Regulation of albumin expression in fetal rat hepatocytes cultured under proliferative conditions: role of epidermal growth factor and hormones.

abstract：:Focal adhesion kinase (FAK), MAP kinases and the nuclear transcription factor Elk-1 have been reported to be implicated in the same cellular processes, however, their direct or indirect interaction and potential function(s) has not been documented. Here, we explored the association of FAK with Elk-1, the implication o...

journal_title：Journal of cellular physiology

authors： Mamali I,Kotsantis P,Lampropoulou M,Marmaras VJ

更新日期：2008-07-01 00:00:00

abstract：:Hepatic sinusoidal Ito cells have the capacity to produce interstitial collagen types I and III as well as other matrix proteins and may be involved in hepatic fibrogenesis. Transforming growth factor beta (TGF beta) responsiveness was evaluated during in vitro cell culture, since increasing evidence suggests that thi...

journal_title：Journal of cellular physiology

authors： Davis BH

更新日期：1988-09-01 00:00:00

abstract：:Membrane vesicles derived principally from the plasma membrane and endoplasmic reticulum of mouse 3T3 cells transformed by Simian virus 40 take up alpha-aminoisobutyric acid (AIB) and phosphate (Pi). When NaCl is added simultaneously with AIB or Pi, uptake rises two- to three-times above the equilibrium to accumulate ...

journal_title：Journal of cellular physiology

authors： Nilsen-Hamilton M,Hamilton RT

更新日期：1976-12-01 00:00:00

abstract：:Parkinson's disease (PD) is one of the most common movement disorders with loss of dopaminergic neurons and the presence of Lewy bodies in certain brain areas. However, it is not clear how Lewy body (inclusion with protein aggregation) formation occurs. Mutations in leucine-rich repeat kinase 2 (LRRK2) can cause a gen...

journal_title：Journal of cellular physiology

authors： Thomas JM,Wang X,Guo G,Li T,Dai B,Nucifora LG,Nucifora FC Jr,Liu Z,Xue F,Liu C,Ross CA,Smith WW

更新日期：2020-10-01 00:00:00

abstract：:Mitochondrial (mt) dysfunction and oxidative stress are involved in the pathogenesis of ischemia/reperfusion (I/R)-injury. Lycopene, a lipophilic antioxidant found mainly in tomatoes and in other vegetables and fruits, can protect mtDNA against oxidative damage. However, the role of mtDNA in myocardial I/R-injury is u...

journal_title：Journal of cellular physiology

authors： Yue R,Xia X,Jiang J,Yang D,Han Y,Chen X,Cai Y,Li L,Wang WE,Zeng C

更新日期：2015-09-01 00:00:00

abstract：:Vimentin-positive, desmin-negative cells were established in culture from the nodule and from apparently normal palmar aponeurosis of a patient with Dupuytren's disease and compared with normal human embryonic and adult fibroblasts or sarcomatous cells. Cells from the nodule display in vitro biological properties that...

journal_title：Journal of cellular physiology

authors： Azzarone B,Failly-Crepin C,Daya-Grosjean L,Chaponnier C,Gabbiani G

更新日期：1983-12-01 00:00:00

abstract：:Control of the terminal event in cellular differentiation is an important normal regulatory process, and the expression of defects in the control of this process has been implicated in the pathogenesis of cancer. To determine if tumor necrosis factor (TNF), which is an important biological response modifier, can inhib...

journal_title：Journal of cellular physiology

authors： Filipak M,Sparks RL,Tzen CY,Scott RE

更新日期：1988-11-01 00:00:00

abstract：:The C3H/10T 1/2 embryo cell line, which is nontumorigenic when inoculated subcutaneously in saline suspension, produces tumors when implanted subcutaneously attached to 1 X 5 X 10 mm plastic plates. Under these in vivo conditions there is direct selection for "spontaneous" transformants that have undergone the specifi...

journal_title：Journal of cellular physiology

authors： Paranjpe M,del Ande Eaton S,Boone CW

更新日期：1978-07-01 00:00:00

abstract：:Uptake and phosphorylation of externally supplied [3H]-thymidine are fully stimulated in fertilized sea urchin eggs exposed to 5.0 micrograms/ml aphidicolin. As in untreated controls, the rate of uptake in aphidicolin-treated eggs increases greater than 50-fold shortly after fertilization, and greater than 85% of the ...

journal_title：Journal of cellular physiology

authors： Nishioka D,Killian CE,Chacon CT,Sgagias MK

更新日期：1984-01-01 00:00:00

abstract：:Wound healing is critically affected by age, ischemia, and growth factors such as TGFbeta1. The combined effect of these factors on fibroblast migration, an essential component of wound healing, is poorly understood. To address this deficiency, we examined expression of TGFbeta receptor type I and II (TGFbetaRI and RI...

