chemotherapy. The present study demonstrates that Cu(2+) inhibi...

journal_title：Journal of cellular physiology

authors： Zhai Q,Ji H,Zheng Z,Yu X,Sun L,Liu X

更新日期：2000-08-01 00:00:00

abstract：:Oral administration of ajulemic acid (AjA), a cannabinoid acid devoid of psychoactivity, prevents joint tissue injury in rats with adjuvant induced arthritis. Because activation of osteoclasts is central to the pathogenesis of bone erosion in patients with rheumatoid arthritis (RA), we investigated the influence of Aj...

journal_title：Journal of cellular physiology

authors： George KL,Saltman LH,Stein GS,Lian JB,Zurier RB

更新日期：2008-03-01 00:00:00

abstract：:Gicerin/CD146 is a cell adhesion molecule, which belongs to the immunoglobulin (Ig) superfamily. We have reported that it has a homophilic binding activity, which participates in the neurite extension from embryonic neurons. To elucidate how gicerin is involved in the neurite extension mechanism, we employed PC12 cell...

journal_title：Journal of cellular physiology

authors： Taira E,Kohama K,Tsukamoto Y,Okumura S,Miki N

更新日期：2005-08-01 00:00:00

abstract：:Recent findings point to low oxygen tension (hypoxia) as an important mechanism for the expression of several eukaryotic genes. We have previously shown that hypoxia (2% O2), when compared to standard oxygen tension (20% O2), upregulates the mRNA levels of the human alpha1(I) (COL1A1) procollagen gene and transforming...

journal_title：Journal of cellular physiology

authors： Falanga V,Zhou L,Yufit T

更新日期：2002-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) is a small molecule (19-25 nucleotide) noncoding RNA that inhibits the expression of target messenger RNA (mRNA) at the posttranscriptional level as an endogenous regulator. There is an increasing evidence that miR-199a-3p has a significant effect on the development of multiple tumors. However, the ...

journal_title：Journal of cellular physiology

authors： Chen HP,Wen J,Tan SR,Kang LM,Zhu GC

更新日期：2019-12-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is the most common type of leukemia in adults. AML cells secrete angiogenic factors to remodel vasculature and acquire chemoresistance; however, antiangiogenic drugs are often ineffective in AML treatment. Cancer cell-derived exosomes can induce angiogenesis, but their role in vascular rem...

journal_title：Journal of cellular physiology

authors： Wang B,Wang X,Hou D,Huang Q,Zhan W,Chen C,Liu J,You R,Xie J,Chen P,Huang H

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:This study aims to investigate the effect of polo-like kinase 1 (PLK1) inhibition on cisplatin (DDP)-resistant gastric cancer (GC) cells. METHODS:The transcriptional level of PLK1 was measured by quantitative reverse-transcription polymerase chain reaction. Expressions of PLK1 and its downstream mediators as...

journal_title：Journal of cellular physiology

authors： Chen Z,Chai Y,Zhao T,Li P,Zhao L,He F,Lang Y,Qin J,Ju H

更新日期：2019-05-01 00:00:00

abstract：:Studies were conducted to explore hormonal and nutritional factors that might be involved in the regulation of retinol-binding protein (RBP) synthesis and secretion by the liver. The studies employed primary cultures of hepatocytes from normal rats. When cells were cultured in Dulbecco's modified Eagle's medium alone,...

journal_title：Journal of cellular physiology

authors： Dixon JL,Goodman DS

更新日期：1987-01-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have been shown to have critical regulatory roles in tumorigenesis. lncRNA LINC01561 (LINC01561) is a newly identified tumor-related lncRNA and its dysregulation has been demonstrated in several tumors. However, whether LINC01561 is involved in the progression of non-small-cell lung carci...

journal_title：Journal of cellular physiology

authors： Gao W,Qi CQ,Feng MG,Yang P,Liu L,Sun SH

更新日期：2020-10-01 00:00:00

abstract：:The polyphenolic compounds curcumin and quercetin increased sensitivity of ovarian cancer cells (CAOV3 and SKOV3) to cisplatin. The effect was obtained when the compounds were added simultaneously with cisplatin, as well as when they were added 24 h before. High serum levels of certain cytokines, for example interleuk...

journal_title：Journal of cellular physiology

authors： Chan MM,Fong D,Soprano KJ,Holmes WF,Heverling H

更新日期：2003-01-01 00:00:00

abstract：:When calcium is removed from culture medium, motility of cultured cells is decreased. The effect is rapid, reversible and pronounced. Decreased motility is observed with normal mouse Balb/c 3T3 cells, mouse L929 cells, rat kidney fibroblasts and chick embryo fibroblasts. The calcium dependence of movement can be obser...

journal_title：Journal of cellular physiology

authors： Moore L,Pastan I

更新日期：1979-10-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) in the tumor microenvironment play major roles in supporting cancer progression. A previous report showed that SPIN90 downregulation is correlated with CAF activation and that SPIN90-deficient CAFs promote breast cancer progression. However, the mechanisms that mediate cancer-strom...

journal_title：Journal of cellular physiology

authors： Kwon A,Chae IH,You E,Kim SH,Ahn SY,Lee OJ,Park ZY,Rhee S,Huh YH,Song WK

更新日期：2020-05-01 00:00:00

abstract：:Various types of anesthesia are being utilized to maintain physiologically secured surgical conditions. Nearly all categories of general anesthesia are characterized by various perioperative and postoperative complications. These shortcomings are important aspects that need to be considered by the anesthesiologist and...

journal_title：Journal of cellular physiology

authors： Alizadeh R,Fard ZA

更新日期：2019-08-01 00:00:00

abstract：:HeLa (substrain Ho) grown in serum free medium showed an increase in the specific activity of alkaline phosphatase when fetal calf serum (10%) was added to the medium (9.7 nmoles/sec/mg protein to 86.8). Under the same conditions, eight intracellular enzymes showed no increase in activity. Similar results were obtaine...

journal_title：Journal of cellular physiology

authors： Carlson CW

更新日期：1979-01-01 00:00:00