Abstract：
:Hepatic sinusoidal Ito cells have the capacity to produce interstitial collagen types I and III as well as other matrix proteins and may be involved in hepatic fibrogenesis. Transforming growth factor beta (TGF beta) responsiveness was evaluated during in vitro cell culture, since increasing evidence suggests that this ubiquitous polypeptide can stimulate the production of collagenous proteins in a variety of cell types. TGF beta induced marked inhibition of Ito cell proliferation for cells grown on either a type I or a type IV collagen matrix. In marked contrast, the collagen synthetic response was considerably different for cells grown on a type I versus a type IV collagen matrix. When cells were grown on a type I collagen matrix, TGF beta caused a significant increase in the accumulation of collagen type I and III. When Ito cells were grown on a type IV collagen matrix, there was no stimulation of collagen production. TGF beta responsiveness was also evaluated in the setting of altered vitamin A concentrations. Freshly isolated Ito cells are engorged with vitamin A, the usual physiologic storage site for hepatic vitamin A. During in vitro culture and during in vivo fibrogenesis, Ito cells lose their vitamin A stores coincident with a transformation to a collagen-producing myofibroblast-like cell. When cultured Ito cells were grown on a type I collagen matrix and re-exposed to an increased concentration of vitamin A, the production of interstitial collagen was reduced. However, when the vitamin A-enriched Ito cells were exposed to TGF beta, the production of interstitial collagen was increased, similar to cells that had not received vitamin A.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Davis BHdoi
10.1002/jcp.1041360323subject
Has Abstractpub_date
1988-09-01 00:00:00pages
547-53issue
3eissn
0021-9541issn
1097-4652journal_volume
136pub_type
杂志文章abstract：:Despite the advantages of transplantation of umbilical cord blood's (UCB's) hematopoietic stem cells (uHSCs) for hematologic malignancy treatment, there are two major challenges in using them: (a) Insufficient amount of uHSCs in a UCB unit; (b) a defect in uHSCs homing to bone marrow (BM) due to loose binding of their...
journal_title：Journal of cellular physiology
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journal_title：Journal of cellular physiology
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更新日期：2006-08-01 00:00:00
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更新日期：2019-08-01 00:00:00
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journal_title：Journal of cellular physiology
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更新日期：2018-12-01 00:00:00
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更新日期：2019-05-01 00:00:00
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journal_title：Journal of cellular physiology
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4652(199605)167:2<204::AID-JCP3
更新日期：1996-05-01 00:00:00
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journal_title：Journal of cellular physiology
pub_type： 杂志文章
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更新日期：2019-12-01 00:00:00
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journal_title：Journal of cellular physiology
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4652(199607)168:1<155::AID-JCP1
更新日期：1996-07-01 00:00:00
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更新日期：2020-09-23 00:00:00
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journal_title：Journal of cellular physiology
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4652(199810)177:1<1::AID-JCP1>3
更新日期：1998-10-01 00:00:00
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journal_title：Journal of cellular physiology
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更新日期：1995-04-01 00:00:00
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更新日期：1992-03-01 00:00:00
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更新日期：1979-12-01 00:00:00
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更新日期：2000-08-01 00:00:00
abstract：:During the early period after poliovirus infection of HeLa cells, cellular Na+/K+ ATPase activity is transiently activated. We investigated the possibility that Na+/K+ ATPase activation is a consequence of Na+/H+ antiporter activation. Increased uptake of the weak organic acid 5,5-dimethyloxazolidine-2,4-dione by infe...
journal_title：Journal of cellular physiology
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更新日期：1990-03-01 00:00:00
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journal_title：Journal of cellular physiology
pub_type： 杂志文章
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更新日期：1989-12-01 00:00:00
abstract：:This study is performed to examine the impacts of microRNA-218 (miR-218) on cardiac microvascular endothelial cells (CMECs) injury induced by coronary artery disease (CAD). Reverse-transcription quantitative polymerase chain reaction (RT-qPCR) was applied for detecting miR-218 expression in serum of patients with CAD ...
journal_title：Journal of cellular physiology
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更新日期：2020-03-01 00:00:00
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journal_title：Journal of cellular physiology
pub_type： 杂志文章,评审
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更新日期：2019-12-01 00:00:00
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journal_title：Journal of cellular physiology
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更新日期：1977-04-01 00:00:00
abstract：:We report that cultured vascular endothelial cells release into the culture medium a vasoconstrictor peptide, a substance we call an endothelium-derived constricting factor (EDCF). Conditioned medium from cultured bovine aortic and pulmonary artery endothelial cells caused sustained, dose-dependent isometric constrict...
journal_title：Journal of cellular physiology
pub_type： 杂志文章
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更新日期：1987-08-01 00:00:00
abstract：:The cells of the bone marrow microenvironment are emerging as important contributors and regulators of normal hematopoiesis. This microenvironment is perturbed during leukemogenesis, and evidence points toward a bidirectional communication between leukemia cells and the normal cells of the bone marrow, mediated by dir...
journal_title：Journal of cellular physiology
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更新日期：2019-11-01 00:00:00