journal_title：Journal of cellular physiology

authors： Mogford JE,Tawil N,Chen A,Gies D,Xia Y,Mustoe TA

更新日期：2002-02-01 00:00:00

abstract：:Tumor suppressor pRb2/p130 gene belongs to the retinoblastoma (Rb) gene family, which also includes pRb/p105 and pRb/p107. The members of the Rb gene family have attracted a great deal of interest because of their essential role in regulating cell cycle and, consequently, cell proliferation. This mini review discusses...

journal_title：Journal of cellular physiology

authors： Giordano A,Rossi A,Romano G,Bagella L

更新日期：2007-11-01 00:00:00

abstract：:Nucleotides released from cells due to stress, injury or inflammation, induce mitogenic effects in monocytes via activation of P2Y(2) nucleotide receptors (P2Y(2)Rs). Here we show that P2Y(2) nucleotide receptors in U937 monocytic cells regulate the activation of extracellular signal-regulated kinases 1 and 2 (ERK 1/2...

journal_title：Journal of cellular physiology

authors： Chorna NE,Chevres M,Santos-Berrios C,Orellano EA,Erb L,González FA

更新日期：2007-05-01 00:00:00

abstract：:Cellular growth has been found to be directly related to the amount of sodium pumping activity in mouse lymphoblasts (L5178-Y) cultured in varying concentrations of the cardiac glycoside, ouabain. No short-term adaptation (within one generation) occured; i.e., neither growth rate nor (Na+ + K+)-ATPase activity increas...

journal_title：Journal of cellular physiology

authors： Shank BB,Smith NE

更新日期：1976-03-01 00:00:00

abstract：:An increasing body of evidence shows that many of the key inositol lipids and enzymes responsible for their metabolism reside in nuclei. Moreover, the association of the nuclear phosphoinositide cycle with progression through the cell cycle and commitment toward differentiation has built a wider picture of the implica...

journal_title：Journal of cellular physiology

authors： Maraldi NM,Zini N,Santi S,Manzoli FA

更新日期：1999-11-01 00:00:00

abstract：:Cells isolated from fetal rat calvaria (RC) and maintained in vitro in medium containing ascorbic acid and B-glycerophosphate form three-dimensional, mineralized nodules having the histological, immunohistological, and ultrastructural characteristics of woven bone. We have studied the effects of forskolin (FSK), a dit...

journal_title：Journal of cellular physiology

authors： Turksen K,Grigoriadis AE,Heersche JN,Aubin JE

更新日期：1990-01-01 00:00:00

abstract：:Cytoskeleton not only controls cell morphology but also regulates cell growth, migration, differentiation, and gene expression, events which are fundamental to embryogenesis, carcinogenesis, and wound healing. We have recently reported that reorganization of cytoskeleton induces expression of mRNA for transforming gro...

journal_title：Journal of cellular physiology

authors： Varedi M,Ghahary A,Scott PG,Tredget EE

更新日期：1997-08-01 00:00:00

abstract：:Obesity is a risk factor for endometrial cancer in pre- and post-menopausal women. Leptin, an adipocyte-derived hormone, in addition to the control weight homeostasis, is implicated in multiple biological actions. A recent study demonstrated that leptin promotes endometrial cancer growth and invasiveness through STAT/...

journal_title：Journal of cellular physiology

authors： Catalano S,Giordano C,Rizza P,Gu G,Barone I,Bonofiglio D,Giordano F,Malivindi R,Gaccione D,Lanzino M,De Amicis F,Andò S

更新日期：2009-03-01 00:00:00

abstract：:Prkdc encodes for the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs) playing a key role in nonhomologous end joining pathway during DNA double-strand break repair and also influencing the homologous recombination (HR) repair system by phosphorylation of proteins involved in HR. In addition, Prkdc has...

journal_title：Journal of cellular physiology

authors： Soleimani F,Babaei E,H Feizi MA,Fathi F

更新日期：2020-04-01 00:00:00

abstract：:Previously we showed a rapid and transient inhibition of gap junctional communication (GJC) by platelet-derived growth factor (PDGF) in T51B rat liver epithelial cells expressing wild-type platelet-derived growth factor beta receptors (PDGFrbeta). This action of PDGF correlated with the hyperphosphorylation of the gap...

journal_title：Journal of cellular physiology

authors： Hossain MZ,Ao P,Boynton AL

更新日期：1998-08-01 00:00:00

abstract：:Hair follicle stem cells (HFSCs) are able to differentiate into neurons and glial cells. Distinct microRNAs (miRNAs) regulate the proliferation and differentiation of HFSCs. However, the exact role of miR-124 in the neural differentiation of HFSCs has not been elucidated. HFSCs were isolated from mouse whisker follicl...

journal_title：Journal of cellular physiology

authors： Mokabber H,Najafzadeh N,Mohammadzadeh Vardin M

更新日期：2019-06-01 00:00:00

abstract：:Irritable bowel syndrome (IBS) is a prolonged and disabling functional gastrointestinal disorder with the incidence rate of 18% in the world. IBS could seriously affect lifetime of patients and cause high economic burden on the community. The pathophysiology of the IBS is hardly understood, whereas several possible me...

journal_title：Journal of cellular physiology

authors： Shariati A,Fallah F,Pormohammad A,Taghipour A,Safari H,Chirani AS,Sabour S,Alizadeh-Sani M,Azimi T

更新日期：2019-06-01 00:00:00

abstract：:To study the role of noncollagenous proteins in bone formation, the synthesis and tissue distribution of BSP (bone sialoprotein), OPN (osteopontin) and SPARC (secreted protein acidic and rich in cysteine) were analyzed using pulse-chase and continuous labeling protocols during bone formation by cultures of rat calvari...

journal_title：Journal of cellular physiology

authors： Kasugai S,Nagata T,Sodek J

更新日期：1992-09-01 00:00:00

abstract：:Serine racemase (SR) is responsible for the biosynthesis of D-serine (D-Ser), an endogenous co-agonist for the glycine (Gly)-binding site on N-methyl-D-aspartate (NMDA) receptors, from L-Ser in the brain. We have previously demonstrated high expression of SR by chondrocytes in cartilage. In this study, we attempted to...

journal_title：Journal of cellular physiology

authors： Takarada T,Takahata Y,Iemata M,Hinoi E,Uno K,Hirai T,Yamamoto T,Yoneda Y

更新日期：2009-09-01 00:00:00

abstract：:The physiological approach suggests that an environment associating the mesenchymal stromal cells (MSC) and low O(2) concentration would be most favorable for the maintenance of hematopoietic stem cells (HSCs) in course of ex vivo expansion of hematopoietic grafts. To test this hypothesis, we performed a co-culture of...

journal_title：Journal of cellular physiology

authors： Hammoud M,Vlaski M,Duchez P,Chevaleyre J,Lafarge X,Boiron JM,Praloran V,Brunet De La Grange P,Ivanovic Z

更新日期：2012-06-01 00:00:00

abstract：:Stimulation of amiloride-sensitive sodium (Na+) influx and the subsequent activation of NA+, K+-ATPase by serum or growth factors have been implicated as early events leading to initiation of cell proliferation. We recently demonstrated that amiloride inhibits thrombin-initiated DNA synthesis not by inhibiting an earl...

journal_title：Journal of cellular physiology

authors： Stiernberg J,Carney DH,Fenton JW 2nd,LaBelle EF

更新日期：1984-09-01 00:00:00

abstract：:Proteinuria in diabetic nephropathy has been correlated with reduction in heparan sulfate proteoglycan (HSPG) content of the glomerular basement membrane. We have previously shown that the underlying mechanism probably involves reduction in the synthesis by glomerular epithelial cells. In this study we explored whethe...

journal_title：Journal of cellular physiology

authors： Kasinath BS,Grellier P,Choudhury GG,Abboud SL

更新日期：1996-04-01 00:00:00

abstract：:These are the reflections of a retired physician who was introduced to cellular physiology in 1947 at the University of Pennsylvania. I majored in Zoology. I took the required major courses, which were interesting but not exciting. I was a premedical student at the time. Fortunately I was introduced to cellular physio...

journal_title：Journal of cellular physiology

authors： Perelman A

更新日期：2015-11-01 00:00:00

abstract：:The nuclear Ki-67 protein (pKi-67) has previously been shown to be exclusively expressed in proliferating cells. As a result, antibodies against this protein are widely used as prognostic tools in cancer diagnostics. Here we show, that despite the strong downregulation of pKi-67 expression in non-proliferating cells, ...

journal_title：Journal of cellular physiology

authors： Bullwinkel J,Baron-Lühr B,Lüdemann A,Wohlenberg C,Gerdes J,Scholzen T

更新日期：2006-03-01 00:00:00

abstract：:The purpose of this study was to investigate the potential mechanism of interleukin-6 (IL-6) on the stimulation of excessive androgen secretion in human NCI-H295R adrenocortical cells. We performed transcriptome sequencing of cancer and paracancerous tissues obtained from functional adrenal cortical adenomas. The secr...

journal_title：Journal of cellular physiology

authors： Wei X,Zhang J,Peng W,Xu H,Wei Z,Pang L,Liu J,Wang T

更新日期：2020-12-01 00:00:00

abstract：:Intratympanic injection of gentamicin has proven to be an effective therapy for intractable vestibular dysfunction. However, most studies to date have focused on the cochlea, so little is known about the distribution and uptake of gentamicin by the counterpart of the auditory system, specifically vestibular hair cells...

journal_title：Journal of cellular physiology

authors： Qian X,He Z,Wang Y,Chen B,Hetrick A,Dai C,Chi F,Li H,Ren D

更新日期：2020-12-23 00:00:00